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Large Language Models (LLMs) like GPT-4, MedPaLM-2, and Med-Gemini achieve performance competitively with human experts across various medical benchmarks. However, they still face challenges in making professional diagnoses akin to physicians, particularly in efficiently gathering patient information and reasoning the final diagnosis. To this end, we introduce the RuleAlign framework, designed to align LLMs with specific diagnostic rules. We develop a medical dialogue dataset comprising rule-based communications between patients and physicians and design an alignment learning approach through preference learning. Experimental results demonstrate the effectiveness of the proposed approach. We hope that our work can serve as an inspiration for exploring the potential of LLMs as AI physicians., Comment: Ongoing work

In recent years, large-scale pre-trained diffusion models have demonstrated their outstanding capabilities in image and video generation tasks. However, existing models tend to produce visual objects commonly found in the training dataset, which diverges from user input prompts. The underlying reason behind the inaccurate generated results lies in the model's difficulty in sampling from specific intervals of the initial noise distribution corresponding to the prompt. Moreover, it is challenging to directly optimize the initial distribution, given that the diffusion process involves multiple denoising steps. In this paper, we introduce a Fine-tuning Initial Noise Distribution (FIND) framework with policy optimization, which unleashes the powerful potential of pre-trained diffusion networks by directly optimizing the initial distribution to align the generated contents with user-input prompts. To this end, we first reformulate the diffusion denoising procedure as a one-step Markov decision process and employ policy optimization to directly optimize the initial distribution. In addition, a dynamic reward calibration module is proposed to ensure training stability during optimization. Furthermore, we introduce a ratio clipping algorithm to utilize historical data for network training and prevent the optimized distribution from deviating too far from the original policy to restrain excessive optimization magnitudes. Extensive experiments demonstrate the effectiveness of our method in both text-to-image and text-to-video tasks, surpassing SOTA methods in achieving consistency between prompts and the generated content. Our method achieves 10 times faster than the SOTA approach. Our homepage is available at \url{https://github.com/vpx-ecnu/FIND-website}.

Large language models (LLMs), such as GPT series models, have received substantial attention due to their impressive capabilities for generating and understanding human-level language. More recently, LLMs have emerged as an innovative and powerful adjunct in the medical field, transforming traditional practices and heralding a new era of enhanced healthcare services. This survey provides a comprehensive overview of Medical Large Language Models (Med-LLMs), outlining their evolution from general to the medical-specific domain (i.e, Technology and Application), as well as their transformative impact on healthcare (e.g., Trustworthiness and Safety). Concretely, starting from the fundamental history and technology of LLMs, we first delve into the progressive adaptation and refinements of general LLM models in the medical domain, especially emphasizing the advanced algorithms that boost the LLMs' performance in handling complicated medical environments, including clinical reasoning, knowledge graph, retrieval-augmented generation, human alignment, and multi-modal learning. Secondly, we explore the extensive applications of Med-LLMs across domains such as clinical decision support, report generation, and medical education, illustrating their potential to streamline healthcare services and augment patient outcomes. Finally, recognizing the imperative and responsible innovation, we discuss the challenges of ensuring fairness, accountability, privacy, and robustness in Med-LLMs applications. Finally, we conduct a concise discussion for anticipating possible future trajectories of Med-LLMs, identifying avenues for the prudent expansion of Med-LLMs. By consolidating above-mentioned insights, this review seeks to provide a comprehensive investigation of the potential strengths and limitations of Med-LLMs for professionals and researchers, ensuring a responsible landscape in the healthcare setting.

Let A be a commutative noetherian local DG-ring with bounded cohomology. The Intersection Theorem for DG-modules is examined and some of its applications are provided. The first is to prove the DG-setting of the amplitude inequality, New Intersection Theorem and Krull's principle ideal theorem. The second is to solve completely the Minamoto's conjecture in [Israel J. Math. 242 (2021) 1-36]. The third is to show the DG-version of the Bass conjecture about Cohen-Macaulay rings and the Vasconcelos conjecture about Gorenstein rings., Comment: 18 pages, comments welcome!

Large language models (LLMs) are gaining increasing interests to improve clinical efficiency for medical diagnosis, owing to their unprecedented performance in modelling natural language. Ensuring the safe and reliable clinical applications, the evaluation of LLMs indeed becomes critical for better mitigating the potential risks, e.g., hallucinations. However, current evaluation methods heavily rely on labor-intensive human participation to achieve human-preferred judgements. To overcome this challenge, we propose an automatic evaluation paradigm tailored to assess the LLMs' capabilities in delivering clinical services, e.g., disease diagnosis and treatment. The evaluation paradigm contains three basic elements: metric, data, and algorithm. Specifically, inspired by professional clinical practice pathways, we formulate a LLM-specific clinical pathway (LCP) to define the clinical capabilities that a doctor agent should possess. Then, Standardized Patients (SPs) from the medical education are introduced as the guideline for collecting medical data for evaluation, which can well ensure the completeness of the evaluation procedure. Leveraging these steps, we develop a multi-agent framework to simulate the interactive environment between SPs and a doctor agent, which is equipped with a Retrieval-Augmented Evaluation (RAE) to determine whether the behaviors of a doctor agent are in accordance with LCP. The above paradigm can be extended to any similar clinical scenarios to automatically evaluate the LLMs' medical capabilities. Applying such paradigm, we construct an evaluation benchmark in the field of urology, including a LCP, a SPs dataset, and an automated RAE. Extensive experiments are conducted to demonstrate the effectiveness of the proposed approach, providing more insights for LLMs' safe and reliable deployments in clinical practice.

Despite significant strides in multimodal tasks, Multimodal Large Language Models (MLLMs) are plagued by the critical issue of hallucination. The reliable detection of such hallucinations in MLLMs has, therefore, become a vital aspect of model evaluation and the safeguarding of practical application deployment. Prior research in this domain has been constrained by a narrow focus on singular tasks, an inadequate range of hallucination categories addressed, and a lack of detailed granularity. In response to these challenges, our work expands the investigative horizons of hallucination detection. We present a novel meta-evaluation benchmark, MHaluBench, meticulously crafted to facilitate the evaluation of advancements in hallucination detection methods. Additionally, we unveil a novel unified multimodal hallucination detection framework, UNIHD, which leverages a suite of auxiliary tools to validate the occurrence of hallucinations robustly. We demonstrate the effectiveness of UNIHD through meticulous evaluation and comprehensive analysis. We also provide strategic insights on the application of specific tools for addressing various categories of hallucinations., Comment: Accepted by ACL 2024 (main conference)