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1. Research on the Dynamic Response of High-speed Trains under Different Curve Radii Caused by Wind–sand Flow

Author

Y. Bai, Z. N. Zhang, Z. F. Wang, T. M. Li, and Y. J. Wang

Subjects
lanzhou-urumqi high-speed railway, wind-sand two-phase flow, discrete-phase model, aerodynamic characteristics, dynamic performance, Mechanical engineering and machinery, TJ1-1570
Abstract

To investigate how the curve radius parameter affects the safety of high-speed train operation in a wind–sand environment, researchers used the wind–sand section of the Lanzhou–Urumqi high-speed railway as their research backdrop. The Euler‒Lagrange method was used to discretize the sand particles based on train aerodynamics theory, and the wind–sand flow model of the head–middle–tail three-member formation was established. The accuracy of the model was verified by comparing the data from published papers, and then the train's wind–sand load was calculated and extracted. Subsequently, a dynamic model of a CRH2 train was created, and the dynamic response of the train was estimated by choosing various curve radii and adding wind–sand loads. The results demonstrated that as wind speed increases, the forces acting on the train due to wind rise. Due to the different shapes and positions of the carriages, the wind–sand load on each car differs; the middle car is subjected to greater lift, lateral force, and overturning moment, as well as lower resistance, nodding moment, and head shaking moment, while the head and tail cars move in the opposite direction and, as a whole, are exposed more adverse forces. The study found that when the curve radius increased from 7000 to 9000 m, the derailment coefficient and wheel-rail lateral force are reduced by approximately 29%~32%, along with an approximately 20%~23% decrease in the wheel load reduction rate. When the radius reaches 10000 m, there is a decrease in the derailment coefficient and wheel-rail lateral force of approximately 5%~8%, as well as a reduction in the wheel weight load reduction rate of approximately 3%~6%.It has been concluded that increasing the curve radius can significantly reduce the safety indices in the wind-blown sand environment, thus improving operational safety. However, it should be noted that a radius of 8000~9000 m is appropriate, and the effect of further increase is not obvious. The results of this study can provide certain guidance for the selection of curve radius and the evaluation of the operational safety of high-speed trains in windy–sandy areas.

Published
2024
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2. Detection of Very High-energy Gamma-Ray Emission from the Radio Galaxy M87 with LHAASO

