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Short texts on social platforms often suffer from insufficient emotional semantic expressions, sparse features, and polysemy. To enhance the accuracy achieved by sentiment analysis for short texts, this paper proposes an emoji-based multifeature fusion sentiment analysis model (EMFSA). The model mines the sentiments of emojis, topics, and text features. Initially, a pretraining method for feature extraction is employed to enhance the semantic expressions of emotions in text by extracting contextual semantic information from emojis. Following this, a sentiment- and emoji-masked language model is designed to prioritize the masking of emojis and words with implicit sentiments, focusing on learning the emotional semantics contained in text. Additionally, we proposed a multifeature fusion method based on a cross-attention mechanism by determining the importance of each word in a text from a topic perspective. Next, this method is integrated with the original semantic information of emojis and the enhanced text features, attaining improved sentiment representation accuracy for short texts. Comparative experiments conducted with the state-of-the-art baseline methods on three public datasets demonstrate that the proposed model achieves accuracy improvements of 2.3%, 10.9%, and 2.7%, respectively, validating its effectiveness. [ABSTRACT FROM AUTHOR]

Following the Fukushima Daiichi nuclear disaster, utilities firms increase their commitments to corporate social responsibility (CSR), emphasizing on addressing environmental concerns over non‐environmental ones. The intensified focus on CSR is especially significant in utilities firms with substantial institutional ownerships. Concurrent to the increase in CSR, utilities firms also exhibit a decline in advertising expenditures, a trend more pronounced in firms facing more financial constraints. Our findings suggest that utilities firms substitute CSR for advertising following the Fukushima accident. This shift appears driven by investors' heightened focus on environmental issues in the aftermath of the accident. [ABSTRACT FROM AUTHOR]

Aim: To evaluate the advantages and problems in the diagnosis and treatment of diabetic foot (DF) patients by analyzing the results of a 5-year follow-up of the organ system based (TOSF) treatment model. Methods: A retrospective study was conducted in 229 patients with diabetic foot. Chi-square test and rank-sum test were used to analyze the effects of patients' general condition, behavioral and nutritional status, degree of infection (inflammatory markers), comorbidity, diabetic foot grade/classification, and revascularization on readmission rate, amputation rate, all-cause mortality, incidence of other complications, and wound healing time. Logistic regression was used to analyze the risk factors affecting the prognosis of diabetic foot. Kaplan-Meier survival curve was used to analyze the differences in amputation rate and mortality rate at each time point. Results: This study showed that nutritional status, degree of infection, and revascularization influenced readmission rates. General condition, behavior and nutritional status, degree of infection, Wagner grade and revascularization affect the amputation rate. General conditions, behavioral and nutritional status, degree of infection, comorbidities, classification and revascularization affect the mortality of patients. Age and white blood cell(WBC) count affected the incidence of other complications. Influence of infection degree and Wagner grade and revascularization in patients with wound healing time. Revascularization was an independent protective factor for readmission, amputation, and mortality.Elevated serum inflammatory markers are an independent risk factor for amputation. Hypoproteinemia is an independent risk factor for mortality. Conclusion: In the "TOSF" diagnosis and treatment pattern, diabetic foot patients have a good prognosis. Special attention should be paid to the screening and revascularization of lower extremity vascular disease in patients with diabetic foot. [ABSTRACT FROM AUTHOR]

Obstruction and/or reflux compromise during venous emptying can facilitate different pathophysiologies in chronic venous insufficiency (CVI). We present a patient with persistent lower limb CVI edema caused by post-thrombotic syndrome (PTS), who responded well to femoral vein valve therapy via axillary vein bypass after unsuccessful valvuloplasty, and led a normal life. During a 12 month observation period, bridging vessels completely restored original anatomical structures. In a literature study, no similar surgeries were reported, but we show that this operation may be feasible in selected patients. [ABSTRACT FROM AUTHOR]

