28 results on '"Urbani, Andrea"'
Search Results
2. Biliverdin Reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3β
- Author
-
Lanzillotta, Chiara, Tramutola, Antonella, Lanzillotta, Simona, Greco, Viviana, Pagnotta, Sara, Sanchini, Caterina, Di Angelantonio, Silvia, Forte, Elena, Rinaldo, Serena, Paone, Alessio, Cutruzzolà, Francesca, Cimini, Flavia Agata, Barchetta, Ilaria, Cavallo, Maria Gisella, Urbani, Andrea, Butterfield, D. Allan, Di Domenico, Fabio, Paul, Bindu D., Perluigi, Marzia, Duarte, Joao M.N., and Barone, Eugenio
- Published
- 2024
- Full Text
- View/download PDF
3. Integrated One Health strategies in Dengue
- Author
-
Procopio, Anna Caterina, Colletta, Simona, Laratta, Emanuela, Mellace, Matteo, Tilocca, Bruno, Ceniti, Carlotta, Urbani, Andrea, and Roncada, Paola
- Published
- 2024
- Full Text
- View/download PDF
4. Artemisia spp. Essential Oils: From Their Ethnobotanical Use to Unraveling the Microbiota Modulation Potential
- Author
-
Polito, Flavio, Di Mercurio, Mattia, Rizzo, Silvia, Di Vito, Maura, Sanguinetti, Maurizio, Urbani, Andrea, Bugli, Francesca, De Feo, Vincenzo, Di Vito, Maura (ORCID:0000-0002-2991-0855), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Urbani, Andrea (ORCID:0000-0001-9168-3174), Bugli, Francesca (ORCID:0000-0001-9038-3233), Polito, Flavio, Di Mercurio, Mattia, Rizzo, Silvia, Di Vito, Maura, Sanguinetti, Maurizio, Urbani, Andrea, Bugli, Francesca, De Feo, Vincenzo, Di Vito, Maura (ORCID:0000-0002-2991-0855), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Urbani, Andrea (ORCID:0000-0001-9168-3174), and Bugli, Francesca (ORCID:0000-0001-9038-3233)
- Abstract
Background: The 2015 Nobel Prize in Medicine, awarded for the discovery of artemisinin in Artemisia annua, reignited interest in aromatic plants, including Artemisia absinthium L. This article delves into the historical, ethnopharmacological and medicinal significance of A. absinthium, examining its bitter taste noted since ancient Greek times and its association with medicinal properties throughout history. Despite being banned in the 20th century due to perceived health risks; recent research has led to the reconsideration of A. absinthium's potential applications. This study focuses on the prebiotic efficacy of essential oils (EOs) from two Artemisia species: A. absinthium and A. annua. Materials and methods: A broth microdilution test, growth curve test and in vivo models were used to study the impact of low doses (from 0.5% v/v to 0.00048 v/v) of Artemisia spp-EO on the three probiotic strains (Lactobacillus, Lactobacillus casei and Saccharomyces boulardii). Results: These essential oils, when used in minimal concentrations (lower than 0.06% v/v), are safe and exhibit prebiotic effects on major probiotic strains, supporting the traditional culinary use of Artemisia spp. Conclusion: This research opens avenues for potential applications in the food industry, emphasizing the need for further exploration into the prebiotic properties of Artemisia spp-EOs and their influence on the microbiota.
