Search

Objective Methods Results Conclusions This retrospective study involving a large dataset of unilateral multifocal papillary thyroid carcinoma (UM‐PTC) sought to identify factors that predict central lymph node metastases (CLNM) in patients.We identified a cohort of 158 patients who underwent cervical ultrasonography followed by UM‐PTC diagnosis based on postoperative pathology. The relationship between CLNM and UM‐PTC clinical ultrasound features was evaluated using univariate and multivariate analyses. Receiver operating characteristic (ROC) curve analysis was used to determine the ability of total tumor diameter (TTD) to predict CLNM.Among the 158 UM‐PTC patients, the incidence of CLNM was 29.7% (47/158). Univariate and multivariate analyses revealed that a number of similarity of sonographic features (NSSF) ≥4 (odds ratio [OR] = 11.335, 95% confidence interval [CI]: 3.95–32.50, p = 0.000), microcalcifications (OR = 3.54, 95% CI: 1.30–9.70, p = 0.014), a TTD of ≥2 cm (OR = 4.48, 95% CI: 1.62–12.34, p = 0.004), number of nodules ≥3 (OR = 13.17, 95% CI: 3.24–53.52, p = 0.000), and Lateral cervical lymph node metastasis (LLNM) (OR = 5.57, 95% CI: 1.59–19.48, p = 0.007) were independently associated with CLNM in UM‐PTC. ROC curve analysis revealed that the TTD cut‐off of 1.795 cm had a sensitivity of 0.723 and a specificity of 0.676 for predicting CLNM.Patients with UM‐PTC are at high risk of CLNM. NSSF ≥4, microcalcifications, TTD of ≥2 cm, LLNM, and a number of nodules ≥3 were independently associated with CLNM. Our data show that ultrasound may guide surgical decisions in the treatment of UM‐PTC. [ABSTRACT FROM AUTHOR]