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Abstract Circadian clock serves as a regulator of gastrointestinal health, and the disruption of circadian rhythm may trigger the dysregulation of the intestinal barrier functions. This study investigated the effectiveness of capsaicin (CAP) in mitigating intestinal barrier dysfunction induced by circadian disruption in male SPF C57BL/6J mice. Our findings indicated that CAP supplementation attenuated abnormal weight gain, alterations in serum lipid levels, and misalignment in hepatic and colonic circadian clock gene expressions in mice caused by constant darkness (CD) treatment. The restoration of the intestinal barrier integrity was also observed through the increase in mucosal thickness and goblet cell numbers. Both the diversity and the circadian rhythm of gut microbiota were improved in CAP‐treated group. Correlation analysis indicated that CAP could modulate the gut microbiota by affecting intestinal barrier function and systemic metabolism in CD‐treated mice. These results highlight the potential of CAP as a functional food component in maintaining the intestinal barrier homeostasis through regulating gut microbiota.

Abstract Background Topoisomerase II α(TOP2A) is usually highly expressed in rapidly proliferating cells, and its expression is regulated by cell cycle. The relationship between TOP2A and oral squamous cell carcinoma (OSCC) needs further study. Methods TOP2A immunoreactivity was analyzed using immunohistochemical (IHC) staining analysis in specimens from 20 OSCC patients. Based on the high-throughput sequencing and gene microarray database, the expression of TOP2A mRNA in OSCC was calculated and its ability to identify OSCC tissues was evaluated by diagnostic analysis. CRISPR screen was used to select the genes necessary for OSCC cell growth, and the gene set was analyzed for function enrichment. Single-cell RNA sequencing analysis was conducted to evaluate the expression level of TOP2A mRNA in OSCC cells. Results Compared with normal oral tissues, the expression of TOP2A protein was up-regulated in OSCC tissues. A total of 1240 OSCC and 428 non-OSCC oral tissue samples were included based on high-throughput dataset retrieval, and it was confirmed that TOP2A mRNA was highly expressed in OSCC tissues [SMD = 1.51 (95% CI 0.94–2.07), sROC AUC = 0.96 (95% CI 0.94–0.98)]. As an essential gene for OSCC cell growth, single-cell RNA sequencing data also confirmed that TOP2A mRNA expression was up-regulated in OSCC cells. Conclusion The up-regulation of TOP2A may play a pivotal role in OSCC.

Abstract Background Selective antegrade cerebral perfusion (sACP) is a crucial cerebral protection technique employed during aortic dissection surgeries involving cardiopulmonary bypass. However, postoperative neurological complications, particularly those related to cannulation issues and perfusion problems, remain a significant concern. Case Presentation This case report details an unusual instance where a 38-year-old male patient with Marfan syndrome experienced cerebral hypoperfusion during emergency surgery for Stanford Type A aortic dissection. Despite following standard protocols, a significant drop in regional cerebral oxygen saturation (rSO2) and abnormal blood pressure fluctuations were observed shortly after initiating sACP via the innominate artery. After initial attempts to optimize perfusion flow proved ineffective, the cannulation position was adjusted, leading to improvements. Nevertheless, the patient subsequently exhibited signs of cerebral hypoperfusion and was found to have suffered a new cerebral infarction. Conclusions This case report underscores the importance of precise cannula placement during sACP procedures and the dire consequences that can arise from improper positioning. It emphasizes the need for continuous monitoring and prompt intervention in cases of abnormal cerebral oxygenation and blood pressure, as well as the value of considering cannulation-related issues as potential causes of postoperative neurological complications.

Abstract Background The purpose of this in vitro study was to investigate the effect of polishing post-treatment process on the torque loss ratio and microgap of Selective Laser Melting (SLM) abutments before and after mechanical cycling test through improving the surface roughness of the implant-abutment interface. Materials and methods Forty SLM abutments were fabricated, with 20 underwent minor back-cutting, designated as polishing, in the implant-abutment interface. The abutments were divided into three groups: SLM abutments (group A), original abutments (group B), and polished SLM abutments (group C), each containing 20 abutments. Surface roughness was evaluated using a laser microscope. Implant-abutment specimens were subjected to mechanical cycling test, and disassembly torque values were measured before and after. Scanning electron microscope (SEM) was used to measure microgap after longitudinal sectioning of specimens. Correlation between surface roughness, torque loss ratio, and microgap were evaluated. LSD’s test and Tamhane’s T2 comparison were used to analyze the data (α = 0.05). Results The Sz value of polished SLM abutments (6.86 ± 0.64 μm) demonstrated a significant reduction compared to SLM abutments (26.52 ± 7.12 μm). The torque loss ratio of polished SLM abutments (24.16%) was significantly lower than SLM abutments (58.26%), while no statistically significant difference that original abutments (18.23%). The implant-abutment microgap of polished SLM abutments (2.38 ± 1.39 μm) was significantly lower than SLM abutments (8.69 ± 5.30 μm), and this difference was not statistically significant with original abutments (1.87 ± 0.81 μm). A significant positive correlation was identified between Sz values and the ratio of torque loss after cycling test (r = 0.903, P

Asphalt pavement is widely applied to the surface in high-grade highway tunnels due to its prominent preponderance in road performance. However, asphalt is flammable as the binder material to adhere the aggregates and other additives, resulting that a fire in the semi-closed space of the tunnel can ignite and burn asphalt pavement to generate a large amount of heat and smoke. Therefore, further promoting the advance of flame-retardant asphalt pavement is essential to ensure security in tunnels. We gathered the relevant standards or regulations of diverse nations and test methods concerning flame retardancy of asphalt. Then we reviewed the research status of flame-retardant asphalt mixture, including thermal characteristics of the asphalt and four fractions, the flame retardants applicable to asphalt, and effects on other components. This review demonstrated that establishing universal standards and test methods is a research basis specifically for flame-retardant asphalt pavement. To optimize the flame retardancy of asphalt pavement, it should focus on the synergy with diversified aspects such as asphalt binders, multiple flame retardants, aggregates, mineral powders, fibers, and other additives.

