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The article is devoted to monitoring the condition of the respiratory tract during general anesthesia, which is the most important duty of an anesthesiologist. Despite advances in airway monitoring devices, rigid laryngoscopy and intubation remain preferred methods. Airway treatment during intubation causes a hemodynamic reaction due to stimulation of the upper respiratory tract, which leads to an increase in catecholamine levels, which leads to hypertension, tachycardia and rhythm disturbances. This reaction reaches its maximum immediately after intubation and usually lasts 5-10 minutes. Despite the successful use of both nitroglycerin for intravenous administration and magnesium sulfate for this purpose, there is currently no direct comparison of these two drugs in the literature with respect to attenuation of hemodynamic changes during laryngoscopy and intubation. Therefore, our research is aimed at conducting such a comparative study. The study was a double-blind, prospective, randomized study involving sixty patients aged 18 to 60 years who were scheduled for surgery requiring general anesthesia and endotracheal intubation, with the status of asa I and II.Both intravenous administration of MgSO4 (30 mg/kg) and NTG (1 mcg/kg) were effective in attenuating the pressor reaction caused by laryngoscopy and endotracheal intubation. However, MgSO4 was significantly superior to NTG in reducing heart rate. Key words: Airway management, general anaesthesia, nitroglycerine, magnesium sulphate, haemodynamic stress