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The conversion of CO 2 into carbon-neutral fuels such as methane (CH 4 ) through selective photoreduction is highly sought after yet remains challenging due to the slow multistep proton-electron transfer processes and the formation of various C 1 intermediates. This research highlights the cooperative interaction between Fe 3+ and Cu 2+ ions transitioning to Fe 2+ and Cu + ions, enhancing the photocatalytic conversion of CO 2 to methane. We introduce an S-scheme heterojunction photocatalyst, CuFe 2 O 4 /ZnIn 2 S 4 , which demonstrates significant efficiency in CO 2 methanation under light irradiation. The CuFe 2 O 4 /ZnIn 2 S 4 heterojunction forms an internal electric field that aids in the mobility and separation of exciton carriers under a wide solar spectrum for exceptional photocatalytic performance. Remarkably, the optimal CuFe 2 O 4 /ZnIn 2 S 4 heterojunction system achieved an approximately 68-time increase in CO 2 conversion compared with ZnIn 2 S 4 and CuFe 2 O 4 nanoparticles using only pure water, with nearly complete CO selectivity and yields of CH 4 and CO reaching 172.5 and 202.4 μmol g -1 h -1 , respectively, via a 2-electron oxygen reduction reaction (ORR) process. The optimally designed CuFe 2 O 4 /ZnIn 2 S 4 heterojunctional system achieved approximately 96% conversion of BA and 98.5% selectivity toward benzaldehyde (BAD). Additionally, this photocatalytic system demonstrated excellent cyclic stability and practical applicability. The photogenerated electrons in the CuFe 2 O 4 conduction band enhance the reduction of Fe 3+ /Cu 2+ to Fe 2+ /Cu + , creating a microenvironment conducive to CO 2 reduction to CO and CH 4 . Simultaneously, the appearance of holes in the ZnIn 2 S 4 valence band facilitates water oxidation to O 2 . The synergistic function within the CuFe 2 O 4 /ZnIn 2 S 4 heterojunction plays a pivotal role in facilitating charge transfer, accelerating water oxidation, and thereby enhancing CO 2 reduction kinetics. This study offers valuable insights and a strategic framework for designing efficient S-scheme heterojunctions aimed at achieving carbon neutrality through solar fuel production.

Background: Increased expression of MRP 1 in AML patients results in the efflux of drugs from the cells, preventing the patient from achieving remission or potentially leading to relapse. Several studies have demonstrated that early identification of ABC transporter may yield favorable outcomes., Aims and Objectives: The objectives of the study were to investigate the correlation between MRP 1 gene expression and MRP 1 protein levels and the response to remission induction in AML patients., Method: A total of 40 AML patients were recruited from March 2021 to June 2022. Peripheral blood was collected in two tubes (yellow and purple top) to assess the MRP 1 gene and protein. For MRP 1 gene assessment, RNA was isolated from blood samples, cDNA was prepared, and qRT-PCR was performed to analyze gene expression. The relationship between the gene and complete remission was determined. Identification of MRP 1 protein was conducted using ELISA, and the relationship between protein levels and complete remission (CR) was explored., Results: Most of the patients were aged between 25 and 39 years, encompassing both males and females. This study observed a clinical correlation between MRP 1 gene expression and complete remission. The findings revealed that 69.2 percent of patients with high gene expression failed to achieve complete remission, whereas the analysis of MRP 1 protein in relation to complete remission showed no statistical significance. The MRP1 gene showed high expression (66.7%) in patients with FLT3 mutation, whereas low expression of MRP1 was associated with a high occurrence (60%) of NMP1 mutation., Conclusion: Further comprehensive multicenter studies with larger sample sizes are required to validate the findings of this study. It is recommended to pinpoint the mechanism and regulation of MRP 1 and its interaction with other molecular pathways., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Constructing a heterojunction by combining two semiconductors with similar band structures is a successful approach to obtaining photocatalysts with high efficiency. Herein, a CuPc/DR-MoS 2 heterojunction involving copper phthalocyanine (CuPc) and molybdenum disulfide with S-rich vacancies (13.66%) is successfully prepared by the facile hydrothermal method. Experimental results and theoretical calculations firmly demonstrated that photoelectrons exhibit an S-scheme charge transfer mechanism in the CuPc/DR-MoS 2 heterojunction. The S-scheme heterojunction system has proven significant advantages in promoting the charge separation and transfer of photogenerated carriers, enhancing visible-light responsiveness, and achieving robust photoredox capability. As a result, the optimized 3CuPc/DR-MoS 2 S-scheme heterojunction exhibits photocatalytic yields of CO and CH 4 at 200 and 111.6 μmol g -1 h -1 , respectively. These values are four times and 4.5 times greater than the photocatalytic yields of pure DR-MoS 2 . This study offers novel perspectives on the advancement of innovative and highly effective heterojunction photocatalysts., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)