- Published
- 2024
5. A novel risk score predicting 30-day hospital re-admission of patients with acute stroke by machine learning model
- Author
-
Mercurio, Giovanna, Gottardelli, Benedetta, Lenkowicz, Jacopo, Patarnello, Stefano, Bellavia, Simone, Scala, Irene, Rizzo, Pierandrea, de Belvis, Antonio Giulio, Del Signore, Anna Benedetta, Maviglia, Riccardo, Bocci, Maria Grazia, Olivi, Alessandro, Franceschi, Francesco, Urbani, Andrea, Calabresi, Paolo, Valentini, Vincenzo, Antonelli, Massimo, Frisullo, Giovanni, Olivi, Alessandro (ORCID:0000-0002-4489-7564), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Urbani, Andrea (ORCID:0000-0001-9168-3174), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Antonelli, Massimo (ORCID:0000-0003-3007-1670), Mercurio, Giovanna, Gottardelli, Benedetta, Lenkowicz, Jacopo, Patarnello, Stefano, Bellavia, Simone, Scala, Irene, Rizzo, Pierandrea, de Belvis, Antonio Giulio, Del Signore, Anna Benedetta, Maviglia, Riccardo, Bocci, Maria Grazia, Olivi, Alessandro, Franceschi, Francesco, Urbani, Andrea, Calabresi, Paolo, Valentini, Vincenzo, Antonelli, Massimo, Frisullo, Giovanni, Olivi, Alessandro (ORCID:0000-0002-4489-7564), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Urbani, Andrea (ORCID:0000-0001-9168-3174), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), and Antonelli, Massimo (ORCID:0000-0003-3007-1670)
- Abstract
Background: The 30-day hospital re-admission rate is a quality measure of hospital care to monitor the efficiency of the healthcare system. The hospital re-admission of acute stroke (AS) patients is often associated with higher mortality rates, greater levels of disability and increased healthcare costs. The aim of our study was to identify predictors of unplanned 30-day hospital re-admissions after discharge of AS patients and define an early re-admission risk score (RRS).Methods: This observational, retrospective study was performed on AS patients who were discharged between 2014 and 2019. Early re-admission predictors were identified by machine learning models. The performances of these models were assessed by receiver operating characteristic curve analysis.Results: Of 7599 patients with AS, 3699 patients met the inclusion criteria, and 304 patients (8.22%) were re-admitted within 30 days from discharge. After identifying the predictors of early re-admission by logistic regression analysis, RRS was obtained and consisted of seven variables: hemoglobin level, atrial fibrillation, brain hemorrhage, discharge home, chronic obstructive pulmonary disease, one and more than one hospitalization in the previous year. The cohort of patients was then stratified into three risk categories: low (RRS = 0-1), medium (RRS = 2-3) and high (RRS >3) with re-admission rates of 5%, 8% and 14%, respectively.Conclusions: The identification of risk factors for early re-admission after AS and the elaboration of a score to stratify at discharge time the risk of re-admission can provide a tool for clinicians to plan a personalized follow-up and contain healthcare costs.
- Published
- 2024
6. Characterization of shared neoantigens in Endometrial Cancer with Microsatellite Instability
- Author
-
Urbani, Andrea, primary, De Paolis, Elisa, additional, Nero, Camilla, additional, Micarelli, Elisa, additional, Leoni, Guido, additional, Piermattei, Alessia, additional, Trozzi, Rita, additional, Scarselli, Elisa, additional, D'Alise, Anna Morena, additional, Giacò, Luciano, additional, De Bonis, Maria, additional, Daniele, Gennaro, additional, Piana, Diletta, additional, Pasciuto, Tina, additional, Zannoni, Gian Franco, additional, Minucci, Angelo, additional, Scambia, Giovanni, additional, and Fanfani, Francesco, additional
- Published
- 2024
- Full Text
- View/download PDF
7. WED-261-YI Prognostic significance of ELF test compared to liver biopsy in patients with metabolic dysfunction-associated steatotic liver disease (MASLD)
- Author
-
Liguori, Antonio, primary, D'Ambrosio, Francesca, additional, Viceconti, Nicholas, additional, Termite, Fabrizio, additional, Petrucci, Lucrezia, additional, Beschi, Riccardo, additional, Orienti, Marco, additional, Cardinali, Sara, additional, Galletti, Simone, additional, Riccardi, Laura, additional, Pizzolante, Fabrizio, additional, De Matthaeis, Nicoletta, additional, Ainora, Maria Elena, additional, Zocco, Maria Assunta, additional, Giustiniani, Maria Cristina, additional, Marrone, Giuseppe, additional, Biolato, Marco, additional, Vecchio, Fabio Maria, additional, Grieco, Antonio, additional, Urbani, Andrea, additional, Sanguinetti, Maurizio, additional, Gasbarrini, Antonio, additional, and Miele, Luca, additional
- Published
- 2024
- Full Text
- View/download PDF
8. Mitochondrial Biomarkers in the Omics Era: A Clinical-Pathophysiological Perspective
- Author
-
Gervasoni, Jacopo, primary, Primiano, Aniello, additional, Cicchinelli, Michela, additional, Santucci, Lavinia, additional, Servidei, Serenella, additional, Urbani, Andrea, additional, Primiano, Guido, additional, and Iavarone, Federica, additional
- Published
- 2024
- Full Text
- View/download PDF
9. Enhancing fluconazole reactivation against Candida auris: efficacy of Cinnamomum zeylanicum essential oil versus cinnamaldehyde
- Author
-
Di Vito, Maura, Rosato, Roberto, Rizzo, Silvia, Cacaci, Margherita, Urbani, Andrea, Sanguinetti, Maurizio, Bugli, Francesca, Di Vito, M (ORCID:0000-0002-2991-0855), Rosato, R, Rizzo, S, Cacaci, M (ORCID:0000-0002-5433-9400), Urbani, A (ORCID:0000-0001-9168-3174), Sanguinetti, M (ORCID:0000-0002-9780-7059), Bugli, F (ORCID:0000-0001-9038-3233), Di Vito, Maura, Rosato, Roberto, Rizzo, Silvia, Cacaci, Margherita, Urbani, Andrea, Sanguinetti, Maurizio, Bugli, Francesca, Di Vito, M (ORCID:0000-0002-2991-0855), Rosato, R, Rizzo, S, Cacaci, M (ORCID:0000-0002-5433-9400), Urbani, A (ORCID:0000-0001-9168-3174), Sanguinetti, M (ORCID:0000-0002-9780-7059), and Bugli, F (ORCID:0000-0001-9038-3233)
- Abstract
n/a
- Published
- 2024
10. Comparative Analysis of Comprehensive Genomic Profile in Thymomas and Recurrent Thymomas Reveals Potentially Actionable Mutations for Target Therapies.