Abstract Background Intraventricular hemorrhage (IVH) refers to bleeding within the brain’s ventricular system, and hydrocephalus is a life-threatening complication of IVH characterized by increased cerebrospinal fluid accumulation in the ventricles resulting in elevated intracranial pressure. IVH poses significant challenges for healthcare providers due to the complexity of the underlying pathophysiology and lack of standardized treatment guidelines. Herein, we performed a systematic review of the treatment strategies for hydrocephalus secondary to IVH. Methods This systematic review was prospectively registered with PROSPERO (CRD42023450786). The search was conducted in PubMed, Cochrane Library, and Web of Science on July 15, 2023. We included original studies containing valid information on therapy management and outcome of hydrocephalus secondary to primary, spontaneous, and subarachnoid or intracranial hemorrhage following IVH in adults that were published between 2000 and 2023. Glasgow Outcome Scale (GOS) or modified Ranking Scale (mRS) scores during follow-up were extracted as primary outcomes. The risk of bias was assessed using the Newcastle–Ottawa Scale for Cohort Studies or Cochrane Risk of Bias 2.0 Tool. Results Two hundred and seven patients from nine published papers, including two randomized controlled trials, were included in the analysis. The GOS was used in five studies, while the mRS was used in four. Seven interventions were applied, including craniotomy for removal of hematoma, endoscopic removal of hematoma with/without endoscopic third ventriculostomy (ETV), traditional external ventricular drainage (EVD), and various combinations of EVD, lumbar drainage (LD), and intraventricular fibrinolysis (IVF). Endoscopic removal of hematoma was performed in five of nine studies. Traditional EVD had no obvious benefit compared with new management strategies. Three different combinations of EVD, LD, and IVF demonstrated satisfactory outcomes, although more studies are required to confirm their reliability. Removal of hematoma through craniotomy generated reliable result. Generally, endoscopic removal of hematoma with ETV, removal of hematoma through craniotomy, EVD with IVF, and EVD with early continuous LD were useful. Conclusion EVD is still crucial for the management of IVH and hydrocephalus. Despite a more reliable result from the removal of hematoma through craniotomy, a trend toward endoscopic approach was observed due to a less invasive profile.

Abstract Reconstruction of the neurovascular unit is essential for the repair of spinal cord injury (SCI). Nonetheless, detailed documentation of specific vascular changes following SCI and targeted interventions for vascular treatment remains limited. This study demonstrates that traumatic pathological vascular remodeling occurs during the chronic phase of injury, characterized by enlarged vessel diameter, disruption of blood‐spinal cord barrier, endothelial‐to‐mesenchymal transition (EndoMT), and heightened extracellular matrix deposition. After SCI, osteopontin (OPN), a critical factor secreted by immune cells, is indispensable for early vascular regeneration but also contributes to traumatic pathological vascular remodeling. This work further elucidates the mechanism by which OPN influences spinal cord microvascular endothelial cells, involving Akt‐mediated Foxo1 phosphorylation. This process facilitates the extranuclear transport of Foxo1 and decreases Smad7 expression, leading to excessive activation of the TGF‐β signaling pathway, which ultimately results in EndoMT and fibrosis. Targeted inhibition of Foxo1 phosphorylation through an endothelium‐specific aptamer‐liposome small molecule delivery system significantly mitigates vascular remodeling, thereby enhancing axon regeneration and neurological function recovery following SCI. The findings offer a novel perspective for drug therapies aimed at specifically targeting pathological vasculature after SCI.

Abstract The Early Paleozoic paleolatitudinal position of the terranes in the northern Tibetan Plateau is the key to unraveling the evolution of the Proto‐Tethys Ocean. We present the first Late Cambrian paleomagnetic results from the Oulongbuluke terrane (OT), in the northern Tibetan Plateau. The mean paleomagnetic direction for 16 sites is Ds = 196.2°, Is = −36.9° with κs = 31.5, α95 = 6.7°, corresponding to a paleopole at 68.2°S/51.9°E with dp/dm = 4.6°/7.8°. Rock magnetic and petrologic analyses demonstrate the primary origin of the magnetic mineralogy. This paleomagnetic result defines the Late Cambrian paleolatitude of the OT as 20.6 ± 4.6°S (reference point: 37.2°N/96.6°E). Combined paleomagnetic and geological evidence suggests that the terranes in the northern Tibetan Plateau were located to the northwest of the Indian plate of Gondwana during the Late Cambrian.

Electroactive polyvinylidene fluoride (PVDF) with predominantly the β-phase is now challenging the fabricating of PVDF toward energy storage applications. Here, the comprehensive effect of BaTiO3 nano-particles and mechanical stretching on the improvement of the β-phase of PVDF was investigated. In situ synchrotron wide-angle X-ray diffraction (WAXD) and small-angle X-ray scattering (SAXS) measurements were performed to investigate this behavior. Consequently, the transformation rate of β-crystal for both pure PVDF (BT0) and PVDF/BaTiO3 (90/10) nanocomposites (BT1) decreases as the stretching temperature increases, implying that the high temperature is unfavorable to the formation of β-crystal phase. A synergistic enhancement of the β-phase of nano-particle additives and stretching was discovered. It was surprisingly observed that α-phase of PVDF would completely transform into β-crystal in BT1 sample at 100 °C during stretching. The mechanism of the synergistic effect of BaTiO3 nano-particles and mechanical stretching was proposed. Moreover, machine learning was implemented to predict the fraction of β-crystal phase (F(β)) of the PVDF/BaTiO3 composites under various uni-axial stretching conditions by Python 3.8. The results show that the machine learning technique can rapidly and efficiently discover the ideal value of F(β) and the optimal multivariate coupling conditions.

