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Ganglion cysts are the most common soft-tissue tumors observed in the finger. Some tumors could be easily confused clinically with ganglion cysts due to their localization, mobility, shape, and being soft in nature. In this article, two cases of schwannoma and superficial acral myxoma that were clinically and radiologically confused with ganglion cysts are presented. Suspecting this tumor type in the preoperative diagnosis is essential to avoid unnecessary surgical approaches. Masses in close proximity to the nerve or nerve sheath are very important as they require preservation of the nerve during surgery. For these masses, surgeons should be prepared as these cases can have many intraoperative surprises in store.

Abstract Although Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have been approved in multiple diseases, including BRCA1/2 mutant breast cancer, responses are usually transient requiring the deployment of combination therapies for optimal efficacy. Here we thus explore mechanisms underlying sensitivity and resistance to PARPi using two intrinsically PARPi sensitive (T22) and resistant (T127) syngeneic murine breast cancer models in female mice. We demonstrate that tumor associated macrophages (TAM) potentially contribute to the differential sensitivity to PARPi. By single-cell RNA-sequencing, we identify a TAM_C3 cluster, expressing genes implicated in anti-inflammatory activity, that is enriched in PARPi resistant T127 tumors and markedly decreased by PARPi in T22 tumors. Rps19/C5aR1 signaling is selectively elevated in TAM_C3. C5aR1 inhibition or transferring C5aR1hi cells increases and decreases PARPi sensitivity, respectively. High C5aR1 levels in human breast cancers are associated with poor responses to immune checkpoint blockade. Thus, targeting C5aR1 may selectively deplete pro-tumoral macrophages and engender sensitivity to PARPi and potentially other therapies.

Copyright of Necmettin Erbakan University School of Law Review is the property of Necmettin Erbakan University School of Law Review and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Turkish Journal of Health & Sport is the property of Turkish Journal of Health & Sport and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim: Multisystem Inflammatory Syndrome in Children (MIS-C) is a disease developed after about eight weeks of the new coronavirus disease (COVID-19) infection in children. The underlying reason for MIS-C is still unknown. This study aims to assess the nasopharyngeal expressions of Angiotensin-converting enzyme 2 (ACE2), the differentiation 147 receptor cluster (CD147), and the transmembrane serine protease 2 (TMPRSS2) receptors in the MIS-C population. Since these receptors are related to COVID-19 infection, children with previous COVID-19 history were included as a control group. This study is essential for future studies to see if there is any significant expression difference between these receptors in control and MIS-C populations. Materials and Methods: The prospective cohort study took place at Ondokuz Mayıs University. The participants of this study consisted of patients aged 0-18 years who were diagnosed with MIS-C due to COVID-19 infection or patients with only previous COVID- 19 pneumonia but without MIS-C development. A total of 79 cases were registered in this study. Nasopharyngeal samples of children were collected. Total RNA was isolated from all samples. The expression of ACE2, CD147, and TMPRSS2 genes was accessed by real-time quantitative PCR (RT-qPCR). Results: Nasopharyngeal expression of CD147 and TMPRSS2 were not changed in COVID-19 (n=42) and MIS-C (n=37) cases. Expression of ACE2 was increased in the under 10-year-old MIS-C group (n=23) (p=0.004381). Conclusion: Future studies may exclude the nasopharyngeal expression of CD147 and TMPRSS2 to develop MIS-C. Further investigations are required to learn how ACE2 expression contributes to MIS-C development. [ABSTRACT FROM AUTHOR]

Summary: The promising results of ML (machine learning) methods in various disciplines have led to the frequent use of these methods in health fields such as disease diagnosis, personalized medicine, medical image‐based diagnosis, and predicting the number of deaths and cases in a pandemic. However, a neglected area in the field of healthcare is the lack of study with ML to predict treatment outcomes for tuberculosis (TB) patients, particularly children experiencing failed treatment. This need has become more apparent as the coronavirus pandemic has reversed the gains of health institutions with TB disease, especially in children. Therefore, this article conducted a study using the stacked ensemble ML method to early predict the risk for children experiencing a failed treatment outcome of TB. To fulfill this need and determine the most appropriate technique, a two‐stage methodology was followed in this work. First, predictions were obtained by combining the information gain feature selection (IGFS) approach with a variety of single‐based ML algorithms, including logistic regression (LR), deep belief neural networks (DBN), random forest (RF), and decision tree (DT). Second, the proposed method, which includes a stacked ensemble ML technique, was used. The latter model uses LR as a meta‐learner and the aforementioned single‐based ML algorithms (DBN, LR, RF, and DT). The performance results of ML models used in the two stages were compared, and the proposed model which is the combination of the stack‐based ensemble learning model and the IGFS technique provided better ROC curves, accuracy, precision, and recall results. [ABSTRACT FROM AUTHOR]