- Author
-
Lococo, Filippo, De Paolis, Elisa, Evangelista, Jessica, Dell'Amore, Andrea, Giannarelli, Diana, Chiappetta, Marco, Campanella, Annalisa, Sassorossi, Carolina, Cancellieri, Alessandra, Calabrese, Fiorella, Conca, Alessandra, Vita, Emanuele, Minucci, Angelo, Bria, Emilio, Castello, Angelo, Urbani, Andrea, Rea, Federico, Margaritora, Stefano, and Scambia, Giovanni
- Subjects
GENETIC profile ,PROPENSITY score matching ,GENOMICS ,CELL cycle ,INDIVIDUALIZED medicine - Abstract
Molecular profiles of thymomas and recurrent thymomas are far from being defined. Herein, we report an analysis of a comprehensive genetic profile (CGP) in a highly selected cohort of recurrent thymomas. Among a cohort of 426 thymomas, the tissue was available in 23 recurrent tumors for matching the biomolecular results obtained from primary and relapse samples. A control group composed of non-recurrent thymoma patients was selected through a propensity score match analysis. CGP was performed using the NGS Tru-SightOncology assay to evaluate TMB, MSI, and molecular alterations in 523 genes. CGP does not differ when comparing initial tumor with tumor relapse. A significantly higher frequency of cell cycle control genes alterations (100.0% vs. 57.1%, p = 0.022) is detected in patients with early recurrence (<32 months) compared to late recurrent cases. The CGPs were similar in recurrent thymomas and non-recurrent thymomas. Finally, based on NGS results, an off-label treatment or clinical trial could be potentially proposed in >50% of cases (oncogenic Tier-IIC variants). In conclusion, CGPs do not substantially differ between initial tumor vs. tumor recurrence and recurrent thymomas vs. non-recurrent thymomas. Cell cycle control gene alterations are associated with an early recurrence after thymectomy. Multiple target therapies are potentially available by performing a comprehensive CGP, suggesting that a precision medicine approach on these patients could be further explored. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
11. Sarcoidosis and Cancer: The Role of the Granulomatous Reaction as a Double-Edged Sword.
- Author
-
Di Francesco, Angela Maria, Pasciuto, Giuliana, Verrecchia, Elena, Sicignano, Ludovico Luca, Gerardino, Laura, Massaro, Maria Grazia, Urbani, Andrea, and Manna, Raffaele
- Subjects
SARCOIDOSIS ,METASTASIS ,CANCER diagnosis ,TUMORS ,CARCINOGENESIS ,MACROPHAGES - Abstract
Background/Objectives: The relationship between sarcoidosis and the occurrence of neoplasia deserves to be investigated, but this relation has been observed in different and heterogeneous populations, leading to conflicting data. To clarify the causal relationship between these two diseases, different risk factors (e.g., smoking), concurrent comorbidities, corticosteroid therapy, and metastasis development—as an expression of cancer aggressiveness—were investigated. Methods: In a retrospective study on 287 sarcoidosis outpatients at the Pneumological Department of the Gemelli Foundation (Rome, Italy) between 2000 and 2024, the diagnosis of cancer was recorded in 36 subjects (12.5%). Results: The reciprocal timeline of the diseases showed three different scenarios: (1) cancer preceding sarcoidosis or sarcoid-like reactions (63.8%); (2) cancer arising after sarcoidosis diagnosis (8.3%); and (3) sarcoidosis accompanying the onset of malignancy (27.8%). Only two subjects with sarcoidosis and cancer showed metastasis, and one of them was affected by lymphoma. Conclusions: These data suggest that granulomatous inflammation due to sarcoidosis may assume an ambivalent role as a "double-edged sword", according to the M1/M2 macrophage polarization model: it represents a protective shield, preventing the formation of metastasis through the induction of immune surveillance against cancer while, on the other hand, it can be a risk factor for carcinogenesis due to the persistence of a chronic active inflammatory status. Low-dose steroid treatment was administered in only 31.6% of the cancer–sarcoidosis subjects for less than six months to control inflammation activity, with no promotive effect on carcinogenesis observed. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
