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A letter to the editor discusses a study on the effectiveness of combining platelet-rich plasma (PRP) with supervised exercise for knee osteoarthritis. The authors highlight the importance of considering participants' baseline activity levels and prior medication use in such studies to ensure accurate results. They suggest further research on combining different treatments, like hyaluronic acid injections, to improve outcomes for patients with knee osteoarthritis. The study provides valuable data but could benefit from more detailed analysis and consideration of various treatment modalities for a more comprehensive understanding of managing knee osteoarthritis. [Extracted from the article]