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Vernonia amygdalina (VA) leaves contain many potential active ingredients and exhibit diverse pharmacological activities. The antihypertensive, anti-inflammatory, and analgesic effects of VA crude and fraction extracts were carried out using Swiss albino mice models. VAE is considered safe to be administered due to LD50 being greater than 10,000 mg/kg body weight. A dose-dependent increase in antihypertensive, anti-inflammatory, and analgesic activities was observed in both VAE and fractions, similar to the reference drugs. The antihypertensive effect of the VAE 2.0 (2000 mg/kg, SBP: ↓26.05 %, DBP: ↓34.51 %) was nearly equivalent to Captopril (100 mg/kg, SBP: ↓30.28 %, DBP: ↓40.71 %) with no statistically significant difference (p > 0.05). The VAE 1.0 (1000 mg/kg), and EA 30 (30 mg/kg) showed potent anti-inflammatory activity when reducing the total edematous paw volume significantly (p 500 mg/kg), and W 400 (water, 400 mg/kg) fraction extracts showed a potent analgesic effect equivalent to Para 50 (paracetamol 50 mg/kg) for the highest protection (>65 %) against the acetic acid-induced writhing after 35 min. Moreover, cepharanthine, cynaroside, and vernoniosides of VA leaf extract exhibited the highest affinity (>10 kcal/mol) in anti-inflammatory and analgesic targets (iNOS and COX-2) and antihypertensive targets (ACE and β1 adrenoreceptor). Therefore, the crude and fraction extracts of VA leaves from the percolation method and bioactive metabolites are a potential source that can be developed into antihypertensive, anti-inflammatory, and analgesic agents in herbal medicine.

Coupled microring lattices are versatile photonic systems that can be used to realize various topological phases of matter. In two‐dimensional (2D) microring lattices, the periodic and unidirectional circulation of light in each microring gives rise to a time‐like dimension, so that the lattice emulates a (2 + 1)D system with much richer topological behaviors than static 2D lattices. Accurate treatment of these systems requires a departure from the static tight‐binding model of coupled resonators and take into account the periodic coupling sequence of light in the lattice network. This article provides an overview of the theory and design of (2 + 1)D microring lattices for realizing Floquet topological photonic insulators (TPIs). Particular focus is placed on the microring Lieb lattice with perfect couplings, which emulates an anomalous Floquet insulator with all flat bands. Such a system exhibits some unique properties, including wide edge mode continuum exceeding a Floquet–Brillouin zone, super‐robustness to lattice disorder, Aharonov–Bohm (AB) caging and compact localized flat‐band states that can be used to realize high‐quality factor topological resonators. All‐bands‐flat Floquet–Lieb microring lattices provide a versatile platform for investigating topological physics as well as potential applications in realizing topologically‐protected photonic devices.