The contributions of the tourism sector and its development to economic growth are widely recognized across the economies. However, development in this sector also has its impacts on environmental quality and sustainability. In addition, elevated economic policy uncertainty also has repercussions on the environment. The objective of this study is to examine the impact of international tourism on environmental sustainability while considering EPU, renewable energy consumption (REC), and service sector output (SSO) in the model estimated based on panel data from 17 economies. Having the heteroskedasticity and autocorrelation issues in the panel data, the author used multiple econometric methods (pooled OLS with Drisk/Kraay standard errors (DKSEs), GLS, PCSE, and quantile regressions) to examine the relationship between international tourism and environmental sustainability. DKSEs address the common issue of heteroskedasticity and GLS also accounts for both heteroskedasticity and autocorrelation. PCSE method corrects these errors. Finally, quantile regression estimates the relationships between variables at different points of the distribution. The results show that international tourism and EPU adversely impact environmental quality and sustainability by increasing GHG emissions. The findings show that increased GHG emissions from international tourism and EPU harm environmental sustainability. Furthermore, SSO and REC significantly reduce GHG emissions and enhance sustainability. Nevertheless, the tourism sector should adopt sustainable practices like using eco-friendly lodging, conserving energy and water, and utilizing renewable energy (RE) to reduce negative environmental impacts. Conserving biodiversity and regional cultures while minimizing waste and resource use is also essential. Tourists should embrace eco-friendly practices such as choosing green hotels, conserving energy and water, and supporting environmental causes while adhering to regulations to reduce emissions. The study recommends establishing uniform trade laws that support green technology and RE to reduce EPU. The findings stress the need for international collaboration to promote eco-friendly tourist practices and minimize the sector's environmental impact., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

China faces a healthcare challenge due to its aging population, necessitating an integrated old-age healthcare system considering multiple stakeholders' interests. Conflict and inequality may arise from varying stakeholder interests. This study develops a conflict resolution strategy for the coordination of stakeholders involved in the old-age healthcare service system, promoting harmonization and minimizing conflict to establish an equitable system meeting elderly needs. It contributes to a robust healthcare system for comprehensive, quality care. The focus of the study is to identify relevant stakeholders and decision-makers involved in developing an integrated old-age healthcare service system and explore a feasible solution through stakeholder analysis using the Mitchell score-based technique and stakeholder theory. Decision-makers' preferences are estimated using the Analytic Hierarchy Process (AHP). Solution strategies are developed through multiple stability concepts within the graph model for conflict resolution (GMCR). The conflict resolution analysis based on the integrated AHP-GMCR approach reveals that the development of an integrated old-age healthcare system is feasible by addressing potential conflicts among the stakeholders. Considering the current predicament of comprehensive medical services in China, governments should distribute authority, simplify procedures, and improve the insurance system. Furthermore, medical institutions should explore funding options, expand services, and enhance accessibility. Elderly individuals should prioritize healthy aging and seek suitable healthcare providers. Stakeholder participation is crucial for effective implementation. These recommendations enable China to advance integrated elderly care successfully, addressing challenges posed by the aging population., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Author(s).)

