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The strong temperature dependence of the contribution of nitrogen to diamond growth enhancement by microwave plasma chemical vapor deposition (MPCVD) have been firstly reported and systematically studied. Generally, an enhanced hydrogen desorption from the growing surface induced by the incorporated nitrogen atoms in diamond sublayer has been successfully used to explain the weak temperature depended growth enhancement of diamond by nitrogen addition, but cannot be employed to explain the observed strong temperature dependence of nitrogen contribution to diamond growth enhancement observed in this work. This indicates a significant change of surface kinetics of diamond growth induced by nitrogen addition should be occurred around 700 °C where a maximum value achieved. At this relative low temperature, the growing surface sites should be almost fully covered with hydrogen atoms with relative low nitrogen incorporated in the diamond. The adsorbed nitrogen may then make a contribution to promote hydrogen desorption, which is believed to play a dominant role in affecting the contribution of nitrogen. Experimental and calculation results do show that both the nitrogen adsorbed on the growing surface and incorporated in the sublayer may have different contribution to the growth rate enhancement, resulting in strong and weak temperature dependence, respectively. [Display omitted] [ABSTRACT FROM AUTHOR]

Silicon vacancies in diamond, one of the most promising single photon sources, is difficult to be achieved in a controlled and reproducible way due to complicated doping behavior of silicon in diamond by microwave plasma CVD. In this work, the underneath mechanism of silicon vacancies formed by unintentional silicon (The silicon source is SiO 2 from the microwave plasma CVD quartz window) doping in diamond was investigated from the view of growing surface kinetics through a series of experiments. During deposition, the addition of N 2 to the CH 4 -H 2 reaction gas mixture is beneficial to the formation of silicon vacancies in diamond from unintentional silicon doping, and the addition of a minor amount of oxygen will enhance the plasma etching. The increased number of the dangling bonds is beneficial to the formation of silicon vacancies and nitrogen vacancies in diamond, while excessive oxygen will passivation the dangling bonds and thus inhibit the formation of vacancies. Finally, the vertical distributions of the surface topography, growth rate, intensity of photoluminescence of NV and SiV color centers doped in the diamond film, are measured with high spatial resolution on growth surface, which are also related to the plasma electron temperature and density. These findings are of importance for searching of optimal growth regimes of NV and SiV doped single crystals by microwave plasma CVD. • The addition of nitrogen to the growth gas is beneficial to the formation of SiV−. • A minor amount of oxygen promotes while excessive oxygen inhibits the formation of NV− and SiV−. • The growth and distribution of NV− and SiV− in diamonds are related to the plasma on the surface of the substrate. [ABSTRACT FROM AUTHOR]

Rapid urbanization has made road construction and maintenance imperative, but detecting road diseases has been time-consuming with limited accuracy. To overcome these challenges, we propose an efficient YOLOv7 road disease detection model. Our approach involves integrating MobilieNetV3 as the backbone feature extraction network to reduce the network's parameters and computational requirements. Additionally, we introduce the BRA attention module into the spatial pyramid pooling module to eliminate redundant information and enhance the network's feature representation capability. Moreover, we utilize the F-ReLU activation function in the backbone network, expanding the convolutional layers' receptive field range. To optimize the model's boundary loss, we employ the Wise-IoU loss function, which places more emphasis on the quality of ordinary samples and enhances the overall performance and generalization ability of the network. Experimental results demonstrate that our improved detection algorithm achieves a higher recall rate and mean average precision (mAP) on the public dataset (RDD) and the NJdata dataset in Nanjing's urban area. Specifically, compared to YOLOv7, our model increases the recall rate and mAP on RDD by 3.3% and 2.6%, respectively. On the NJdata dataset, our model improves the recall rate and mAP by 1.9% and 1.3%, respectively. Furthermore, our model reduces parameter and computational requirements by 30% and 22.5%, respectively, striking a balance between detection accuracy and speed. In conclusion, our road disease detection model presents an effective solution to address the challenges associated with road disease detection in urban areas. It offers improved accuracy, efficiency, and generalization capabilities compared to existing models. [ABSTRACT FROM AUTHOR]

The injectable micro-nano hydrogel we developed can be administered into articular cavities using a minimally invasive puncture needle. It undergoes degradation facilitated by MMP13, leading to the controlled release of celecoxib. This property effectively mitigates the inflammatory response and precisely reverses the OA process. [Display omitted] • The significance of MMP13 in osteoarthritis precise interventions was discussed. • Adapting to inflammatory levels and MMP13 changes, the microsphere achieves a responsive release of celecoxib. • This controllable drug delivery system holds promise for precise therapeutic interventions in diverse degenerative diseases. Osteoarthritis (OA) is characterized by cartilage degradation, inflammatory responses, and osteophyte formation. Matrix metalloproteinase 13 (MMP13) is a hallmark of OA development, and increased MMP13 expression is closely associated with extracellular matrix degradation. MMP13 expression varies significantly at different stages of OA progression. While cyclooxygenase 2 (COX-2) inhibitors are commonly used to treat OA, their long-term systemic administration increases the risks of adverse effects. Therefore, with the aim of achieving localized and responsive delivery of the COX-2 inhibitor celecoxib, the current study investigated an innovative MMP13-responsive micro-nano hydrogel microsphere system. Celecoxib-loaded cationic liposomes are non-covalently attached within the microsphere, enabling controlled drug release for OA treatment. In an OA environment with elevated MMP13 expression, the system is degraded via the action of MMP13 substrate peptide (MMP13sp), facilitating accelerated release of drug-loaded liposomes to improve the inflammatory microenvironment and treat OA rapidly. Compared to a phosphate-buffered saline solution with hyaluronidase (HAase), the prepared hyaluronic acid methacrylate microspheres HAMA/MMP13sp/Lipo@celecoxib exhibited rapid degradation in a solution containing a physiological concentration of MMP13/HAase, demonstrating specific enzyme responsiveness for precise anti-inflammatory drug release. The MMP13-responsive hydrogel microsphere system achieves intelligent and controllable drug release in OA, effectively decelerating disease progression and promoting articular cartilage repair. [ABSTRACT FROM AUTHOR]