Author

Zhen Cao, F. Aharonian, Axikegu, Y. X. Bai, Y. W. Bao, D. Bastieri, X. J. Bi, Y. J. Bi, W. Bian, A. V. Bukevich, Q. Cao, W. Y. Cao, Zhe Cao, J. Chang, J. F. Chang, A. M. Chen, E. S. Chen, H. X. Chen, Liang Chen, Lin Chen, Long Chen, M. J. Chen, M. L. Chen, Q. H. Chen, S. Chen, S. H. Chen, S. Z. Chen, T. L. Chen, Y. Chen, N. Cheng, Y. D. Cheng, M. C. Chu, M. Y. Cui, S. W. Cui, X. H. Cui, Y. D. Cui, B. Z. Dai, H. L. Dai, Z. G. Dai, Danzengluobu, X. Q. Dong, K. K. Duan, J. H. Fan, Y. Z. Fan, J. Fang, J. H. Fang, K. Fang, C. F. Feng, H. Feng, L. Feng, S. H. Feng, X. T. Feng, Y. Feng, Y. L. Feng, S. Gabici, B. Gao, C. D. Gao, Q. Gao, W. Gao, W. K. Gao, M. M. Ge, T. T. Ge, L. S. Geng, G. Giacinti, G. H. Gong, Q. B. Gou, M. H. Gu, F. L. Guo, J. Guo, X. L. Guo, Y. Q. Guo, Y. Y. Guo, Y. A. Han, O. A. Hannuksela, M. Hasan, H. H. He, H. N. He, J. Y. He, Y. He, Y. K. Hor, B. W. Hou, C. Hou, X. Hou, H. B. Hu, Q. Hu, S. C. Hu, C. Huang, D. H. Huang, T. Q. Huang, W. J. Huang, X. T. Huang, X. Y. Huang, Y. Huang, Y. Y. Huang, X. L. Ji, H. Y. Jia, K. Jia, H. B. Jiang, K. Jiang, X. W. Jiang, Z. J. Jiang, M. Jin, M. M. Kang, I. Karpikov, D. Khangulyan, D. Kuleshov, K. Kurinov, B. B. Li, C. M. Li, Cheng Li, Cong Li, D. Li, F. Li, H. B. Li, H. C. Li, Jian Li, Jie Li, K. Li, S. D. Li, W. L. Li, X. R. Li, Xin Li, Y. Z. Li, Zhe Li, Zhuo Li, E. W. Liang, Y. F. Liang, S. J. Lin, B. Liu, C. Liu, D. Liu, D. B. Liu, H. Liu, H. D. Liu, J. Liu, J. L. Liu, M. Y. Liu, R. Y. Liu, S. M. Liu, W. Liu, Y. Liu, Y. N. Liu, Q. Luo, Y. Luo, H. K. Lv, B. Q. Ma, L. L. Ma, X. H. Ma, J. R. Mao, Z. Min, W. Mitthumsiri, H. J. Mu, Y. C. Nan, A. Neronov, K. C. Y. Ng, L. J. Ou, P. Pattarakijwanich, Z. Y. Pei, J. C. Qi, M. Y. Qi, B. Q. Qiao, J. J. Qin, A. Raza, D. Ruffolo, A. Sáiz, M. Saeed, D. Semikoz, L. Shao, O. Shchegolev, X. D. Sheng, F. W. Shu, H. C. Song, Yu. V. Stenkin, V. Stepanov, Y. Su, D. X. Sun, Q. N. Sun, X. N. Sun, Z. B. Sun, J. Takata, P. H. T. Tam, Q. W. Tang, R. Tang, Z. B. Tang, W. W. Tian, L. H. Wan, C. Wang, C. B. Wang, G. W. Wang, H. G. Wang, H. H. Wang, J. C. Wang, Kai Wang, L. P. Wang, L. Y. Wang, P. H. Wang, R. Wang, W. Wang, X. G. Wang, X. Y. Wang, Y. Wang, Y. D. Wang, Y. J. Wang, Z. H. Wang, Z. X. Wang, Zhen Wang, Zheng Wang, D. M. Wei, J. J. Wei, Y. J. Wei, T. Wen, C. Y. Wu, H. R. Wu, Q. W. Wu, S. Wu, X. F. Wu, Y. S. Wu, S. Q. Xi, J. Xia, G. M. Xiang, D. X. Xiao, G. Xiao, Y. L. Xin, Y. Xing, D. R. Xiong, Z. Xiong, D. L. Xu, R. F. Xu, R. X. Xu, W. L. Xu, L. Xue, D. H. Yan, J. Z. Yan, T. Yan, C. W. Yang, C. Y. Yang, F. Yang, F. F. Yang, L. L. Yang, M. J. Yang, R. Z. Yang, W. X. Yang, Y. H. Yao, Z. G. Yao, L. Q. Yin, N. Yin, X. H. You, Z. Y. You, Y. H. Yu, Q. Yuan, H. Yue, H. D. Zeng, T. X. Zeng, W. Zeng, M. Zha, B. B. Zhang, F. Zhang, H. Zhang, H. M. Zhang, H. Y. Zhang, J. L. Zhang, Li Zhang, P. F. Zhang, P. P. Zhang, R. Zhang, S. B. Zhang, S. R. Zhang, S. S. Zhang, X. Zhang, X. P. Zhang, Y. F. Zhang, Yi Zhang, Yong Zhang, B. Zhao, J. Zhao, L. Zhao, L. Z. Zhao, S. P. Zhao, X. H. Zhao, F. Zheng, W. J. Zhong, B. Zhou, H. Zhou, J. N. Zhou, M. Zhou, P. Zhou, R. Zhou, X. X. Zhou, B. Y. Zhu, C. G. Zhu, F. R. Zhu, H. Zhu, K. J. Zhu, Y. C. Zou, and X. Zuo

Subjects
Active galactic nuclei, High energy astrophysics, Astrophysics, QB460-466
Abstract