The construction of van der Waals (vdW) heterojunctions is a key approach for efficient and stable photocatalysts, attracting marvellous attention due to their capacity to enhance interfacial charge separation/transfer and offer reactive sites. However, when a vdW heterojunction is made through an ex-situ assembly, electron transmission faces notable obstacles at the components interface due to the substantial spacing and potential barrier. Herein, we present a novel strategy to address this challenge via wet chemistry by synthesizing a functionalized graphene-modulated Z-scheme vdW heterojunction of zinc phthalocyanine/tungsten trioxide (xZnPc/yG-WO 3 ). The functionalized G-modulation forms an electron "bridge" across the ZnPc/WO 3 interface to improve electron transfer, get rid of barriers, and ultimately facilitating the optimal transfer of excited photoelectrons from WO 3 to ZnPc. The Zn 2+ in ZnPc picks up these excited photoelectrons, turning CO 2 into CO/CH 4 (42/22 μmol.g -1 .h -1 ) to deliver 17-times better efficiency than pure WO 3 . Therefore, the introduction of a molecular "bridge" as a means to establish an electron transfer conduit represents an innovative approach to fabricate efficient photocatalysts designed for the conversion of CO 2 into valued yields., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Low-cost ambient sensors have been identified as a promising technology for monitoring air pollution at a high spatio-temporal resolution. However, the pollutant data captured by these cost-effective sensors are less accurate than their conventional counterparts and require careful calibration to improve their accuracy and reliability. In this paper, we propose to leverage temporal information, such as the duration of time a sensor has been deployed and the time of day the reading was taken, in order to improve the calibration of low-cost sensors. This information is readily available and has so far not been utilized in the reported literature for the calibration of cost-effective ambient gas pollutant sensors. We make use of three data sets collected by research groups around the world, who gathered the data from field-deployed low-cost CO and NO 2 sensors co-located with accurate reference sensors. Our investigation shows that using the temporal information as a co-variate can significantly improve the accuracy of common machine learning-based calibration techniques, such as Random Forest and Long Short-Term Memory.

Broomrape (Orobanche cumana) negatively affects sunflower, causing severe yield losses, and thus, there is a need to control O. cumana infestation. Brassinosteroids (BRs) play key roles in plant growth and provide resilience to weed infection. This study aims to evaluate the mechanisms by which BRs ameliorate O. cumana infection in sunflower (Helianthus annuus). Seeds were pretreated with BRs (1, 10, and 100 nM) and O. cumana inoculation for 4 weeks under soil conditions. O. cumana infection significantly reduced plant growth traits, photosynthesis, endogenous BRs and regulated the plant defence (POX, GST), BRs signalling (BAK1, BSK1 to BSK4) and synthesis (BRI1, BR6OX2) genes. O. cumana also elevated the levels of malondialdehyde (MDA), hydroxyl radical (OH - ), hydrogen peroxide (H 2 O 2 ) and superoxide (O 2 •- ) in leaves/roots by 77/112, 63/103, 56/97 and 54/89%, as well as caused ultrastructural cellular damages in both leaves and roots. In response, plants activated a few enzymes, superoxide dismutase (SOD), peroxidase (POD) and reduced glutathione but were unable to stimulate the activity of ascorbate peroxidase (APX) and catalase (CAT) enzymes. The addition of BRs (especially at 10 nM) notably recovered the ultrastructural cellular damages, lowered the production of oxidative stress, activated the key enzymatic antioxidants and induced the phenolic and lignin contents. The downregulation in the particular genes by BRs is attributed to the increased resilience of sunflower via a susceptible reaction. In a nutshell, BRs notably enhanced the sunflower resistance to O. cumana infection by escalating the plant immunity responses, inducing systemic acquired resistance, reducing oxidative or cellular damages, and modulating the expression of BR synthesis or signalling genes., (© 2024 Scandinavian Plant Physiology Society.)