Abstract Cellular senescence assumes pivotal roles in various diseases through the secretion of proinflammatory factors. Despite extensive investigations into vascular senescence associated with aging and degenerative diseases, the molecular mechanisms governing microvascular endothelial cell senescence induced by traumatic stress, particularly its involvement in senescence-induced inflammation, remain insufficiently elucidated. In this study, we present a comprehensive demonstration and characterization of microvascular endothelial cell senescence induced by spinal cord injury (SCI). Lysine demethylase 6A (Kdm6a), commonly known as UTX, emerges as a crucial regulator of cell senescence in injured spinal cord microvascular endothelial cells (SCMECs). Upregulation of UTX induces senescence in SCMECs, leading to an amplified release of proinflammatory factors, specifically the senescence-associated secretory phenotype (SASP) components, thereby modulating the inflammatory microenvironment. Conversely, the deletion of UTX in endothelial cells shields SCMECs against senescence, mitigates the release of proinflammatory SASP factors, and promotes neurological functional recovery after SCI. UTX forms an epigenetic regulatory axis by binding to calponin 1 (CNN1), orchestrating trauma-induced SCMECs senescence and SASP secretion, thereby influencing neuroinflammation and neurological functional repair. Furthermore, local delivery of a senolytic drug reduces senescent SCMECs and suppresses proinflammatory SASP secretion, reinstating a local regenerative microenvironment and enhancing functional repair after SCI. In conclusion, targeting the UTX-CNN1 epigenetic axis to prevent trauma-induced SCMECs senescence holds the potential to inhibit SASP secretion, alleviate neuroinflammation, and provide a novel treatment strategy for SCI repair.

Abstract Background Colorectal cancer (CRC) is a global health issue with noticeably high incidence and mortality. Microsimulation models offer a time-efficient method to dynamically analyze multiple screening strategies. The study aimed to identify the efficient organized CRC screening strategies for Shenzhen City. Methods A microsimulation model named CMOST was employed to simulate CRC screening among 1 million people without migration in Shenzhen, with two CRC developing pathways and real-world participation rates. Initial screening included the National Colorectal Polyp Care score (NCPCS), fecal immunochemical test (FIT), and risk-stratification model (RS model), followed by diagnostic colonoscopy for positive results. Several start-ages (40, 45, 50 years), stop-ages (70, 75, 80 years), and screening intervals (annual, biennial, triennial) were assessed for each strategy. The efficiency of CRC screening was assessed by number of colonoscopies versus life-years gained (LYG). Results The screening strategies reduced CRC lifetime incidence by 14–27 cases (30.9–59.0%) and mortality by 7–12 deaths (41.5–71.3%), yielded 83–155 LYG, while requiring 920 to 5901 colonoscopies per 1000 individuals. Out of 81 screening, 23 strategies were estimated efficient. Most of the efficient screening strategies started at age 40 (17 out of 23 strategies) and stopped at age 70 (13 out of 23 strategies). Predominant screening intervals identified were annual for NCPCS, biennial for FIT, and triennial for RS models. The incremental colonoscopies to LYG ratios of efficient screening increased with shorter intervals within the same test category. Compared with no screening, when screening at the same start-to-stop age and interval, the additional colonoscopies per LYG increased progressively for FIT, NCPCS and RS model. Conclusion This study identifies efficient CRC screening strategies for the average-risk population in Shenzhen. Most efficient screening strategies indeed start at age 40, but the optimal starting age depends on the chosen willingness-to-pay threshold. Within insufficient colonoscopy resources, efficient FIT and NCPCS screening strategies might be CRC initial screening strategies. We acknowledged the age-dependency bias of the results with NCPCS and RS.

Spinal cord injury (SCI) causes severe axon damage, usually leading to permanent paraparesis, which still lacks effective regenerative therapy. Recent studies have suggested that exosomes derived from neural stem cells (NSCs) may hold promise as attractive candidates for SCI treatment. Epidermal Growth Factor Receptor positive NSC (EGFR+NSC) is a subpopulation of endogenous NSCs, showing strong regenerative capability in central nervous system disease. In the current study, we isolated exosomes from the EGFR+NSCs (EGFR+NSCs-Exos) and discovered that local delivery of EGFR+NSCs-Exos can effectively promote neurite regrowth in the injury site of spinal cord-injured mice and improve their neurological function recovery. Using the miRNA-seq, we firstly characterized the microRNAs (miRNAs) cargo of EGFR+NSCs-Exos and identified miR-34a-5p which was highly enriched in EGFR+NSCs derived exosomes. We further interpreted that exosomal miR-34a-5p could be transferred to neurons and inhibit the HDAC6 expression by directly binding to its mRNA, contributing to microtubule stabilization and autophagy induction for aiding SCI repair. Overall, our research demonstrated a novel therapeutic approach to improving neurological functional recovery by using exosomes secreted from a subpopulation of endogenous NSCs and providing a precise cell-free treatment strategy for SCI repair.

Robotic fish with pectoral fin swing have many outstanding features, especially forward swimming stability, but the research on their backward swimming performance is insufficient. Therefore, this article specifically discussed the hydrodynamic performance of the robotic cow-nosed ray with backward swimming in pectoral fin swing propulsion mode. Complete pectoral fin and split pectoral fin were designed, and the superiority of split pectoral fin structure over complete pectoral fin structure in terms of backward thrust was verified through experimental testing. The energy conversion efficiency was analyzed through the ratio of thrust to current. According to the collected current data, the equivalent thrust efficiency and amplitude and frequency variation curves of the two pectoral fin structures under forward and backward swimming conditions were drawn. The reasons for the thrust generation and equivalent thrust efficiency of two types of pectoral fin structures were analyzed. The experimental results show that under the forward swimming condition, the two types of pectoral fins have similar thrust values. Under the backward swimming condition, with the increase in amplitude and frequency, the thrust of the split pectoral fin structure increases significantly, reaching a maximum of 0.22 N. Under the forward swimming condition, the split pectoral fin structure is slightly worse than that of a complete pectoral fin. Under the backward swimming condition, with the increase in amplitude and frequency, the equivalent thrust efficiency of the split pectoral fin structure is significantly improved. The design of the split pectoral fin structure in the article provides a reference for exploring the backward swimming performance of robotic fish based on the swing mechanism.