The nearby radio galaxy M87 is a very high-energy (VHE) gamma-ray emitter established by observations with ground-based gamma-ray detectors. Here we report the long-term monitoring of M87 from 2021 to 2024 with the Large High Altitude Air Shower Observatory (LHAASO). M87 has been detected by LHAASO with a statistical significance ∼ 9 σ . The observed energy spectrum extends to 20 TeV, with a possible hardening at ∼20 TeV and then a clear softening at higher energies. Assuming that the intrinsic spectrum is described by a single power law up to 20 TeV, a tight upper bound on the extragalactic background light intensity is obtained. A strong VHE flare lasting 8 days, with a rise time of ${\tau }_{r}^{\mathrm{rise}}=1.05\pm 0.49$ days and decay time of ${\tau }_{d}^{\mathrm{decay}}=2.17\pm 0.58$ days, was found in early 2022. A possible GeV flare is seen also in Fermi Large Area Telescope data during the VHE flare period. The variability time as short as 1 day seen in the LHAASO data suggests a compact emission region with a size of ∼3 × 10 ^15 δ cm ( δ being the Doppler factor of the emitting region), corresponding to a few Schwarzschild radii of the central supermassive black hole in M87. The continuous monitoring of the source reveals a duty cycle of ∼1% for VHE flares with a flux above 10 ^−11 erg cm ^−2 s ^−1 .

Published
2024
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3. Discovery of Very High Energy Gamma-Ray Emissions from the Low-luminosity AGN NGC 4278 by LHAASO

Author

Zhen Cao, F. Aharonian, Axikegu, Y. X. Bai, Y. W. Bao, D. Bastieri, X. J. Bi, Y. J. Bi, W. Bian, A. V. Bukevich, Q. Cao, W. Y. Cao, Zhe Cao, J. Chang, J. F. Chang, A. M. Chen, E. S. Chen, H. X. Chen, Liang Chen, Lin Chen, Long Chen, M. J. Chen, M. L. Chen, Q. H. Chen, S. Chen, S. H. Chen, S. Z. Chen, T. L. Chen, Y. Chen, N. Cheng, Y. D. Cheng, M. Y. Cui, S. W. Cui, X. H. Cui, Y. D. Cui, B. Z. Dai, H. L. Dai, Z. G. Dai, Danzengluobu, X. Q. Dong, K. K. Duan, J. H. Fan, Y. Z. Fan, J. Fang, J. H. Fang, K. Fang, C. F. Feng, H. Feng, L. Feng, S. H. Feng, X. T. Feng, Y. Feng, Y. L. Feng, S. Gabici, B. Gao, C. D. Gao, Q. Gao, W. Gao, W. K. Gao, M. M. Ge, L. S. Geng, G. Giacinti, G. H. Gong, Q. B. Gou, M. H. Gu, F. L. Guo, X. L. Guo, Y. Q. Guo, Y. Y. Guo, Y. A. Han, M. Hasan, H. H. He, H. N. He, J. Y. He, Y. He, Y. K. Hor, B. W. Hou, C. Hou, X. Hou, H. B. Hu, Q. Hu, S. C. Hu, D. H. Huang, T. Q. Huang, W. J. Huang, X. T. Huang, X. Y. Huang, Y. Huang, X. L. Ji, H. Y. Jia, K. Jia, K. Jiang, X. W. Jiang, Z. J. Jiang, M. Jin, M. M. Kang, I. Karpikov, D. Kuleshov, K. Kurinov, B. B. Li, C. M. Li, Cheng Li, Cong Li, D. Li, F. Li, H. B. Li, H. C. Li, Jian Li, Jie Li, K. Li, S. D. Li, W. L. Li, X. R. Li, Xin Li, Y. Z. Li, Zhe Li, Zhuo Li, E. W. Liang, Y. F. Liang, S. J. Lin, B. Liu, C. Liu, D. Liu, D. B. Liu, H. Liu, H. D. Liu, J. Liu, J. L. Liu, M. Y. Liu, R. Y. Liu, S. M. Liu, W. Liu, Y. Liu, Y. N. Liu, Q. Luo, Y. Luo, H. K. Lv, B. Q. Ma, L. L. Ma, X. H. Ma, J. R. Mao, Z. Min, W. Mitthumsiri, H. J. Mu, Y. C. Nan, A. Neronov, L. J. Ou, P. Pattarakijwanich, Z. Y. Pei, J. C. Qi, M. Y. Qi, B. Q. Qiao, J. J. Qin, A. Raza, D. Ruffolo, A. Sáiz, M. Saeed, D. Semikoz, L. Shao, O. Shchegolev, X. D. Sheng, F. W. Shu, H. C. Song, Yu. V. Stenkin, V. Stepanov, Y. Su, D. X. Sun, Q. N. Sun, X. N. Sun, Z. B. Sun, J. Takata, P. H. T. Tam, Q. W. Tang, R. Tang, Z. B. Tang, W. W. Tian, C. Wang, C. B. Wang, G. W. Wang, H. G. Wang, H. H. Wang, J. C. Wang, Kai Wang, L. P. Wang, L. Y. Wang, P. H. Wang, R. Wang, W. Wang, X. G. Wang, X. Y. Wang, Y. Wang, Y. D. Wang, Y. J. Wang, Z. H. Wang, Z. X. Wang, Zhen Wang, Zheng Wang, D. M. Wei, J. J. Wei, Y. J. Wei, T. Wen, C. Y. Wu, H. R. Wu, Q. W. Wu, S. Wu, X. F. Wu, Y. S. Wu, S. Q. Xi, J. Xia, G. M. Xiang, D. X. Xiao, G. Xiao, Y. L. Xin, Y. Xing, D. R. Xiong, Z. Xiong, D. L. Xu, R. F. Xu, R. X. Xu, W. L. Xu, L. Xue, D. H. Yan, J. Z. Yan, T. Yan, C. W. Yang, C. Y. Yang, F. Yang, F. F. Yang, L. L. Yang, M. J. Yang, R. Z. Yang, W. X. Yang, Y. H. Yao, Z. G. Yao, L. Q. Yin, N. Yin, X. H. You, Z. Y. You, Y. H. Yu, Q. Yuan, H. Yue, H. D. Zeng, T. X. Zeng, W. Zeng, M. Zha, B. B. Zhang, F. Zhang, H. Zhang, H. M. Zhang, H. Y. Zhang, J. L. Zhang, Li Zhang, P. F. Zhang, P. P. Zhang, R. Zhang, S. B. Zhang, S. R. Zhang, S. S. Zhang, X. Zhang, X. P. Zhang, Y. F. Zhang, Yi Zhang, Yong Zhang, B. Zhao, J. Zhao, L. Zhao, L. Z. Zhao, S. P. Zhao, X. H. Zhao, F. Zheng, W. J. Zhong, B. Zhou, H. Zhou, J. N. Zhou, M. Zhou, P. Zhou, R. Zhou, X. X. Zhou, B. Y. Zhu, C. G. Zhu, F. R. Zhu, H. Zhu, K. J. Zhu, Y. C. Zou, X. Zuo, and The LHAASO Collaboration

