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Inadequate lateral branch development can lead to decreased apple (Malus ×domestica Borkh.) orchard productivity and profitability in modern high-density orchard systems. Although plant growth regulator applications are used to increase lateral branching on leaders of young apple trees, inconsistent responses have been observed in the southeastern United States. In North Carolina and Washington, three experiments were conducted to identify effective leader management strategies to increase lateral branching. Effects and interactions of leader bagging, 6-benzyladenine (6-BA), and 6-BA + gibberellic acid (GA4+7) on lateral branch development of 1-year-old leaders were evaluated. Across all experiments, leader bagging was an influential factor. When compared with unbagged trees, leader bagging increased lateral branch number (20% to 48%), number of feathers (74% to 125%), average branch length (28% to 34%), and total linear bearing surface (428%) of the treated section of the leader. Blossom cluster density and final fruit set were increased in bagged trees, 65% and 36%, respectively. At the rates and timings tested, 6-BA and 6-BA + GA4+7 were generally ineffective in stimulating lateral branching and interactions among the factors evaluated were not influential. Leader bagging was an effective lateral branch induction strategy, although the mechanism of action is poorly understood. Future research to characterize the bagged environment and/or physiological responses to bagging may aid in the development of future environmentally sustainable technologies to stimulate lateral branching of apple trees.