12. Phenotyping Tumor Heterogeneity through Proteogenomics: Study Models and Challenges.
- Author
-
Piana, Diletta, Iavarone, Federica, De Paolis, Elisa, Daniele, Gennaro, Parisella, Federico, Minucci, Angelo, Greco, Viviana, and Urbani, Andrea
- Subjects
PHENOTYPIC plasticity ,NUCLEOTIDE sequencing ,CRITICAL currents ,MASS spectrometry ,ANIMAL models in research - Abstract
Tumor heterogeneity refers to the diversity observed among tumor cells: both between different tumors (inter-tumor heterogeneity) and within a single tumor (intra-tumor heterogeneity). These cells can display distinct morphological and phenotypic characteristics, including variations in cellular morphology, metastatic potential and variability treatment responses among patients. Therefore, a comprehensive understanding of such heterogeneity is necessary for deciphering tumor-specific mechanisms that may be diagnostically and therapeutically valuable. Innovative and multidisciplinary approaches are needed to understand this complex feature. In this context, proteogenomics has been emerging as a significant resource for integrating omics fields such as genomics and proteomics. By combining data obtained from both Next-Generation Sequencing (NGS) technologies and mass spectrometry (MS) analyses, proteogenomics aims to provide a comprehensive view of tumor heterogeneity. This approach reveals molecular alterations and phenotypic features related to tumor subtypes, potentially identifying therapeutic biomarkers. Many achievements have been made; however, despite continuous advances in proteogenomics-based methodologies, several challenges remain: in particular the limitations in sensitivity and specificity and the lack of optimal study models. This review highlights the impact of proteogenomics on characterizing tumor phenotypes, focusing on the critical challenges and current limitations of its use in different clinical and preclinical models for tumor phenotypic characterization. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
13. Single-Base Substitution Causing Dual-Exon Skipping Event in PKD2 Gene: Unusual Molecular Finding from Exome Sequencing in a Patient with Autosomal Dominant Polycystic Kidney Disease.
- Author
-
De Paolis, Elisa, Raspaglio, Giuseppina, Ciferri, Nunzia, Zangrilli, Ilaria, Ricciardi Tenore, Claudio, Urbani, Andrea, Ferraro, Pietro Manuel, Minucci, Angelo, and Concolino, Paola
- Subjects
POLYCYSTIC kidney disease ,ALTERNATIVE RNA splicing ,NUCLEOTIDE sequencing ,GENETICS - Abstract
Background: Pathogenic variants in the Polycystic Kidney Disease 2 (PKD2) gene are associated with Autosomal Dominant Polycystic Kidney Disease (ADPKD) in approximately 30% of cases. In recent years, the high-throughput sequencing techniques have significantly increased the number of variants identified in affected patients. Here, we described the peculiar effect of a PKD2 splicing variant, the c.1717-2A>G, identified in an Italian male patient with ADPKD. This variant led to the unusual and rare skipping of two consecutive exons, causing a large in-frame deletion. Methods: The genetic evaluation of the patient was performed using the Next-Generation Sequencing (NGS) assay Clinical Exome Solution
® (SOPHiA Genetics). Bioinformatics analysis was performed using the SOPHiA DDM platform (SOPHiA Genetics). Prediction of pathogenicity was carried out by integrating several in silico tools. RNA evaluation was performed to test the effect of the variant on the PKD2 splicing using a Reverse-Transcription PCR coupled with cDNA sequencing. Results: NGS revealed the presence of the PKD2 c.1717-2A>G variant that lies in the canonical splice site of intron 7. This rare variant was predicted to have a significant impact on the splicing, proved by the RNA-based analysis. We identified the presence of a transcript characterised by the simultaneous skipping of exons 8 and 9, with a retained reading frame and the merging of exons 7–10. Conclusions: We described for the first time a dual-exon skip event related to the presence of a single-base substitution in the PKD2 gene in an ADPKD-affected patient. We assumed that the molecular basis of such a rare mechanism lies in the specific order of intron removal. The finding represents novel evidence of an alternative and unusual splicing mechanism in the PKD2 gene, adding insights to the pathogenesis of the ADPKD. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
14. Oxidative Cysteine Post Translational Modifications Drive the Redox Code Underlying Neurodegeneration and Amyotrophic Lateral Sclerosis.
