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This study focuses on optimizing process parameters for pyramid solar still using Multi-Criteria Decision-Making Grey Relational Analysis (MCDM-GRA) and bio-inspired metaheuristic Artificial Bee Colony (ABC) algorithm. The objective is to enhance the performance of the pyramid solar still (PSS) performance integrated with a peripheral solar water heater under different operational parameters, including saline water flow rate, temperature, and solar intensity. Experiments are designed using Taguchi's L9(33) orthogonal array (OA), and the outputs are optimized with MCDM-GRA. The optimum conditions for maximized productivity and system efficiency are a solar intensity of 1000 W/m2, a saline water mass of 3 kg, and a saline water temperature of 40 °C. With these settings, the system achieves an efficiency of 65.33 % and produces 1.96 kg of potable water. The ABC Algorithm, on the other hand, suggests that the optimal conditions for achieving maximum productivity and system efficiency involve a solar intensity of 1000 W/m2, a mass of 3 kg for the saline water, and a water inlet temperature of 30 °C. In this scenario, the system produced 1.92 kg of potable water with an efficiency rate of 64 %. Analysis of variance (ANOVA) shows that solar intensity contributes significantly towards productivity by 81.72 % with an error of 3.82 % and regression coefficient of 96.18 %. Regression models are developed from the results obtained and fed to ABC for further optimization, yielding results similar to MCDM-GRA.

Aims:To assess the safety and feasibility of erythropoietin (EPO) in asphyxiated neonates undergoing therapeutic hypothermia (TH).Subjects and methods:This study enrolled 60 neonates with HIE undergoing TH. 30 neonates were divided into EPO with TH group, where neonates received EPO (dose), at a dose rate of 1000 IU/kg/48 hours, for four doses and the remaining 30 neonates undergoing TH were into control group. Magnetic resonance imaging brain was undertaken between 10 and 14 days of life in surviving neonates. The Bayley Scales of Infant (BSI) Development IV was performed at regular intervals up to the age of 12 months.Results:Amplitude-integrated electroencephalogram (aEEG) showed burst suppression (19% vs. 11%), low voltage (10% vs. 4%), and flat trace (7% vs. 3%) in control group in comparison with EPO concurrent with TH group which was statistically significant. Brain magnetic-resonance imaging (MRI) done at 12 days (±2 days) showed significant brain injury patterns such as severe brain injury (4% vs. 9% P = .05) and regional specific HIE (7% vs. 13%, P = .03) in control group of only TH neonates. At 12 months, neurodevelopment outcomes in EPO with TH group neonates showed a favorable outcome.Conclusion:rhEPO concurrent with TH in HIE neonates resulted in significantly less severe brain injuries in MRI brain in HIE neonates. aEEG changes were less statistically significant in EPO with TH group with favorable neurodevelopmental outcomes at 12 months of age.