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Objectives The most important reason for considering hypertension as a major health problem, especially in older adults, is its severe complications. This study aims to investigate the prevalence of hypertension complications and identify the related factors among older adults in Semnan, Iran. Methods & Materials This cross-sectional study was conducted on 400 older adults with hypertension in Semnan, in January-February 2023. The data collection tool was a researcher-made questionnaire, whose content validity was confirmed based on the opinion of 10 experts (CVR=0.95 and CVI=0.98) and internal consistency was conmfired using Cronbach's alpha (α=0.895). Descriptive statistics (mean, standard deviation, frequency, and percentage) were used to present the data. The statistical difference in hypertension complications based on the demographic and contextual factors was investigated using chi-square test. All the statistical analyses were performed in SPSS software, version 27 and P

The aim of this study was to determine the lysine requirement for tambaqui and estimate other essential amino acids (EAA) requirement based on the ideal protein concept. A total of 144 tambaqui juveniles (184.1 g ± 1.96) were randomly assigned into 18 500 L-aquaria connected to a water recirculation system. The experiment was performed in a completely randomized design with six treatments and three replicates. A basal control diet (52.5 g of protein kg−1 dry matter) was supplemented with six levels of synthetic lysine (9, 12, 15, 18, 21, and 24 g kg−1 diet). Then, a dose-response trial was conducted to determine the optimal level of lysine for enhancing fish growth and nutrient utilization. Additional analyses were carried out to understand and correlate the fish responses to the dietary lysine levels, including blood chemistry analysis, enzymatic activity, and muscle development patterns. Weight gain increased until reaching 2.27 g at 17.4 g kg−1 diet lysine. Protein (25.6 g) and lysine (55.6 g) retention plateaued at 18 g kg−1 lysine. The lipid concentration declined linearly (P < 0.001, R2 = 0.81) according to the increase in dietary lysine levels. Plasma ammonia and alanine aminotransferase activity decreased as lysine levels increased (P < 0.05, R2 = 0.95, 0.84, respectively). No differences were observed for muscle morphology. Regardless the dietary lysine levels, the predominance of muscle growth was via hypertrophy. In sum, the estimated lysine requirement based on weight gain for tambaqui was 17.4 g kg−1 diet or 54.37 g kg−1 of dietary protein.

Background: Drugs containing the 4-anilinoquinazolines scaffold play a critical role in cancer treatment by inhibiting protein kinases, especially tyrosine kinases. In this study, a novel series of 4-anilinoquinazoline derivatives were synthesized and evaluated as cytotoxic agents. Methods: All final compounds were synthesized using two methods, including a conventional approach using potassium iodide and dimethylformamide as well as a green method using a deep eutectic solvent (DES) comprising choline chloride: urea. The cytotoxicity was tested on the A431, HUVEC, and HU02 cell lines. To evaluate the binding pattern of the compounds with EGFR and VEGFR-2, a molecular docking investigation was performed. Finally, the wound healing assay was carried out to assess the potency of compounds in inhibiting cell migration. Results: The final reaction time was approximately 15-20 min with yields of 60-72% using DES, while the conventional method took 3 to 4 h to complete, with yields between 30% and 42%. Compounds 8k and 8l showed better cytotoxicity against both cell lines compared to vandetanib (IC50=0.11 µM and 0.26 µM on A431 and IC50=5.01 µM and 5.24 µM on HUVEC, respectively). Molecular docking studies revealed that compound 8k, which contained 3-methylaniline at the 4-position of the quinazoline core, showed efficient binding affinity to both EGFR and VEGFR-2. An essential hydrogen bond was formed between quinazoline N1 of 8k and the Met796 residue of EGFR with a docking score of -8.76 kcal/mol. The imidazole N3 of 8k interacted with the Cyc919 residue of VEGFR-2, forming a hydrogen bond with a docking score of -9.03 kcal/mol. Moreover, compound 8k exhibited the best inhibitory activity on cell migration and wound healing. Conclusion: DES significantly improved the time and yield of the final reactions. Compound 8k, which showed the best cytotoxicity and inhibitory activity on cell migration, could be a suitable candidate for further structural optimization.

