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A novel intercalated nanocomposite of mercapto-modified cellulose/bentonite (LCS-BE-SH) was synthesized by high-speed shearing method in one step at room temperature, and was applied to remove Cd from solution and remediate Cd-contaminated soil. Results revealed that cellulose long-chain molecules have intercalated into bentonite nanolayers and interlayer spacing was increased to 1.411 nm, and grafting –SH groups improved adsorption selectivity, which enabled LCS-BE-SH to have distinct capability of Cd adsorption (q max = 147.21 mg/g). Kinetic and thermodynamics showed that Cd adsorption onto LCS-BE-SH was well fitted by pseudo-second-order and Langmuir adsorption isotherm. Characterizations of the adsorbents revealed that synergistic effect of complexation (e.g., CdS, CdO) and precipitation (e.g., Cd(OH) 2 , CdCO 3) mechanism played a major role in Cd removal. In soil remediation, application of LCS-BE-SH was most effective (67.31 %) in Cd immobilization compared to the control (8.85 %), which reduced exchangeable Cd from 37.03 % to 11.44 %. Meanwhile, soil pH, soil organic matter, available phosphorus, and enzyme activities (catalase, urease, and dehydrogenase) were improved LCS-BE-SH treatment. The main immobilization mechanism in soil included complexation (e.g., CdS, CdO) and precipitation (e.g., Cd(OH) 2 , Cd–Fe-hydroxide). Overall, this work applied a promising approach for Cd removal in aqueous and Cd remediation in soil by using an effective eco-friendly LCS-BE-SH nanocomposites. [Display omitted] • Mercapto-modified cellulose/bentonite intercalated nanocomposite was synthesized. • Cellulose was intercalated into bentonite nanolayers by high-speed shearing methods. • Adsorption selectivity by grafting –SH improved Cd adsorption of nanocomposite. • Such remediation improved Cd immobilization, soil fertility and soil enzyme. • Mechanism of Cd removal in aqueous and remediation of Cd-contaminated soil was revealed. [ABSTRACT FROM AUTHOR]

A new series of thiophenpiperazine amide derivatives as potent dual ligands for the μ-opioid (MOR) and sigma-1 (σ 1 R) receptors are reported. Compound 23 exhibited good affinity to σ 1 R (K i = 44.7 ± 7.05 nM) and high selectivity to σ 2 R. Furthermore, Compound 23 exerted MOR agonism and σ1R antagonism and potent analgesic activity in animal moldes (the abdominal constriction test (ED 50 = 3.83 mg/kg) and carrageenan-induced inflammatory hyperalgesia model (ED 50 = 5.23 mg/kg)). We obtained new dual ligands that might serve as starting points for preparing targeted tools. Furthermore, 23 may be a useful chemical probe for understanding more fully analgesic effects associated with MOR agonism and σ 1 R antagonism. • A series of thiophenpiperazine amide derivatives were synthesised. • The structure activity relationships of the targeted compounds were summarised. • Selected compounds exhibited the desirable potent σ 1 R antagonism and MOR agonism profiles. • The most active compound exerted potent analgesic activity in in vivo animal model. [ABSTRACT FROM AUTHOR]