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Abstract Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and the expression and function of an uncharacterized protein RNF214 in HCC are still unknown. Phase separation has recently been observed to participate in the progression of HCC. In this study, we investigated the expression, function, and phase separation of RNF214 in HCC. We found that RNF214 was highly expressed in HCC and associated with poor prognosis. RNF214 functioned as an oncogene to promote the proliferation, migration, and metastasis of HCC. Mechanically, RNF214 underwent phase separation, and the coiled-coil (CC) domain of RNF214 mediated its phase separation. Furthermore, the CC domain was necessary for the oncogenic function of RNF214 in HCC. Taken together, our data favored that phase separation of RNF214 promoted the progression of HCC. RNF214 may be a potential biomarker and therapeutic target for HCC.

Abstract Clinical studies have shown that there may be a certain relationship between pathological changes of the myodural bridge complex (MDBC) and chronic headaches of unknown cause. But there is still a lack of experimental evidence to explain the possible mechanism. This study aims to further confirm this relationship between MDBC and chronic headaches and explore its potential occurrence mechanism in rats. Bleomycin (BLM) or phosphate-buffered saline (PBS) was injected into the myodural bridge fibers of rats to establish the hyperplastic model of MDBC. After 4 weeks, the occurrence of headaches in rats was evaluated through behavioral scores. The immunohistochemistry staining method was applied to observe the expression levels of headache-related neurotransmitters in the brain. Masson trichrome staining results showed that the number of collagen fibers of MDBC was increased in the BLM group compared to those of the other two groups. It revealed hyperplastic changes of MDBC. The behavioral scores of the BLM group were significantly higher than those of the PBS group and the blank control group. Meanwhile, expression levels of CGRP and 5-HT in the headache-related nuclei of the brain were increased in the BLM group. The current study further confirms the view that there is a relationship between pathological changes of MDBC and chronic headaches of unknown cause. This study may provide anatomical and physiological explanations for the pathogenesis of some chronic headaches of unknown cause.

Background and purpose: Daily cone-beam computed tomography (CBCT) in image-guided radiotherapy administers radiation exposure and subjects patients to secondary cancer risk. Reducing imaging dose remains challenging as image quality deteriorates. We investigated three imaging dose levels by reducing projections and correcting images using two deep learning algorithms, aiming at identifying the lowest achievable imaging dose. Materials and methods: CBCTs were reconstructed with 100%, 25%, 15% and 10% projections. Models were trained (30), validated (3) and tested (8) with prostate cancer patient datasets. We optimized and compared the performance of 1) a cycle generative adversarial network (cycleGAN) with residual connection and 2) a contrastive unpaired translation network (CUT) to generate synthetic computed tomography (sCT) from reduced imaging dose CBCTs. Volumetric modulated arc therapy plans were optimized on a reference intensity-corrected full dose CBCTcor and recalculated on sCTs. Hounsfield unit (HU) and positioning accuracy were evaluated. Bladder and rectum were manually delineated to determine anatomical fidelity. Results: All sCTs achieved average mean absolute mean absolute error/structural similarity index measure/peak signal-to-noise ratio of ⩽59HU/⩾0.94/⩾33 dB. All dose-volume histogram parameter differences were within 2 Gy or 2%. Positioning differences were ⩽0.30 mm or 0.30°. cycleGAN with Dice similarity coefficients (DSC) for bladder/rectum of ⩾0.85/⩾0.81 performed better than CUT (⩾0.83/⩾0.76). A significantly lower DSC accuracy was observed for 15% and 10% sCTs. cycleGAN performed better than CUT for contouring, however both yielded comparable outcomes in other evaluations. Conclusion: sCTs based on different CBCT doses using cycleGAN and CUT were investigated. Based on segmentation accuracy, 25% is the minimum imaging dose.

To weaken the adverse effects of traditional planar heterojunctions on phototransistors, an effective strategy for achieving low dark-current and high photoresponsive organic phototransistors via constructing a sandwich heterostructure is demonstrated. This work offers a new route for the design and development of high-performance phototransistor devices. [ABSTRACT FROM AUTHOR]

