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Abstract Fully homomorphic encryption (FHE) has experienced significant development and continuous breakthroughs in theory, enabling its widespread application in various fields, like outsourcing computation and secure multi-party computing, in order to preserve privacy. Nonetheless, the application of FHE is constrained by its substantial computing overhead and storage cost. Researchers have proposed practical acceleration solutions to address these issues. This paper aims to provide a comprehensive survey for systematically comparing and analyzing the strengths and weaknesses of FHE acceleration schemes, which is currently lacking in the literature. The relevant researches conducted between 2019 and 2022 are investigated. We first provide a comprehensive summary of the latest research findings on accelerating FHE, aiming to offer valuable insights for researchers interested in FHE acceleration. Secondly, we classify existing acceleration schemes from algorithmic and hardware perspectives. We also propose evaluation metrics and conduct a detailed comparison of various methods. Finally, our study presents the future research directions of FHE acceleration, and also offers both guidance and support for practical application and theoretical research in this field.

Alkali-activated slag cement (AASC) has shown immense potential for application as a low-carbon and eco-friendly cementitious material. It’s crucial to modify the AASC with superhydrophobic property to obtain excellent durability performance. In this paper, low-cost and non-toxic stearic acid (SA) is selected as a hydrophobic agent to impart integral hydrophobic property to the alkali-activated Portland slag cement mortar (AAPSCM). The SA-modified AAPSCM (M-AAPSCM) shows superhydrophobicity with a contact angle of 150.6° and a sliding angle of 9.5°, even when hammered to reveal its broken inner structure. The characterization analysis indicates that stearic acid not only successfully grafts onto the mortar surface but also forms calcium stearate, which successfully reduces the surface energy of the material. Combined with the porous rough structure constructed by medium sand and ethanol volatilization, the originally hydrophilic material achieves hydrophobic modification under the dual synergistic effect. The M-AAPSCM reached a compressive strength of 20.8 MPa after 28 days of curing, satisfying the requirements for hydraulic engineering applications. And the M-AAPSCM not only exhibits an excellent self-cleaning ability against contaminants like sand particles and chalk powder, but also demonstrates remarkable mechanical robustness, even after being subjected to blade scratching or mechanical fracture. Concurrently, the initial and final setting times of M-AAPSCM were determined to be 32 minutes and 41 minutes respectively, demonstrating its rapid-setting characteristic. Additionally, following the hydrophobic modification, AAPSCM effectively overcomes its inherent issues of severe autogenous shrinkage and poor carbonation resistance. Furthermore, when compared with the ordinary AAPSCM (O-AAPSCM), the durability of the M-AAPSCM against dry-wet cycles, icing, and freeze-thaw cycles is significantly enhanced.

As inorganic rigid waterproof materials with excellent substrate compatibility, non-toxicity, harmless, and deep penetration depth, cementitious capillary crystalline waterproof materials (CCCW) hold great potential for application in concrete structures. However, the formulations of commercially available CCCW are currently undisclosed, hindering the mechanism study of CCCW, which is not conducive to the development of more efficient and cost-effective CCCW materials. In this study, a new formulation of CCCW active chemicals was developed, consisting of calcium carbonate, sodium silicate, glycine, EDTA-4Na, and sodium acetate. The effectiveness of sodium acetate as a high-quality impermeable admixture to CCCW was explored to enhance the impermeability of the substrate. Subsequently, the fundamental performance of the coatings was subjected to further examination. After application of the coating, the impermeability and strength of the substrate were enhanced, and the fist impermeability strength reached 1.5 MPa. Micro characteristics testing indicated that the coated sample had a denser microstructure, resulting in an increase of calcium carbonate crystals and hydrated calcium silicate in the pores. The harmful pores (100–3000 nm) were transformed into less harmful or harmless pores (< 100 nm). The durability tests indicated a 12.37 % drop in carbonation area over 14 days, with an approximately 30 % drop in the Coulomb electric flux of chloride ions.

Migration-based Dynamic Platform (MdyPlat) is a type of Moving Target Defense (MTD) techniques to protect the task executed on the platform. MdyPlat actively hinders sophisticated attacks through randomly and dynamically setting up a platform for executing the task. This paper aims to investigate how MdyPlat-related factors make quantitative impact on the capability of MdyPlat technique. We develop a semi-Markov model for describing the system dynamics and then derive metric calculation formulas for investigation. Compared to the existing analytical-modeling-based evaluation methods, our modeling approach can work even the times of all MdyPlat-related events follow any type of distribution. The comparison between simulation and numerical results validates the approximate accuracy of the model and formulas. Numerical experiment results uncover that 1) MdyPlat technique can effectively enhance the task security, particularly under high attack intensity; 2) The security risk of the executed task varies in different task-execution scenarios, which are denoted by the number of platforms and the probability distribution of the times of MDP-related events; and 3) Different cumulative distribution function of event time under the same mean value leads to different analysis result of the task security.

OBJECTIVES/GOALS: Early life pain/stress impacts infants’ neurodevelopmental outcomes. Mitochondrial dysfunction may interface between infants’ stress and neurodevelopment. The study aims to investigate the associations between pain/stress, proteins associated with mitochondrial dysfunction, and neurobehavioral responses in preterm infants. METHODS/STUDY POPULATION: A prospective cohort study was conducted with 33 preterm infants enrolled between September 2017 and July 2022 at two affiliated NICUs in Hartford and Farmington, CT. Daily pain/stress experienced during NICU was documented. At 36-38 weeks post-menstrual age (PMA), neurobehavioral outcomes were evaluated using the NICU Network Neurobehavioral Scale (NNNS) and buccal swabs for Mass spectrometry-based proteomics analysis. Lasso statistical methods were conducted to study the association between protein abundance and infants’ NNNS summary scores. Multiple linear regression and Gene Ontology (GO) enrichment analyses were performed to examine how clinical characteristics and neurodevelopmental outcomes may be associated with protein levels and underlying molecular pathways. RESULTS/ANTICIPATED RESULTS: During NICU hospitalization, preterm premature rupture of membrane (PPROM) was negatively associated with neurobehavioral outcomes. The protein functions, including leptin receptor binding activity, glutathione disulfide oxidoreductase activity, and response to oxidative stress, lipid metabolism, phosphate, and proton transmembrane transporter activity, were negatively associated with neurobehavioral outcomes. In contrast, cytoskeletal regulation, epithelial barrier, and protection function were found to be positively associated with neurodevelopmental outcomes. In addition, mitochondrial dysfunction-related proteins (SPRR2A, PAIP1, S100A3, MT-CO2, PiC, GLRX, PHB2, and BNIPL-2, ABLIM1, UNC45A, Keratins, MUC1, and CYB5B) were found to be associated with neurobehavioral outcomes. DISCUSSION/SIGNIFICANCE: Mitochondrial dysfunction-related proteins were observed to be associated with early life pain/stress and neurodevelopmental outcomes in infants. Buccal proteins could be used to predict potential neurobehavioral outcomes. In addition, individualized skin integrity protection should be provided to preterm infants during their NICU stay.