Subjects
High energy astrophysics, Gamma-ray astronomy, Low-luminosity active galactic nuclei, LINER galaxies, Blazars, Fanaroff-Riley radio galaxies, Astrophysics, QB460-466
Abstract

The first source catalog of the Large High Altitude Air Shower Observatory (LHAASO) reported the detection of a very high energy gamma-ray source, 1LHAASO J1219+2915. This Letter presents a further detailed study of the spectral and temporal behavior of this pointlike source. The best-fit position of the TeV source (R.A. = 185.°05 ± 0.°04, decl. = 29.°25 ± 0.°03) is compatible with NGC 4278 within ∼0.°03. Variation analysis shows an indication of variability on a timescale of a few months in the TeV band, which is consistent with low-frequency observations. Based on these observations, we report the detection of TeV γ -ray emissions from this low-luminosity active galactic nucleus. The observation by LHAASO's Water Cherenkov Detector Array during the active period has a significance level of 8.8 σ with a best-fit photon spectral index Γ = 2.56 ± 0.14 and a flux f _1–10 TeV = (7.0 ± 1.1 _sta ± 0.35 _syst ) × 10 ^−13 photons cm ^−2 s ^−1 , or approximately 5% of the Crab Nebula. The discovery of VHE gamma-ray emission from NGC 4278 indicates that compact, weak radio jets can efficiently accelerate particles and emit TeV photons.

Published
2024
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4. Study on the Temporal Evolution of the Radial Differential Rotation of Solar Corona Using Radio Emissions