The realization of 2D/2D Van der Waals (VDW) heterojunctions represents an advanced approach to achieving superior photocatalytic efficiency. However, electron transfer through Van der Waals heterojunctions formed via ex-situ assembly encounters significant challenges at the interface due to contrasting morphologies and potential barriers among the nanocomposite substituents. Herein, a novel approach is presented, involving the insertion of a phosphate group between copper phthalocyanine (CuPc) and B-doped and N-deficient g-C 3 N 4 (BDCNN), to design and construct a Van der Waals heterojunction labeled as xCu[acs]/yP-BDCNN. The introduction of phosphate as a charge modulator and efficient conduit for charge transfer within the heterojunction resulted in the elimination of spatial barriers and induced electron movement from BDCNN to CuPc in the excited states. Consequently, the catalytic central Cu 2+ in CuPc captured the photoelectrons, leading to the conversion of CO 2 to C 2 H 4 , CO and CH 4 . Remarkably, this approach resulted in a 78-fold enhancement in photocatalytic efficiency compared to pure BDCNN. Moreover the findings confirm that the 2D-2D 4Cu[acs]/9P-BDCNN sheet-like heterojunction effectively boosts photocatalytic activity for persistent pollutants such as methyl orange (MO), methylene blue (MB), rhodamine B (RhB), and tetracycline antibiotics (TCs). The introduction of "interfacial interacting" substances to establish an electron transfer pathway presents a novel and effective strategy for designing photocatalysts capable of efficiently reducing CO 2 into valuable products., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Background: Despite global efforts to eliminate mother-to-child-transmission of HIV (MTCT), many children continue to become infected. We determined the prevalence of HIV among children with severe acute malnutrition (SAM) and that of their mothers, at admission to Mwanamugimu Nutrition Unit, Mulago Hospital, Uganda. We also assessed child factors associated with HIV-infection, and explored factors leading to HIV-infection among a subset of the mother-child dyads that tested positive., Methodology: We conducted a cross-sectional evaluation within the REDMOTHIV (Reduce mortality in HIV) clinical trial that investigated strategies to reduce mortality among HIV-infected and HIV-exposed children admitted with SAM at the Nutrition Unit. From June 2021 to December 2022, we consecutively tested children aged 1 month to 5 years with SAM for HIV, and the mothers who were available, using rapid antibody testing upon admission to the unit. HIV-antibody positive children under 18 months of age had a confirmatory HIV-DNA PCR test done. In-depth interviews (IDIs) were conducted with mothers of HIV positive dyads, to explore the individual, relationship, social and structural factors associated with MTCT, until data saturation. Quantitative data was analyzed using descriptive statistics and logistic regression in STATAv14, while a content thematic approach was used to analyze qualitative data., Results: Of 797 children tested, 463(58.1%) were male and 630(79.1%) were ≤18months of age; 76 (9.5%) tested positive. Of 709 mothers, median (IQR) age 26 (22, 30) years, 188(26.5%) were HIV positive. Sixty six of the 188 mother-infant pairs with HIV exposure tested positive for HIV, an MTCT rate of 35.1% (66/188). Child age >18 months was marginally associated with HIV-infection (crude OR = 1.87,95% CI: 1.11-3.12, p-value = 0.02; adjusted OR = 1.72, 95% CI: 0.96, 3.09, p-value = 0.068). The IDIs from 16 mothers revealed associated factors with HIV transmission at multiple levels. Individual level factors: inadequate information regarding prevention of MTCT(PMTCT), limited perception of HIV risk, and fear of antiretroviral drugs (ARVs). Relationship level factors: lack of family support and unfaithfulness (infidelity) among sexual partners. Health facility level factors: negative attitude of health workers and missed opportunities for HIV testing. Community level factors: poverty and health service disruptions due to the COVID-19 pandemic., Conclusion: In this era of universal antiretroviral therapy for PMTCT, a 10% HIV prevalence among severely malnourished children is substantially high. To eliminate vertical HIV transmission, more efforts are needed to address challenges mothers living with HIV face intrinsically and within their families, communities and at health