Aiming to contribute to the energy transition, this study provides an integrated picture of the geothermal system hosted in the West Netherlands Basin and shows how the reconstruction of the basin's geological history can contribute to the correct exploration and exploitation of its geothermal resources. In the West Netherlands Basin, the main geothermal targets are found in the Cretaceous and Jurassic strata that were deposited during the rifting and post-rifting stages and were deformed during the subsequent basin inversion. Despite multiple studies on the tectonic setting, the timing and tectono-stratigraphic architecture of the rift system and its overall control on the development and evolution of geothermal systems are still to be fully deciphered. In this study, a detailed seismo-stratigraphic interpretation of the syn- and post-rift intervals in the West Netherlands Basin will be given within the framework of geothermal exploration. A recently released and reprocessed 3D seismic cube is used, covering a large portion of the onshore section of the basin. We identified two major Jurassic rifting episodes and a Late Cretaceous inversion event. During the Jurassic rifting phases, the compartmentalization of the basin and the creation of accommodation space led to the deposition of the Late Jurassic Nieuwerkerk Formation, which is the main regional geothermal producing target. Within this formation, we individuate growth synclines located in the central portions of the Jurassic half-grabens as sites that show good potential for geothermal exploration.

Objective(s): The healthcare environment should provide the highest level of safety for staff and clients. This study aimed to assess the structural and non-structural safety status of Tabriz primary health care centers. Methods: This cross-sectional study assessed 40 comprehensive healthcare centers in Tabriz, Iran in 2019. The data collection instrument was a self-designed questionnaire We assessed the compliance of comprehensive healthcare centers with the standards checklist through conducting interviews, considering observations, and reviewing the documents. The descriptive results for qualitative data were reported as frequency (percentage) and for quantitative data as mean (standard deviation). Furthermore, to evaluate the association between contextual variables and physical safety status of centers, t-test, ANOVA, and Tukey’s post hoc tests were used as appropriate (structural or non-structural). Results: The results of the study showed that the level of structural, non-structural, and total safety for the physical space of the centers was 48.2%, 37.4%, and 43%, respectively. Accordingly, based on cutting points, the level of structural safety and total safety was identified as moderate, and the level of non-structural safety was identified as low. In addition, descriptive results showed that there is a statistically significant relationship between urban area and non-structural safety so that non-structural safety of centers located in zone 4 was significantly higher than the safety of centers located in zone 10 (P = 0.011). Conclusions: Based on the findings, the safety status of Tabriz health centers was identified as unfavorable and will not able to provide proper services to their covering population in serious hazards.

Background: Prior guidelines recommended maintaining normothermia following traumatic brain injury (TBI), but recent studies suggest therapeutic hypothermia as a viable option in pediatric cases. However, some others demonstrated a higher mortality rate. Hence, the impact of hypothermia on neurological symptoms and overall survival remains contentious. Methods: We conducted a systematic review and meta-analysis to evaluate the effects of hypothermia on neurological outcomes in pediatric TBI patients. The PubMed/Medline, Scopus, and Web of Science databases were searched until 1 January 2024 and data were analyzed using appropriate statistical methods. Results: A total of eight studies, comprising nine reports, were included in this analysis. Our meta-analysis did not reveal significant differences in mortality (RR = 1.58; 95% CI = 0.89–2.82, p = 0.055), infection (RR = 0.95: 95% CI = 0.79–1.1, p = 0.6), arrhythmia (RR = 2.85: 95% CI = 0.88–9.2, p = 0.08), hypotension (RR = 1.54: 95% CI = 0.91–2.6, p = 0.10), intracranial pressure (SMD = 5.07: 95% CI = −4.6–14.8, p = 0.30), hospital length of stay (SMD = 0.10; 95% CI = −0.13–0.3, p = 0.39), pediatric intensive care unit length of stay (SMD = 0.04; 95% CI = −0.19–0.28, p = 0.71), hemorrhage (RR = 0.86; 95% CI = 0.34–2.13, p = 0.75), cerebral perfusion pressure (SMD = 0.158: 95% CI = 0.11–0.13, p = 0.172), prothrombin time (SMD = 0.425; 95% CI = −0.037–0.886, p = 0.07), and partial thromboplastin time (SMD = 0.386; 95% CI = −0.074–0.847, p = 0.10) between the hypothermic and non-hypothermic groups. However, the heart rate was significantly lower in the hypothermic group (−1.523 SMD = −1.523: 95% CI = −1.81–−1.22 p < 0.001). Conclusions: Our findings challenge the effectiveness of therapeutic hypothermia in pediatric TBI cases. Despite expectations, it did not significantly improve key clinical outcomes. This prompts a critical re-evaluation of hypothermia’s role as a standard intervention in pediatric TBI treatment.

