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There is widespread recognition of the need for new homes to feature only low or zero-carbon (LZC) heating. However, residential developers continue to choose conventional high-carbon options such as natural gas boilers over net-zero compatible alternatives. This study explores how UK local authorities (LAs) within the English planning systemcan encourage residential developers to deploy LZC heating systems within their projects. We adopt an embedded case study design and analyse 30 residential project proposals within two LA areas. Our study examines local planning policies and interactions between developers and LA officers, along with the resultant outcomes, through documentary analysis and expert interviews with local stakeholders. We find that LAs can encourage developers to adopt LZC heating technologies above and beyond what is required nationally. The conditions for this to occur are (1) a planning policy which restricts allowable heating technology options, (2) empowering LA officers to enforce policies, (3) advice and support for developers to consider alternatives, and where necessary, (4) political backing to challenge unwilling developers. Study findings highlight the important role of LAs in creating the conditions for the transition to LZC heating, which show how they can use powers within the planning system to encourage developers to make low carbon choices without the need for direct investment. [ABSTRACT FROM AUTHOR]

Reported herein is the development of assays for the spectrophotometric quantification of biocatalytic silicon−oxygen bond hydrolysis. Central to these assays are a series of chromogenic substrates that release highly absorbing phenoxy anions upon cleavage of the sessile bond. These substrates were tested with silicatein, an enzyme from a marine sponge that is known to catalyse the hydrolysis and condensation of silyl ethers. It was found that, of the substrates tested, tert-butyldimethyl(2-methyl-4-nitrophenoxy)silane provided the best assay performance, as evidenced by the highest ratio of enzyme catalysed reaction rate compared with the background (uncatalysed) reaction. These substrates were also found to be suitable for detailed enzyme kinetics measurements, as demonstrated by their use to determine the Michaelis−Menten kinetic parameters for silicatein. [ABSTRACT FROM AUTHOR]

AbstractWe consider a two-class priority queue in which the priority of a customer increases linearly at some constant, class-dependent rate. We describe the related maximum priority process {(M1(t),M2(t)):t≥0}, which is of interest since the stationary distribution of the maximum priority process at the times of the commencement of service gives information about the waiting time distributions of the two classes of customers. In the case where service times are exponential, we map a two-class maximum priority process {(M1(t),M2(t)):t≥0} to a tandem fluid queue, and use this mapping in order to derive the stationary distribution of {(M1(t),M2(t)):t≥0}. Further, we extended these results to the maximum priority process in which service times are phase-type distributed. We illustrate the theory with numerical examples. [ABSTRACT FROM AUTHOR]

Macromolecule branching upon polyhedral oligomeric silsesquioxanes (POSS) via "click" chemistry has previously been reported for promoting natural biological responses in vitro , particularly when regarding their demonstrated biocompatibility and structural robustness as potential macromolecule anchoring points. However, "clicking" of large molecules around POSS structures uncovers two main challenges: (1) a synthetic challenge encompassing multi-covalent attachment of macromolecules to a single nanoscale-central position, and (2) purification and separation of fully adorned nanocages from those that are incomplete due to their similar physical characteristics. Here we present peptide decoration to a T 8 POSS nanocage through the attachment of azido-modified trimers. Triglycine- and trialanine-methyl esters "clicked" to 97% and 92% completion, respectively, resulting in 84% and 68% yields of the fully-adorned octamers. The "clicks" halt within 27-h of the reaction time, and efforts to further increase the octamer yield were of negligible benefit. Exploration of reaction conditions reveals multiple factors preventing full octa-arm modification to all available POSS nanocages, and offers insights into macromolecule attachment between both peptides and small inorganic-organic structures, all of which require consideration for future work of this nature.