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22 results on '"Stockwell A"'

1. Expanding on the BRIAR Dataset: A Comprehensive Whole Body Biometric Recognition Resource at Extreme Distances and Real-World Scenarios (Collections 1-4)

Author

Jager, Gavin, Cornett III, David, Glenn, Gavin, Aykac, Deniz, Johnson, Christi, Zhang, Robert, Shivers, Ryan, Bolme, David, Davies, Laura, Dolvin, Scott, Barber, Nell, Brogan, Joel, Burchfield, Nick, Dukes, Carl, Duncan, Andrew, Ferrell, Regina, Garrett, Austin, Goddard, Jim, Hines, Jairus, Murphy, Bart, Pharris, Sean, Stockwell, Brandon, Thompson, Leanne, and Yohe, Matthew

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence, Computer Science - Machine Learning
Abstract

The state-of-the-art in biometric recognition algorithms and operational systems has advanced quickly in recent years providing high accuracy and robustness in more challenging collection environments and consumer applications. However, the technology still suffers greatly when applied to non-conventional settings such as those seen when performing identification at extreme distances or from elevated cameras on buildings or mounted to UAVs. This paper summarizes an extension to the largest dataset currently focused on addressing these operational challenges, and describes its composition as well as methodologies of collection, curation, and annotation., Comment: 10 pages, 11 figures, 2 tables, submitted to CVPR

Published
2025

2. A multiplex method for rapidly identifying viral protease inhibitors

Author

Hong, Seo Jung, Resnick, Samuel J, Iketani, Sho, Cha, Ji Won, Albert, Benjamin Alexander, Fazekas, Christopher T, Chang, Ching-Wen, Liu, Hengrui, Dagan, Shlomi, Abagyan, Michael R, Fajtová, Pavla, Culbertson, Bruce, Brace, Brooklyn, Reddem, Eswar R, Forouhar, Farhad, Glickman, J Fraser, Balkovec, James M, Stockwell, Brent R, Shapiro, Lawrence, O’Donoghue, Anthony J, Sabo, Yosef, Freundlich, Joel S, Ho, David D, and Chavez, Alejandro

Published
2025
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3. Verifying Components of Arm® Confidential Computing Architecture with ESBMC

Author

Wu, Tong, Xiong, Shale, Manino, Edoardo, Stockwell, Gareth, Cordeiro, Lucas C., Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Giacobazzi, Roberto, editor, and Gorla, Alessandra, editor

Published
2025
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6. Stress and Strain: Differentiating the Responses to High and Moderate Heat Loads and Subsequent Recovery in Grain-Fed Feedlot Steers—Metabolic Hormones.

Author

Wijffels, Gene, Sullivan, Megan L., Stockwell, Sally, Briscoe, Suzie, Pearson, Roger, Anderson, Stephen T., Li, Yutao, de Melo Costa, Cintia C., McCulloch, Russell, and Gaughan, John B.

Subjects
HEAT production (Biology), THYROID hormones, BEEF cattle, HEATING load, LIVESTOCK productivity, FEEDLOTS
Abstract

Simple Summary: Rising summer temperature averages along with greater frequency, intensity and duration of moderate and severe heatwaves are negatively impacting livestock welfare and productivity. We are investigating the immediate and post-heatwave effects (strain) of different levels of heat stress on grain-fed feedlot steers. Under a moderate heat load challenge, the steers adjust by reducing feed intake and increasing drinking and sweating. In recovery, they soon return to normal. However, the high heat load challenge appears to push the steers into a new less productive physiological state in recovery and sometime after. This study follows the changes in the major metabolic hormones during and after a high heat load challenge. The findings reinforce the idea that steers are altered by high heat load, and this new state directs them to reduced feed intake and slower growth, which ensures a lower metabolic rate, and less heat production by the body. In this state, they are much less vulnerable to the next severe heatwave. The extent of endocrine changes in response to various levels of heat stress and subsequent recovery is not well understood. Two cohorts of 12 Black Angus steers were housed in climate-controlled rooms (CCR) and subjected to three thermal periods: PreChallenge (5 d), Challenge (7 d) and Recovery (5 d). PreChallenge and Recovery provided thermoneutral conditions. The Challenge simulated a strong heatwave. Finally, the steers were maintained in outdoor pens for 38 d. Rumen temperature (RumT), respiration rate (RR) and panting score (PS) were intensively measured in the CCR. Dry matter intake (DMI) was determined daily. The steers were bled most days, and a rectal temperature (RecT) was taken also. Plasma concentrations of TSH, prolactin, T3, T4, insulin, leptin and adiponectin were determined. During the Challenge, RumT, RecT, RR and PS rose; DMI was reduced. Plasma T3, T4 and adiponectin levels fell also. In Recovery, RumT, RecT, RR and PS fell below the PreChallenge mean. DMI partially recovered. T4 and adiponectin levels remained suppressed alongside lowered insulin. There were linear relationships between T3 concentration and THI, and T3 and T4 levels and DMI only. We highlight comparisons with previously reported metabolic hormone responses of grain-fed Black Angus steers to a moderate-heat-load challenge. [ABSTRACT FROM AUTHOR]

