1. A genetic survey of patients with familial idiopathic intracranial hypertension residing in a Middle Eastern village: genetic association study
- Author
-
Eran Berkowitz, Tzipora C. Falik Zaccai, Dana Irge, Inbar Gur, Beatrice Tiosano, and Anat Kesler
- Subjects
Idiopathic intracranial hypertension ,GWAS ,PTC ,Genetic association ,Familial ,Medicine - Abstract
Abstract Background The aim of this study was to determine whether genetic variants are associated with idiopathic intracranial hypertension (IIH) in a unique village where many of the IIH patients have familial ties, a homogenous population and a high prevalence of consanguinity. Several autosomal recessive disorders are common in this village and its population is considered at a high risk for genetic disorders. Methods The samples were genotyped by the Ilumina OmniExpress-24 Kit, and analyzed by the Eagle V2.4 and DASH software package to cluster haplotypes shared between our cohort. Subsequently, we searched for specific haplotypes that were significantly associated with the patient groups. Results Fourteen patients and 30 controls were included. Samples from 22 female participants (11 patients and 11 controls) were evaluated for haplotype clustering and genome-wide association studies (GWAS). A total of 710,000 single nucleotide polymorphisms (SNPs) were evaluated. Candidate areas positively associated with IIH included genes located on chromosomes 16, 8 (including the CA5A and BANP genes, p
- Published
- 2024
- Full Text
- View/download PDF