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Algorithms for detecting point targets in hyperspectral imaging commonly employ the spectral inverse covariance matrix to whiten inherent image noise. Since data cubes often lack stationarity, segmentation appears to be an attractive preprocessing operation. Surprisingly, the literature reports both successful and unsuccessful segmentation cases, with no clear explanations for these divergent outcomes. This paper elucidates the conditions under which segmentation might improve detector performance. Focusing on a representative algorithm and assuming a target additive model, the study examines all influential factors through theoretical analysis and extensive simulations. The findings offer fundamental insights and practical guidelines for characterizing segmented datasets, enabling a thorough evaluation of segmentation’s utility for detector performance. They outline the range of target scenarios and parameters where segmentation may prove beneficial and help assess the potential impact of proposed segmentation strategies on detection outcomes.