Published
2025
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8. Contributors

Author

Abel, Dori, Abelman, Rebecca A., Abu Kar, Sarah, Abughazaleh, Saeed, Abu-Nejim, Husam, Afari, Maxwell Eyram, Ahmed, Hammood, Akoto, Shanice, Alabre, Kenneth, Ali, Fahad, Ali, Tanya, Alipanah-Lechner, Narges, Altunel, Erdem, Alzoebie, Lama, Anderson, Chelsie, Andrews, Christine B., Anthony, AnnGene, Arcand, Paul-Hugo, Arora, Sohrab, Asaro, Joseph A., Astashchanka, Anna, Atchison, Douglas, Aulakh, Sudeep K., Aurora, Taruna, Avasare, Rupali, Babadi, Baktash, Babar, Tania B., Bachman, Emelia Argyropoulos, Bains, Ashika, Balabanov, Roumen, Balaguera, Pedro, Balda, Javier, Bank, T. Caroline, Banwell, Brenda, Barrera, Francisco J., Barta, Samantha, Basman, Craig L., Bass, Crystal T., Beach, Scott R., Bediako, Persey, Belcher, Ren, Bell, Jennifer, Bellinghausen, Amy L., Bennett, Colleen E., Berkowitz, Carol D., Betageri, Omkar, Bharmal, Murtaza, Bhatt, Harikrashna B., Bhuptani, Prachi H., Bido-Medina, Richard O., Bielak, Kendall, Bilodeau, Courtney Clark, Bird, Lisa, Bishop, Erin, Bitar, Ghamar, Blakeney, Craig, Blatz, Allison M., Block, Brian, Bortz, Christina M., Bosse, Kristopher R., Bouton, Tara C., Bove, Mary E., Bowlby, Lynn A., Boyden, Sean, Brady, Mark F., Braide, Biobele, Brar, Jessica K., Bratman, Russell E., Brodowsky, Emily Chan, Brown, Austin K., Brown, Emily C.B., Brugnoni, Jessalyn, Bui, Eric, Burke, Christine, Burton, Lauren, Butler, Blythe, Butler, William, Byanova, Katerina L., Byg, Blaire, Callanan, Tucker C., Cantos, Adriana, Canty, Katherine W., Carragee, Eugene, Carrel-Lammert, Meredith, Castillo, Jorge J., Chait, Daniel, Chan, Philip A., Chapman, Arlene, Chatterjee-Paer, Sudeshna, Cheng, Vicky, Chien, Michael, Chilcote, Jeffrey, II, Childs, Candicee, Chopra, Amit, Chou, Stella T., Choudhury, Natasha, Christian, Cindy W., Chua, Winona, Chun, Andrew S., Claman, David, Clark, Grace V., Clark, Seth, Clarke, Ross, Clay, Alexandra, Clebak, Karl T., Cleland, Derrick, Cohen, Debbie L., Cohen, Lisa, Congdon, Morgan, Constantinou, Maria, Cooper, James Elliott, Corley, James Earl, Cosgrove, Abigail, Covarrubias, Oscar, Craine, Rebecca, Criddle, Sarah, Cristofaro, Patricia, Cunha, Joanne Szczygiel, Cunningham, Karlene, Cusano, Joseph, D’Alessandro, Frank B., Dado, Lynn, Daneshdoost, Shanaz, Daneshvari, Nicholas Omid, Darwiche, Sabrina, Das, Abhijit, DaSilva, Manuel F., De La Garza, Carlos, DeDent, Alison, Deeb, Mery, Denninger, John W., Desrochers, Colette, Devon, Erin Pete, Diaz, Joseph A., DiGrande, Kyle, Dina, Ayodeji, Doo, Kathleen, Drury, Brian, Dus, Bethany, Dutta, Roop, Dworkin, Myles, Dyster, Timothy G., Ebert, Eric, Edmund, Joseph, Edward, Heather L., Eggers, Erica, Eisenhower, Christine, Ellsworth, Pamela, Elnair, Radowan, Escamilla-Ocañas, César E., Espinosa, Patricio Sebastian, Faber, Mark D., Facer, Evan, Fadale, Paul D., Fallon, Ryan T., Farias, Michael J., Farkas, Jon, Farrand, Erica, Farrell, Ronan, Fay, Kevin S., Fender, Robert Zachary, Hernandez, Samantha Fernandez, Fernandez-Robles, Carlos, Ferreira, Jason D., Ferri, Fred F., Ferri, Heather, Fields, Jessica C., Fields, Lauren, Fischer, Staci A., Fiske, Hannah, Florez, Maria Camila Velez, Forbes, Kellie C., Forcier, Michelle, Ford, Sydney, Fort, Frank G., Fort, Glenn G., Frankel, Eitan S., Freeman, Nancy, Friedman, Ryan, Frisch, Daniel R., Fru, Relindis Azenwi, Fullenkamp, Lynn C., Gaffney, Michael, Garcia, Jose P., Garcia, Paloma Jolin, Ge, Jonathan S., Gesthalter, Yaron B., Ghimire, Anil, Gibson, Christopher, Gidwani, Nisha H., Gilek-Seibert, Katarzyna, Gilvaz, Vinit J., Glueck, Jacob, Goetz, Jennifer Leah, Goldburt, Alla, Goldsmith, Corey Elam, Rao