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Although there has been a considerable amount of research on near-infrared (NIR) phosphor-converted light-emitting diodes (pc-LEDs), narrow-band emission and poor thermal stability continue to be problems associated with NIR phosphors. To solve these problems, La3ZrxSn1−xGa5O14:0.015Cr3+ phosphors with ultra-broadband NIR emission were obtained by partially replacing Sn4+ with Zr4+ through a strategy of multiple lattice site occupancy and cationic modulation, which altered the crystal field environment of the material. The spectrum was broadened, and the luminous intensity and thermal stability of the material were successfully improved. Finally, the phosphor was combined with a blue LED chip package, and the broad prospects of the phosphor in the NIR application field were proved by experiments of level detection, biomedical imaging, and night vision monitoring. [ABSTRACT FROM AUTHOR]

Sediment erosion around submarine pipelines is a popular topic, widely investigated in both ocean and submarine-pipeline engineering. In this paper, the incompressible smoothed-particle hydrodynamics (ISPH) method is modified for simulation of local scouring process around the submarine pipeline under the action of unidirectional flow. The erosion model is based on the Clear Water Particle–Turbid Water Particle–Critical Shear Stress (CWP-TWP-CSS) concept, and a sand–water two-phase model is proposed to deal with the sediment-entrained flow. The results of the numerical simulation are compared with the experimental data to verify the accuracy and applicability of the numerical model. The scouring process around the pipeline is investigated under different conditions, i.e., pipeline diameters, gap ratios, and flow velocities. The ISPH model is further used to study the flow characteristics of the scour pits around the submarine pipeline and the influence of the vortices on the maximum scour depth, to provide a theoretical basis for the stability design of submarine pipelines. [ABSTRACT FROM AUTHOR]

Background: Identifying cell subpopulations conferring unfavorable prognosis in cancer holds clinical significance. Here, we sought to identify prognostic cell subsets and develop a novel, prognostic signature for head neck squamous cell carcinoma (HNSCC). Methods: Highly prognostic cell subpopulations in HNSCC were identified by integrating single‐cell and bulk transcriptomic datasets. The prognostic signature and nomogram were developed by least absolute shrinkage and selection operator and multivariate Cox regression analyses based on significantly upregulated genes in this specific cell subpopulation, respectively. The qRT‐PCR experiments were utilized for independent validation in our patient cohort. Results: A specific cancer cell subset associated with unfavorable prognoses was identified. Functional dissections revealed that its transcriptional programs were significantly enriched in E2F, epithelial‐to‐mesenchymal transition, and glycolysis. A novel prognostic signature comprising six genes was developed and further validated. Risk scores based on qRT‐PCR data robustly stratified patients into subgroups with distinct prognoses. A nomogram integrated from this signature and clinical stage had superior performance. Conclusion: Our model derived from integrative analyses of single‐cell and bulk RNA‐sequencing is a novel, robust prognostic biomarker for HNSCC. [ABSTRACT FROM AUTHOR]

A magnetic composite of CoFe2O4 and carbon nanotube (CNT) was prepared using the solvothermal approach and then employed for the activation of peroxydisulfate (PDS) to degrade reactive black 5 (RB5) and other organic pollutants. Characterization results of the composite catalyst revealed the successful loading of spherical CoFe2O4 particles on CNTs, possessing abundant porosity as well as magnetic separation capability. Under the degradation conditions of 0.2 g/L CoFe2O4-CNT dosage and 4 mM PDS dosage, the removal efficiencies of 10 mg/L RB5 and other pollutants were in the range of 94.5 to ~ 100%. The effects of pH, co-existing ions/humic acid, and water matrices as well as the reusability of the catalyst were also investigated in detail. Furthermore, the degradation mechanism and pathway were proposed based on quenching experiments, LC–MS analysis, and density functional theory (DFT) calculations, and the toxicity of the degradation products was evaluated in the quantitative structure–activity relationship approach. [ABSTRACT FROM AUTHOR]