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The combination of reversible angular dispersion-induced microbunching (ADM) and the rapid damping storage ring provides a storage-ring-based light source with the capability to produce longitudinal coherent radiation with a high repetition rate. This paper presents a prototype design for a test facility based on the study by Jiang et al. [Sci. Rep. (2022), 12, 3325]. The modulation-demodulation section is inserted into a long straight section of the storage ring instead of a bypass line, which poses great challenges for the optimization of the nonlinear dynamics of the storage ring. However, this design avoids the challenging injection and extraction system connecting to the bypass line. To utilize mature laser technology and reduce the difficulty of the reversible ADM lattice design, we use a long-wavelength 1030 nm seed laser. In the simulation, we achieved 20th harmonic radiation with a bunching factor of about 7.2%. The growth rate of vertical emittance and energy spread of the electron beam for a single pass are about 11% and 0.02%, respectively. When the energy of the electron beam is 800 MeV and two sets of damping wigglers are employed, the damping time in the vertical plane is reduced to 8.31 ms. This results in a 438 kHz repetition rate of the coherent radiation at the new equilibrium state., (open access.)

Photodynamic therapy (PDT) eliminates cancer cells by converting endogenous oxygen into reactive oxygen species (ROS). However, its efficacy is significantly hindered by hypoxia in solid tumors. Hence, to engineer filamentous fd phage, a human-friendly bacteria-specific virus is proposed, into a nanozyme-nucleating photosensitizer-loaded tumor-homing nanofiber for enhanced production of ROS in a hypoxic tumor. Specifically, Pt-binding and tumor-homing peptides are genetically displayed on the sidewall and tip of the fd phage, respectively. The Pt-binding peptides induced nucleation and orientation of Pt nanozymes (PtNEs) on the sidewall of the phage. The resultant PtNE-coated tumor-homing phage exhibits significantly enhanced sustained catalytic conversion of hydrogen peroxide in hypoxic tumors into O 2 for producing ROS needed for PDT, compared to non-phage-templated PtNE. Density functional theory (DFT) calculations verify the catalytic mechanism of the phage-templated PtNE. After intravenous injection of the PtNE-coated indocyanine green (ICG)-loaded tumor-homing phages into breast tumor-bearing mice, the nanofibers home to the tumors and effectively inhibit tumor growth by the PtNE-enhanced PDT. The nanofibers can also serve as a tumor-homing imaging probe due to the fluorescence of ICG. This work demonstrates that filamentous phage, engineered to become tumor-homing nanozyme-nucleating tumor-hypoxia-relieving nanofibers, can act as cancer-targeting nanozymes with improved catalytic performance for effective targeted PDT., (© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.)