At present, the protection of birds, especially endangered birds, faces major challenges. In the process of protection, birds are often mixed with various drones, and it is difficult to accurately count the number of endangered birds, especially at night, which brings great difficulties to bird protection work. So tracking and identifying birds and drones is essential to ensure the accuracy and efficiency of bird conservation efforts. To solve these problems, this paper proposes a new multi-target tracking (MOT) model based on the combination of YOLOv9 detection algorithm and DeepSORT tracking algorithm. Firstly, the original RepNSCPELAN4 module is replaced by CAM context feature enhancement module in Backbone to improve the model’s ability to extract small target features. Following this, the AFF channel attention mechanism has been integrated with RepNSCPELAN4 in the Head section to create the RepNSCPELAN4-AFF module, which aims to better address semantic and scale inconsistencies. Finally, a new RepNSCPELAN4-AKConv module has been developed using the AKConv dynamic Convolution module to replace the RepNSCPELAN4 module in the original Head section, enabling the model to more effectively capture detailed and contextual information. In the bird-UAV visible light comprehensive dataset proposed in this study, the mAP0.50 and F1 Score of all categories are 81.3% and 71.9% respectively by the improved YOLOv9-DeepSORT model. The mAP0.50 and F1 scores of individual birds are 89.1% and 82.4%, respectively. Compared to the Basic YOLOv9 model, the former improves by 7.9% and 5.3%, while the latter improves by 23.9% and 17.0%. On infrared datasets, compared to the original model, the mAP0.50 and F1 scores of the improved model improved by 3.2% and 1.4% across all categories compared to the original model. The average accuracy of identifying individual birds and similarly shaped fixed-wing drones also improved by 2.2% and 7.5% respectively. Moreover, on the mixed visible light and infrared data sets, the model get mAP0.50 of 81.8% higher 0.9% than that of the YOLOv9. These experiments demonstrate the improved YOLOv9-DeepSORT method can expand the multiscene application range of bird recognition and tracking models, effectively promoting the extraction of video frame features in multi-target tracking.

Semantic segmentation plays a pivotal role in interpreting high-resolution remote sensing images (RSIs), where contextual information is essential for achieving accurate segmentation. Despite the common practice of partitioning large RSIs into smaller patches for deep model input, existing methods often rely on adaptations from natural image semantic segmentation techniques, limiting their contextual scope to individual images. To address this limitation and harness a broader range of contextual information from original large-scale RSIs, this study introduces a global feature fusion network (GFFNet). GFFNet employs a novel approach by incorporating a group transformer structure alternated with group convolution, forming a lightweight global context learning branch. This design facilitates the extraction of global contextual features from the large-scale RSIs. In addition, we propose a cross feature fusion module that seamlessly integrates local features obtained from the convolutional network with the global contextual features. GFFNet serves as a versatile plugin for existing RSI semantic segmentation models, particularly beneficial when the target dataset involves cropping. This integration enhances the model's performance, especially in terms of segmenting large-scale objects. Experimental results on the ISPRS and GID-15 datasets validate the effectiveness of GFFNet in improving segmentation capabilities for large-scale objects in RSIs.

Abstract The limited surface coverage and activity of active hydrides on oxide surfaces pose challenges for efficient hydrogenation reactions. Herein, we quantitatively distinguish the long-puzzling homolytic dissociation of hydrogen from the heterolytic pathway on Ga2O3, that is useful for enhancing hydrogenation ability of oxides. By combining transient kinetic analysis with infrared and mass spectroscopies, we identify the catalytic role of coordinatively unsaturated Ga3+ in homolytic H2 dissociation, which is formed in-situ during the initial heterolytic dissociation. This site facilitates easy hydrogen dissociation at low temperatures, resulting in a high hydride coverage on Ga2O3 (H/surface Ga3+ ratio of 1.6 and H/OH ratio of 5.6). The effectiveness of homolytic dissociation is governed by the Ga-Ga distance, which is strongly influenced by the initial coordination of Ga3+. Consequently, by tuning the coordination of active Ga3+ species as well as the coverage and activity of hydrides, we achieve enhanced hydrogenation of CO2 to CO, methanol or light olefins by 4-6 times.

IntroductionDendrolimus punctatus, a major pest endemic to the native Pinus massoniana forests in China, displays major outbreak characteristics and causes severe destructiveness. In the context of global climate change, this study aims to investigate the effects of climatic variations on the distribution of D. punctatus and its host, P. massoniana. MethodsWe predict their potential suitable distribution areas in the future, thereby offering a theoretical basis for monitoring and controlling D. punctatus, as well as conserving P. massoniana forest resources. By utilizing existing distribution data on D. punctatus and P. massoniana, coupled with relevant climatic variables, this study employs an optimized maximum entropy (MaxEnt) model for predictions. With feature combinations set as linear and product (LP) and the regularization multiplier at 0.1, the model strikes an optimal balance between complexity and accuracy.ResultsThe results indicate that the primary climatic factors influencing the distribution of D. punctatus and P. massoniana include the minimum temperature of the coldest month, annual temperature range, and annual precipitation. Under the influence of climate change, the distribution areas of P. massoniana and its pests exhibit a high degree of similarity, primarily concentrated in the region south of the Qinling−Huaihe line in China. In various climate scenarios, the suitable habitat areas for these two species may expand to varying degrees, exhibiting a tendency to shift toward higher latitude regions. Particularly under the high emission scenario (SSP5-8.5), D. punctatus is projected to expand northwards at the fastest rate. DiscussionBy 2050, its migration direction is expected to closely align with that of P. massoniana, indicating that the pine forests will continue to be affected by the pest. These findings provide crucial empirical references for region-specific prevention of D. punctatus infestations and for the rational utilization and management of P. massoniana resources.

