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Abstract Idiopathic Pulmonary Fibrosis (IPF) represents a chronic and progressive pulmonary disorder distinguished by a notable mortality rate. Despite the elusive nature of the pathogenic mechanisms, several signaling pathways have been elucidated for their pivotal roles in the progression of this ailment. This manuscript aims to comprehensively review the existing literature on the signaling pathways linked to the pathogenesis of IPF, both within national and international contexts. The objective is to enhance the comprehension of the pathogenic mechanisms underlying IPF and offer a scholarly foundation for the advancement of more efficacious therapeutic strategies, thereby fostering research and clinical practices within this domain.

The origin and acceleration of solar and heliospheric energetic particles have been prevalent research frontiers in space physics. Solar and heliospheric energetic particles measured in the interplanetary medium (IPM) can be classified into two major groups: continuous "solar wind suprathermal particles" and transient "solar energetic particles". Due to the limited sensitivity of instruments used to investigate energetic particles in the IPM, the origin/acceleration processes of heliospheric energetic particles remain poorly understood. In this study, we designed a new-generation interplanetary ultralow-noise three-dimensional energetic particle spectrometer meeting leading world-class specifications. The spectrometer utilizes a double-ended telescope structure and multi-layer, multi-pixel semiconductor detectors to assess the complete three-dimensional distribution of 20-1000 keV electrons and 25-12000 keV protons in the IPM. The spectrometer integrates the following cutting-edge technologies: (1) utilizing anti-coincidence correlations between adjacent detectors with narrow interlayer spacing to minimize the noise generated by cosmic rays and other high-energy penetrating particles in the semiconductor detectors; (2) a double-ended open telescope structure design, with thin foil covering to stop protons for high-sensitivity electron detection in one direction, magnets to sweep away electrons for high-sensitivity proton detection in the opposite direction, multi-layer detectors for dE/dX analysis, and high-precision discrimination of electron, proton, and helium ion types; (3) a large-area silicon semiconductor detector, combined with a large field of view covering nearly 4π solid angles, to improve the geometric factor and temporal resolution of the spectrometer; (4) four layers of a 5-pixel silicon semiconductor detector array to achieve high angular resolution; and (5) low-noise multi-channel Application Specific Integrated Circuit (ASIC) technology to achieve precise energy level observation and high energy resolution. The spectrometer will provide key measurements that reveal the physical nature of the origin/acceleration processes of solar and heliospheric energetic particles, which will prove beneficial for the upcoming interplanetary and deep space explorations by China.

Abstract BackgroundPhysical therapy has demonstrated efficacy in managing nonspecific low back pain (NLBP) among patients. Nevertheless, the prevalence of NLBP poses a challenge, as the existing medical infrastructure may be insufficient to care for the large patient population, particularly in geographically remote regions. Telerehabilitation emerges as a promising method to address this concern by offering a method to deliver superior medical care to a greater number of patients with NLBP. ObjectiveThe purpose of this study is to demonstrate the physical and psychological effectiveness of a user-centered telerehabilitation program, consisting of a smartphone app and integrated sensors, for patients with NLBP. MethodsThis was a single-center, prospective, randomized controlled trial for individuals with NLBP for a duration exceeding 3 months. All participants were assigned randomly to either the telerehabilitation-based exercise group (TBEG) or the outpatient-based exercise group (OBEG). All participants completed a 30-minute regimen of strength and stretching exercises 3 times per week, for a total of 8 weeks, and were required to complete assessment questionnaires at 0, 2, 4, and 8 weeks. The TBEG completed home-based exercises and questionnaires using a telerehabilitation program, while the OBEG completed them in outpatient rehabilitation. The Oswestry Disability Index (ODI) served as the primary outcome measure, assessing physical disability. Secondary outcomes included the Numeric Pain Rating Scale, Fear-Avoidance Beliefs Questionnaire, and 36-item Short-Form Health Survey. ResultsIn total, 54 of 129 eligible patients were enrolled and randomly assigned to the study. The completion of all the interventions and assessments in the TBEG and OBEG was 89% (24/27) and 81% (22/27). The findings indicate that no statistical significance was found in the difference of ODI scores between the TBEG and the OBEG at 2 weeks (mean difference −0.91; odds ratio [OR] 0.78, 95% CI −5.96 to 4.14; PPPPP ConclusionsTelerehabilitation interventions demonstrate comparable therapeutic efficacy for individuals with NLBP when compared to conventional outpatient-based physical therapy, yielding comparable outcomes in pain reduction and improvement in functional limitations.

