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Vitamin D toxicity is a rare but potentially serious condition that can lead to severe hypercalcaemia and subsequent complications, such as acute renal failure, nephrocalcinosis, congestive heart failure and coronary calcium deposition, resulting in myocardial injury. We present a case of a 76-year-old male patient who developed severe hypercalcaemia and acute kidney injury due to excessive long-term over-the-counter vitamin D supplementation. The patient was initially treated with aggressive intravenous fluids and furosemide. However, a failed effective response prompted the addition of pamidronate, resulting in the gradual improvement of hypercalcaemia and renal function. We have presented, in this case, a rare adverse effect of vitamin D toxicity and its multiorgan effect., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Khan et al.)