Abstract Nonfused ring electron acceptors (NFREAs) are promising candidates for future commercialization of organic solar cells (OSCs) due to their simple synthesis. Still, the power conversion efficiencies (PCEs) of NFREA‐based OSCs have large room for improvement. In this work, by merging end group halogenation and side chain engineering, we developed four A–D–A'–D–A type NFREAs, which we refer to as EH‐4F, C4‐4F, EH‐4Cl, and C4‐4Cl. Single crystal X‐ray diffraction revealed that multiple intermolecular S···F interactions between cyclopentadithiophene and 5,6‐difluoro‐3‐(dicyanomethylene)indanone could cause an unfavorable dimer formation, leading to ineffective π–π stackings in EH‐4F and C4‐4F, whereas no such dimer was found in EH‐4Cl and C4‐4Cl after replacing with 5,6‐dichloro‐3‐(dicyanomethylene)indanone. Moreover, although the shorter n‐butyl side chain resulted in a closer molecular packing in C4‐4Cl, EH‐4Cl (2‐ethylhexyl substitution) with proper crystallinity exhibited enhanced face‐on orientation in thin film, which is favorable for vertical charge transport and further reducing charge recombination. As a result, a PCE of 13.0% is obtained for EH‐4Cl‐based OSC with a fill factor of 0.70. This work highlights the importance of molecular packing and orientation control toward future high‐performance A–D–A'–D–A type NFREAs.

Nowadays, Megalobrama hoffmanni is a typical cultured fish in south China due to its resource decline in the Pearl River. Meanwhile, since antibiotics had been banned internationally, Chinese medical herbal plant serving as alternative to antibiotics has been adopted in aquaculture. In the present study, to ensure the health growth of M. hoffmanni, extract of traditional medical herbal plant Ampelopsis grossedentata was dietary supplemented and a series experiments were performed, including growth performance determination, physiological/biochemical detection, nutrition analysis, histology analysis, and 16S rRNA amplicon sequencing. Growth performance enhancement was determined since the weight gain rate (WGR), specific growth rate (SGR), and condition factor (CF) of M. hoffmanni increased as feeding inclusion A. grossedentata extract. Interestingly, the total content of muscle fatty acids ascended via supplementing A. grossedentata extract at middle level, in which group the activities of superoxide dismutase (SOD) and catalase (CAT) significantly increased and thus retarded the lipid peroxidation process (manifesting as malondialdehyde (MDA) content rising). Additionally, immune response and inflammatory reaction was stimulated in low and high level A. grossedentata extract added groups, indicating a suitable dosage of A. grossedentata extract benefited in safety production. Moreover, gut microbiota community varied hugely as daily supplementation A. grossedentata extract and the keystone species were tightly related to lipid transformation, which ultimately led to fatty acids composition variation. Our results confirmed that dietary supplementation A. grossedentata extract at the middle level (0.5‰, w/w) is suitable for serving as feed additive in healthful aquaculture of M. hoffmanni.

ObjectiveBenign Brenner tumor (BBT) is a rare ovarian tumor, and there are few discrete reports about its manifestation in an ultrasound. This study sought to investigate the two-dimensional (2D) and contrast-enhanced ultrasound (CEUS) features of this entity.MethodsThis is a retrospective single-center study. The clinical manifestations, laboratory examination, and ultrasound data of 25 female patients with BBT were confirmed by pathology when they underwent 2D and/or CEUS examination at Ningbo First Hospital from January 2012 to June 2023. The ultrasound findings of the patients were analyzed using the terminology of the International Organization for the Analysis of Ovarian Tumor and were read by two senior sonographers who reached an agreement.ResultsAmong the all 25 patients, most of them were unilateral, and only one patient was bilateral. Thus, 26 lesions were found: 44.0% (11/25) were in the left and 52.0% (13/25) were in the right. Moreover, 53.84% (14/26) were solid lesions, 15.38% (4/26) were mixed lesions, and 26.92% (7/26) were cystic lesions. Among the solid-type patients, 42.85% (6/14) of the cases were with calcification. Upon laboratory examination, 12.0% (3/25) of the patients had high carbohydrate antigen 125 (CA-125) level, and 19.04% (4/21) of the patients had an elevated carbohydrate antigen724 (CA-724) level in the serum tumor markers. In the hormone test, 14.28% (3/21) were found to have a high postmenopausal estrogen level and 14.28%(3/21) were found to have a high level of follicle-stimulating hormone (FSH). One patient with complex manifestations and three with solid manifestations were examined by CEUS to observe the microcirculation perfusion of the tumor. One with solid and cystic separation was rapidly hyperenhanced and cleared, and the filling subsided faster than the uterus. The postoperative pathological diagnosis was benign Brenner tumor with mucinous cystadenoma. The other three cases were solid adnexal lesions, which showed isoenhancement on CEUS and disappeared slowly, synchronizing with the uterus. The CEUS results were considered as benign tumors and confirmed by pathology.ConclusionsBBT can show ovarian cystic, mixed cystic and solid type, and solid echo in 2D ultrasound. Unilateral ovarian fibrosis with punctate calcification is an important feature of BBT in 2D ultrasound. However, for solid adnexal masses and mixed cystic and solid masses with unclear diagnosis, if CEUS shows isoenhancement or hyperenhancement, the possibility of BBT cannot be excluded.

Caroli disease is a rare congenital malformation that predisposes to segmental cystic dilatation of the intrahepatic bile ducts. Banti syndrome is characterized by persistent splenomegaly due to chronic congestion, resulting in a low hematocrit and ultimately leading to pancytopenia. In this report, we describe a 29-year-old woman who presented with a >20-year history of hepatitis B surface antigen positivity and a >1-year history of recurrent fatigue and malaise. On examination, the patient had abdominal distension with marked splenomegaly (7 cm below the ribs) and ascites with tenderness of the abdominal muscles to palpation. A complete blood count showed a low white blood cell count, red blood cell count, and hemoglobin concentration. During the course of treatment, the patient developed multiple symptoms of pancytopenia and concomitant splenomegaly, and she was discharged after total splenectomy with good recovery. The combination of Banti syndrome and Caroli disease results in severe symptoms of portal hypertension.