The extraordinary gamma-ray burst GRB 221009A provides a great opportunity to investigate the enigmatic origin and evolution of gamma-ray bursts (GRBs). However, the complexity of the observations associated with this GRB provides significant challenges to developing a theoretical modeling in a coherent framework. In this paper, we present a theoretical interpretation of the GRB 221009A afterglow within the relativistic fireball scenario, aiming to describe the broadband data set with a consistent model evolution. We find that the adiabatic fireball evolution in the slow-cooling regime provides a viable scenario in good agreement with observations. Crucial to our analysis is the set of simultaneous GeV and TeV gamma-ray data obtained by AGILE and LHAASO during the early afterglow phases. Having successfully modeled as inverse Compton emission the high-energy spectral and lightcurve properties of the afterglow up to 10 ^4 s, we extend our model to later times when also optical and X-ray data are available. This approach results in a coherent physical framework that successfully describes all observed properties of the afterglow up to very late times, approximately 10 ^6 s. Our model requires time-variable microphysical parameters, with a moderately increasing efficiency ε _e of a few percent for transferring the shock energy to radiating particles and a decreasing efficiency for magnetic field generation ε _B in the range 10 ^−5 –10 ^−7 . Fitting the detailed multifrequency spectral data across the afterglow provides a unique test of our model.

The γ-ray sky above a few tens of megaelectronvolts (MeV) reveals some of the most powerful and energetic phenomena of our Universe. The Astrorivelatore Gamma ad Immagini LEggero (AGILE) Gamma-ray Mission was launched in 2007 with the aim of observing celestial sources by means of three instruments covering a wide range of energies, from hard X-rays up to 30 GeV. Thanks to its wide field of view, AGILE set to observe and detect emission from pulsars, pulsar wind nebulae, gamma-ray bursts, active galactic nuclei, fast radio bursts, terrestrial gamma-ray flashes, and the electromagnetic counterparts of neutrinos and gravitational waves. In particular, the fast on-ground processing and analysis chain allowed the AGILE team to promptly respond to transient events, and activate or participate in multiwavelength observing campaigns. Eventually, after 17 years of operations, the AGILE Italian scientific satellite re-entered the atmosphere on 14 February 2024, ending its intense activity as a hunter of some of the most energetic cosmic sources in the Universe that emit X and γ-rays. We will review the most relevant AGILE results to date and their impact on the advancements of theoretical models.

The AGILE space mission was launched in 2007 to study X-ray and gamma-ray astrophysics. AGILE operated in spinning mode from 2009 until 2024 February 14, when it re-entered the Earth’s atmosphere. This work uses data acquired from the AGILE anticoincidence system (ACS) from 2019 January 1 to 2022 December 31. The ACS is designed to reject charged background particles. It also detects X-ray photons in the 50–200 KeV energy range and saves each panel count rate in the telemetry as ratemeter data, a time series with a resolution of 1.024 s. We developed a method that uses a deep learning model to predict the background count rates of the AGILE ACS top panel (perpendicular to the pointing direction of the payload detectors) using the satellite’s orbital parameters as input. Then, we use the difference between predicted and acquired count rates to detect gamma-ray bursts (GRB). We trained the model with a background-only data set. After the training, the model can predict the ACS count rates with a mean reconstruction error of 3.8%. We used the GRBs listed in the GRBweb catalog to search for significant anomalies in the ACS data. We extracted light curves of 140 bins of 1.024 s for each GRB from the AGILE ACS to cover the trigger time of the GRBs. The model detected 39 GRBs with a significance of σ ≥ 3. The results contain four GRBs detected for the first time in the AGILE data.