Golla, Maheswara Satya Gangadhara, Gomez, Alexander, Slagle, Helen B. Gomez, Greenblatt, H. Karl, Greenfield, Morgan, Gugerty, Lindsay, Gultawatvichai, Patan, Gunning, Samantha, Guo, David, Gupta, Simran, Guttadauria, Brittany, Gwinn, Meghan, Hadi, Mohanad, Hafeez, Muhammad Ubaid, Hall, Hayden, Hall, Sarah, Handa, Sajeev, Hanna, John R., Harbord, Nikolas, Hardacker, Kyle, Hardesty, Anna, Haribhakti, Nirav, Harris, Daniel J., Hartmann, Abigail, Hartnett, Davis A., Hartvigsen, Nathan, Hawkins, Brian, He, Elaine, Heinle, Rachel Wright, Helm, Leesha A., Helm, Matthew F., Herlevich, Thomas, Hermez, Klodia M., Hilliard, Ross W., Hocker, Nathaniel, Hoffman, R. Scott, Holton, Siri M., Homer, Alexander S., Hook, Benjamin E., Hsu, Raymond, Huang, Laurence, Hull, Mariam, Hume, Anne L., Hussain, Zilla, Huynh, Donny V., Hyder, Sarah, Ingraham, Caitlin, Insalaco, Louis F., Jackson, James, Jafari-Esfahani, Shadi, Jain, Rishubh, Jain, Vanita B.D., Jain, Vipul V., Jamal, Fariha, Janigian, Robert H., Jr., Jasuja, Sonia, Javier, Noelle Marie, Jayachandran, Nishant, Jetty, Vybhav, Johnson, Michael P., Johnson, Steven D., Jones, Amanda, Joseph, Tatiana, Joseph-Senatus, Ganaelle, Joshi, Shyam, Justice, Joshua, Kabashneh, Sohaip, Kadiyala, Vishnu, Kalligeros, Markos, Karthikeyan, Vanji, Kaske, Erika, Kasper, Vania, Kass, Joseph S., Kass, Naomi R., Kasthuri, Viknesh S., Katz, Luca, Kazakova, Vera, Keim, Jennifer L., Kensey, Nicholas, Kent, Victoria, Kerrigan, Danielle, Keselman, Dennis, Khare, Sarthak, Khatri, Surya, Khawaja, Hussain R., Khurana, Saranya S., Kifle, Betelhem, Kim, Chan Woo, Kim, Jinseong, Kisare, Samantha, Kohrman, Samuel I., Kokkirala, Aravind Rao, Konstantino, Yuval, Kontos, Nicholas, Kopyt, Nelson, Kothadia, Savan, Koti, Ajay S., Koulouridis, Ioannis, Kreider, Timothy R., Kron, Kevin, Krumm, Ilana, Kuhn, Elizabeth, Kumbar, Lalathaksha, Kuo, Sheng-Han, Kuris, Eren O., Kurss, David I., Kutschke, Michael J., Laband, William F., LaCombe, Philip, Lam, Uyen T., Lam, Wilson, Laredo, Jonathan, Larijani, Mary, Le, Peter, Leahy, Caroline, Leard, Lorriana E., Leavitt, David A., Leba, Christopher T., Lee, Hyung Jin, Lee, Kachiu C., LeGros, Tracy Leigh, Lemme, Nicholas J., L’Etoile, Nathan, Li, Jian, Lim, Carol, Lin, Chi-Ying (Roy), Lippincott, Jordan, Liu, Jonathan, Logue, Teresa C., Longtain, Riley, López, Gabriela, Lord, Kito Akin, Loscalzo, Kirsten, Lucas, Mathew J., Lucier, David J., Jr., Ma’ayeh, Marwan, MacLean, Rachel L., MacMurdo, Maeve G., Madva, Elizabeth N., Maher, Lewena, Makai, Gretchen, Malpica, Luis, Marks, Jonathan, Pinheiro, Ana Paula Marques, Marr, Mollie C., Martinez, Adali, Matin, Adiba, Mazzaglia, Peter J., Mbuyi, Nadine N., McCulloh, Russell J., McDonald-McGinn, Donna M., McGowen, Alexandra, McGraw, Katherine Elizabeth, McKenna, Jaclyn, McNamara, Kelly, Meleveedu, Kapil S., Mendez-Miller, Megan, Mercado, Jorge, Mercado, Osvaldo, Merritt, Rory, Michaels, Marian G., Michel, Jeremy, Mikolasko, Brian D., Milner, John D., Min, May, Minami, Taro, Mohamed, Mouhand F., Najjar-Mojarrab, Javad, Molinari, John, Montgrain, Philippe, Moon, Heesung, Moore, Michael Z., Moore, Shawn D., Morelli, Leah, Morrissey, Patrick J., Mughal, Aleem I., Mukkamalla, Shiva Kumar R., Mullen, Marguerite A., Mulliken, Alexandra, Mumtaz, Tayebah, Muraina, Fadeke, Mustafa, Ahmad, Myers, Ellen, Mylhousen, Emily, Nadaud, Jack, Nadella, Akash, Nadella, Mohnish, Nadjarian, Albert, Nagpal, Nikita, Nathan, Miriam, Naveed, Asim, Nawaiseh, Ahmad Al, Neff, Robert, Neithardt, Adrienne B., Nestlerode, Christina, Niazi, Azfar K., Nisavic, Mladen, Nokoff, Natalie, Noorbhai, Ibrahim Z.D., Novak, James E., Novarra, Austin, John, Audrey R. Odom, Okewunmi, Jeffrey, Oliver, Rebecca, Olszewski, Adam