There are various magnetic field waves with frequencies ranging from mHz to thousands of Hz in the Earth's magnetosphere. These waves can be categorized into three classes depending on their period: ULF (mHz to ~ Hz), ELF (~ Hz to hundreds of Hz), and VLF (hundreds of Hz to thousands of Hz). The regular and continuous ultra-low-frequency (ULF) waves in the magneto-sphere, ranging from 1 mHz to a few Hz, are important to geomagnetic micropulsations. Recently, whistler mode waves generated by lightning and extremely low-frequency (ELF) bursts, which can be attributed to earthquakes, were detected near the surface; their frequencies range from several Hz to a few hundred Hz. The research on the characteristics of ionospheric plasma disturbance caused by the known ground-based very low frequency (VLF) transmitters, whose frequencies range from a few hundred to a few thousand Hz, is of great significance for analyzing changes in the ionospheric environment. These magnetic field waves are crucial for studying various space physical phenomena. As the wave monitoring equipment of global geomagnetic stations measures relative changes and a lack of unified calibration, they cannot conduct joint observations from high to low latitudes and unified comparative studies of the observational data from multiple sensors. The magnetoresistance sensor (ULF: 0.1 mHz–2 Hz), giant magneto-inductance sensor (ELF: 0.2 Hz–2 kHz), and coil sensor (VLF: 0.2–10 kHz) is used to develop a new generation of broadband geomagnetic wave monitors, which are placed on the geomagnetic stations in typical areas such as Mohe (high latitude), Beijing's Ming Tombs (middle latitude), and Sanya Ledong (low latitude), near the 120° meridian chain. Combined with the data of near-Earth space satellites such as FY-3E and SMILE, the observation ability of various wave phenomena in the Earth's magnetosphere will be comprehensively improved. The performance test experiment shows that the developed wave monitor can detect the fluctuating magnetic field at a particular frequency (1 mHz–10 kHz); magnetic field detection ranges of: ± 65000 nT (ULF frequency band), ± 1000 nT (ELF frequency band), and ± 100 pT (VLF band); with low nonlinear errors: ULF frequency band ≤ 0.0446 %, ELF frequency band ≤0.51 %, and VLF frequency band ≤ 1.18 %; and low noise levels: RMS ≤0.5554 nT (ULF frequency band), NPS ≤0.028 nT /√Hz (ELF frequency band), and NPS ≤0.24 pT/√Hz (VLF band). These characteristics enable the proposed broadband geomagnetic wave monitor to meet the Phase II of Chinese Meridian Project magnetic field detection requirements.

Bupleurum is a kind of medicinal plant that has made a great contribution to human health because of the presence of bioactive metabolites: Bupleurum saikosaponins and flavonoids. Despite their importance, it has been a challenge to visually characterize the spatial distribution of these metabolites in situ within the plant tissue, which is essential for assessing the quality of Bupleurum. The development of a new technology to identify and evaluate the quality of medicinal plants is therefore necessary. Here, the spatial distribution and quality characteristics of metabolites of three Bupleurum species: Bupleurum smithii (BS), Bupleurum marginatum var. stenophyllum (BM), and Bupleurum chinense (BC) were characterized by Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). Twenty-nine metabolites, including saikosaponins, non-saikosaponins, and compounds from the saikosaponin synthesis pathway, were characterized. Some of these were successfully localized and visualized in the transverse section of roots. In these Bupleurum species, twelve saikosaponins, five non-saikosaponins, and five saikosaponin synthesis pathway compounds were detected. Twenty-two major influencing components, which exhibit higher ion intensities in higher quality samples, were identified as potential quality markers of Bupleurum. The final outcome indicates that BC has superior quality compared to BS and BM. MALDI-MSI has effectively distinguished the quality of these Bupleurum species, providing an intuitive and effective marker for the quality control of medicinal plants.