Objectives The most important reason for considering hypertension as a major health problem, especially in older adults, is its severe complications. This study aims to investigate the prevalence of hypertension complications and identify the related factors among older adults in Semnan, Iran. Methods & Materials This cross-sectional study was conducted on 400 older adults with hypertension in Semnan, in January-February 2023. The data collection tool was a researcher-made questionnaire, whose content validity was confirmed based on the opinion of 10 experts (CVR=0.95 and CVI=0.98) and internal consistency was conmfired using Cronbach's alpha (α=0.895). Descriptive statistics (mean, standard deviation, frequency, and percentage) were used to present the data. The statistical difference in hypertension complications based on the demographic and contextual factors was investigated using chi-square test. All the statistical analyses were performed in SPSS software, version 27 and P<0.05 was considered statistically significant Results The mean age of participants was 68.35±5.23 years, ranged 60-94. Participants were 196 men (49%) 204 women (51%). The prevalence of hypertension complications was 26.75% in overall (95% CI: 22.42%-31.08%). Also, the prevalence of heart failure was 14.3% (95% CI:11.13%-17.47%), the prevalence of retinopathy was 7.5% (95% CI:4.92%-10.08%), the prevalence of renal failure was 5.5% (95% CI:3.27%- 7.73%), the prevalence of heart attack was 4% (95% CI:2.08%-5.92%), and the prevalence of stroke was 1.5% (95% CI:0.31%-2.65%). Moreover, the prevalence of hypertension complications had a statistical relationship with age, marital status, educational level, time elapsed since the initial diagnosis, interval between the initial diagnosis and the start of treatment, the disease control, no history of receiving the necessary treatment, and receiving financial aid to cover medical expenses (P≤0.05). Conclusion Most of older adults in Semnan suffer from serious complication of hypertension, which is related to several demographic and contextual factors. The results can help managers and policymakers in the health sector in Iran to make correct decisions and develop effective interventions for the hyspetensive elderly. [ABSTRACT FROM AUTHOR]

Perceived collective (or group) continuity (PCC) is the perception of a link between a group's past, present, and future in both aspects: via permanent cultural traits (e.g., values, beliefs, traditions, habits) that are transmitted (essentialist PCC) or historical group events that are part of a causal-effect chain (narrativist PCC). PCC has not been investigated in the particular historical context of France. Moreover, previous studies have often focused on the beneficial effects of PCC as a whole (i.e., without considering these two dimensions independently), such as on social well-being (e.g., Sani et al., 2007). The initial objective of this research (Study 1), using a cross-sectional design, was to validate a French version of the PCC scale. Results showed that PCC had psychometric qualities that were quite satisfactory. This research also aimed, using a longitudinal design (Study 2), to test whether PCC and essentialist PCC, more than narrativist PCC, had a positive mediated effect on individual well-being (here satisfaction with personal life). Hypotheses were partially confirmed. But in general, the more French participants perceived collective continuity and the more they perceived their group to be an entity, the more strongly they identified with their group and the more satisfied they were with their life. These results and the experimental limits allow us to propose a set of recommendations and reflections for future research on collective continuity, and their bearing on and implications for individual and group dynamics. Public Significance Statement: The perception of collective continuity (i.e., the perception of a link between the past, present, and future of a group on two main domains: narrativist—link between historical events and essentialist—permanent group traits) can be assessed from a self-reported questionnaire in the French national context. Then, essentialist and collective continuity are positively associated with better personal life satisfaction (through group entitativity perception and French national identification). [ABSTRACT FROM AUTHOR]

The San Potito area in central Apennines (Italy), enclosed within the Latium‐Abruzzi carbonate platform, exposes anomalously pelagic carbonates filling an intraplatform basin formed during Jurassic rifting. Oriented obliquely to the regional NW‐SE trend of Cenozoic thrusts and extensional faults, the basin's eastern boundary fault system, striking N‐S, played a pivotal role in structuring orogenic and post‐orogenic features. Large tracts of the fault experienced double reactivation: positive inversion during Miocene shortening, and negative during post‐orogenic extension. Double reactivation is evidenced by older‐on‐younger extensional contacts, and by the change in orientation of thrusts and recent extensional faults from NW‐SE to NNW‐SSE, the latter being consistent with the trend of Jurassic rift‐related structures of the area. This structural interplay highlights the importance of Jurassic faults and their ability in forcing the structural trends, by surviving across multiple deformation stages, even controlling active extensional seismicity. [ABSTRACT FROM AUTHOR]

The γ -ray sky above a few tens of megaelectronvolts (MeV) reveals some of the most powerful and energetic phenomena of our Universe. The Astrorivelatore Gamma ad Immagini LEggero (AGILE) Gamma-ray Mission was launched in 2007 with the aim of observing celestial sources by means of three instruments covering a wide range of energies, from hard X-rays up to 30 GeV. Thanks to its wide field of view, AGILE set to observe and detect emission from pulsars, pulsar wind nebulae, gamma-ray bursts, active galactic nuclei, fast radio bursts, terrestrial gamma-ray flashes, and the electromagnetic counterparts of neutrinos and gravitational waves. In particular, the fast on-ground processing and analysis chain allowed the AGILE team to promptly respond to transient events, and activate or participate in multiwavelength observing campaigns. Eventually, after 17 years of operations, the AGILE Italian scientific satellite re-entered the atmosphere on 14 February 2024, ending its intense activity as a hunter of some of the most energetic cosmic sources in the Universe that emit X and γ -rays. We will review the most relevant AGILE results to date and their impact on the advancements of theoretical models. [ABSTRACT FROM AUTHOR]