- Author
-
Percio, Anna, Cicchinelli, Michela, Masci, Domiziana, Summo, Mariagrazia, Urbani, Andrea, and Greco, Viviana
- Subjects
AMYOTROPHIC lateral sclerosis ,PARKINSON'S disease ,REACTIVE oxygen species ,ALZHEIMER'S disease ,POST-translational modification ,NITROGEN - Abstract
Redox dysregulation, an imbalance between oxidants and antioxidants, is crucial in the pathogenesis of various neurodegenerative diseases. Within this context, the "redoxome" encompasses the network of redox molecules collaborating to maintain cellular redox balance and signaling. Among these, cysteine-sensitive proteins are fundamental for this homeostasis. Due to their reactive thiol groups, cysteine (Cys) residues are particularly susceptible to oxidative post-translational modifications (PTMs) induced by free radicals (reactive oxygen, nitrogen, and sulfur species) which profoundly affect protein functions. Cys-PTMs, forming what is referred to as "cysteinet" in the redox proteome, are essential for redox signaling in both physiological and pathological conditions, including neurodegeneration. Such modifications significantly influence protein misfolding and aggregation, key hallmarks of neurodegenerative diseases such as Alzheimer's, Parkinson's, and notably, amyotrophic lateral sclerosis (ALS). This review aims to explore the complex landscape of cysteine PTMs in the cellular redox environment, elucidating their impact on neurodegeneration at protein level. By investigating specific cysteine-sensitive proteins and the regulatory networks involved, particular emphasis is placed on the link between redox dysregulation and ALS, highlighting this pathology as a prime example of a neurodegenerative disease wherein such redox dysregulation is a distinct hallmark. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
15. The novel CFTR haplotype E583G/F508del in CFTR-related disorder.
- Author
-
De Paolis, Elisa, Tilocca, Bruno, Inchingolo, Riccardo, Lombardi, Carla, Perrucci, Alessia, Maneri, Giulia, Roncada, Paola, Varone, Francesco, Luca, Richeldi, Urbani, Andrea, Minucci, Angelo, and Santonocito, Concetta
- Abstract
Background: CFTR-related disorder (CFTR-RD) is a clinical entity associated to complex diagnostic paths and newly upgraded standard of care. In CFTR-RD, CFTR genotyping represents a diagnostic surrogate marker. In case of novel haplotype, the diagnosis could represents an area of concern. We described the molecular evaluation of the rare CFTR variant E583G identified in trans with the F508del in a novel haplotype. Methods and results: An adult woman was referred to our pulmonary unit for persistent respiratory symptoms. CFTR Next Generation Sequencing was performed to evaluate full-gene mutational status. The variant identified was evaluated for its pathogenicity integrating clinical evidences with dedicated bioinformatics analyses. Clinical evaluation of patient matched with a mono-organ CFTR-RD diagnosis. Genotyping revealed the novel CFTR haplotype F508del/E583G. Multiple evidences of a deleterious effect of the CFTR E583G rare variant emerged from the bioinformatics analyses performed. Conclusions: Guidelines for CFTR-RD are available with the purpose of harmonizing clinical and molecular investigations. In such context, the identification of novel CFTR haplotype need to a deeper evaluation with a combination of skills. The novel E583G variant could be considered of clinical interest and overall a CFTR-RD Variants of Varying Clinical Consequences. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
16. The Bee Gut Microbiota: Bridging Infective Agents Potential in the One Health Context
- Author
-
Tilocca, Bruno, primary, Greco, Viviana, additional, Piras, Cristian, additional, Ceniti, Carlotta, additional, Paonessa, Mariachiara, additional, Musella, Vincenzo, additional, Bava, Roberto, additional, Palma, Ernesto, additional, Morittu, Valeria Maria, additional, Spina, Anna Antonella, additional, Castagna, Fabio, additional, Urbani, Andrea, additional, Britti, Domenico, additional, and Roncada, Paola, additional
- Published
- 2024
- Full Text
- View/download PDF
17. Artemisia spp. Essential Oils: From Their Ethnobotanical Use to Unraveling the Microbiota Modulation Potential
- Author
-
Polito, Flavio, primary, Di Mercurio, Mattia, additional, Rizzo, Silvia, additional, Di Vito, Maura, additional, Sanguinetti, Maurizio, additional, Urbani, Andrea, additional, Bugli, Francesca, additional, and De Feo, Vincenzo, additional
- Published
- 2024
- Full Text
- View/download PDF
18. Focus on RAS Codon 61 Mutations in Metastatic Colorectal Cancer: A Retrospective Analysis
- Author
-
Schietroma, Francesco, primary, Anghelone, Annunziato, additional, Valente, Giustina, additional, Beccia, Viria, additional, Caira, Giulia, additional, Spring, Alexia, additional, Trovato, Giovanni, additional, Di Bello, Armando, additional, Ceccarelli, Anna, additional, Chiofalo, Laura, additional, Perazzo, Serena, additional, Bensi, Maria, additional, Minucci, Angelo, additional, Urbani, Andrea, additional, Larocca, Luigi Maria, additional, Basso, Michele, additional, Pozzo, Carmelo, additional, Salvatore, Lisa, additional, Calegari, Maria Alessandra, additional, and Tortora, Giampaolo, additional
- Published
- 2024
- Full Text
- View/download PDF
19. Essential oils from Anethum graveolens L. and their phytotoxic and antibiofilm potential
- Author
-
Polito, Flavio, primary, Khammassi, Marwa, additional, Kouki, Habiba, additional, Amri, Ismail, additional, Di Vito, Maura, additional, Urbani, Andrea, additional, Nazzaro, Filomena, additional, Fratianni, Florinda, additional, and De Feo, Vincenzo, additional
