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Following with the social-economy development and the increase of the incidence of various respiratory diseases, countries all over the world are increasingly paying attention to the issue of air pollution. This study uses the tracking data of 31 provincial capitals in China from 2013 to 2020, empirically tests the impact of air pollution on public health based on the ordinary least squares regression, and investigates the reliability of research conclusions with single instrumental variables and double instrumental variables based on the 2-Stage Least Squares and 3-stage Least Squares method. The results showed that air pollution significantly increased the “the number of respiratory diseases deaths per 10,000 people,” the effect reached 24.97%; and there were significant differences in the effects due to different pollution levels, along with the cumulation of the number of days with the air pollution index exceeds 300, the deterioration effects of air pollution on public health will reach the highest value as 0.42%. After replacing the indicators of public health and the treating of endogeneity, the above results are still robust. The impact coefficients significantly increased compare to benchmark model, which has increased to 89.66%. The variable coefficients of days with air pollution index exceeding 300 has increased to 6.66%. In the formation mechanism of air pollution, both industrial pollution and domestic pollution play significant roles, their effects reached 14.79% and 39.61%, respectively; they jointly increase the deterioration degree of air pollution and transmit to the impact of air pollution on public health, the interaction effect reached 5.86%. The air pollution has considerable impact on public health, and when the degree of air pollution increases, its impact is enhanced. The main impact mechanism of air pollution is presented as the joint influences of industrial pollution and domestic pollution that transmitting to the public health.

The Nitrogen Nutrition Index (NNI), based on the Critical Nitrogen Concentration (Nc), is widely utilized to evaluate crop nitrogen nutrition. However, the impact of water deficit on crop Nc remains unclear. To address this, a 3-year joint water-nitrogen regulation experiment on winter wheat was conducted to investigate the responses of Nc dilution curve parameters (A1 and A2 in Nc ​= ​A1DM−A2, where DM represents aboveground dry biomass), nitrogen accumulation (NA), and grain yield (GY) to different water management strategies. The study employed Bayesian statistical methods to establish the Nc dilution curve, which revealed a slightly lower curve compared to that derived using classical methods. The posterior distribution indicated substantial overlap in parameters A1 (89.8%) and A2 (89.4%) between deficit irrigation (DI) and full irrigation (FI). The overlap of parameter A1 was 67.2% between rainfed and irrigated (DI and FI) treatments, whereas for parameter A2, it was only 29.9%. Analysis of variance showed a significant difference (p ​ ​0.05) between DI and FI treatments. Additionally, NA and GY of winter wheat displayed insignificant differences between irrigation treatments; however, they were, on overage, significantly higher by 31.2% and 23.2%, respectively, under irrigated conditions compared to rainfed conditions. This study is the first to demonstrate that severe water deficit (rainfed conditions) significantly affects parameter A2 of the Nc dilution curve, underscoring the importance of considering actual water conditions in applying the NNI for nitrogen fertilizer management.

The relationship between stress and strength in granular soil differs under low confining pressure as compared to high confining pressure, which is of great importance for the geotechnical engineering. Numerical simulations using discrete element method (DEM) are conducted to model consolidated-drained triaxial compression tests, with the confining pressure σc ranging from 1 to1000 kPa. From the analysis of the shear strength of granular soils under various confining pressures and void ratios, it is found that the peak stress ratio ηp under a low σc is significantly lower than that under the high σc, particularly for samples with the same initial void ratio. As the confining pressure increases, ηp for samples with the same initial void ratio increases up to 29 % under the low σc while stabilizing under the high σc. Conversely, ηp for samples with the same void ratio after the consolidation can increase up to 13.5 % under the low σc while declining under the high σc. In addition, the critical confining pressure distinguishing the low and high confining pressures is about 200 kPa for dense samples with initial void ratio of 0.605 used in the study, and it increases as the sample void ratio increases. From the microscopic analysis, the variation of ηp under the low σc can be attributed to the enhanced anisotropy of normal contact force and contact normal under the low confining pressure. Finally, a modified Mohr-Coulomb failure criterion is proposed, which can determine the strength of granular soils under the low confining pressure with different void ratios.