Synthetic Aperture Radar (SAR) has emerged as a pivotal technology in geosciences, offering unparalleled insights into Earth's surface. Indeed, its ability to provide high‐resolution, all‐weather, and day‐night imaging has revolutionized our understanding of various geophysical processes. Recent advancements in SAR technology, that is, developing new satellite missions, enhancing signal processing techniques, and integrating machine learning algorithms, have significantly broadened the scope and depth of geosciences. Therefore, it is essential to summarize SAR's comprehensive applications for geosciences, especially emphasizing recent advancements in SAR technologies and applications. Moreover, current SAR‐related review papers have primarily focused on SAR technology or SAR imaging and data processing techniques. Hence, a review that integrates SAR technology with geophysical features is needed to highlight the significance of SAR in addressing challenges in geosciences, as well as to explore SAR's potential in solving complex geoscience problems. Spurred by these requirements, this review comprehensively and in‐depth reviews SAR applications for geosciences, broadly including various aspects in air‐sea dynamics, oceanography, geography, disaster and hazard monitoring, climate change, and geosciences data fusion. For each applied field, the scientific advancements produced because of SAR are demonstrated by combining the SAR techniques with characteristics of geophysical phenomena and processes. Further outlooks are also explored, such as integrating SAR data with other geophysical data and conducting interdisciplinary research to offer comprehensive insights into geosciences. With the support of deep learning, this synergy will enhance the capability to model, simulate, and forecast geophysical phenomena with greater accuracy and reliability. Plain Language Summary: Synthetic aperture radar (SAR) uses microwaves to remotely see the Earth's surface under all weather conditions, day and night. SAR has been providing high‐resolution images for many decades and they have been applied to many fields in geosciences. Several SAR sensors have been launched in recent years, significantly increasing the SAR data volume and leading to great developments in SAR technology, thereby improving our understanding of geophysical phenomena and processes. This work comprehensively overviews the application of SAR in geosciences, including oceanography, geography, geodesy, climatology, seismology, meteorology, and environmental science. Moreover, this review paper highlights the significance of SAR in various aspects of geosciences, summarizes recent advancements in SAR technology, and demonstrates unique insights and important contributions of SAR in understanding and solving geophysical questions. Future directions and outlooks include integrating SAR with other geophysical data and interdisciplinary applications for complex questions. This review serves as an up‐to‐date guide to the cutting‐edge uses of SAR technology in comprehensive geophysical studies. It is aimed at researchers and practitioners in geosciences, as well as policymakers and stakeholders interested in leveraging SAR for geosciences. Key Points: Synthetic Aperture Radar (SAR) for geosciences is comprehensively reviewed broadly including oceanography, geography, hazards, and climate changeScientific advances contributed by SAR techniques for each topic are overviewed in‐depth with recent developments and frontiers highlightedData, techniques, and scientific insights of SAR are summarized and prospected, highlighting the role of machine learning [ABSTRACT FROM AUTHOR]

Linear complexity is an important pseudo-random measure of the key stream sequence in a stream cipher system. The 1-error linear complexity is used to measure the stability of the linear complexity, which means the minimal linear complexity of the new sequence by changing one bit of the original key stream sequence. This paper contributes to calculating the exact values of the linear complexity and 1-error linear complexity of the binary key stream sequence with two prime periods defined by Ding–Helleseth generalized cyclotomy. We provide a novel method to solve such problems by employing the discrete Fourier transform and the M–S polynomial of the sequence. Our results show that, by choosing appropriate parameters p and q, the linear complexity and 1-error linear complexity can be no less than half period, which shows that the linear complexity of this sequence not only meets the requirements of cryptography but also has good stability. [ABSTRACT FROM AUTHOR]

Titanium oxide (TiO2) coated polyimide has broad application prospects under extreme conditions. In order to obtain a high-quality ultra-thin TiO2 coating on polyimide by atomic layer deposition (ALD), the polyimide was activated by in situ oxygen plasma. It was found that a large number of polar oxygen functional groups, such as carboxyl, were generated on the surface of the activated polyimide, which can significantly promote the preparation of TiO2 coating by ALD. The nucleation and growth of TiO2 were studied by x-ray photoelectron spectroscopy monitoring and scanning electron microscopy observation. On the polyimide activated by oxygen plasma, the size of TiO2 nuclei decreased and the quantity of TiO2 nuclei increased, resulting in the growth of a highly uniform and dense TiO2 coating. This coating exhibited excellent resistance to atomic oxygen. When exposed to 3.5 × 1021 atom cm−2 atomic oxygen flux, the erosion yield of the polyimide coated with 100 ALD cycles of TiO2 was as low as 3.0 × 10−25 cm3/atom, which is one order less than that of the standard POLYIMIDE-ref Kapton® film. [ABSTRACT FROM AUTHOR]