J., Onyeaka, Henry K., Orchowski, Lindsay M., Osorio, Marcela, Osorio, Luis, O’Sullivan, Cassidy, Outlaw, Jasmine, Oyelakin, Ayotomide, Pace, Paolo G., Paddock, John E., Painter, David F., Palmieri, Alicia, Pappas-Taffer, Lisa, Paranandi, Sneha, Parikh, Mihir, Partin, Michael T., Patel, Birju B., Patel, Melissa D., Patel, Minta, Patel, Nima R., Patel, Pranav M., Patel, Vishal I., Patrick, Brett, Paudel, Shreedhar, Pelcovits, Ari, Perez, David L., Perez, Jose J. Hermina, Pétron, Clément, Pfeuti, Courtney, Pham, Lily C., Phillips, Katharine A., Phillips, Oliver W., Phillips, Tara M., Piana, Lauren E., Portnoff, Brandon S., Pou, Sovijja, Prashar, Rohini, Pulice, Christine, Punko, Diana, Purkayastha, Ayan, Qawi, Imrana, Qu, David, Quesada, Adrian, Quinn, Matthew S., Racchi, Nicholas, Rachu, Gregory S., Rajadurai, Suvithan, Ramachandran, Lintu, Rana, Tanvi, Rathore, Bharti, Rathore, Ritesh, Raukar, Neha P., Ravindra, Lakshmi, Reagan, John L., Reardon, P.K., Reddy, Bharathi V., Reddy, Snigdha T., Reed-Weston, Anne, Reginato, Anthony M., Reichart, James P., Reus, Victor I., Reuter, Matthew, Riaz, Sana, Ricci, Brittany, Rich, Harlan G., Richter, Savanah, Rivera, Lauren Davis, Robertson, Melena J., Roby, Lauren C., Roche, Meaghan, Rodriguez, Alejandra E. Morfin, Gómez, Perla M. Romero, Ron, Hayley A., Rossi, Michael, Rubin, David, Rubin, Lila, Rushworth, Parker, Rutstein, Beth H., Sadeghi, Noushine, Sahota, Ruchi Jalota, Saks, Emily, Sall, Jeffrey W., Salvi, Joshua D., Sanchez, Frank A., Sanchez, Martha C., Sanka, Pranavi, Santhosh, Lekshmi, Santos, Linda Herrera, Sauck, Emily, Saylor, Leah, Scheuing, William J., Sciscione, Anthony, Scott, Matthew Thomas, Sederdahl, Bethany K., Seeber, Richard E., II, Sellers, Kyle, Sen, Aritra, Sewell, Rachel, Shaban, Hesham, Shah, Ankur, Shah, Isha, Shakil, Omair, Sharma, Animesh, Sharma, Yuvraj, Sharp, Lydia, Sherman, Alexander, Shill, Jessica E., Shimanovsky, Alexei, Shipp, Michael M., Shlossman, Philip A., Siddiqui, Khawja A., Siegel, Alyssa, Sigman, Mark, Singh, Harinder P., Singh, Jasneet, Singh, Manjot, Slingsby, Brett, Sloane, Amy J., Smick, Alexandra H., Smith, Jeanette G., Smith, Matthew J., Sohaney, Ryann, Soi, Vivek, Soinski, Rebecca, Soler, Maria E., Soman, Sandeep, Sorg, Emily, Sosnoski, Olivia, Sperati, C. John, Stanford, Nathan, Steele, Emery, Steele, Jacqueline, Stern, Ella, Stier, James, Stockwell, Philip, Subramanian, Lakshmi, Suen, Angela, Suh, Edward, Sundaramoorthy, Anjali, Sunkara, Naveena, Supanakorn, Varut, Suri, Priyasha, Sweeney, Hannah, Takasaki, Kaoru, Takei, Ryosuke, Tan, Laren, Tarawneh, Mohammad, Taylor, Alan, Taylor, Kathryn Marie, Taylor, Matthew A., Taylor, S. Trevor, Tenney-Soeiro, Rebecca, Thomas, Anthony G., Thompson, Stefani, Tien, Alexandra Meyer, Tien, David Robbins, Tierney, Anna-Marie, Toma, Helen, Lopez, Kim Tran, Tryforos, Margaret, Tsaban, Gal, Tschoe, Christine, Tungate, Robert, Turn, Christina S., Uduman, Junior, Umanath, Kausik, Ungar, Stephanie P., Vakili, Babak, van Deventer, Ella, Vemula, Ridhima, Venado, Aida, Vollum, Kathryn G., Vorel, Ethan, Walson, Ifeanyi, Wang, Angela, Wang, Emily, Wang, Li, Wehner, Linsey, Westreich, Roi, Wheeler, Ericka, Wighton, Nakia, Wildman, Alexis, Wilson, Annise, Winikor, Jared M., Wininger, Bryce, Winschel, Julia M., Wold, Jaclyn, Wolpaw, Adam J., Wolpert, Marlene Fishman, Wong, Elisabeth A., Wylie, John, Yang, Anna, Yao, Xuan, Yesodharan, Gemini, Yeung, Jennifer, Yin, Chun H., Yip, Agustin G., Yu, Diana H., Yu, Elizabeth An, Yung, Jeffrey, Zainelabdin, Sarah, Zambrano, Juliana, Zargarian, Emin, Zha, B. Shoshana, Zhang, Helen, Zhao, Leon, Zhou, Diana X., Ziaie, Navid, and Zorin, Danylo