- Published
- 2024
- Full Text
- View/download PDF
20. Salivary biomarkers in COVID-19 patients: the rabbit out of the hat!
- Author
-
Napodano, Cecilia, primary, Callà, Cinzia Anna, additional, Fiorito, Antonella, additional, Marino, Mariapaola, additional, Taddei, Eleonora, additional, Cesare, Tiziana Di, additional, Passali, Giulio Cesare, additional, Santo, Riccardo Di, additional, Fantoni, Massimo, additional, Urbani, Andrea, additional, Paludetti, Gaetano, additional, Rapaccini, Gian Ludovico, additional, Ciasca, Gabriele, additional, and Basile, Umberto, additional
- Published
- 2024
- Full Text
- View/download PDF
21. Association between Plasma HLA-DR+ Placental Vesicles and Preeclampsia: A Pilot Longitudinal Cohort Study
- Author
-
Onori, Marianna, primary, Franco, Rita, additional, Lucchetti, Donatella, additional, Tartaglia, Silvio, additional, Buongiorno, Silvia, additional, Beneduce, Giuliana, additional, Sannino, Fabio, additional, Baroni, Silvia, additional, Urbani, Andrea, additional, Lanzone, Antonio, additional, Scambia, Giovanni, additional, Di Simone, Nicoletta, additional, and Tersigni, Chiara, additional
- Published
- 2024
- Full Text
- View/download PDF
22. Initial real-world data on catheter ablation in patients with persistent atrial fibrillation using the novel lattice-tip focal pulsed-field ablation catheter.
- Author
-
Tohoku, Shota, Bordignon, Stefano, Schaack, David, Hirokami, Jun, Urbanek, Lukas, Urbani, Andrea, Kheir, Joseph, Schmidt, Boris, and Chun, Kyoung-Ryul Julian
- Abstract
Aims Technological advancements have contributed to the enhanced precision and lesion flexibility in pulsed-field ablation (PFA) by integrating a three-dimensional mapping system combined with a point-by-point ablation strategy. Data regarding the feasibility of this technology remain limited to some clinical trials. This study aims to elucidate initial real-world data on catheter ablation utilizing a lattice-tip focal PFA/radiofrequency ablation (RFA) catheter in patients with persistent atrial fibrillation (AF). Methods and results Consecutive patients who underwent catheter ablation for persistent AF via the lattice-tip PFA/RFA catheter were enrolled. We evaluated acute procedural data including periprocedural data as well as the clinical follow-up within a 90-day blanking period. In total, 28 patients with persistent AF underwent AF ablation either under general anaesthesia (n = 6) or deep sedation (n = 22). In all patients, pulmonary vein isolation was successfully achieved. Additional linear ablations were conducted in 21 patients (78%) with a combination of successful anterior line (n = 13, 46%) and roof line (n = 19, 68%). The median procedural and fluoroscopic times were 97 (interquartile range, IQR: 80–114) min and 8.5 (IQR: 7.2–9.5) min, respectively. A total of 27 patients (96%) were interviewed during the follow-up within the blanking period, and early recurrent AF was documented in four patients (15%) including one case of recurrent AF during the hospital stay. Neither major nor minor procedural complication occurred. Conclusion In terms of real-world data, our data confirmed AF ablation feasibility utilizing the lattice-tip focal PFA/RFA catheter in patients with persistent AF. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
23. The cleavage of Cyclophilin D N-terminus potentiates its ability to bind ATP Synthase
- Author
-
Coluccino, Gabriele, Canetti, Diana, Urbani, Andrea, Bean, Camilla, Mimmi, Maria Chiara, Negro, Alessandro, Filippi, Antonio, Muraca, Valentina Pia, Gissi, Clarissa, Zamprogno, Elisa, Comelli, Marina, Carraro, Michela, Bernardi, Paolo, Corazza, Alessandra, and Lippe, Giovanna
- Published
- 2024
- Full Text
- View/download PDF
24. Essential oils from Anethum graveolensL. and their phytotoxic and antibiofilm potential
- Author
-
Polito, Flavio, Khammassi, Marwa, Kouki, Habiba, Amri, Ismail, Di Vito, Maura, Urbani, Andrea, Nazzaro, Filomena, Fratianni, Florinda, and De Feo, Vincenzo
- Abstract