Author

N. B. Xiang, X. H. Zhao, L. H. Deng, F. Y. Li, Y. J. Wang, and X. W. Tan

Subjects
Solar corona, Solar rotation, Astrophysics, QB460-466
Abstract

The daily measurements of the disk-integrated solar radio flux, observed by the Radio Solar Telescope Network, at 245, 410, 610, 1415, 2695, 4995, and 8800 MHz during the time interval of 1989 January 1 to 2019 December 17, are used to investigate the temporal evolution of radial differential rotation of the solar corona using the methods of ensemble empirical mode decomposition (EEMD) and wavelet analysis. Overall, the results reveal that over the 30 yr period, the rotation rates for the observed solar radio flux within the frequency range of 245–8800 MHz show an increase with frequency. This verifies the existence of the radial differential rotation of the solar corona over long timescales of nearly three solar cycles. Based on the radio emission mechanism, to some extent, the results can also serve as an indicator of how the rotation of the solar upper atmosphere varies with altitude within a specific range. From the temporal variation of rotation cycle lengths of radio flux, the coronal rotation at different altitudes from the low corona to approximately 1.3 R _⊙ exhibits complex temporal variations with the progression of the solar cycle. However, in this altitude range, over the past 30 yr from 1989 to 2019, the coronal rotation consistently becomes gradually slower as the altitude increases. Finally, the EEMD method can extract rotation cycle signals from these highly randomized radio emissions, and so it can be used to investigate the rotation periods for the radio emissions at higher or lower frequencies.

Published
2024
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5. The First LHAASO Catalog of Gamma-Ray Sources

Author

Zhen Cao, F. Aharonian, Q. An, Axikegu, Y. X. Bai, Y. W. Bao, D. Bastieri, X. J. Bi, Y. J. Bi, J. T. Cai, Q. Cao, W. Y. Cao, Zhe Cao, J. Chang, J. F. Chang, A. M. Chen, E. S. Chen, Liang Chen, Lin Chen, Long Chen, M. J. Chen, M. L. Chen, Q. H. Chen, S. H. Chen, S. Z. Chen, T. L. Chen, Y. Chen, N. Cheng, Y. D. Cheng, M. Y. Cui, S. W. Cui, X. H. Cui, Y. D. Cui, B. Z. Dai, H. L. Dai, Z. G. Dai, Danzengluobu, D. della Volpe, X. Q. Dong, K. K. Duan, J. H. Fan, Y. Z. Fan, J. Fang, K. Fang, C. F. Feng, L. Feng, S. H. Feng, X. T. Feng, Y. L. Feng, S. Gabici, B. Gao, C. D. Gao, L. Q. Gao, Q. Gao, W. Gao, W. K. Gao, M. M. Ge, L. S. Geng, G. Giacinti, G. H. Gong, Q. B. Gou, M. H. Gu, F. L. Guo, X. L. Guo, Y. Q. Guo, Y. Y. Guo, Y. A. Han, H. H. He, H. N. He, J. Y. He, X. B. He, Y. He, M. Heller, Y. K. Hor, B. W. Hou, C. Hou, X. Hou, H. B. Hu, Q. Hu, S. C. Hu, D. H. Huang, T. Q. Huang, W. J. Huang, X. T. Huang, X. Y. Huang, Y. Huang, Z. C. Huang, X. L. Ji, H. Y. Jia, K. Jia, K. Jiang, X. W. Jiang, Z. J. Jiang, M. Jin, M. M. Kang, T. Ke, D. Kuleshov, K. Kurinov, B. B. Li, Cheng Li, Cong Li, D. Li, F. Li, H. B. Li, H. C. Li, H. Y. Li, J. Li, Jian Li, Jie Li, K. Li, W. L. Li, X. R. Li, Xin Li, Y. Z. Li, Zhe Li, Zhuo Li, E. W. Liang, Y. F. Liang, S. J. Lin, B. Liu, C. Liu, D. Liu, H. Liu, H. D. Liu, J. Liu, J. L. Liu, J. Y. Liu, M. Y. Liu, R. Y. Liu, S. M. Liu, W. Liu, Y. Liu, Y. N. Liu, R. Lu, Q. Luo, H. K. Lv, B. Q. Ma, L. L. Ma, X. H. Ma, J. R. Mao, Z. Min, W. Mitthumsiri, H. J. Mu, Y. C. Nan, A. Neronov, Z. W. Ou, B. Y. Pang, P. Pattarakijwanich, Z. Y. Pei, M. Y. Qi, Y. Q. Qi, B. Q. Qiao, J. J. Qin, D. Ruffolo, A. Sáiz, D. Semikoz, C. Y. Shao, L. Shao, O. Shchegolev, X. D. Sheng, F. W. Shu, H. C. Song, Yu. V. Stenkin, V. Stepanov, Y. Su, Q. N. Sun, X. N. Sun, Z. B. Sun, P. H. T. Tam, Q. W. Tang, Z. B. Tang, W. W. Tian, C. Wang, C. B. Wang, G. W. Wang, H. G. Wang, H. H. Wang, J. C. Wang, K. Wang, L. P. Wang, L. Y. Wang, P. H. Wang, R. Wang, W. Wang, X. G. Wang, X. Y. Wang, Y. Wang, Y. D. Wang, Y. J. Wang, Z. H. Wang, Z. X. Wang, Zhen Wang, Zheng Wang, D. M. Wei, J. J. Wei, Y. J. Wei, T. Wen, C. Y. Wu, H. R. Wu, S. Wu, X. F. Wu, Y. S. Wu, S. Q. Xi, J. Xia, J. J. Xia, G. M. Xiang, D. X. Xiao, G. Xiao, G. G. Xin, Y. L. Xin, Y. Xing, Z. Xiong, D. L. Xu, R. F. Xu, R. X. Xu, W. L. Xu, L. Xue, D. H. Yan, J. Z. Yan, T. Yan, C. W. Yang, F. Yang, F. F. Yang, H. W. Yang, J. Y. Yang, L. L. Yang, M. J. Yang, R. Z. Yang, S. B. Yang, Y. H. Yao, Z. G. Yao, Y. M. Ye, L. Q. Yin, N. Yin, X. H. You, Z. Y. You, Y. H. Yu, Q. Yuan, H. Yue, H. D. Zeng, T. X. Zeng, W. Zeng, M. Zha, B. B. Zhang, F. Zhang, H. M. Zhang, H. Y. Zhang, J. L. Zhang, L. X. Zhang, Li Zhang, P. F. Zhang, P. P. Zhang, R. Zhang, S. B. Zhang, S. R. Zhang, S. S. Zhang, X. Zhang, X. P. Zhang, Y. F. Zhang, Yi Zhang, Yong Zhang, B. Zhao, J. Zhao, L. Zhao, L. Z. Zhao, S. P. Zhao, F. Zheng, B. Zhou, H. Zhou, J. N. Zhou, M. Zhou, P. Zhou, R. Zhou, X. X. Zhou, C. G. Zhu, F. R. Zhu, H. Zhu, K. J. Zhu, X. Zuo, and (The LHAASO Collaboration)