Purpose: The sandy environment is one of the typical environments in which helicopters operate. Air-sand two-phase flow in sandy environments may be an important factor affecting flight safety. Taking a typical example, this paper aims to investigate the aerodynamic and rotor trim characteristics of the UH-60 helicopter in sandy environments. Design/methodology/approach: A computational study is conducted to simulate the air-sand flow over airfoils based on the Euler–Lagrange framework. The simulation uses the S-A turbulence model and the two-way momentum coupling methodology. Additionally, the trim characteristics of the UH-60 rotor are calculated based on the isolated rotor trim algorithm. Findings: The simulation results show that air-sand flow significantly affects the aerodynamic characteristics of the SC1095 airfoil and the SC1094R8 airfoil. The presence of sand particles leads to a decrease in lift and an increase in drag. The calculation results of the UH-60 helicopter rotor indicate that the thrust decreases and the torque increases in the sandy environment. To maintain a steady forward flight in sandy environments, it is necessary to increase the collective pitch and the longitudinal cyclic pitch. Originality/value: In this paper, the aerodynamic characteristics of airfoils and the trim characteristics in the air-sand flow of the UH-60 helicopter are discussed, which might be a new view to analyse the impact of sandy environments on helicopter safety and manoeuvring. [ABSTRACT FROM AUTHOR]

Objectives: The therapeutic effect of platelet-rich plasma on lower extremity venous ulcers was systematically analyzed., Methods: A computerized system search was conducted to screen literature that met the inclusion criteria using the method of "subject words + free words." Keywords included "platelet-rich plasma," "lower extremity venous disease," "lower extremity chronic venous insufficiency," "venous ulcer," and "lower extremity venous ulcer." Literature that met the inclusion criteria was searched in four commonly used Chinese databases (HowNet, Chinese biomedical literature, Wanfang, and VIP) and three commonly used foreign databases (Embase, PubMed, and Cochrane Library). The search period extended from the establishment of the databases to December 2021. After extracting the relevant data, a meta-analysis was performed using RevMan 5.3 software to compare the overall effective rate and adverse effects of platelet-rich plasma in the treatment of lower extremity venous ulcers., Results: The meta-analysis of the overall efficacy rate in the four selected papers showed no heterogeneity among the studies (P = .35 > 0.1, I2 = 0% < 50%); therefore, a fixed-effect model was used to combine the statistical data. The software analysis results indicated a significant difference in the overall efficacy rate between the experimental group and the control group (OR = 2.09, 95% CI = 1.23-3.34, P = .002), with the experimental group showing better results than the control group. The analysis of the four selected papers also suggested potential differences in adverse reactions between the two groups after treatment, but the comparison of safety differences was not significant (OR = 2.13, 95% CI = 0.45-6.79, P = .17)., Conclusion: Platelet-rich plasma is effective in the treatment of lower extremity venous ulcers; however, there is no clear safety advantage. This finding needs to be confirmed by large-scale, multi-center research.

Small cell lung cancer (SCLC) has garnered significant attention due to its high malignancy, propensity for distant metastasis, and poor prognosis. Radiotherapy remains the cornerstone of treatment for limited-stage small cell lung cancer (LS-SCLC). However, outcomes with radiotherapy alone or in combination with chemotherapy remain suboptimal. Radiotherapy can induce lymphopenia by directly irradiating hematopoietic organs or destroying mature circulating lymphocytes, leading to immunosuppression and consequently diminishing therapeutic efficacy. The estimated dose of radiation to immune cells (EDRIC) model integrates factors such as hemodynamics, lymphocyte radiosensitivity, and proliferation capacity. This study employs the EDRIC model with enhancements to calculate the circulating immune cell radiation dose. By utilizing the EDRIC methodology, the study explores the correlation between EDRIC and tumor target size, average lung dose, average heart dose, clinical features, and peripheral blood lymphocytopenia during radiotherapy for LS-SCLC, aiming to inform personalized patient treatment strategies. This study analyzed data from 64 LS-SCLC patients who met the inclusion criteria at the General Hospital of Ningxia Medical University from January 2023 to January 2024, all of whom received radical thoracic conventional fractionated radiotherapy. Lymphocyte counts were recorded at the following points: before radiotherapy, at the lowest observed value during radiotherapy, at the end of radiotherapy, and one-month post-radiotherapy. Dosimetric data, including average lung, heart, and body doses, were extracted from the treatment planning system, and the circulating EDRIC was calculated using this model. The relationship between EDRIC values and therapeutic outcomes was analyzed. In LS-SCLC, the EDRIC model effectively predicts lymphocyte count reduction, correlating with planning target volume (PTV; cm 3 ), TNM stage, and the percentage of target lesion shrinkage. Post-radiotherapy, there was a significant decrease in peripheral blood lymphocyte counts, with greater EDRIC values indicating more pronounced lymphocyte reduction.