Published
2025
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10. HISTORY SPEAKS: Exposing challenges in historical renovations.

Author

Stockwell, Chrysanthi

Abstract

The article focuses on the complexities of lighting design in historical renovations, where the process requires a balance of creativity, restraint, and respect for the building's history. Topics include the role of lighting designers in uncovering a space's past, collaborating with preservationists to inform the design, and the challenges of restoring or repurposing existing lighting fixtures to maintain historical accuracy.

Published
2025
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14. Ferroptosis regulates hemolysis in stored murine and human red blood cells

Author

D’Alessandro, Angelo, Keele, Gregory R., Hay, Ariel, Nemkov, Travis, Earley, Eric J., Stephenson, Daniel, Vincent, Matthew, Deng, Xutao, Stone, Mars, Dzieciatkowska, Monika, Hansen, Kirk C., Kleinman, Steven, Spitalnik, Steven L., Roubinian, Nareg, Norris, Philip J., Busch, Michael P., Page, Grier P., Stockwell, Brent R., Churchill, Gary A., and Zimring, James C.

Abstract

•QTL analyses identified >400 gene-metabolite associations in fresh and stored RBCs from 350 diversity outbred mice.•Steap3 or ferroptosis-related genes FADS1/2, EPHX2, and LPCAT3regulate lipid oxidation, PTR in mice, hemolysis, and Hgb increments in human RBCs.

Published
2025
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17. FluSAFE: Flu SMS Alerts to Freeze Exposure

Author

National Institute of Allergy and Infectious Diseases (NIAID) and Melissa Stockwell, Associate Professor of Pediatrics and Population and Family Health

Published
2025

18. Tracking a large‐scale and highly toxic Arctic algal bloom: Rapid detection and risk communication

Author

Evangeline Fachon, Robert S. Pickart, Gay Sheffield, Emma Pate, Mrunmayee Pathare, Michael L. Brosnahan, Eric Muhlbach, Kali Horn, Nathaniel N. Spada, Anushka Rajagopalan, Peigen Lin, Leah T. McRaven, Loreley S. Lago, Jie Huang, Frank Bahr, Dean A. Stockwell, Katherine A. Hubbard, Thomas J. Farrugia, Kathi A. Lefebvre, and Donald M. Anderson

Subjects
Oceanography, GC1-1581
Abstract

Abstract In recent years, blooms of the neurotoxic dinoflagellate Alexandrium catenella have been documented in Pacific Arctic waters, and the paralytic shellfish toxins (PSTs) that this species produces have been detected throughout the food web. These observations have raised significant concerns about the role that harmful algal blooms (HABs) will play in a rapidly changing Arctic. During a research cruise in summer 2022, a massive bloom of A. catenella was detected in real time as it was advected through the Bering Strait region. The bloom was exceptional in both spatial scale and density, extending > 600 km latitudinally, reaching concentrations > 174,000 cells L−1, and producing high‐potency PST congeners. Throughout the event, coastal stakeholders in the region were engaged and a multi‐faceted community response was mobilized. This unprecedented bloom highlighted the urgent need for response capabilities to ensure safe utilization of critical marine resources in a region that has little experience with HABs.