Objective: To determine the efficacy of femoral neck system compared to dynamic hip screws in treating femoral neck fractures. Method: The systematic review was conducted from January to March 2023, and comprised literature search on PubMed, Embase, Scopus, Ovid, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure and Wanfang databases for relevant studies published up to March 1, 2023. Study data as well as demographic and outcome parameters related to the patients were extracted, and the methodological index for non-randomised studies was used to assess the risk of bias. Review Manager software was used to conduct meta-analysis. Results: Of the 567 studies initially found, 6(1%) were included, with the publication date ranging from August 2021 to February 2023. There were 5(83.3%) studies published in English and 1(16.7%) in Chinese. Of the 577 patients with femoral neck fractures, 287(49.7%) were treated with femoral neck system and 290(50.3%) with dynamic hip screws. Significant differences were shown between the two groups regarding operation duration, blood loss, internal fixation failure rate and Harris hip score (p=0.05). Conclusion: The novel femoral neck system could optimise surgical procedures, with shorter operation times and lesser blood loss. The femoral neck system and dynamic hip screws were comparable in terms of complication rates and postoperative hip function. Key Words: Femoral neck fractures, Internal fixators, Meta-analysis.

A two-dimensional plasma–wave interaction model, which is based on the cold collisional plasma dielectric tensor, is applied to investigate the wave propagation and power depositions under different magnetic configurations in helicon plasmas. The varied magnetic configurations are formed by changing the radius of the magnetic coil. When the magnetic coil was positioned closer to the plasma, the magnetic field within the plasma became stronger and more curved. Consequently, the simulation results show that the wave propagation and power deposition in plasmas follow the curved magnetic field lines. In the axial direction, the periodic distribution of wave fields and power deposition are clearly observed and keep consistency in helicon plasmas due to the eigenmodes of helicon waves. Furthermore, a concave dark area where the wave cannot propagate is observed in the closest magnetic coil case and leads to limited power deposition.

The computer numerically controlled (CNC) system is the key functional component of CNC machine tool control systems, and the servo drive system is an important part of CNC systems. The complex working environment will lead to frequent failure of servo drive systems. Taking effective health management measures is the key to ensure the normal operation of CNC machine tools. In this paper, the comprehensive effect of fault prediction and fault diagnosis is considered for the first time, and a health management system for machine tool servo drive systems is proposed and applied to operation and maintenance management. According to the data collected by the system and related indicators, the technology can predict the state trend of equipment operation, identify the hidden fault characteristics in the data, and further diagnose the fault types. A health management system mainly includes fault prediction and fault diagnosis. The core of fault prediction is the gated recurrent unit (GRU). The attention mechanism is introduced into a GRU neural network, which can solve the long-term dependence problem and improve the model performance. At the same time, the Nadam optimizer is used to update the model parameters, which improves the convergence speed and generalization ability of the model and makes it suitable for solving the prediction problem of large-scale data. The core of fault diagnosis is the self-organizing mapping (SOM) neural network, which performs cluster analysis on data with different characteristics, to realize fault diagnosis. In addition, feature standardization and principal component analysis (PCA) are introduced to balance the influence of different feature scales, enhance the feature of fault data, and achieve data dimensionality reduction. Compared with the other two algorithms and their improved versions, the superiority of the health management system with high-dimensional data and the enhancement effect of fault identification are verified. The relative relationship between fault prediction and diagnosis is further revealed, and the adjustment idea of the production plan is provided for decision makers. The rationality and effectiveness of the system in practical application are verified by a series of tests of fault data sets.

The manta ray, exemplifying an agile swimming mode identified as the median and paired fin (MPF) mode, inspired the development of underwater robots. Robotic manta typically comprises a central rigid body and flexible pectoral fins. Flexible fins provide excellent maneuverability. However, due to the complexity of material mechanics and hydrodynamics, its dynamics are rarely studied, which is crucial for the advanced control of robotic manta (such as trajectory tracking, obstacle avoidance, etc.). In this paper, we develop a multibody dynamic model for our novel manta robot by introducing a pseudo-rigid body (PRB) model to consider passive deformation in the spanwise direction of the pectoral fins while avoiding intricate modeling. In addressing the rigid-flexible coupling dynamics between flexible fins and the actuation mechanism, we employ a sequential coupling technique commonly used in fluid-structure interaction (FSI) problems. Numerical examples are provided to validate the MPF mode and demonstrate the effectiveness of the dynamic model. We show that our model performs well in the rigid-flexible coupling analysis of the manta robot. In addition to the straight-swimming scenario, we elucidate the viability of tailoring turning gaits through systematic variations in input parameters. Moreover, compared with finite element and CFD methods, the PRB method has high computational efficiency in rigid-flexible coupling problems. Its potential for real-time computation opens up possibilities for future model-based control.

Photonic spin Hall effect (PSHE) in chiral PT-symmetric systems exhibits many exotic features, but the underlying physical mechanism has not been well elucidated. Here, through rigorous calculations based on full-wave theory, we reveal the physical mechanism of the exotic PSHE and identify a chirality-enabled topological phase transition. When circularly polarized light is incident on a chiral PT-symmetric system, the transmitted beam contains two components: a spin-flipped abnormal mode that acquires a geometric phase (exhibiting a vortex or a spin-Hall shift), and a spin-maintained normal mode that does not exhibit such a phase. If the phase difference between the cross-polarized Fresnel coefficients cannot be ignored, it results in a chirality-enabled phase and intensity distribution in the abnormal mode, which induces an exotic PSHE. Consequently, as the incident angle increases, a chirality-induced topological phase transition occurs, namely the transition from the vortex generation to the exotic PSHE. Finally, we confirm that the asymmetric and periodic PSHE in the chiral slab is also related to the phase difference between the cross-polarized Fresnel coefficients. These concepts and findings also provide an opportunity for unifying the phenomena of topological phase transitions in various spin-orbit photonic systems.