facilities., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Musiime et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Drug delivery techniques based on polymers have been investigated for their potential to improve drug solubility, reduce systemic side effects, and controlled and targeted administration at infection site. In this study, we developed a co-polymeric hydrogel composed of graphene sheets (GNS), polyvinyl alcohol (PVA), and chitosan (CS) that is loaded with methotrexate (MTX) for in vitro liver cancer treatment. Fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM) was employed to check the structural properties and surface morphology. Moreover, tests were conducted on the cytotoxicity, hemolytic activity, release kinetics, swelling behaviour and degradation of hydrogels. A controlled release of drug from hydrogel in PBS at pH 7.4 was examined using release kinetics. Maximal drug release in six hours was 97.34%. The prepared hydrogels did not encourage the HepG2 growth and were non-hemolytic. The current study highlights the potential of GNS-based hydrogel loaded with MTX as an encouraging therapy for hepatocellular carcinoma. HepG2 cell viability of MTX-loaded CS-PVA-GNS hydrogel was (IC50 5.87 µg/200 mL) in comparison to free MTX (IC50 5.03 µg/200 mL). These outcomes recommend that hydrogels with GNS ensure improved drug delivery in cancer microenvironment while lessening adverse consequences on healthy cells.

Semiconductor-based photocatalysis has attracted significant interest due to its capacity to directly exploit solar energy and generate solar fuels, including water splitting, CO 2 reduction, pollutant degradation, and bacterial inactivation. However, achieving the maximum efficiency in photocatalytic processes remains a challenge owing to the speedy recombination of electron-hole pairs and the limited use of light. Therefore, significant endeavours have been devoted to addressing these issues. Specifically, well-designed heterojunction photocatalysts have been demonstrated to exhibit enhanced photocatalytic activity through the physical distancing of electron-hole pairs generated during the photocatalytic process. In this review, we provide a systematic discussion ranging from fundamental mechanisms to material strategies, focusing on TiO 2 -based heterojunction photocatalysts. Current efforts are focused on developing heterojunction photocatalysts based on TiO 2 for a variety of photocatalytic applications, and these projects are explained and assessed. Finally, we offer a concise summary of the main insights and challenges in the utilization of TiO 2 -based heterojunction photocatalysts for photocatalysis. We expect that this review will serve as a valuable resource to improve the efficiency of TiO 2 -based heterojunctions for energy generation and environmental remediation.

Magnesium oxide nanoparticles (MgO NPs) have great potential to enhance the crop productivity and sustainability of agriculture. Still, a thorough understanding is lacking about its essentiality or toxicity and precise dose for the safe cultivation of oilseed crops. Thus, we assessed the dual effects of MgO NPs (control, 5, 10, 20, 40, 80, and 200 mg/L) on the seed germination, growth performance, photosynthesis, total soluble protein, total carbohydrates, oxidative stress markers (hydrogen peroxide as H 2 O 2 and superoxide anion as O 2 •‒ ), lipid peroxidation as MDA, and antioxidant defence machinery (SOD, CAT, APX, and GR activities, and GSH levels) of seven different oilseeds (Brassica napus L.) cultivars (ZY 758, ZD 649, ZD 635, ZD 619, GY 605, ZD 622, and ZD 630). Our findings revealed that low doses of MgO NPs (mainly at 10 mg/L) markedly boosted the seed germination, plant growth (shoot and root lengths) (15‒22%), and biomass (fresh and dry) (11‒19%) by improving the levels of photosynthetic pigments (14‒27%), net photosynthetic rate, stomatal conductance, photosynthetic efficiency (Fv/Fm), total soluble protein and total carbohydrates (16‒36%), antioxidant defence, and reducing the oxidative stress in B. napus tissues. Among all B. napus cultivars, these beneficial effects of MgO NPs were pronounced in ZD 635. ile, elevated levels of MgO NPs (particularly at 200 mg/L) induced oxidative stress, impaired antioxidant scavenging potential, photosynthetic inhibition, protein oxidation, and carbohydrate degradation and lead to inhibit the plant growth attributes. These