Published
2025
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19. Urban ozone formation and sensitivities to volatile chemical products, cooking emissions, and NOx upwind of and within two Los Angeles Basin cities

Author

C. E. Stockwell, M. M. Coggon, R. H. Schwantes, C. Harkins, B. Verreyken, C. Lyu, Q. Zhu, L. Xu, J. B. Gilman, A. Lamplugh, J. Peischl, M. A. Robinson, P. R. Veres, M. Li, A. W. Rollins, K. Zuraski, S. Baidar, S. Liu, T. Kuwayama, S. S. Brown, B. C. McDonald, and C. Warneke

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

Volatile chemical products (VCPs) and other non-traditional anthropogenic sources, such as cooking, contribute substantially to the volatile organic compound (VOC) budget in urban areas, but their impact on ozone formation is less certain. This study employs Lagrangian box modeling and sensitivity analyses to evaluate ozone response to sector-specific VOC and nitrogen oxide (NOx) emissions in two Los Angeles (LA) Basin cities during the summer of 2021. The model simulated the photochemical processing and transport of temporally and spatially gridded emissions from the FIVE-VCP-NEI17NRT inventory and accurately simulates the variability and magnitude of O3, NOx, and speciated VOCs in Pasadena, CA. VOC sensitivity analyses show that anthropogenic VOCs (AVOC) enhance the mean daily maximum 8 h average ozone in Pasadena by 13 ppb, whereas biogenic VOCs (BVOCs) contribute 9.4 ppb. Of the ozone influenced by AVOCs, VCPs represent the largest fraction at 45 %, while cooking and fossil fuel VOCs are comparable at 26 % and 29 %, respectively. NOx sensitivity analyses along trajectory paths indicate that the photochemical regime of ozone varies spatially and temporally. The modeled ozone response is primarily NOx-saturated across the dense urban core and during peak ozone production in Pasadena. Lowering the inventory emissions of NOx by 25 % moves Pasadena to NOx-limited chemistry during afternoon hours and shrinks the spatial extent of NOx saturation towards downtown LA. Further sensitivity analyses show that using VOCs represented by a separate state inventory requires steeper NOx reductions to transition to NOx sensitivity, further suggesting that accurately representing VOC reactivity in inventories is critical to determining the effectiveness of future NOx reduction policies.

Published
2025
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20. Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening

Author

Hengrui Liu, Arie Zask, Farhad Forouhar, Sho Iketani, Alana Williams, Daniel R. Vaz, Dahlya Habashi, Karenna Choi, Samuel J. Resnick, Seo Jung Hong, David H. Lovett, Tian Bai, Alejandro Chavez, David D. Ho, and Brent R. Stockwell

Subjects
Science
Abstract

Abstract Variants of SARS-CoV-2 have continued to emerge across the world and cause hundreds of deaths each week. Due to the limited efficacy of vaccines against SARS-CoV-2 and resistance to current therapies, additional anti-viral therapeutics with pan-coronavirus activity are of high interest. Here, we screen 2.8 billion compounds from a DNA-encoded chemical library and identify small molecules that are non-covalent inhibitors targeting the conserved 3CL protease of SARS-CoV-2 and other coronaviruses. We perform structure-based optimization, leading to the creation of a series of potent, non-covalent SARS-CoV-2 3CL protease inhibitors, for coronavirus infections. To characterize their binding mechanism to the 3CL protease, we determine 16 co-crystal structures and find that optimized inhibitors specifically interact with both protomers of the native homodimer of 3CL protease. Since 3CL protease is catalytically competent only in the dimeric state, these data provide insight into the design of drug-like inhibitors targeting the native homodimer state. With a binding mode different from the covalent 3CL inhibitor nirmatrelvir, the protease inhibitor in the COVID drug Paxlovid, these compounds may overcome resistance reported for nirmatrelvir and complement its clinical utility.

Published
2025
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21. Ethnic and racial differences in children and young people with respiratory and neurological post-acute sequelae of SARS-CoV-2: an electronic health record-based cohort study from the RECOVER InitiativeResearch in context