Formulating warning signals for canopy growth status at different stages are an effective way to dynamically regulate the water and fertilizer management based on the relationship between growth information and orchard productivity. In the study, the response of leaf nitrogen content (LNC), leaf area index (LAI), fruit yield, quality and water and nitrogen use efficiency to irrigation levels and nitrogen rates was investigated in a field experiment from 2017 to 2022. Principal component analysis was used to construct an orchard production comprehensive evaluation index (OPCEI) to assess orchard productivity, and the relationship between LAI, LNC and OPCEI was analyzed by the structural equation modeling. The results showed that nitrogen rates had significant effect on OPCEI in the different years, but irrigation levels had significant effect in 2019 and 2021. Compared to no fertilization, the OPCEI of 120, 240, and 360 kg ha−1 under low irrigation amount showed average increased 28.90%, 48.54%, and 25.85%, while it increased by an average of 33.51%, 55.65%, and 32.44% for 120, 240, and 360 kg ha−1 under high irrigation amount. Also, low irrigation amount did not significantly reduce OPCEI at 240 kg ha−1 compared to high irrigation amount. Structural equation modeling revealed that LNC had significant positive effect on fruit yield, while had significant negative effect on total soluble solids. Furthermore, LAI had a significant positive effect on fruit yield and sugar-acid ratio. On the basis of the relationship of LAI, LNC and OPCEI, the reference value of LNC was proposed. The suitable range of LNC in the shoot growth and young fruit stage is 2.96%-3.79% and 2.62%-3.30%, and that is 2.43%-3.17%, 2.21%-2.97%, and 2.13%-2.63% in the early, middle and late fruit expansion stage, respectively. The study results provide a basis for canopy nitrogen diagnosis, which is guide for achieving precise nitrogen application in apple orchards.

The deoxygenation of organic acids, important biomass feedstocks and derivatives, to synthesize hydrocarbon products under mild electrochemical conditions, holds significant importance for the production of carbon-neutral biofuels. There is still limited research on the influential factors of the electrochemical decarboxylation reaction of medium-chain fatty acids. In this study, n-octanoic acid (OA) was chosen as the research subject to investigate the electrochemical decarboxylation behavior of OA on a platinum electrode, focusing on the influence of different alkali metal cations (Li+, Na+, K+), common anions (SO42−, Cl−), and electrolyte pH. It was found that KOH as an electrolyte exhibited the best performance for OA. Possibly, the larger size of K+ increased the alkalinity of the electrode surface, facilitating OA deprotonation. LiOH electrolyte reduced the solubility of OA, thereby inhibiting the decarboxylation reaction. SO42− exhibited a weak promoting effect on the decarboxylation reaction of OA, while Cl− showed no adverse effect although Cl− may adsorb on the electrode surface. Furthermore, unlike short-chain fatty acids, medium-chain OA can only achieve efficient decarboxylation under alkaline conditions due to its solubility properties. This study provides references and foundations for future efforts to enhance the efficiency of electrochemical decarboxylation synthesis of hydrocarbon biofuels from medium-chain fatty acids.

Appropriate water and nitrogen fertilizer management is crucial for achieving sustainable development in the apple industry. However, the soil nitrogen supply capacity and residual nitrate characteristics under drip fertigation remain poorly understood. Therefore, this study aims to (1) investigate the coupling effects of irrigation and nitrogen levels on the concentrations and distribution characteristics of soil soluble nitrogen fractions and residual soil nitrate; (2) explore the relationships between Christiansen uniformity coefficient (CU) of soil nitrate and apple yield, water productivity (WPc) and nitrogen use efficiency (nitrogen agronomic efficiency, AEn). The field experiment was conducted in a drip-fertigated apple orchard starting in 2017, which included two irrigation levels, 85% (W1) and 100% (W2) of field capacity (FC), and four nitrogen rates, 0 (N1), 120 (N2), 240 (N3) and 360 (N4) kg ha–1. The results showed that nitrogen inputs significantly increased soil soluble inorganic nitrogen and soluble organic nitrogen (SON) contents. However, the SON content significantly decreased when 360 kg N ha–1 was applied, particularly at W1. The maximum nitrate accumulation in the 0–3 m soil layer at N4 reached 2540.97 kg ha–1 in 2021, but the maximum value decreased to 1251.62 kg ha–1 in 2022 due to extreme rainfall. The average CU of residual nitrate across irrigation levels in the 0–3 m soil layer was highest at N3, with values of 0.68 and 0.57 in 2021 and 2022, respectively. High irrigation level increased the diffusion distances of nitrate both vertically and horizontally, resulting in a significant effect on CU. Apple yield and WPc first increased and then decreased with increasing nitrogen rates, while AEn consistently decreased, but they were all greater with a higher CU. The recommended combination of irrigation and nitrogen application was 85% FC and 240 kg N ha–1, which can achieve the dual goals of enhancing soil nitrogen supply capacity and minimizing environmental risks while improving orchard productivity.