AbstractEssential oils (EOs) from inflorescences (EO-i), stems (EO-s) and leaves (EO-l) of Anethum graveolensare analyzed by GC and GC-MS. The main components are α-phellandrene (51.44%) and p-cymene (22.65%) in the EO-i, p-cymene (50.75%) and α-phellandrene (35.73%) in EO-s and p-cymene (40.01%) and α-phellandrene (36.38%) in EO-l. The phytotoxic activity was tested against germination and growth of aerial parts and roots of dicotyledones (Sinapis arvensisand Trifolium campestre) and monocotyledone (Lolium multiflorum) weeds. The EOs proved to be particularly active against S. arvensisand T. campestre, causing total inhibition of germination and growth at the highest doses (2.0 and 1.5 μL/mL) with IC50values included between 0.3 and 1.6 mg/mL. The antibacterial and antibiofilm activity was tested against Gram positive (Staphylococcus aureussubsp. aureusand Listeria monocytogenes) and Gram negative (Acinetobacter baumannii, Pseudomonas aeruginosaand Escherichia coli) pathogenic bacterial strains. EOs presented MICs lower than those of Tetracycline (20-24 mg/mL) against most bacterial strains (from 4 to 6 mg/mL). EOs were found to be active in inhibiting bacterial biofilm formation with IC50values between 1.47 and 3.85 mg/mL. The activity against bacterial metabolism occurred for EO-i and EO-s against A. baumanniiand E. coliwith IC50between 0.99 and 5.39 mg/mL. This investigation provides data about the chemical variation among different parts of A. graveolensand encourages the use of its EOs as natural phytotoxic and antibacterial agents in agriculture, food and pharmaceutical sectors.
- Published
- 2024
- Full Text
- View/download PDF
25. Structural and functional characterization of two distinct forms of cyclophilin D in mammalian mitochondria
- Author
-
Coluccino, Gabriele, Canetti, Diana, Urbani, Andrea, Bean, Camilla, Negro, Alessandro, Filippi, Antonio, Muraca, Valentina P., Gissi, Clarissa, Carraro, Michela, Bernardi, Paolo, Corazza, Alessandra, and Lippe, Giovanna
- Published
- 2024
- Full Text
- View/download PDF
26. Serum-free light chains as a dependable biomarker for stratifying patients with metabolic dysfunction-associated steatotic liver disease.
- Author
-
Liguori A, D'Ambrosio F, Napodano C, Gentili V, Giustiniani MC, Pompili M, Grieco A, Rapaccini G, Urbani A, Gasbarrini A, Basile U, and Miele L
- Abstract
Background and Aims: Adaptive immunity is gaining a significant role in progression of metabolic dysfunction-associated steatotic liver disease (MASLD). B-cell activity can be assessed by serum-free light chains (sFLCs) k and λ levels. The objective of the present investigation is to examine the utility of sFLCs as non-invasive biomarkers for the stratification of MASLD., Methods: We enrolled a consecutive cohort from an outpatient liver unit. Diagnosis of metabolic dysfunction-associated steatohepatitis (MASH) was made with liver biopsy according to current guidelines. Compensated advanced chronic liver disease (cACLD) and clinically significant portal hypertension (CSPH) were defined according to Baveno VII criteria. sFLCs were measured by turbidimetry using an immunoassay., Results: We evaluated 254 patients, 162/254 (63.8%) were male. Median age was 54 years old, and the median body mass index was 28.4 kg/m
2 . A total of 157/254 (61.8%) subjects underwent liver biopsy: 88 had histological diagnosis of MASH, 89 were considered as simple metabolic dysfunction-associated steatotic liver (MASL) and 77/254 (30.3%) patients with compensated metabolic dysfunction-associated cirrhosis. By using Baveno VII criteria, 101/254 (39.7%) patients had cACLD; among them, 45/101 (44.5%) had CSPH. Patients with cACLD showed higher sFLC levels compared with patients without cACLD (p < .01), and patients with CSPH showed higher sFLC levels than patients without CSPH (p < .01). At multivariable analysis, sFLCs were associated with cACLD (p < .05) independently from γ-globulins and other known dysmetabolic risk factors. κFLC was associated with CSPH (p < .05) independently from γ-globulins and other known dysmetabolic risk factors., Conclusion: sFLCs could be a simple biomarker for stratification of cACLD in MASLD patients., (© 2024 The Author(s). Liver International published by John Wiley & Sons Ltd.)- Published
- 2024
- Full Text
- View/download PDF
27. Initial real-world data on catheter ablation in patients with persistent atrial fibrillation using the novel lattice-tip focal pulsed-field ablation catheter.
