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Multiview clustering (MVC) can achieve more accurate results by utilizing complementary information from multiple perspectives, compared to traditional single-view methods. However, current multiview techniques require all views to be available upfront, making them inadequate for dealing with prevalent data sources that arrive as streams, such as stem cell analysis and multicamera surveillance. To address this problem, in this article, we propose a method called lifelong stream-view clustering (LSVC), which comprises an embedding anchor knowledge library and three key components, enabling the capability to perform asynchronous clustering on stream views. These three components are specifically: 1) the knowledge extraction module that extracts the abstract knowledge of the newcome view over time and updates the shared knowledge library; 2) the knowledge transfer module that aligns the newcome view with the historical knowledge library, enabling the transfer of structure information to the knowledge library; and 3) the knowledge rule module that constraints the knowledge library to enjoy a fair amount of anchors for each cluster, improving the discrimination of knowledge. The experimental results show that LSVC outperforms traditional single-view clustering (SVC) and MVC methods as it gradually improves with the accumulation of stream views and tends to be stable over time.

Study Question: Do singleton children conceived by ART have a higher asthma risk than naturally conceived (NC) singletons?, Summary Answer: The asthma risk was similar for ART-conceived singletons and NC singletons, and there were no clear differences between the various types of ART., What Is Known Already: Whether ART increases asthma risk in offspring is questionable. The evidence is inconsistent and limited by ethnicity, geographic distribution, inadequate confounder adjustment, unsatisfactory control groups, and specific methods of ART. Furthermore, the mediating effects of obstetric and neonatal outcomes on the association between ART and asthma remain unclear., Study Design Size Duration: This observational, single-centre study was conducted at a reproductive centre of an affiliated university hospital between September 2009 and April 2023. A total of 3227 singletons aged 3-6 years conceived by IVF versus ICSI or fresh versus frozen embryo transfer were retrospectively enrolled, and a total of 1206 NC singletons of the same age were subsequently recruited., Participants/materials Setting Methods: Asthma was defined as a self-reported physician diagnosis or wheezing in the past 12 months. We performed multivariable logistic regression analyses to examine associations between asthma in offspring and ART use, adjusting for parental characteristics (age, education level, occupation type, BMI, asthma), smoking exposure, residence type, child sex, child age, and year of follow-up. Mediating effects were explored using longitudinal mediation structural equation modelling., Main Results and the Role of Chance: Asthma was reported for 51 (4.2%) of the 1206 NC singletons (median [interquartile range] age 5 [4-5] years; 48.1% females) and 169 (5.2%) of the 3227 ART-conceived singletons (5 [5-5] years; 47.6% females). We found that risks of childhood asthma in singletons conceived by ART were, overall, similar to those of NC singletons before (odds ratio [OR], 1.25 [95% CI, 0.92-1.74]; P  =   0.170) and after adjustment (adjusted OR [aOR], 0.66 [95% CI, 0.44-1.03]; P  =   0.126). The results were similar in multiple sensitivity analyses, and there were no clear differences in asthma risks according to the method of ART. Mediation analysis revealed a significant positive indirect effect of neonatal intensive care unit (NICU) admission (standard path coefficient, b  = 0.025, P  <   0.05) and a negative indirect effect of breastfeeding ( b  = -0.012, P  <   0.05) on the association between ART and asthma in singleton offspring., Limitations Reasons for Caution: This study is limited to singletons only and cannot be generalized. The study is also limited by its retrospective observational single-centre nature and sample size. Mediation analyses were exploratory. Therefore, the findings need to be interpreted with caution., Wider Implications of the Findings: These findings can help infertile couples undergoing ART be reassured about the risk of childhood asthma in singleton offspring. Breastfeeding is recommended as a potentially feasible intervention to reduce the asthma risks in ART-conceived children who are at increased potential risk of asthma, such as those with NICU admissions., Study Funding/competing Interests: This work was supported by the Key Research and Development Program of Zhejiang Province (2021C03100), the National Key Research and Development Program of China (2021YFC2700603), and the Program for Key Subjects of Zhejiang Province in Medicine and Hygiene to Y. Z., the Zhejiang Province Natural Science Foundation (No. LQ22H040006) and the National Natural Science Foundation of China (No.82101759) to M.T., and the National Natural Science Foundation of China (No. 82201860) to J.Y. The authors declare no competing interests., Trial Registration Number: ChiCTR2300069906., Competing Interests: The authors declare no competing interests., (© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.)