Background: Bone metastases of lung cancer (BMLC) severely diminish patients' quality of life due to bone-related events, and the lack of clear guidelines globally regarding medical and surgical treatment significantly reduces patient survival. While knowledge about BMLC has grown exponentially over the past two decades, a comprehensive and objective bibliometric analysis remains absent., Methods: A comprehensive bibliometric analysis was conducted on relevant literature on BMLC extracted from the Web of Science database from 2004 to 2023 by Biblioshiny, VOSviewer, Scimago Graphica, CiteSpace, and Microsoft Office Excel Professional Plus 2016 software. 936 papers related to BMLC were extracted from the Web of Science Core Collection (WoSCC). The number of publications, countries, institutions, global collaborations, authors, journals, keywords, thematic trends, and cited references were then visualized. Finally, the research status and development direction in the last 20 years were analyzed., Results: This study included a total of 936 papers on BMLC from 2004 to 2023. There has been a steady increase in global publications each year, peaking in 2021. China had the highest number of publications, followed by Japan and the United States. Additionally, China had the most citations with an H-index of 35, while the US followed with an H-index of 34, highlighting their significant contributions to the field. "Frontiers in Oncology" had the highest number of publications. CiteSpace analysis identified "lung cancer," "bone metastasis," and "survival" as the top high-frequency keywords, encapsulating the core research focus. Keyword clustering analysis revealed six main clusters representing the primary research directions. Burst analysis of keywords showed that "skeletal complications" had the highest burst intensity from 2005 to 2013, while recent research trends include "immunotherapy" and "denosumab," with bursts from 2021 to 2023. Trend topic analysis indicated that "non-small cell lung cancer," "immunotherapy," and "immune checkpoint inhibitors" represent the cutting-edge research directions in this field., Conclusion: This article reveals the current status and trend of research on BMLC, which is increasing worldwide. China and the United States have contributed the most, but international cooperative research on BMLC should be strengthened. The pathogenesis, early prevention, and individualized treatment of BMLC need to be strengthened for further study, and immunotherapy is the next hotspot of lung cancer bone metastasis research., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Tang, Gu, Yang, Ma, Liu, Shi, Niu and Wang.)

Introduction: Gliomas are the most common malignant brain tumors, with complicated etiology and poor prognosis. However, there is still a lack of specific biomarkers for the diagnosis, treatment and prognosis assessment for glioma patients. Hence, the purpose of this study was to screen biomarkers for prognostic assessment and therapeutic interventions in gliomas., Material and Methods: We utilized The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases to investigate the role of colony-stimulating factor 3 receptor (CSF3R) in glioma. Data analysis was conducted using R, GEPIA 2, TISCH and DepMap., Results: CSF3R was up-regulated in glioma and associated with the clinical pathological features of the patients. Kaplan-Meier survival analysis indicated a significant association between the expression of CSF3R and prognosis in patients. Univariate and multivariate Cox analyses revealed that patients with high expression of CSF3R have a worse prognosis, and the expression of CSF3R was an independent prognostic factor in gliomas. The nomogram constructed based on the expression of CSF3R demonstrated lower 1-, 3-, and 5-year overall survival (OS) in patients with high CSF3R expression. The biological functional analysis of CSF3R demonstrated its association with various immune regulatory signals. Furthermore, CSF3R was linked to the expression of immune checkpoints and resistance to immunotherapy. Notably, CSF3R was predominantly detected in monocytes/macrophages., Conclusions: Our study suggested that CSF3R might potentially function as an independent prognostic factor for glioma and hold promise as a biomarker and target for immunotherapy in glioma., Competing Interests: The authors declare no conflict of interest., (Copyright © 2024 Termedia.)

Bacterial proteins targeting the appropriate subcellular sites are the base for their proper function. Several studies have shown that the anionic phospholipid cardiolipin (CL), a conical lipid preferring negative membrane curvature, modulates the lipid bilayers' structure, which impacts the activity of their resident proteins. Due to the favor of negative membrane curvature, CL is not randomly distributed in the bacterial plasma membrane. In contrast, it gathers in particular parts of the cell membrane to form microdomains, in which many functional membrane proteins are accumulated and carry out diverse physiological processes of bacteria, such as cell division, metabolism, infection, and antibiotic residence. In addition, CL has a unique structure that carries two negative charges, which makes it play a pivotal role in protein assembly, interaction, and location. These characteristics of CL make it closely related to many crucial physiological functions of bacteria. Here, we have reviewed the mechanism of protein dynamics mediated by CL initiated on the bacterial membrane. Furthermore, we studied the effect of CL on bacterial infection and antibiotic residence. Finally, the CL-targeting therapeutic agents for antibacterial therapy are also examined., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)