Subjects
Gamma-ray astronomy, Gamma-ray observatories, Catalogs, Astrophysics, QB460-466
Abstract

We present the first catalog of very-high-energy and ultra-high-energy gamma-ray sources detected by the Large High Altitude Air Shower Observatory. The catalog was compiled using 508 days of data collected by the Water Cherenkov Detector Array from 2021 March to 2022 September and 933 days of data recorded by the Kilometer Squared Array from 2020 January to 2022 September. This catalog represents the main result from the most sensitive large coverage gamma-ray survey of the sky above 1 TeV, covering decl. from −20° to 80°. In total, the catalog contains 90 sources with an extended size smaller than 2° and a significance of detection at >5 σ . Based on our source association criteria, 32 new TeV sources are proposed in this study. Among the 90 sources, 43 sources are detected with ultra-high energy ( E > 100 TeV) emission at >4 σ significance level. We provide the position, extension, and spectral characteristics of all the sources in this catalog.

Published
2024
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6. A. castellanii and P. aeruginosa mutually exacerbate damage to corneal cells during coinfection.

Author

Chen C-H, Liao C-C, Wang Y-J, Huang F-C, and Lin W-C

Subjects
Humans, Pseudomonas aeruginosa, Cornea, Coinfection pathology, Keratitis pathology, Corneal Injuries pathology
Abstract

Importance: At the National Cheng Kung University Hospital, numerous cases of amoebic keratitis had been identified with concurrent bacterial infections. Among these bacterial coinfections, Pseudomonas aeruginosa accounted for 50% of the reported cases. However, the impact of pathogenic bacteria on amoeba-induced corneal damage remains unclear. In our study, we successfully demonstrated that P. aeruginosa accumulated on the Acanthamoeba castellanii surface and caused more severe corneal damage. We also indicated that the exposure of P. aeruginosa to amoeba-soluble antigens enhanced its adhesion ability, promoted biofilm formation, and led to more severe corneal cell damage. These findings significantly contributed to our understanding of the risk associated with P. aeruginosa coinfection in the progression of amoeba keratitis., Competing Interests: The authors declare no conflict of interest.

Published
2024
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