Author

Suchitra Rao, Rodrigo Azuero-Dajud, Vitaly Lorman, Jeremy Landeo-Gutierrez, Kyung E. Rhee, Julie Ryu, C. Kim, Megan Carmilani, Rachel S. Gross, Sindhu Mohandas, Srinivasan Suresh, L. Charles Bailey, Victor Castro, Yalini Senathirajah, Shari Esquenazi-Karonika, Shawn Murphy, Steve Caddle, Lawrence C. Kleinman, Leah Castro-Baucom, Carlos R. Oliveira, Jonathan D. Klein, Alicia Chung, Lindsay G. Cowell, Charisse Madlock-Brown, Carol Reynolds Geary, Marion R. Sills, Lorna E. Thorpe, Jacqueline Szmuszkovicz, Kelan G. Tantisira, Ivan Diaz, Rachel Kenny, Parsa Mirhaji, Ravi Jhaveri, Marc Rosenman, Christopher Forrest, Beth Tarini, Hiroki Morizono, Nathan Pajor, W. Schuyler Jones, Kieler Curtis, Rishi Kamaleswaran, Nita Deshpande, Saul Blecker, Claudia Pulgarin, Marion Sills, Erin Hinkman, Dan Fort, Timothy Guthrie, Cynthia Chuang, Wenke Hwang, Dimitri Christakis, Daksha Ranade, Shannon Herring, Aaron Mishkin, Soledad Fernandez, Neena Thomas, Yuriy Bisyuk, Jyotsna Fuloria, Elizabeth Chrischilles, Boyd Knosp, Asa Oxner, Athanasios Tsalatsanis, Lindsay Cowell, Phillip Reeder, Stephen M. Downs, Brian Ostasiewski, Rainu Kaushal, Thomas Campion, Jessica Snowden, Katherine Irby, Paul Darden, Lexie Dixon, Danielle Evans, Connor Garbe, Laura Hobart-Porter, Lee Howard, Kathy Hummel, Hannah Krehbiel, Haley Spradlin, Phaedra Yount, Amy Elliott, Grace Adam, Jyoti Angal, Maria Barber, Katelynne Clark, Clayton Dos Reis, Mandy Freesemann, Christa Friedrich, Christine Hockett, Rachel Johannsen, Emily Johnson-Vonk, Cassidy Kaiser, Alexa Kruse, Jennifer Lang, Peter Lim, Meggie McCoy, Lorie Miller, Shelby Petereit (Cerkovnik), Jaime RiChard (Werpy), Jessica Seiler, Bret Sundleaf, Joshua Svendsen, Billy Trosper, Olivia Vermeulen, Scott Young, Aul Palumbo, Sean Dabney, Marie-Christine Fahrner, Torrey Gallagher, Karilyn Martini, Mary McNally, Sarah Vivensi Stiverson, Jessica Kosut, Venkataraman Balaraman, JoAnn Cheung, Travis K.F. Hong, Shanelle Kalua, Evan Minami, Andrea Siu, Micah Tong, Ronald J. Teufel, II, Andy Atz, Marina Dantas, Tyler Kasmarcak, Kreighton Milks, Judith Ross, Chijoke Ikomi, Marisa Meyer, Connie Nguyen, Gwen Pellicciotti, Thao-Ly Phan, Karen Ravin, Victoria Reynolds, Abigail Strang, Deepika Thacker, Dan Eckrich, Annabelle Goetter, Cheyenne Katz, Karen Kowal, Carol McDevitt, Emily Zimmerman, Genesis Agosto Roman, Akram Alshawabkeh, Ishwara Ayala Ortiz, Virginia Casey, Jose Cordero, Jocelyn De Jesus, Crystal Galan, Gredia Huerta-Montanez, Nilda Otero, Mayra Rivera Robles, Priscilla Roman, Genesis Roman, Zaira Rosario-Pabon, Xiodenis Santiago, Carmen Velez-Vega, Carlos Vergara, Daniel S. 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Mu, Robin Rowe, Brooke Sayles, Mo Zhang, Pei-Ni Jone, Michael Carr, Lauren Goodell, Wantanabe Kar, Kathleen Van't Hof, Kristin Sexson, Elias Moussi, David Olukayode, Sandra Pena, Ricardo Pignatelli, Faridis Serrano, Sara Sexson Tejtel, Lara Shekerdemian, Audrey Dionne, Annette Baker, Sarah DeFerrantini, Thomas Giorgio, Numaira Khan, Simran Mahanta, MaryBeth Son, Matt Oster, Melissa Burnett, Kolby Sanders-Lewis, Sonia Chavez, Georgia Reis, Jackie Szmuszkovicz, Fariborz Behzadian, Carla Canas, Andrew Cheng, Mike Gawad, Paige Johnson, Alicia Kazarians, Anastasia Sarkissian, Brandi Scott, Consuelo Secules, Jennifer Su, Crystal Vargas, Jodie Votava-Smith, Sharon Wagner-Lees, Shuo Wang, Pierre Wong, Yamuna Sanil, Sanjeev Aggarwal, Aiman Almasnaah, Nirupama Kannikeswaran, Kathleen Meert, Gautam Singh, Priya Spencer, Nancy Sullivan, Sureja Sundaralingam, Vishnu Undyala, Emily Ward, Amanda Weber, Charmaine Williams Farr, Tamara Bradford, Marla Johnston, Matthew Elias, Alex Fiks, Chris Forrest, Dana Albizem, Susan Coffin, Therese Giglia, Katherine Lupton, Grace Marks, Tonia Morrison, Shawn O'Connor, Daniel Forsha, Jennifer Nelson, Rachel Sachdeva, Dara Watkins, Ashraf S. Harahsheh, Jordyn Britton, Alix Fetch, Anita Krishnan, Onais Tariq, Sean Lang, Marisa Almaguer, Jim Cnota, Lauryn Dugan, Elise Pickering, Kathleen Rathge, Elizabeth Mitchell, Christine Capone, Nilanjana Misra, Olga Shamailova, Mark Russell, Tammy Doman, Lori Harris, Keren Hasbani, Sagar Jani, Brian McCrindle, Jessica Bainton, Maryanne Chrisant, Doris Alaby, Norma Barton, Danielle Katz, Paulette Smith, Stephanie Handler, Joe Block, Regina Cole, Jennifer Maldonado, Kim McHugh, Andrew Atz, Megan Bickford, Jason Buckley, John Costello, Delany Dennis, Elizabeth Emrath-Zwick, Mary Freeman, Lanier Jackson, Madison Johnson, Elizabeth Mack, Scott Pletzer, Natasha Ruth, Carolyn Taylor, Sinai Zyblewski, Katrina Golub, Chanel Rojas, Korsin Rosalind, Chantal Sanchez, Shubhika Srivastava, Carol Prospero, Ed Williams, Varsha Zadokar, Arash Sabati, Kylie Domian, Ashley Herzberg, Sanjana Khanna, Todd Nowlen, Susan Park, Jade Porche, Samantha Stack, Dongngan Truong, Andrea Dunn, Lilly Fagatele, Emma Joyce, Linda Lambert, Kirsten Dummer, Sherrie Bandy, Jane Burns, Katheryn Crane, Sanjeet Hedge, Joan Pancheri, Adriana Tremoulet, Ronald Mark Payne, Mary Stumpf, Michael Portman, Hidemi Kajimoto, Camden Hebson, Krissie Hock, Onyekachukwu Osakwe, Jemylle Morato, Divya Shakti, Matt Kadish, Kavita Sharma, William Anguiano, Catherine Ikemba, Alejandra Lozano, Maria Martinez, Wendy Rojas, Lerraughn Morgan, Isaura Macias, Carl Owada, Mayra Rangel, and Michelle Sykes

