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Your search keyword '"Teunissen, Charlotte Elisabeth"' showing total 2 results
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2. Blood Pressure Variability and Plasma Biomarkers of Neuronal Injury and Alzheimer's Disease: A Clinic-Based Study of Patients with Diseases Along the Heart-Brain Axis.

Author

Starmans, Naomi Louisa Paula, Kappelle, Laurens Jaap, Muller, Majon, Staals, Julie, Teunissen, Charlotte Elisabeth, Biessels, Geert Jan, van der Flier, Wiesje Maria, and Wolters, Frank Johannes

Subjects
ALZHEIMER'S disease, BLOOD pressure, ORTHOSTATIC hypotension, HEART failure, PLASMA pressure, BIOMARKERS, HYPERTENSION, MILD cognitive impairment
Abstract

Higher blood pressure variability (BPV) predisposes to cognitive decline. To investigate underlying mechanisms, we measured 24-h ambulatory BPV, nocturnal dipping and orthostatic hypotension in 518 participants with vascular cognitive impairment, carotid occlusive disease, heart failure, or reference participants. We determined cross-sectional associations between BPV indices and plasma biomarkers of neuronal injury (neurofilament light chain) and Alzheimer's disease (phosphorylated-tau-181 and Aβ42/Aβ40). None of the BPV indices were significantly associated with any of the biomarkers. Hence, in patients with diseases along the heart-brain axis, we found no evidence for an association between BPV and selected markers of neuronal injury or Alzheimer's disease. [ABSTRACT FROM AUTHOR]

Published
2024
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