Context: Hashimoto thyroiditis (HT) is related to intestinal microbiota alteration, but the causal relationship remains unclear. Hydrogen sulfide (H2S) is a microbiota-derived metabolite. We speculated that abnormal intestinal microbiota might limit H2S production capacity, promoting HT pathogenesis. Objective: This work aimed to illustrate that the intestinal microbiota plays important roles in HT pathogenesis via microbiota-derived H2S levels. Methods: We collected feces from HT patients and healthy donors for fecal microbiota transplantation (FMT). Thirty-six female CBA/J mice were randomly assigned to 4 groups: experimental autoimmune thyroiditis (EAT) group, EAT + Healthy group, EAT + HT group, and EAT + HT + H2S group. 16S ribosomal RNA sequencing was performed to examine gut microbiota alterations and the H2S production pathway. Serum TgAb and H2S levels were assayed by enzyme-linked immunosorbent assay and H2S-selective sensors, respectively. T-cell subpopulations in the spleen were detected by flow cytometry. Results: The gut microbiota was different after FMT among the EAT, EAT + Healthy, and EAT + HT groups. The thyroiditis score assessed by hematoxylin and eosin staining was higher in the EAT + HT group than that in the EAT and EAT + HT + H2S groups. Helper T (Th1) and Th17 cell differentiation ratios were increased in the EAT + HT group compared to the other 3 groups. Serum H2S levels were decreased and the dissimilatory sulfate reduction (DSR) pathway was attenuated in the EAT + HT group compared to the EAT + Healthy group. Conclusion: H2S alleviated thyroiditis severity and related immune disorders, which were aggravated by the FMT from HT patients. The attenuated DSR pathway in the gut microbiota from HT patients might be involved in thyroiditis pathogenesis. [ABSTRACT FROM AUTHOR]

Chiral lead halide perovskites have captivated considerable attentions due to their distinctive attributes, such as ferroelectricity, spin‐dependent transport, and chiroptical activity. However, lead toxicity and weak circularly polarized luminescence (CPL) have cast a pall over their practical applications. Here, a series of 0D lead‐free chiral enantiomorphic hybrids, such as (R‐/S‐MBA)3In1‐xSbxCl6 (x = 0–1) is successfully developed. By optimizing the Sb3+ doping concentration to 0.55%, the resultant (R‐/S‐MBA)3In99.45%Sb0.55%Cl6 not only shows a near‐unity quantum yield but also emanates potent CPL, boasting a dissymmetry factor (glum) of 6.3 × 10–3. These efficient CPL activities are intricately tied to the presence of a twisted luminescent cluster [SbCl6]3– induced by structural chirality. The comprehensive results reveal that the emission of the chiral perovskite originated from self‐trapped excitons (STEs) of 5s2 Sb3+ ions. Moreover, (MBA)3In99.45%Sb0.55%Cl6 single crystals also exhibit bright orange emission and UV detector signals. These findings will pave the way for the further investigation in efficient CPL and detectors based on lead‐free chiral optoelectronic materials. [ABSTRACT FROM AUTHOR]

A Study on Relationship between Single-Slice Hounsfield Unit(HU) value of the Chinese proximal humerus and Bone Mineral Density(BMD) Using Routine Chest CT and Dual-energy X-ray Absorptiometry(DEXA) was performed. Data were collected from 240 individuals who underwent DEXA and routine chest CT scans (including full images of the proximal humerus) on the same day at 967 Hospitals between January 2019 and December 2021. The method of measuring single-slice HU values of the proximal humerus on routine chest CT scans exhibited high reliability and repeatability (intraclass correlation coefficient > 0.961, P < 0.001). A strong positive correlation was observed between single-slice HU values of the proximal humerus and DEXA results, with the 20-mm HU value demonstrating the highest correlation. Across different BMI groups, the Area Under Curve (AUC) for the 20-mm HU value was consistently the largest (AUC=0.701-0.813, P< 0.05). Therefore, the 20-mm HU value can be considered a reliable reference for the opportunistic screening of low BMD, with reference values of -4HU for underweight individuals, -13HU for normal weight individuals, -7HU for overweight individuals, and -16HU for obese individuals. Values below these thresholds indicate a risk of low BMD. This study enriches the Chinese BMD data and offers a swift and effective approach for opportunistically screening low BMD. [ABSTRACT FROM AUTHOR]

The polar channels formed by the curing of waterborne anticorrosive coatings compromise their water resistance, leading to coating degradation and metal corrosion. To enhance the anticorrosive performance of waterborne coatings, this study proposed a novel method of depositing ultrathin Al 2 O 3 films on the surface of waterborne epoxy coatings by atomic layer deposition, a technique that can modify the surface properties of polymer materials by depositing functional films. The Al 2 O 3 -modified coatings exhibited improved sealing and barrier properties by closing the polar channels and surface defects and cracks. The surface structure and morphology of the modified coatings were characterized by x-ray photoelectron spectroscopy and scanning electron microscopy. The hydrophilicity and corrosion resistance of the modified coatings were evaluated by water contact angle measurement, Tafel polarization curve, and electrochemical impedance spectroscopy. The results indicated that the water contact angle of the Al 2 O 3 -modified coating increased by 48° compared to the unmodified coating, and the protection efficiency of the modified coating reached 99.81%. The Al 2 O 3 -modified coating demonstrated high anticorrosive efficiency and potential applications for metal anticorrosion in harsh marine environments., (© 2024 IOP Publishing Ltd.)