inhibitory effects were more pronounced in ZD 622. Collectively, low-dose MgO NPs reinforced the Mg contents, protected the plant growth, photosynthesis, total soluble carbohydrates, enzyme activities, and minimized the oxidative stress. While, the excessive MgO NP levels impaired the above-reported traits. Overall, ZD 622 was highly susceptible to MgO NP toxicity and ZD 635 was found most tolerant to MgO NP toxicity., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Tryptophan, as a signal molecule, mediates many biotic and environmental stress-induced physiological responses in plants. Therefore, an experiment was conducted to evaluate the effect of tryptophan seed treatment in response to cadmium stress (0, 0.15, and 0.25 mM) in sunflower plants. Different growth and biochemical parameters were determined to compare the efficiency of the treatment agent. The results showed that cadmium stress reduced the growth attributes, including root and shoot length, dry and fresh weight, rate of seed germination, and the number of leaves. Cadmium stress also significantly reduced the contents of chlorophyll a , b , and total chlorophyll, carotenoid contents, phenolics, flavonoids, anthocyanin, and ascorbic acid. Whereas cadmium stress (0.15 and 0.25 mM) enhanced the concentrations of malondialdehyde (45.24% and 53.06%), hydrogen peroxide (-11.07% and 5.86%), and soluble sugars (28.05% and 50.34%) compared to the control. Tryptophan treatment decreased the effect of Cd stress by minimizing lipid peroxidation. Seed treatment with tryptophan under cadmium stress improved the root (19.40%) and shoot length (38.14%), root (41.90%) and shoot fresh weight (13.58%), seed germination ability (13.79%), average leaf area (24.07%), chlorophyll b (51.35%), total chlorophyll (20.04%), carotenoids (43.37%), total phenolic (1.47%), flavonoids (19.02%), anthocyanin (26.57%), ascorbic acid (4%), and total soluble proteins (12.32%) compared with control conditions. Overall, the tryptophan seed treatment showed positive effects on sunflower plants' growth and stress tolerance, highlighting its potential as a sustainable approach to improve crop performance.

Natural Resource Protection (NRP) has been on the agenda of the Sustainable Development Goals (SDGs) and is considered a pathway to sustainable development. The analysis of the determinants of NRP has received the attention of policymakers in framing evidence-based policies and strategies. Renewable energy (RE) is a major contributor to natural resource protection. However, existing studies have provided inconclusive evidence on the role of renewable energy in the NRP. This study primarily focuses on the assessment of how RE influences NRP in 22 developing economies. This study considers the nonlinear association between RE and NRP. Moreover, the role of governance effectiveness, financial technology, urbanization, and FDI in the NRP were also assessed. Furthermore, the analyses also explore the NRP-Kuznets curve by examining the role of economic growth in the NRP. The study, which detected cross-sectional dependence (CSD), heterogeneity, autocorrelation, and heteroskedasticity in the data, uses pooled regression with Driscoll-Kraay Standard Errors (DKSEs) and GLS for the econometric analysis. The results revealed a U-shaped relationship between renewable energy and NRP. Moreover, governance effectiveness, FINTECH, and FDI contribute to NRP, but urbanization has a negative impact on NRP. The analysis concludes an inverted U-shaped association between GDP per capita and NRP. A Bayesian regression analysis was also performed to validate the robustness of the results. Based on these findings, this study makes policy recommendations for improving NRP. Policymakers should prioritize renewable energy and sustainable resource exploitation through incentives and investments. Improving governance, adopting environmental rules, and involving stakeholders are critical. Financial technology can facilitate long-term investment in sustainability. Sustainable urban design should reduce the adverse effects of urbanization. FDI should be aligned with long-term development goals and appropriate resource management. Balancing economic growth with environmental protection requires multifaceted measures that promote green development and resource efficiency. Policy coherence and stakeholder participation are also critical., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)