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One of the remaining issues regarding the Anthropocene is the lack of stratigraphic evidence indicating when the cumulative human pressure from the early Holocene began to fundamentally change the Earth system. Herein, we compile anthropogenic fingerprints from various high-precision-dated proxy records for 137 global sites to determine the age of the unprecedented surge in these records over the last 7700 y. The cumulative number of fingerprints revealed an unprecedented surge in diverse anthropogenic fingerprints starting in 1952 ± 3 CE, corresponding to the onset of the Great Acceleration. Notably, the period from 1953 to 1958 CE saw a nearly simultaneous surge in fingerprints across all regions, including Antarctica, the Arctic, East Asia, Europe, North America, and Oceania. This synchronous upsurge reflects the moment when human impacts led to rapid transformations in various natural processes and cycles, with humans becoming a geological force capable of inscribing abundant and diverse anthropogenic fingerprints in global strata. Following this global fingerprint explosion, profound planetary-scale changes, including deviations from the established natural climatic conditions, begin. This unprecedented surge in anthropogenic signals worldwide suggests that human influences started to match many natural forces controlling the processes and cycles and overwhelm some of the functioning of the Earth system around 1952., Competing Interests: Competing interests statement:The authors declare no competing interest.

Semi-synthetic and grain-based diets are common rodent diets for biomedical research. Both diet types are considered nutritionally adequate to support breeding, growth, and long life, yet there are fundamental differences between them that may affect metabolic processes. We have characterized the effects of diet type on breeding outcomes, metabolic phenotype, and microbiota profile in adult mice. Healthy 8-week-old female and male C57BL/6J mice were fed a semi-synthetic or a grain-based diet for 12 weeks and changes in body weight and body composition were monitored. Breeding outcomes were determined. Body fat accumulation of female mice was lower on the semi-synthetic diet than on the grain-based diet. Pregnancy rate and newborn pup survival appeared to be lower in mice exposed to semi-synthetic diet compared to grain-based diet. Both female and male mice showed a profound change in fecal microbiota alpha and beta diversity depending on diet type. Our study shows that type of rodent diet may affect breeding outcomes whilst influencing metabolism and health of female laboratory mice. These factors have the potential to influence other experimental outcomes and the results suggest that semi-synthetic and grain-based diets are not interchangeable in research using rodent models. Careful consideration and increased understanding of the consequences of diet choice would lead to improvements in experimental design and reproducibility of study results., Competing Interests: “I have read the journal’s policy and the authors of this manuscript have the following competing interests: LS, ST, ET, JL, MR and LH are employees of the institution that funded the research or were at the time of the study (ET). This does not alter our adherence to PLOS ONE policies on sharing data and materials.”, (Copyright: © 2024 Schipper et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)