Based on the three-year survey data from China Health and Retirement Longitudinal Study (CHARLS) database, in combination with the environmental statistical data of 122 cities, this study empirically tests the effect of air pollution on the labor participation of the elderly and the mechanism. Using the panel data model, two-way fixed effect method, and instrumental variable method, the results show that air pollution significantly reduces the labor participation of the elderly, with a decrement of 0.43%. With the respect of transmission mechanisms, air pollution affects the overall labor participation behavior of the elderly mainly through the number of working days per week and working hours per day. At the same time, along with the cumulating of the days of Air Quality Index (AQI) [Formula: see text], the labor participation of the elderly is significantly reduced. In addition, the impact of air pollution on the labor participation of the elderly shows apparent heterogeneity divided by the gender, education level, urban-rural, and regional economic-level, and there are obvious substitution effects and income effects. This study confirms that air pollution affects the total labor participation of the elderly through the number of working days per week and working hours per day, and this impact reaches a peak when AQI is in the range from 100 to 150.

BackgroundExploring the value orientation of city development from the perspective of people’s well-being is key to clarifying the current debate on city size strategies.MethodsBased on the survey data of the China Health and Retirement Longitudinal Study in two phases, and by using the unbalanced panel-ordered logit model, stepwise analysis method, and KHB method, among others, we discuss the impact of city size on the disability rate of older adults.ResultsThe study finds that city size significantly and positively affects the activities of daily living (ADL) of older adults, with odd ratios of 1.3286 (95% CI = [1.082243, 1.631089]), and exhibits significant group heterogeneity in terms of age, registered residence, income, and education level. City size has indeed played an mediation role through the health improvement effect, disease mitigation effect, emotional effect, and employment structure optimization effect, with a cumulative contribution rate of the mediation effect of 35.17%. In addition, the urban sprawl index has a significant moderation role.DiscussionRobust urban sprawl is conducive to promoting the improvement of the regional health environment, the improvement of the medical security policy, the optimization of the family support policy, and the employment structure, thus helping to reduce the disability rate of older adults.

Abstract Background Lychee seeds were fermented by three kinds of bacteria (Lactobacillus plantarum, Saccharomyces cerevillus and ganoderma lucidum mycelium), and two effective strains were selected by two indexes of activity content and antioxidant, so as to further verify whether lychee seeds have waste multiplication effect and can protect cells damaged by oxidation from anti-inflammatory, anti-aging and safety. Results The contents of polyphenols, flavonoids and proteins in the solution fermented by Ganoderma lucidum mycelium did not increase, thus affecting the antioxidant capacity of the solution was far less than that of the water extract. The active content of the other two fermentation solutions was higher than that of the water extract, and the ability of scavenging free radicals of the two solutions increased with the increase of the volume fraction. At the cellular level, the two fermentation solutions showed repair effects on UVA-induced damaged cells. The contents of type I collagen (COL-1), total antioxidant capacity and ELN were increased, the contents of reactive oxygen species and MDA were decreased, and the expressions of inflammatory factors IL-6, TNF-a, iNOS and COX-2 were decreased in HaCaT cells. From the gene level, the mRNA contents of IL-6, TNF-a, Caspase-3, Caspase-9, Bax and Bcl were significantly decreased. The test of chick embryo chorioallantoic membrane (HTET CAM) showed that there was no bleeding and litchi seed fermentation liquid was not irritating. Conclusions Therefore, two kinds of litchi seed fermentation can be used as natural plant raw materials for cosmetics, and have strong antioxidant, anti-inflammatory and anti-aging functions on skin, and also have good human safety. Graphical Abstract

Abstract Tunable optical information storage is crucial in artificial retinal systems for mimicking neurobiological visual characteristics. The perception and storage of light signals rely heavily on the regulation of the conductivity states of memristor materials (e.g., transition metal oxides). Controlling light memristor behavior via defects and polymorphic phases remains underexplored and differs from traditional plasticity training via repeated testing. In this study, defect‐driven ultraviolet light perception and memristor storage with phase transitions in vanadium dioxide (VO2) thin films are presented. The effects of oxygen defects and the corresponding polymorphic phases on ultraviolet light memristors are investigated. The dependence of phonon vibrations and insulator–metal transition behavior on defect levels are revealed. Self‐doping and polymorphs enable VO2 to exhibit distinct ultraviolet memristor performance. It is anticipated that defect‐driven light memristors significantly contribute to the realization of artificial synaptic devices and the implementation of advanced electronic neuron systems.

