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Your search keyword '"Tomi-Pekka Tuomainen"' showing total 1 results
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1. In vivo vitamin D targets reveal the upregulation of focal adhesion-related genes in primary immune cells of healthy individuals

Author

Ranjini Ghosh Dastidar, Julia Jaroslawska, Marjo Malinen, Tomi-Pekka Tuomainen, Jyrki K. Virtanen, Igor Bendik, and Carsten Carlberg

Subjects
Vitamin D, Vitamin D intervention study, Transcriptome, Vitamin D target genes, Vitamin D response index, Focal adhesion, Medicine, Science
Abstract

Abstract Vitamin D modulates innate and adaptive immunity, the molecular mechanisms of which we aim to understand under human in vivo conditions. Therefore, we designed the study VitDHiD (NCT03537027) as a human investigation, in which 25 healthy individuals were supplemented with a single vitamin D3 bolus (80,000 IU). Transcriptome-wide differential gene expression analysis of peripheral blood mononuclear cells (PBMCs), which were isolated directly before and 24 h after supplementation, identified 452 genes significantly (FDR

Published
2024
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