1. Non-Polio Enterovirus Inhibitors: Scaffolds, Targets, and Potency─What's New?
- Author
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Roux HFG, Touret F, Rathelot P, Sciò P, Coluccia A, Vanelle P, and Roche M
- Subjects
- Humans, Structure-Activity Relationship, Enterovirus Infections virology, Enterovirus Infections drug therapy, Hand, Foot and Mouth Disease virology, Hand, Foot and Mouth Disease drug therapy, Hand, Foot and Mouth Disease prevention & control, Animals, Antiviral Agents pharmacology, Antiviral Agents chemistry, Enterovirus drug effects
- Abstract
Enterovirus (EV) is a genus that includes a large diversity of viruses spread around the world. They are the main cause of numerous diseases with seasonal clusters, like hand-foot-mouth disease (HFMD). A vaccine is marketed in China for the prevention of HFMD caused by EV-A71. Despite the need, no antiviral is marketed to date. Therefore, several compounds have been currently evaluated to inhibit non-polio Enterovirus (NPEV), namely direct antiviral agents and host target inhibitor. We propose to make a review of the latest molecules evaluated as NPEV inhibitors and to summarize structure-activity relationships between these inhibitors and their target. We provide access to all recent information on Enterovirus inhibitors, regardless of the species, to facilitate the design of future broad-spectrum drugs.
- Published
- 2025
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