Gesture recognition has emerged as a significant research domain in computer vision and human-computer interaction. One of the key challenges in gesture recognition is how to select the most useful channels that can effectively represent gesture movements. In this study, we have developed a channel selection algorithm that determines the number and placement of sensors that are critical to gesture classification. To validate this algorithm, we constructed a Force Myography (FMG)-based signal acquisition system. The algorithm considers each sensor as a distinct channel, with the most effective channel combinations and recognition accuracy determined through assessing the correlation between each channel and the target gesture, as well as the redundant correlation between different channels. The database was created by collecting experimental data from 10 healthy individuals who wore 16 sensors to perform 13 unique hand gestures. The results indicate that the average number of channels across the 10 participants was 3, corresponding to an 75% decrease in the initial channel count, with an average recognition accuracy of 94.46%. This outperforms four widely adopted feature selection algorithms, including Relief-F, mRMR, CFS, and ILFS. Moreover, we have established a universal model for the position of gesture measurement points and verified it with an additional five participants, resulting in an average recognition accuracy of 96.3%. This study provides a sound basis for identifying the optimal and minimum number and location of channels on the forearm and designing specialized arm rings with unique shapes.

The synthesis and structural analysis of (Me3SiC5H4)TiCl2(OAr) [OAr = O-2,6-iPr2-4-RC6H2; R = H, SiEt3] revealed that it exhibits higher catalytic activities than (tBuC5H4)TiCl2(OAr), Cp*TiCl2(OAr), with efficient comonomer incorporation in ethylene/styrene copolymerization in the presence of a methylaluminoxane (MAO) cocatalyst. The catalytic activity in the copolymerization increased upon increasing the charged styrene concentration along with the increase in the styrene content in the copolymers, whereas the activities of other catalysts showed the opposite trend. (Me3SiC5H4)TiCl2(O-2,6-iPr2C6H3) displayed the most suitable catalyst performance in terms of its activity and styrene incorporation, affording amorphous copolymers with styrene contents higher than 50 mol% (up to 63.6 mol%) and with random styrene incorporation confirmed by 13C-NMR spectra.

The coastal regions of Fujian, characterized by a subtropical maritime monsoon climate, experience a high frequency of windy days throughout the year, which significantly impacts residents’ lives. Local traditional villages, through long-term practical exploration, have developed a unique “maze-like” spatial layout adapted to withstand harsh wind conditions. This study aims to quantitatively analyze the climatic adaptability advantages of this traditional layout, providing theoretical support for the protection of historical cultural heritage and guidance for modern village construction. The methodology includes field wind measurement for data acquisition, construction of current and regularized divergent models, and comparative numerical simulations under scenarios of strong winter winds and typhoons. The results indicate that wind speeds within traditional villages are generally lower. The layout’s nonlinear roads and clusters of buildings form multiple buffer zones that effectively reduce wind speeds. In contrast, areas in the divergent model experience excessively high wind speeds, impacting outdoor activity safety and comfort. The traditional “maze-like” layout encapsulates the climate adaptation wisdom of ancestors, enhancing wind environment regulation, thermal comfort, and disaster resilience. This layout concept merits promotion and innovative application in the new era to construct livable, green, and sustainable human environments.

Aging is a gradual process of natural change that occurs after reaching sexual maturity. It is also a known risk factor for many chronic diseases. Recent research has shown that senolytics can extend the lifespans and health spans of model organisms, and they have also been demonstrated effective in treating age-related diseases. In this study, we conducted a high-throughput screening of 156 drugs that targeted the PI3K/AKT/mTOR pathway to identify potential senolytic medications. Among these drugs, PF-04691502 was selected for further investigation to understand its molecular mechanism of action. Our findings indicate that PF-04691502, a dual inhibitor of PI3K/AKT and mTOR, specifically eliminates senescent cells. It reduces the expression levels of key markers of cellular senescence, such as SA-β-Gal, senescence-associated secretory phenotypes (SASPs) and p16INK4a. Additionally, PF-04691502 inhibits the phosphorylation of S6K and AKT, leading to the apoptosis of senescent cells. These results suggest that PF-04691502 holds promise as a new senolytic drug. This paper provides important insights into the potential application of PF-04691502 in the study of cell senescence.

