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Why you should read this article: • To acknowledge the high demand on specialist mental health services for children and young people • To recognise that non-mental health nurses are well placed to provide mental health assessment of children and young people • To read about a web-based app designed to support non-mental health nurses when assessing the mental health needs and risks for children and young people. There is high demand for specialist mental health services for children and young people in the UK. Non-mental health nurses are well-placed to assess the mental health needs and risks of children and young people to maximise opportunities for early intervention and relieve the pressure on child and adolescent mental health services. This article provides an overview of a service development project to develop a web-based application (app) to support non-mental health nurses when assessing the mental health needs and risks of children and young people. The article describes the development, testing and evaluation process, which involved consultation with children and young people as well as interviews, focus groups and an online survey with a range of professionals working with children and young people. Overall, the findings suggest that the app is appropriate for use by non-mental health nurses in terms of quality, functionality and acceptability. [ABSTRACT FROM AUTHOR]

INTRODUCTION: A ccessible spaceflight may seem a distant concept. As part of a diverse European Space Agency funded Topical Team, we are working on the physiological feasibility of space missions being undertaken by people with physical disabilities. Here, the first activity of this team is presented in the form of key lessons learned from aviation to inform new work on space missions. DISCUSSION: The first lesson is agreeing on realistic expectations about impairments, their severity, and the possibility of flying independently. This is important in terms of astronaut recruitment and societal expectations. The second lesson relates to training and adjustments for people with disabilities. Flexibility is important while maintaining safety for everyone involved. The third lesson is about managing unconscious bias from the different stakeholders. We conclude by arguing that engagement with people from different backgrounds is essential for the success of the first space mission with people with physical disabilities. [ABSTRACT FROM AUTHOR]

The response of the haloarchaeal model organism Haloferax volcanii to iron starvation was analyzed at the proteome level by data-independent acquisition mass spectrometry. Cells grown in minimal medium with normal iron levels were compared to those grown under low iron conditions, with samples being separated into membrane and cytoplasmic fractions in order to focus on import/export processes which are frequently associated with metal homeostasis. Iron starvation not only caused a severe retardation of growth but also altered the levels of many proteins. Using a comprehensive annotated spectral library and data-independent acquisition mass spectrometry (DIA-MS), we found that iron starvation resulted in significant changes to both the membrane and the soluble proteomes of Hfx. volcanii. The most affected protein is the RND family permease HVO_A0467, which is 44-fold enriched in cells grown under iron starvation. The gene HVO_A0467 can be deleted suggesting that it is not essential under standard conditions. Compared to wild type cells the deletion strain shows only slight changes in growth and cell morphologies show no differences. Molecular docking predictions indicated that HVO_A0467 may be an exporter of the siderophore schizokinen for which a potential biosynthesis cluster is encoded in the Hfx. volcanii genome. Together, these findings confirm the importance of iron for archaeal cells and suggest HVO_0467 as a siderophore exporter. [ABSTRACT FROM AUTHOR]

This document is an editorial from the Journal of Maps, discussing the importance of community support and collaboration within the academic community. The editor announces the winner of the 2023 Best Map Competition, which was awarded to a team for their Geological Map of South America in Google Earth. The document also provides a summary of the journal's productivity in 2023, with 133 articles published. The Impact Factor slightly dropped to 2.2 but is still higher than the previous year. The number of downloads for articles in open access journals increased by nearly 10% to 458,576. The top five cited and downloaded articles are listed, with the Best Map prizewinner receiving 10,177 downloads. The author expresses gratitude to the academic community, authors, reviewers, and editorial board members for their contributions to the journal. Additionally, the document is a list of references for various articles published in the Journal of Maps, covering topics such as geological mapping, geospatial analysis, geomorphology, and cartography. The authors are affiliated with universities and research institutions from around the world. The articles are available under an Open Access license, allowing for non-commercial use and distribution. [Extracted from the article]

BACKGROUND: One in 5 people worldwide lives with a disability, frequently facing challenges in aviation. This makes accessible space flight seem like a distant dream. Recently, ESA selected the first astronaut with a physical disability. Our ESA Topical Team supports this opportunity by reviewing the existing literature and lived experience in the field, to investigate the physical and physiological challenges and also the potential advantages of astronauts with disabilities. OVERVIEW: Given the overlap between the medical standards required for pilot medical certification and those for astronaut selection, we started by examining the experience of a disabled flying charity, Aerobility. Three key lessons were learned from this review which will support the collaboration between stakeholders when working with astronauts with physical impairments.The first lesson was to recognise that not everyone will meet the standards for aeromedical certification. Astronauts face similar requirements and a transparent approach to assessment is required. However, these criteria can evolve over time, as advancements in both medical and technological fields may mitigate the impact of physical impairments on an individual's ability to participate in space missions. The second lesson was that people with disabilities can meet the requirements for flying with adapted training and technical modifications. In this context, flexibility and open discussions are needed to understand individual needs and find optimal solutions. Likewise, considering astronauts, dedicated efforts are required to adapt systems and procedures, ensuring accessibility. The third lesson highlighted the significance of involving different stakeholders when reviewing recruitment, training, adaptations, and operations. Unconscious bias remains a challenge in the field. Without scientific evidence demonstrating the suitability of candidates with physical disabilities, space accessibility would remain partial. DISCUSSION: We reviewed the experience of a leading flying charity to define key lessons from aviation that could be translated and adapted for space flight. Our overarching goal is to evaluate the physiological considerations for people with physical disabilities in order to support ESA's team and space missions. This work will become even more relevant with the emergence of space tourism, and the need for accommodating a diverse array of candidates for both short-term and extended space flights. Learning Objectives 1. To discuss the requirements and adjustments for people with disabilities in aviation and how they can inform space missions. 2. To identify the needs and adjustments for astronauts with a physical disability. [ABSTRACT FROM AUTHOR]