Subjects
PEDSnet, PCORnet, Long COVID, Chronic COVID-19 syndrome, Late sequelae of COVID-19, Long-haul COVID, Medicine (General), R5-920
Abstract

Summary: Background: Children from racial and ethnic minority groups are at greater risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but it is unclear whether they have increased risk for post-acute sequelae of SARS-CoV-2 (PASC). Our objectives were to assess whether the risk of respiratory and neurologic PASC differs by race/ethnicity and social drivers of health. Methods: We conducted a retrospective cohort study of individuals

Published
2025
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22. Use of digital facilitation to support the use of digital services in general practice in England: An interview study with key stakeholders.

Author

Treadgold, Bethan Mair, Winder, Rachel, Atherton, Helen, Bryce, Carol, Campbell, John, Marriott, Christine, Newbould, Jenny, Stockwell, Stephanie, and Pitchforth, Emma

Subjects
*PRIMARY care, *DIGITAL inclusion, *SCIENTIFIC community, *DIGITAL technology, *SEMI-structured interviews
Abstract

Digital services in primary care are becoming more common, yet access to and use of services can create inequities. Our aim was to explore the drivers, priorities, and evolving policy context influencing digital facilitation in primary care as reported by national, regional and local level stakeholders in England.We conducted online semi-structured qualitative interviews with stakeholders, including those in NHS England organisations, local commissioners for health care, statutory and third sector organisations, those working within the research community, and digital platform providers. Interviews were analysed using a thematic approach.The majority of stakeholders worked in national level roles, in commissioning or statutory and third sector organisations working in relation to digital inclusion and patient access. Demographic inequalities, poor usability of digital primary care services, and low digital skills were perceived to comprise some of the barriers facing patients in accessing and using digital primary care services. Demand pressures in general practice, inconsistent training opportunities in digital services for staff, and conflicting perceptions around who should be responsible in organising digital facilitation were reported as barriers in the organisation and provision of digital facilitation in primary care. Stakeholders shared future visions for digital primary care and recommended focusing on establishing the concept of digital facilitation and promoting the benefits in its adoption.Policy that is specific to digital facilitation and not just to digital services is required to establish clear lines of responsibility, investment in staff time and training, and the development of digital services that work well for various groups of patients and practice staff. A multi-organisational working team involving decision-makers and those working on the ground in general practice is encouraged to establish principles for supporting patients and staff in accessing and using digital primary care services in the NHS in England. [ABSTRACT FROM AUTHOR]

Published
2025
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