Introduction: The optimal management of relapsed/refractory germ cell tumors remains unsettled. In this study, we aimed to evaluate the efficacy of high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT) as salvage therapy in patients who progressed after at least one line of cisplatin-based chemotherapy. Methods: We retrospectively reported the results of 133 patients who underwent HDCT and ASCT as salvage therapy from 2016 to 2021. Patients received 3 cycles of paclitaxel, ifosfomide and cisplatin (TIP) regimen as induction and 1 cycle of carboplatin 700 mg/m2 on days 1–3 plus etoposide 750 mg/m2 on days 1–3, followed by ASCT. Demographic and clinicopathological features of patients, the International Germ Cell Cancer Collaborative Group (IGCCCG) risk group at diagnosis, serum alpha-fetoprotein (AFP) and beta-human chorionic gonadotropin (HCG) levels before HDCT, treatment-related complications and survival outcomes were recorded. Results: The median age of the patients was 31 (range 18–62). The median follow-up was 31.1 months (95% CI, 28.9–33.3 months). During the median follow-up period, 74 of the 133 patients were still alive, and 63 of these were in complete remission. The median progression-free survival (PFS) was 25.8 months (95% CI, 8.1–43.4 months). The 2-year PFS rate was 50.3% and the 2-year overall survival (OS) rate was 60.8%. Variables that remained statistically significant in multivariable analysis and were associated with poor prognosis were mediastinal primary tumor location, presence of brain metastases, and higher AFP and HCG levels at baseline. Conclusion: One course of HDCT and ASCT after induction with TIP is an effective and feasible treatment option for salvage treatment of relapsed/refractory germ cell tumors, with cure rates of up to 60%. [ABSTRACT FROM AUTHOR]

The objective of this study is to investigate how electroless nickel-phosphorus-coated Manganese Aluminum Bronze (MAB-CU4) alloys react to corrosion in a 0.5 M NaCl environment. Scanning electron microscopy examinations revealed that the coating layer has a cauliflower-like structure, and there are some porosities within the coating from the release of H2 gas during the coating's deposition. EDS analysis detected only Ni and P on the coating, while XRD analysis indicated that the coating has an amorphous and nanocrystalline structure. Electrochemical corrosion tests showed that the untreated MAB-Cu4 alloy's Ecorr value dropped to -0.47 V in 1000 seconds and then stabilized. Within 200 seconds, the Ni-P-coated MAB-Cu4 alloy's corrosion potential dropped to -0.425 V from -0.412 V. Then, a progressive increase brought the potential value to -0.395V around the 2000th second. Upon examination of the anodic polarisation curve for the Ni-P-coated MAB-Cu4 alloy, it was found that the Ecorr value was lower than that of the untreated alloy (-0.532 V). The Ni-P-coated sample exhibits higher intensity values at low and medium frequencies compared to the untreated sample, indicating that the corrosion mechanism is identical for both samples; however, the Ni-P-coated sample exhibits superior corrosion resistance. Considering the frequent exposure of MAB alloys to corrosive environments, the implementation of an electroless nickel phosphorus coating may potentially improve their resistance to corrosion and extend their operational lifespan. [ABSTRACT FROM AUTHOR]

Ganglion cysts are the most common soft‑tissue tumors observed in the finger. Some tumors could be easily confused clinically with ganglion cysts due to their localization, mobility, shape, and being soft in nature. In this article, two cases of schwannoma and superficial acral myxoma that were clinically and radiologically confused with ganglion cysts are presented. Suspecting this tumor type in the preoperative diagnosis is essential to avoid unnecessary surgical approaches. Masses in close proximity to the nerve or nerve sheath are very important as they require preservation of the nerve during surgery. For these masses, surgeons should be prepared as these cases can have many intraoperative surprises in store. [ABSTRACT FROM AUTHOR]

Objectives: This study aims to uncover early detection markers through the immunological analysis of children diagnosed with multisystem inflammatory syndrome (MIS-C) and coronavirus disease-2019 (COVID-19). Methods: We retrospectively analyzed immunological data from thirty-three MIS-C patients and an equivalent number of patients under the age of 18 with a positive polymerase chain reaction (PCR) test for COVID-19. These individuals were admitted to Ondokuz Mayis University between November 2020 and February 2021. In total, the study group consisted of 66 patients and an additional 10 healthy controls. Results: Lymphopenia, thrombocytopenia, anemia, and neutrophilia, along with elevated levels of ferritin, D-dimer, and C-reactive protein, were more pronounced in MIS-C patients (p<0.001). No significant disparities were found in serum IgG, A, M, and E concentrations. Notably, there was an increased proportion of B cells (p<0.001), an inversion of the CD4/CD8 ratio, and a marked presence of CD3+CD38+HLA-DR+active T cells (p=0.009) in the MIS-C cohort. Conclusion: In the early diagnosis of MIS-C, lymphopenia, increase in B cells, reversal of CD4/CD8 ratio, and demonstration of CD3+CD38+HLA-DR+active T cells may be helpful. [ABSTRACT FROM AUTHOR]

Objectives: This study aims to uncover early detection markers through the immunological analysis of children diagnosed with multisystem inflammatory syndrome (MIS-C) and coronavirus disease-2019 (COVID-19)., Methods: We retrospectively analyzed immunological data from thirty-three MIS-C patients and an equivalent number of patients under the age of 18 with a positive polymerase chain reaction (PCR) test for COVID-19. These individuals were admitted to Ondokuz Mayis University between November 2020 and February 2021. In total, the study group consisted of 66 patients and an additional 10 healthy controls., Results: Lymphopenia, thrombocytopenia, anemia, and neutrophilia, along with elevated levels of ferritin, D-dimer, and C-reactive protein, were more pronounced in MIS-C patients (p<0.001). No significant disparities were found in serum IgG, A, M, and E concentrations. Notably, there was an increased proportion of B cells (p<0.001), an inversion of the CD4/CD8 ratio, and a marked presence of CD3+CD38+HLA-DR+active T cells (p=0.009) in the MIS-C cohort., Conclusion: In the early diagnosis of MIS-C, lymphopenia, increase in B cells, reversal of CD4/CD8 ratio, and demonstration of CD3+CD38+HLA-DR+active T cells may be helpful., Competing Interests: None declared., (© Copyright 2024 by The Medical Bulletin of Sisli Etfal Hospital.)