BackgroundThe triglyceride glucose-body mass index (TyG-BMI) has been considered a surrogate marker for assessing insulin resistance. We aimed to correlate the TyG-BMI, triglyceride glucose combined with body mass index, with femoral neck bone mineral density (FN BMD) in non-diabetic elderly men.MethodsUsing data from the National Health and Nutrition Examination Survey (NHANES) database, totally, 1182 eligible men aged ≥ 50 years without diabetes were included in the current study. Smoothed curves were obtained by a two-piecewise linear regression model and the threshold effects were explored by using a smoothing function.ResultsTyG-BMI was positive related with and FN BMD with or without adjustment for confounders. However, no typical dose-dependent positive association between TyG-BMI and FN BMD was observed across the TyG-BMI tertiles, indicating a non-linear association. Further analysis by the weighted two-piecewise linear regression model and recursive algorithm suggested that per SD increase in TyG-BMI increased FN BMD by 0.266 gm/cm2 when TyG-BMI lower than 168.20. However, when TyG-BMI is higher than 168.20, FN BMD only increased 0.046 gm/cm2 for per SD increase of TyG-BMI after fully adjustment (OR = 11.258, 95%CI: 6.034, 16.481). Moreover, subgroup analyses showed that higher TyG-BMI levels were related to elevated FN BMD in all groups, suggesting the consistency of the positive association within these stratas.ConclusionsThis study demonstrated that TyG-BMI is positively associated with FN BMD in a nonlinear fashion among elderly men without diabetes, which may be a reliable marker for the early identification of individuals with lower FN BMD.

Hydrocolloids, as thickeners, have been receiving increasing attention from researchers. Although they exhibit significant free radical quenching abilities, which demonstrate potential heterocyclic amines (HAs) inhibitory capabilities by blocking the free radical pathway, the inhibitory effect and mechanism are still unclear. This study investigated the effects of three typical hydrocolloids (alginic acid, chitosan, and carrageenan) on both free and bound HAs in fried meatballs, along with their mechanisms of free radical quenching using density functional theory. The result showed that all three hydrocolloids can effectively inhibit the generation of HAs. The maximum inhibition rate reached 33.33% for free HAs and 23.18% for bound HAs. Phenylacetaldehyde, glyoxal and methyl glyoxal, were significantly inhibited, indicating that hydrocolloids alleviated the production of HAs by inhibiting the generation of intermediates. At moment, three hydrocolloids effectively inhibited the generation of total free radicals. Frontier orbital and density functional theory analysis revealed that carrageenan had the lowest HOMO-LUMO energy gaps, ionization potential, highest nucleophilic index, chemical potential, and was more likely to react with free radicals. The results of this study indicate that three hydrocolloids can effectively inhibit HAs and provide theoretical support for their applications in food processing and safety.

This article reports on the recent mining and production status of ruby in Longido, Tanzania. Faceted-grade rubies and their matrix from Longido Area, Tanzania, were investigated by standard gemological testing, including FTIR, UV-VIS, Raman spectra, and LA-ICP-MS. Microscopic observations revealed dense needle-like and triangular inclusions, distinct growth lines, and color banding as typical inclusions. In agreement with the Raman results, the transmission FTIR spectrum confirmed the presence of aluminum hydroxide. The Raman spectra identified associated minerals and inclusions, including zoisite, parasites, feldspar within the matrix, rutile, and diaspore in the ruby host. The chemistry analysis revealed a high amount of Cr and relatively low iron as a good indicator of geographic origin.

The design of the enclosure layout is crucial in establishing a comfortable wind environment in Chinese classic landscape gardens. The Ruins Park of the Old Summer Palace exemplifies the mountain construction techniques used in classical Chinese flat gardens, with a diverse and illustrative spatial layout of the hills. In this study, we focused on the earthen hill space of the Old Palace in the Summer Palace Ruins Park. We compared and analyzed the effects of different enclosure layouts of earthen hill spaces on the summer monsoon wind environment. This was achieved via on-site measurements and simulations using computational fluid dynamics (CFD). The results show the following: (1) The direction index of the enclosure layout of the earthen hill space affects wind speed, comfort, and ventilation. Increasing the index reduces speed and comfort but improves ventilation. (2) Increasing the density index of the enclosure layout of the earthen hill space leads to a decrease in wind speed and wind comfort and improved ventilation. (3) Conversely, increasing the area index of the enclosure layout of the earthen hill space results in an increase in wind speed, which can result in better wind comfort but can also lead to poor ventilation. Overall, the results suggest that careful consideration should be given to the enclosure layout of landscape gardens to ensure optimal wind conditions within the space.