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Trichilemmal carcinoma is an extremely rare malignant cutaneous tumor derived from the outer root sheath of the hair follicles, which most commonly occurs in the sun-exposed areas of elderly individuals. This article introduces a case of trichilemmal carcinoma that occurred on the scalp of a 36-year-old male patient, the first case reported and treated with surgical excision combined with photodynamic therapy. [ABSTRACT FROM AUTHOR]

As age increases, children will face more and more adversity. How effectively they cope with stress and difficulties of life is of great significance to the development of children's mental health and academic achievement. However, few studies have explored how different interpersonal relationships and psychological suzhi work together to influence children's healthy behaviors, particularly healthy coping in adversity. Therefore, this research focused on the teacher–student relationships and coping styles, as well as the chain-mediated effects of peer relationships and psychological suzhi. A total of 688 children (360 boys, 52.3%; Mage = 10.98 and SD = 0.89) completed questionnaires that assessed using teacher–student relationships, peer relationships, psychological suzhi, and coping styles. The results indicated that teacher–student relationships correlated positively with coping styles, peer relationships, and psychological suzhi in children. Besides, teacher–student relationships positively affected coping styles through both the mediating roles of peer relationships and psychological suzhi. This research elucidated the extrinsic and intrinsic factors impacting the coping styles of children, thus providing empirical validation of existing theoretical frameworks. In China, interventions aimed at promoting Chinese children's positive coping could benefit from strategies focused on cultivating high-quality relationships and enhancing psychological suzhi. [ABSTRACT FROM AUTHOR]

The purpose of the current study was to examine the serial mediating effects of rejection sensitivity and social withdrawal on parental psychological control and attitudes toward seeking professional psychological help among senior high school students. In November 2022, 648 students completed a self-report questionnaire. The parental psychological control scale, senior high school students' rejection sensitivity scale, social withdrawal scale, and attitudes toward seeking professional psychological help scale were used for measurement. Correlation analysis showed parental psychological control and rejection sensitivity were positively correlated with social withdrawal (r = 0.387, 0.466, 0.495, all p < 0.001). Parental psychological control and rejection sensitivity were significantly negatively correlated with social withdrawal and attitudes toward seeking professional psychological help (r = −0.325, −0.324, −0.397, all p < 0.001). Mediating effect analysis indicated that parental psychological control had a significant direct effect on attitude toward seeking professional psychological help, and rejection sensitivity and social withdrawal had significant serial mediating effects among parental psychological control and attitudes toward seeking professional psychological help in senior high school students. These aspects warrant attention as they play significant roles in influencing students' willingness to seek psychological assistance. [Journal of Psychosocial Nursing and Mental Health Services, 62(7), 47–55.] [ABSTRACT FROM AUTHOR]

Lip defects due to lip tumor surgery need proper reconstruction to preserve their function. Traditional methods offer various options for lip repair, but each has limitations, and can lead to deformity, asymmetry, or functional impairment. This study aimed to investigate the clinical application of mandibular tongue-shaped flap reconstruction for postoperative defects following lip tumor surgery. A retrospective analysis was conducted on the clinical data of 29 patients with lip tumors treated between February 2018 and August 2024. Patients were divided into two groups based on the surgical method: the tongue-shaped flap group (group T, n = 17) and the Abbe flap group (group A, n = 12). Preoperative indicators (preoperative pathology, tumor location), intraoperative and postoperative indicators (operation time, intraoperative blood loss, hospitalization duration, defect repair range), follow-up indicators (scar hyperplasia at 1, 6, and 12 months postoperatively, flap color difference, lip function, patient satisfaction), and complications (postoperative bleeding, flap necrosis, microstomia, incomplete closure, salivation) were compared and analyzed between the two groups. Group T had a significantly shorter operation time, less intraoperative blood loss, and shorter hospitalization duration compared with group A (all p < 0.05). The tongue-shaped flap was suitable for repairing defects ranging from half to the full length of the lip, while the Abbe flap was suitable for defects ranging from one-third to half the length of the lip. Group T demonstrated a wider repair range compared with group A. At 1 month postoperatively, group A showed a statistically significant difference in eating difficulty compared with group T (p < 0.05), while no statistically significant differences were found at 3, 6, and 12 months postoperatively (p > 0.05). There were no statistically significant differences between the two groups in terms of scar hyperplasia, flap color difference, or overall patient satisfaction (p > 0.05). The incidence of microstomia was significantly lower in group T compared with group A (p < 0.05). There were no statistically significant differences between the two groups in the rates of postoperative bleeding, flap necrosis, incomplete lip closure, or salivation (p > 0.05). Mandibular tongue-shaped flap reconstruction is a novel method for repairing postoperative defects following lip tumor surgery. This technique simplifies the surgical procedure while achieving both functional and aesthetic preservation. It offers advantages such as a wider repair range, minimal trauma, shorter operation time, faster postoperative recovery, shorter hospitalization duration, and a lower incidence of microstomia. Patients demonstrate good tolerance, making it particularly suitable for elderly and high-risk patients. This method may become a new option for repairing defects following lip tumor excision., Competing Interests: Declaration of competing interest The authors declare that they have no conflicts of interest., (Copyright © 2024 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

In-58, a peptide derived from indolicidin, shows extraordinary antibacterial activity and lower toxicity than indolicidin toward mammalian cells. Here, we investigated the antifungal activity of In-58 against the human pathogen Sporothrix globosa in vitro and in vivo . In-58 markedly inhibited the growth of Sporothrix globosa isolates in microdilution assays and showed no antagonism with any tested antifungal agent (itraconazole, terbinafine or amphotericin B). Scanning electron microscopy and propidium iodide staining indicated that In-58 alters the cell wall integrity and interacts with DNA, leading to disruption of S. globosa in a dose-dependent manner. In S. globosa , the mitochondrial membrane potential decreased and reactive oxygen species increased after treatment with In-58. In vivo experiments in the Galleria mellonella (greater wax moth) larval infection model revealed the effectiveness of In-58 against S. globosa infection with low toxicity. Our results indicate that In-58 possesses remarkable antifungal activity against S. globosa in vitro and in vivo . It has potential as a novel drug for the treatment of sporotrichosis., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Li, Tang, Liu, Lv, Yao, Wang and Li.)