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Several upper-limb exoskeleton robots have been developed for stroke rehabilitation, but their rather low level of individualized assistance typically limits their effectiveness and practicability. Individualized assistance involves an upper-limb exoskeleton robot continuously assessing feedback from a stroke patient and then meticulously adjusting interaction forces to suit specific conditions and online changes. This paper describes the development of a new upper-limb exoskeleton robot with a novel online generative capability that allows it to provide individualized assistance to support the rehabilitation training of stroke patients. Specifically, the upper-limb exoskeleton robot exploits generative models to customize the fine and fit trajectory for the patient, as medical conditions, responses, and comfort feedback during training generally differ between patients. This generative capability is integrated into the two working modes of the upper-limb exoskeleton robot: an active mirroring mode for patients who retain motor abilities on one side of the body and a passive following mode for patients who lack motor ability on both sides of the body. The performance of the upper-limb exoskeleton robot was illustrated in experiments involving healthy subjects and stroke patients.

Quasi-periodic oscillations in solar flaring emission have been observed over the past few decades. To date, the underpinning processes resulting in the quasi-periodic oscillations remain unknown. In this paper, we report a unique event that exhibits both the long-duration quasi-periodic intensity oscillations of flare loops and the quasi-periodic slipping motion of ribbon substructures during a C9.1-class flare (SOL2015-03-15-T01:15), using the observations from Solar Dynamics Observatory and Interface Region Imaging Spectrograph. The high-temperature flare loops rooted in the straight part of ribbons display a "bright-dim" intensity oscillation, with a period of about 4.5 minutes. The oscillation starts just after the flare onset and lasts over 3 hours. Meanwhile, the substructures within the ribbon tip display the quasi-periodic slipping motion along the ribbon at 1400 \AA images which has a similar periodicity to the stationary intensity oscillation of the flare loops in the straight part of the flare ribbons. We suggest that the quasi-periodic pattern is probably related to the loop-top dynamics caused by the reconnection outflow impinging on the flare loops., Comment: 13 pages, 10 figures, accepted for publication in ApJ

Large Language Models (LLMs) have played an important role in many fields due to their powerful capabilities.However, their massive number of parameters leads to high deployment requirements and incurs significant inference costs, which impedes their practical applications. Training smaller models is an effective way to address this problem. Therefore, we introduce OpenBA-V2, a 3.4B model derived from multi-stage compression and continual pre-training from the original 15B OpenBA model. OpenBA-V2 utilizes more data, more flexible training objectives, and techniques such as layer pruning, neural pruning, and vocabulary pruning to achieve a compression rate of 77.3\% with minimal performance loss. OpenBA-V2 demonstrates competitive performance compared to other open-source models of similar size, achieving results close to or on par with the 15B OpenBA model in downstream tasks such as common sense reasoning and Named Entity Recognition (NER). OpenBA-V2 illustrates that LLMs can be compressed into smaller ones with minimal performance loss by employing advanced training objectives and data strategies, which may help deploy LLMs in resource-limited scenarios.

Graphene based nanomaterials have attracted significant attention for their potentials in biomedical and biotechnology applications in recent years, owing to the outstanding physical and chemical properties. However, the interaction mechanism and impact on biological activity of macro and micro biomolecules still require more concerns and further research in order to enhance their applicability in biosensors, etc. Herein, an integrated method has been developed to predict the protein bioactivity performance when interacting with nanomaterials for protein based biosensor. Molecular dynamics simulation and molecular docking technique were consolidated to investigate several nanomaterials C60 fullerene, single walled carbon nanotube, pristine graphene and graphene oxide, and their effect when interacting with protein. The adsorption behavior, secondary structure changes and protein bioactivity changes were simulated, and the results of protein activity simulation were verified in combination with atomic force spectrum, circular dichroism spectrum fluorescence and electrochemical experiments. The best quantification alignment between bioactivity obtained by simulation and experiment measurements was further explored. The two proteins, RNase A and Exonuclease III, were regarded as analysis model for the proof of concept, and the prediction accuracy of protein bioactivty could reach up to 0.98.

Decoding continuous language from brain activity is a formidable yet promising field of research. It is particularly significant for aiding people with speech disabilities to communicate through brain signals. This field addresses the complex task of mapping brain signals to text. The previous best attempt reverse-engineered this process in an indirect way: it began by learning to encode brain activity from text and then guided text generation by aligning with predicted brain responses. In contrast, we propose a simple yet effective method that guides text reconstruction by directly comparing them with the predicted text embeddings mapped from brain activities. Comprehensive experiments reveal that our method significantly outperforms the current state-of-the-art model, showing average improvements of 77% and 54% on BLEU and METEOR scores. We further validate the proposed modules through detailed ablation studies and case analyses and highlight a critical correlation: the more precisely we map brain activities to text embeddings, the better the text reconstruction results. Such insight can simplify the task of reconstructing language from brain activities for future work, emphasizing the importance of improving brain-to-text-embedding mapping techniques., Comment: Accepted to NAACL 2024 main conference