Background: Although it has been established that the human Solute Carrier Family 22 (SLC22) functions as a cationic transporter, influencing cellular biological metabolism by modulating the uptake of various cations, its impact on cancer prognosis remains unclear. Methods: We conducted a comprehensive analysis utilizing data from The Cancer Genome Atlas (TCGA) and other databases to assess the prognostic value and functional implications across various tumors. Silence of SLC22A1 RNA in glioma U251 cells was performed to access the impact of SLC22A1 on lowergrade glioma (LGG) progression. Results: Our findings demonstrated a significant correlation between SLC22A1 expression and the survival time of patients with various cancers (p < 0.05). Importantly, we found the potential involvement of SLC22A1 in occurrence and progress of certain cancers, with a pronounced impact on LGG. Further examination of the SLC22A1-LGG relationship revealed its status as an independent risk factor for LGG, suggesting its potential involvement in regulating diverse immune pathways and metabolic activities. Chinese Glioma Genome Atlas (CGGA) data supported the reliability of the risk score as a prognostic and recurrence indicator, emphasizing the accuracy of the nomograph (1, 3, and 5-year-AUC >0.8). Cell proliferation and clone formation experiment proved that decreased expression of SLC22A1 in glioma U251 cells inhibited glioma cell growth. Conclusion: Our findings suggest SLC22A1 has huge prospects as a promising biomarker and therapeutic target for LGG prognosis. SLC22A1 has only been proved to support cellular function previously. Our findings demonstrated a robust connection between the tumor microenvironment and functional proteins that maintain basal cell metabolism, which gifts unique tumor immune characteristics of gliomas. Additionally, we provide a highly practical prediction model for estimating the survival rate of LGG patients. [ABSTRACT FROM AUTHOR]

Background: Surgical treatment demonstrated a reduction in mortality among patients suffering from severe spontaneous intracerebral hemorrhage (SSICH). However, which SSICH patients could benefit from surgical treatment was unclear. This study aimed to establish and validate a decision tree (DT) model to help determine which SSICH patients could benefit from surgical treatment. Materials and methods: SSICH patients from a prospective, multicenter cohort study were analyzed retrospectively. The primary outcome was the incidence of neurological poor outcome (modified Rankin scale as 4-6) on the 180th day posthemorrhage. Then, surgically-treated SSICH patients were set as the derivation cohort (from a referring hospital) and validation cohort (from multiple hospitals). A DT model to evaluate the risk of 180-day poor outcome was developed within the derivation cohort and validated within the validation cohort. The performance of clinicians in identifying patients with poor outcome before and after the help of the DT model was compared using the area under curve (AUC). Results: One thousand two hundred sixty SSICH patients were included in this study (middle age as 56, and 984 male patients). Surgically-treated patients had a lower incidence of 180-day poor outcome compared to conservatively-treated patients (147/794 vs. 128/466, P<0.001). Based on 794 surgically-treated patients, multivariate logistic analysis revealed the ischemic cerebrocardiovascular disease history, renal dysfunction, dual antiplatelet therapy, hematoma volume, and Glasgow coma score at admission as poor outcome factors. The DT model, incorporating these above factors, was highly predictive of 180-day poor outcome within the derivation cohort (AUC, 0.94) and validation cohort (AUC, 0.92). Within 794 surgically-treated patients, the DT improved junior clinicians' performance to identify patients at risk for poor outcomes (AUC from 0.81 to 0.89, P< 0.001). Conclusions: This study provided a DT model for predicting the poor outcome of SSICH patients postsurgically, which may serve as a useful tool assisting clinicians in treatment decision-making for SSICH. [ABSTRACT FROM AUTHOR]

In this case report, we will discuss a 74-year-old female who presented with a chief complaint of abdominal pain, bloating, anorexia, and nausea for four days which preceded after catheter ablation and anhydrous ethanol infusion vein of Marshall (VOM) one month prior. She was admitted and treated as a general patient in the general ward. After hospital admission, a pericardiocentesis was guided by B-scan ultrasonography, resulting in the extraction of 20ml of pericardial effusion, followed by catheterization for drainage. The key takeaway in this report is that anhydrous ethanol infusion VOM may not always be without risks. Hence, during the procedure, it is imperative to carefully administer the appropriate volume of anhydrous ethanol into the VOM to prevent vessel damage and associated complications. [ABSTRACT FROM AUTHOR]

Objective • The study aimed to evaluate the impact of OLIF on spinal-pelvic sagittal parameters and its correlation with clinical outcomes in patients with degenerative lumbar spondylolisthesis. Methods • A retrospective analysis of 43 patients (23 males, 20 females) with lumbar 4/5 degenerative spondylolisthesis who underwent OLIF from January 2018 to January 2023 was conducted. Key parameters studied included SP, DH, FH, AS, LL, SS, PT, PI, and LASD. Results • All surgeries were successfully completed according to the original plan, and the minimum followup time was greater than 6 months, with a mean operation time of 198.21±51.32 min; the mean intraoperative bleeding volume was 121.00±56.88 ml. The VAS score of lumbar pain and ODI index decreased from the preoperative VAS score, and the ODI index of lower lumbar pain from the preoperative VAS score of 6.50±1.36 and 74.36±6.27 to the postoperative Lumbar pain of 3.20±1.28 and 32.41±8.21, respectively, and the differences were statistically significant (P < .05). 6.27 to 3.20±1.28 and 32.41±8.21 at the final follow-up visit. The differences were statistically significant (P < .05). The results of Pearson correlation analysis showed positive correlation between postoperative LL and FH, SP and AS, VAS (P < .05), and service correlation between SP and SS, LASD (P < .05), and correlation between pre- and postsurgery difference of LL, FH, SP and the improvement rate of ODI and VAS scores (P < .05), with the difference of pre- and post-surgery difference of LL, FH and the ODI, VAS score improvement rate were the strongest correlation. Postoperatively, significant improvements were observed in LL and FH. Pearson correlation analysis indicated a positive correlation between changes in sagittal parameters and clinical outcomes, measured by VAS and ODI scores. Conclusion • The postoperative spine-pelvis sagittal parameters were significantly improved compared with the preoperative ones, and the changes of the spine-pelvis sagittal parameters before and after the operation were correlated with the clinical outcomes, among which the differences of LL and FH had the strongest correlation with the improvement rates of ODI and VAS scores. OLIF effectively improved spinal-pelvic sagittal parameters and clinical outcomes in degenerative lumbar spondylolisthesis, with changes in LL and FH showing the strongest correlation with patient-reported outcome improvements. An oblique lateral interbody fusion can effectively reconstruct spine-pelvis sagittal parameters in patients with degenerative lumbar spondylolisthesis. [ABSTRACT FROM AUTHOR]

