Search

Fabrication of waterproof decorative paintings has attracted a great deal of interest. In this work, in situ reaction using poly(glycidyl methacrylate) (PGMA) and polyhedral oligomeric silsesquioxane with amino group at end (amino-POSS) was utilized to fabricate coatings at surfaces of papery/cloth decorative paintings via spray, which endowed the decorative paintings with excellent hydrophobicity, transparency, and weather ability. Firstly, ring opening of epoxy groups in PGMA, cross-linking structure in coatings, and strong coating/painting interface adhesion were achieved. Then, surface morphology of coatings was observed, and high surface roughness was confirmed. Next, high transparency and thermal stability of coatings were confirmed. Finally, surface water-contact-angles (WCAs) of coatings with various substrates were tested as a function of POSS content. Weathering resistances of coating surface on cloth substrate were studied. Coatings exhibit excellent properties such as high light transmittance (over 80%), high glass-transition temperature (upper limit ~ 113 ℃), high hydrophobicity (maximum WCA ~ 149°), and strong weathering resistances (the aged WCAs over 140°). Work innovation lies in simultaneously gained high hydrophobicity, good transparency, and strong weather ability. This work might pave a road for fabricating excellent coatings for protecting decorative paintings. [ABSTRACT FROM AUTHOR]

Introduction/Aims: Many small‐sized, single‐center preclinical studies have investigated the benefits of introducing stem cells into the interior of nerve conduit. The aims of this meta‐analysis are to review and contrast the effects of various types of stem cells in in vivo models used to reconstruct peripheral nerve injuries (PNIs) and to assess the reliability and stability of the available evidence. Methods: A systematic search was conducted using Cochrane Library, Embase, PubMed, and Web of Science to identify studies conducted from January 1, 2000, to September 21, 2022, and investigate stem cell therapy in peripheral nerve reconstruction animal models. Studies that met the relevant criteria were deemed eligible for this meta‐analysis. Results: Fifty‐five preclinical studies with a total of 1234 animals were incorporated. Stem cells demonstrated a positive impact on peripheral nerve regeneration at different follow‐up times in the forest plots of five outcome indicators: compound muscle action potential (CMAP) amplitude, latency, muscle mass ratio, nerve conduction velocity, and sciatic functional index (SFI). In most comparisons, stem cell groups showed substantial differences compared with the control groups. The superior performance of adipose‐derived stem cells (ADSCs) in terms of SFI, CMAP amplitude, and latency (p <.001) was identified. Discussion: The findings consistently demonstrated a favorable outcome in the reconstruction process when utilizing different groups of stem cells, as opposed to control groups where stem cells were not employed. [ABSTRACT FROM AUTHOR]

• A macrophage membrane coated curcumin-loaded biomimetic nanosponge system was designed for osteoarthritis alleviation. • This system can alleviate the progression of osteoarthritis by synergistically suppressing inflammation and ferroptosis. • We broadened the biomedical application of macrophage membrane as an anti-ferroptosis agent in OA treatment. Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the degradation of articular cartilage while sustained inflammation and ferroptosis have been demonstrated to play crucial roles in the progression of OA. It is an effective strategy to fabricate nanomedicines for OA treatment. However, current research primarily concentrates on anti-inflammation, whereas nanomedicine systems for anti-ferroptosis in OA treatment are rarely reported. Additionally, there are few studies integrating inflammation inhibition with anti-ferroptosis within a single system to ameliorate OA progression. In this study, we introduce a curcumin-loaded biomimetic nanosponge (CM@Cur-NPs) to alleviate OA by synergistically suppressing inflammation and ferroptosis. CM@Cur-NPs were obtained by encapsulating curcumin within polymeric nanoparticles and coating them with macrophage cell membranes. The in vitro and in vivo synergistic anti-inflammatory and anti-ferroptotic effects of CM@Cur-NPs were investigated. It was discovered that the CM@Cur-NPs significantly reduced pro-inflammatory cytokines (TNF-α, IL-6), iNOS, ROS, and apoptosis levels of chondrocytes while concurrently increasing the anti-inflammatory cytokine (IL-4) and extracellular matrix (ECM) content in vitro. We also found that CM@Cur-NPs decreased the expression of the ferroptosis marker Fe2+, ACSL4, and MDA, coupled with an increase in the levels of SLC7A11 and GPX4 of chondrocytes. Lipid peroxidation of chondrocytes was attenuated by CM@Cur-NPs as well. In vivo results indicated that CM@Cur-NPs effectively alleviated OA progression and achieved cartilage protection by upregulating Aggrecan and collagen II expression, along with downregulating ADAMTS5 and MMP13 expression. This study demonstrated that CM@Cur-NPs exhibited enhanced chondroprotective effects through synergistic anti-inflammatory and anti-ferroptotic actions. It is a promising approach to integrate inflammation and ferroptosis inhibition by bioactive nanomaterials for OA treatment. [ABSTRACT FROM AUTHOR]

The healing of critical-sized bone defects is a major challenge in the field of bone tissue engineering. Gelatin-related hydrogels have emerged as a potential solution due to their desirable properties. However, their limited osteogenic, mechanical, and reactive oxygen species (ROS)-scavenging capabilities have hindered their clinical application. To overcome this issue, we developed a biofunctional gelatin-Mxene nanocomposite hydrogel. Firstly, we prepared two-dimensional (2D) Ti 3 C 2 MXene nanosheets using a layer delamination method. Secondly, these nanosheets were incorporated into a transglutaminase (TG) enzyme-containing gallic acid-imbedded gelatin (GGA) pre-gel solution to create an injectable GGA-MXene (GM) nanocomposite hydrogel. The GM hydrogels exhibited superior compressive strength (44–75.6 kPa) and modulus (24–44.5 kPa) compared to the GGA hydrogels. Additionally, the GM hydrogel demonstrated the ability to scavenge reactive oxygen species (OH- and DPPH radicals), protecting MC3T3-E1 cells from oxidative stress. GM hydrogels were non-toxic to MC3T3-E1 cells, increased alkaline phosphatase secretion, calcium nodule formation, and upregulated osteogenic gene expressions (ALP, OCN, and RUNX2). The GM400 hydrogel was implanted in critical-sized calvarial defects in rats. Remarkably, it exhibited significant potential for promoting new bone formation. These findings indicated that GM hydrogel could be a viable candidate for future clinical applications in the treatment of critical-sized bone defects. • The successful incorporation of MXene nanosheets into a GGA hydrogel • The hydrogel was formed with a mild, simple, and controllable enzymatic method. • Improved compressive strength and modulus • The hydrogel presented in vitro osteogenic and ROS-scavenging properties • Ability to promote rat critical-sized calvarial defects repair. [ABSTRACT FROM AUTHOR]