- Author
-
Tohoku S, Bordignon S, Schaack D, Hirokami J, Urbanek L, Urbani A, Kheir J, Schmidt B, and Chun KJ
- Subjects
- Humans, Male, Female, Middle Aged, Treatment Outcome, Aged, Cardiac Catheters, Recurrence, Time Factors, Atrial Fibrillation surgery, Atrial Fibrillation diagnosis, Atrial Fibrillation physiopathology, Catheter Ablation methods, Catheter Ablation instrumentation, Pulmonary Veins surgery, Equipment Design
- Abstract
Aims: Technological advancements have contributed to the enhanced precision and lesion flexibility in pulsed-field ablation (PFA) by integrating a three-dimensional mapping system combined with a point-by-point ablation strategy. Data regarding the feasibility of this technology remain limited to some clinical trials. This study aims to elucidate initial real-world data on catheter ablation utilizing a lattice-tip focal PFA/radiofrequency ablation (RFA) catheter in patients with persistent atrial fibrillation (AF)., Methods and Results: Consecutive patients who underwent catheter ablation for persistent AF via the lattice-tip PFA/RFA catheter were enrolled. We evaluated acute procedural data including periprocedural data as well as the clinical follow-up within a 90-day blanking period. In total, 28 patients with persistent AF underwent AF ablation either under general anaesthesia (n = 6) or deep sedation (n = 22). In all patients, pulmonary vein isolation was successfully achieved. Additional linear ablations were conducted in 21 patients (78%) with a combination of successful anterior line (n = 13, 46%) and roof line (n = 19, 68%). The median procedural and fluoroscopic times were 97 (interquartile range, IQR: 80-114) min and 8.5 (IQR: 7.2-9.5) min, respectively. A total of 27 patients (96%) were interviewed during the follow-up within the blanking period, and early recurrent AF was documented in four patients (15%) including one case of recurrent AF during the hospital stay. Neither major nor minor procedural complication occurred., Conclusion: In terms of real-world data, our data confirmed AF ablation feasibility utilizing the lattice-tip focal PFA/RFA catheter in patients with persistent AF., Competing Interests: Conflict of interest: K.C. and B.S. have received research grants and speaker fees from Medtronic, Biosense Webster, and Boston Scientific. S.B. received speaker fees from Medtronic. All remaining authors have declared no conflicts of interest., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
- Published
- 2024
- Full Text
- View/download PDF
28. A novel risk score predicting 30-day hospital re-admission of patients with acute stroke by machine learning model.
- Author
-
Mercurio G, Gottardelli B, Lenkowicz J, Patarnello S, Bellavia S, Scala I, Rizzo P, de Belvis AG, Del Signore AB, Maviglia R, Bocci MG, Olivi A, Franceschi F, Urbani A, Calabresi P, Valentini V, Antonelli M, and Frisullo G
- Subjects
- Humans, Retrospective Studies, Risk Factors, Hospitals, Machine Learning, Stroke epidemiology, Stroke therapy
- Abstract
Background: The 30-day hospital re-admission rate is a quality measure of hospital care to monitor the efficiency of the healthcare system. The hospital re-admission of acute stroke (AS) patients is often associated with higher mortality rates, greater levels of disability and increased healthcare costs. The aim of our study was to identify predictors of unplanned 30-day hospital re-admissions after discharge of AS patients and define an early re-admission risk score (RRS)., Methods: This observational, retrospective study was performed on AS patients who were discharged between 2014 and 2019. Early re-admission predictors were identified by machine learning models. The performances of these models were assessed by receiver operating characteristic curve analysis., Results: Of 7599 patients with AS, 3699 patients met the inclusion criteria, and 304 patients (8.22%) were re-admitted within 30 days from discharge. After identifying the predictors of early re-admission by logistic regression analysis, RRS was obtained and consisted of seven variables: hemoglobin level, atrial fibrillation, brain hemorrhage, discharge home, chronic obstructive pulmonary disease, one and more than one hospitalization in the previous year. The cohort of patients was then stratified into three risk categories: low (RRS = 0-1), medium (RRS = 2-3) and high (RRS >3) with re-admission rates of 5%, 8% and 14%, respectively., Conclusions: The identification of risk factors for early re-admission after AS and the elaboration of a score to stratify at discharge time the risk of re-admission can provide a tool for clinicians to plan a personalized follow-up and contain healthcare costs., (© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.