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The letter published in the Indian Journal of Psychological Medicine discusses the potential link between the oral microbiome and treatment-resistant schizophrenia (TRS). The study found that patients with TRS had significantly different oral microbiota compared to treatment-responsive patients, suggesting that oral microbiome could be a potential biomarker for TRS. The findings indicate a need for further research to validate these results and potentially improve identification and outcomes for TRS patients. [Extracted from the article]