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Neural network-level changes underlying symptom remission in major depressive disorder (MDD) are often studied from a single perspective. Multimodal approaches to assess neuropsychiatric disorders are evolving, as they offer richer information about brain networks. A FATCAT-awFC pipeline was developed to integrate a computationally intense data fusion method with a toolbox, to produce a faster and more intuitive pipeline for combining functional connectivity with structural connectivity (denoted as anatomically weighted functional connectivity (awFC)). Ninety-three participants from the Canadian Biomarker Integration Network for Depression study (CAN-BIND-1) were included. Patients with MDD were treated with 8 weeks of escitalopram and adjunctive aripiprazole for another 8 weeks. Between-group connectivity (SC, FC, awFC) comparisons contrasted remitters (REM) with non-remitters (NREM) at baseline and 8 weeks. Additionally, a longitudinal study analysis was performed to compare connectivity changes across time for REM, from baseline to week-8. Association between cognitive variables and connectivity were also assessed. REM were distinguished from NREM by lower awFC within the default mode, frontoparietal, and ventral attention networks. Compared to REM at baseline, REM at week-8 revealed increased awFC within the dorsal attention network and decreased awFC within the frontoparietal network. A medium effect size was observed for most results. AwFC in the frontoparietal network was associated with neurocognitive index and cognitive flexibility for the NREM group at week-8. In conclusion, the FATCAT-awFC pipeline has the benefit of providing insight on the ‘full picture’ of connectivity changes for REMs and NREMs while making for an easy intuitive approach.

Toxic cyanobacterial blooms are a worldwide concern. Nutrients are among the numerous factors that trigger cyanobacterial blooms and the production of cyanotoxins. This study aimed to assess the effect of nitrogen on cyanobacteria and cyanotoxins through a short-term mesocosm experiment. To achieve this, mesocosms were installed in situ in two lakes (the Missisquoi Bay of Lake Champlain and Petit-Lac-St-François) and received 700 μg/L of ammonium or 500 μg/L of nitrate. A shift to Microcystis in the mesocosms with nitrogen addition was observed 2 days after the addition in Missisquoi Bay, where nitrogen was more limited than Petit-Lac-St-François based on nutrient ratios. There was a significant increase of extracellular ΣMCs and MC-LR in mesocosms with the addition of ammonium or nitrate after 48 h compared to control mesocosms. Intracellular and extracellular microcystin concentrations were associated with Microcystis. Microcystis presence was associated with ammonium 48 h after N was added at both sites. Therefore, toxin production following sudden nitrogen addition can occur on short time scales relevant to drinking water treatment plant operations. This information will help treatment plant operators better anticipate the arrival of potentially higher concentrations of cyanotoxins.

Background and Aim: Considering the role of social workers in the health system, the success and stability of organ transplantation, prevention of re-hospitalization of patients and reduction of imposed costs, this study aims to design a protocol for the specialized interventions of social workers in Iran’s medical centers in the transplant process and to create uniformity in practice. Comprehensive services have been provided to patients and their caregivers. Materials and Methods: The study was conducted in two phases of resource review and qualitative. In the resource review phase, reliable databases were examined, and in the qualitative phase, in order to collect information from Delphi techniques and focused group discussion with the presence of fifteen officials and social workers working in the country’s hospitals and experts and experts. The areas of health and treatment assistants of the Ministry of Health, university professors, medical staff and experts in the field of transplantation and organ donation were carried out. The protocol was sent to eight experienced experts for final review and evaluation, and they were asked to review the protocol in terms of the goal and scope of interventions, stakeholders, development steps, clarity of presentation, accessibility and non-dependence in writing according to the checklist to evaluate. Results: In this study, the work process of social workers was drawn in three stages before, during and after transplantation. Also, various roles were considered for social workers in three stages of work, including the role of defender, supporter, case manager, resource mobilizer, trainer, consultant, evaluator and guidance. Interventions such as finding informational support, facilitating the patient hospitalization process, providing psychosocial support to the family with the aim of empowering them for post-transplant care, providing counseling to family members to deal with stress and improving mental health of the patient, providing economic support, Accomodation conditions are provided through hospital companions and communication and interaction with the treatment team, including the doctor, in order to respond to the needs of the family, facilitate treatment and on time discharging. Conclusion: the protocol of specialized interventions of social workers in the transplantation process created a new step and a different look at psychosocial support in transplantation and coordination teams, so that social workers in the field of organ donation and transplantation and working with caregivers, families and the survivors of the patients arrived.