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This study aimed to investigate the long-term clinical outcomes and toxicities of induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) vs. CCRT alone in patients with non-operable esophageal squamous cell carcinoma (ESCC).

This article summarized the Traditional Chinese Medicine nursing practice of a case of type 2 diabetes with hypertension during hospitalization. On the basis of western medicine treatment, the intervention was carried out in combination with Traditional Chinese Medicine nursing techniques such as auricular acupoint pressing pills, acupoint application, and Traditional Chinese medicine cream and rubbing, which fully played the characteristics and advantages of Traditional Chinese Medicine technology, effectively controlled the patient's blood pressure and blood glucose, and improve the patient's quality of life. (本文总结1例2型糖尿病合并高血压患者的中医特色护理经验。基于护理评估和中医辨证, 在病情监测、饮食指导、药物管理等常规干预基础上, 配合耳穴压丸、穴位贴敷、中药膏摩等中医护理技术进行干预, 有效控制患者血压、血糖, 提高患者生活质量。)

Objective: To study the impact of Tremella polysaccharide on the ameliorative effect of probiotic-fermented camel milk on immunity and intestinal mucosal barrier function in cyclophosphamide (CTX)-induced immunosuppressed mice. Methods: The physicochemical indexes and antioxidant activities of probiotic-fermented camel milk with and without added Tremella polysaccharide were determined. BALB/C mice were randomly divided into four groups: normal (NC), model (MD), probiotic-fermented camel milk (FCM), and probiotic-fermented camel milk with Tremella polysaccharide (FYCM), which were gavaged with 0.2 mL of normal saline, normal saline, FCM, and FYCM for 30 days, respectively. During the last four days, all groups except the NC group were intraperitoneally injected with a daily dose of 60 mg/kg·mb CTX to establish an immunosuppression model. Organ indexes, the proliferation activity of spleen lymphocytes, delayed-type allergic reaction, cytokine and immunoglobulin contents, spleen and jejunum morphology were analyzed. Results: During 21 days of low temperature storage, the pH of FYCM decreased slowly from 4.52 to 4.30, the titratable acidity increased gradually from 95.7 to 124.73 °T, the number of lactic acid bacteria decreased from 9.40 × 109 to 8.38 × 109 CFU/mL, and the water holding capacity decreased from 39.23% to 35.13%. Compared with FCM, the antioxidant capacity of FYCM was significantly improved (P < 0.01). Furthermore, compared with the MD group, FYCM significantly improved organ indexes, spleen lymphocyte proliferation activity and delayed-type hypersensitivity (DTH), upregulated the levels of interleukin (IL)-6, interferon-γ (IFN-γ), immunoglobulin G (IgG), immunoglobulin M (IgM), and secretory immunoglobulin A (sIgA), and repaired spleen and jejunum mucosal structures, and its effect was significantly more pronounced than that of FCM. Conclusion: Probiotic-fermented camel milk incorporated with Tremella polysaccharide has the potential to regulate immune and intestinal mucosal barrier function, thereby having broad application prospects in the functional dairy market.

U-Net and its variants have showcased exceptional performance in the domain of breast medical image segmentation. By employing a fully convolutional network (FCN) structure for semantic segmentation, the symmetrical structure of U-Net offers remarkable flexibility and adaptability. It can be tailored to diverse image segmentation tasks and challenges by adjusting network depth and incorporating new modules, leaving a significant impact on subsequent network designs. This paper aims to delve into the application of U-shaped convolutional networks in breast medical image segmentation, categorizing and summarizing U-shaped convolutional networks used for this purpose in recent years. It outlines the widely used breast medical image datasets and evaluation metrics, discusses common data augmentation techniques, and provides a detailed introduction to the network structure of the U-Net model along with traditional segmentation methods for breast medical images. Furthermore, it summarizes the improvements made to the U-Net network structure for breast medical image segmentation, including modifications like residual structures, multi-scale features, dilation mechanisms, attention mechanisms, skip connection mechanisms, and integration with Transformers. Finally, it addresses the current challenges and problems encountered in breast medical image segmentation and offers insights into future research directions.

[Objective] The soil erosion issue is very prominent in the karst region of southwest China and significantly affects the sustainable development of the regional economy. However, it is currently not very clear how the characteristic environmental factors of karst basins affect the direct driving force of soil erosion and runoff erosivity. [Methods] Taking the Yeji River Basin in the karst region of southwest China as an example and basing on the long-term and high-frequency field measurement data at the outlet hydrological station of the basin, the spatiotemporal change characteristics of runoff erosivity from 2005 to 2020 were evaluated and the influence of main karst environmental factors on runoff erosivity was analyzed by the Soil and Water Assessment Tool (SWAT) and the Partial Least Squares Model (PLSR). [Results] The average annual runoff erosivity was 2 326.47 m4/(km2·s), with strong spatial heterogeneity. In 2005, the high runoff erosivity was mainly distributed in the northern and central parts of the basin. During 2010—2020, the high runoff erosivity area gradually shifted to the central and southern parts of the basin. In terms of time, benefiting from the implementation of ecological restoration projects such as comprehensive control of soil and water loss in sloping farmland and comprehensive control of rocky desertification since the 11th Five-Year Plan, the runoff erosivity of the Yeji River Basin had been generally decreasing year by year. Lithology, exposed bedrock, and slope were the dominant control factors, which jointly explained 57.7% of the spatiotemporal variation of runoff erosivity in the Yeji River Basin. [Conclusion] These results can provide a theoretical reference for the comprehensive control of soil erosion in karst basins and help to formulate more precise and effective policies and measures to improve the ecological environment of the karst area and promote the sustainable development of the region.

To retrospectively analyze the accuracy of radiotherapy using cone beam computed tomography (CBCT), Styrofoam fixation, and breast bracket fixation in the chest wall target area and supraclavicular lymphatic drainage area (supraclavicular target area) of patients with breast cancer.and compare the setting efficiency and comfort satisfaction.