Corrosion inhibitors are widely used because they have the characteristics of trace and high efficiency， can prevent metal corrosion，while maintaining the physical and mechanical properties of the metal unchanged， and easy to use.Traditional metal corrosion inhibitors have poor biodegradability， toxicity and are easy to cause environmental pollution.Based on the concepts of environmental protection， sustainable development and green chemistry， the use of traditional metal corrosion inhibitors has been severely restricted， and the research on corrosion inhibitors is gradually shifting to environmentally friendly substances.In this paper， green environmental protection corrosion inhibitors were divided into single system corrosion inhibitors and compound system corrosion inhibitors， and the research progress in recent years were reviewed.Furthermore， the advantages and disadvantages of various types of corrosion inhibitors were classified and summarized， and the current status and research direction of environmentally friendly corrosion inhibitors were prospected.

This paper presents a recently developed full kinetic particle simulation code package, which is a two-dimensional highly integrated and universal framework for low-temperature plasma simulation on both Cartesian and axisymmetric coordinate systems. This code package is named CFIRM, since it is designed based on the continuous Galerkin immersed-finite-element (IFE) particle-in-cell (PIC) model with the polynomial-preserving-recovery (PPR) technique and the Monte-Carlo-collision (MCC) method. Both the traditional and implicit PIC methods were implemented in the package. Incorporating the advantages of all these methods together, the CFIRM code can adopt explicit or implicit PIC schemes to track the motion trajectory of charged particles and deal with the collisions between plasma and neutral gas. Additionally, it can conveniently handle complex interface problems on structured grids. The CFRIM code has excellent versatility in low-temperature plasma simulation and can easily extend to various particle processing modules, such as the variable weights and adaptive particle management algorithms which were incorporated into this code to reduce the memory utilization rate. The implementation for the main algorithms and the overall simulation framework of the CFIRM code package are rigorously described in details. Several simulations of the benchmark cases are carried out to validate the reliability and accuracy of the CFIRM code. Moreover, two typical low-temperature plasma engineering problems are simulated, including a hall thruster and a capacitively coupled plasma reactor, which demonstrates the applicability of this code package. [ABSTRACT FROM AUTHOR]

The effects of Neolamarckia cadamba leaves extract (NCLE), with effective ingredients of flavonoids, on antibiotic resistance genes (ARGs) and relevant microorganisms in cecal contents and feces of broilers treated with or without lipopolysaccharide stimulation (LPS) were investigated. LPS stimulation increased (P < 0.05) the relative abundance of ARGs and mobile genetic elements (MGEs), such as tet(W/N/W), APH(3')-IIIa, ErmB, tet (44), ANT (6)-Ia, tet(O), tet (32), Vang_ACT_CHL, myrA, ANT (6)-Ib, IncQ1, tniB, and rep2 in cecal contents. However, the difference disappeared (P > 0.05) when NCLE was added at the same time. These differential ARGs and MGEs were mainly correlated (P < 0.01) with Clostridiales bacterium, Lachnospiraceae bacterium, and Candidatus Woodwardibium gallinarum. These species increased in LPS-stimulated broilers and decreased when NCLE was applied at the same time. In feces, LPS stimulation decreased (P < 0.05) the relative abundance of tet(Q), adeF, ErmF, Mef(En2), OXA-347, tet (40), npmA, tmrB, CfxA3, and ISCrsp1, while the LPS + NCLE treated group showed no significant effect (P > 0.05) on these ARGs. These differential ARGs and MGEs in feces were mainly correlated (P < 0.01) with Clostridiales bacterium, Pseudoflavonifractor sp. An184, Flavonifractor sp. An10, Ruminococcaceae bacterium, etc. These species increased in LPS-stimulated broilers and increased when NCLE was applied at the same time. In conclusion, LPS stimulation and NCLE influenced microbial communities and associated ARGs in both cecal contents and feces of broilers. NCLE alleviated the change of ARGs and MGEs in LPS-induced broilers by maintaining the microbial balance. [ABSTRACT FROM AUTHOR]

Transition metal-based electrocatalytic materials for hydrogen production through water splitting offer advantages in terms of price and availability compared to noble metal-based catalysts, among which, Fe-, Co-, and Ni-based compounds are the most typical and widely studied materials. Utilizing the synergistic effects between composite components in compounds containing multiple metal elements is an important way to improve the catalytic performance of catalysts, so developing ternary or multiple active center catalysts containing Fe, Co, and Ni is a promising direction. In this mini-review, we provide an summary of the latest achievements of water splitting catalyst materials simultaneously containing Fe, Co, and Ni elements. It was summarized according to several groups including compounds of boron-/carbon-/nitrogen-/phosphorus-/oxygen-group elements, metal-organic framework-based compounds, and compounds in situ grown from alloy matrix. Also challenges that need to be addressed are presented at the end of the article., (© 2024 Wiley-VCH GmbH.)