This research experimentally examined the crossed influences between the emotional valence of collective memory and collective future thinking. As remembering the past and imagining the future are shaped by the present, we additionally test whether perceived anomie (i.e., perceiving present society as disintegrated and disregulated) would moderate these influences. Study 1 (N = 228 French participants) manipulated the valence of collective memory (positive vs. negative French past) to test its effect on the valence of collective future thinking. Results showed that the salience of a negative (vs. positive) French past lead to the projection of a more negative French future only among participants who perceived present society as highly disregulated. Study 2 (N = 215) focused on the influence of the valence of collective future thinking (positive vs. negative French future) on the valence associated with the French past. Results showed that the salience of a negative (vs. positive) French future lead left-wing participants to rate more positively events/figures of the French past that are usually valued by conservatives. Taken together, these studies provided evidence of conditional effects in the crossed influences between the emotional valence of collective memory and collective future thinking, thus contributing to the recent literature on collective mental time travel. [ABSTRACT FROM AUTHOR]

Aiming to contribute to the energy transition, this study provides an integrated picture of the geothermal system hosted in the West Netherlands Basin and shows how the reconstruction of the basin's geological history can contribute to the correct exploration and exploitation of its geothermal resources. In the West Netherlands Basin, the main geothermal targets are found in the Cretaceous and Jurassic strata that were deposited during the rifting and post-rifting stages and were deformed during the subsequent basin inversion. Despite multiple studies on the tectonic setting, the timing and tectono-stratigraphic architecture of the rift system and its overall control on the development and evolution of geothermal systems are still to be fully deciphered. In this study, a detailed seismo-stratigraphic interpretation of the syn- and post-rift intervals in the West Netherlands Basin will be given within the framework of geothermal exploration. A recently released and reprocessed 3D seismic cube is used, covering a large portion of the onshore section of the basin. We identified two major Jurassic rifting episodes and a Late Cretaceous inversion event. During the Jurassic rifting phases, the compartmentalization of the basin and the creation of accommodation space led to the deposition of the Late Jurassic Nieuwerkerk Formation, which is the main regional geothermal producing target. Within this formation, we individuate growth synclines located in the central portions of the Jurassic half-grabens as sites that show good potential for geothermal exploration. [ABSTRACT FROM AUTHOR]

PKS 1830 -211 is a γ-ray emitting, high-redshift (z  =2.507 ± 0.002), lensed flat-spectrum radio quasar. During the period 2019 mid-February to mid-April, this source underwent a series of strong γ-ray flares that were detected by both AGILE-GRID (Gamma-Ray Imaging Detector) and Fermi Large Area Telescope (Fermi -LAT), reaching a maximum γ-ray flux of |$F_{\rm E\gt 100\, MeV}\approx 2.3\times 10^{-5}$|  photons cm−2 s−1. Here, we report on a coordinated campaign from both on-ground [Medicina, Owens Valley Radio Observatory (OVRO), Rapid Eye Mount (REM), and Sardinia Radio Telescope (SRT)] and orbiting facilities (AGILE, Fermi, INTEGRAL, NuSTAR, Swift , and Chandra), with the aim of investigating the multiwavelength properties of PKS 1830-211 through nearly simultaneous observations presented here for the first time. We find a possible break in the radio spectra in different epochs above 15 GHz, and a clear maximum of the 15 GHz data approximately 110 d after the γ-ray main activity periods. The spectral energy distribution shows a very pronounced Compton dominance (> 200) which challenges the canonical one-component emission model. Therefore, we propose that the cooled electrons of the first component are re-accelerated to a second component by, for example, kink or tearing instability during the γ-ray flaring periods. We also note that PKS 1830-211 could be a promising candidate for future observations with both Compton satellites [e.g. enhanced ASTROGAM (e-ASTROGAM)] and Cherenkov arrays [Cherenkov Telescope Array Observatory (CTAO)] which will help, thanks to their improved sensitivity, in extending the data availability in energy bands currently uncovered. [ABSTRACT FROM AUTHOR]