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Your search keyword '"Schouten, Harry C."' showing total 3 results
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3 results on '"Schouten, Harry C."'

1. Pneumocystis Pneumonia After Allogeneic Hematopoietic Cell Transplantation: A Case-Control Study on Epidemiology and Risk Factors on Behalf of the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation

Author

Robin, Christine, Cordonnier, Catherine, Tridello, Gloria, Knelange, Nina, Xhaard, Alienor, Chantepie, Sylvain, Tanguy-Schmidt, Aline, Schouten, Harry C., Yeshurun, Moshe, Rocha, Vanderson, Srour, Micha, Kröger, Nicolaus, Ledoux, Marie-Pierre, Dalgaard, Jakob, Thiebaut, Anne, Giardino, Stefano, Calore, Elisabetta, Zuckerman, Tsila, Groll, Andreas H., Raida, Ludek, Avcin, Simona, Vicent, Marta Gonzalez, Kaare, Ain, Drozd-Sokolowska, Joanna, Turlure, Pascal, Bretagne, Stéphane, Mikulska, Malgorzata, Camara, Rafael de la, Cesaro, Simone, and Styczynski, Jan

Published
2024
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2. Changes in nutritional status and associations with physical and clinical outcomes in acute myeloid leukemia patients during intensive chemotherapy

Author

van Lieshout, Rianne, Tick, Lidwine W., Beckers, Erik A. M., Biesbroek, Willemijn, Dieleman, Jeanne P., Dijkstra, Myrthe, Groenesteijn, Wanda, Koene, Harry R., Kranenburg, Suzanne, van der Lee, Debbie, van der Put - van den Berg, Liesbeth, Rademakers, Nicky, Regelink, Josien C., van Tilborg, Claudia J., Westerweel, Peter E., de Zeeuw, Sandra, Schouten, Harry C., and Beijer, Sandra

Abstract

Background/Objectives: Patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) often receive medical nutrition therapy (MNT) during intensive remission-induction treatment. Since little is known about changes in nutritional status, specifically body composition, in this patient population, these changes and their associations with physical and clinical outcomes were assessed. Subjects/Methods: In this multicenter prospective observational study, newly diagnosed AML/MDS patients who received intensive remission-induction chemotherapy, routine dietary counseling by a dietician and MNT immediately upon inadequate nutritional intake, were included. At treatment initiation and discharge, nutritional status, including Patient-Generated Subjective Global Assessment (PG-SGA)-scores and body composition, physical outcomes and fatigue were assessed. Associations of nutritional status/body composition with physical outcomes, fatigue, fever duration, number of complications, time to neutrophil engraftment and hospital length of stay (LOS) (collected from medical records) were examined using multiple regression analysis. Results: In >91% of the 126 AML/MDS patients included, nutritional intake was adequate, with 61% receiving MNT. Nevertheless, body weight decreased significantly (p< 0.001) and mainly consisted of a loss of muscle/fat-free mass (FFM) (p< 0.001), while fat mass (FM) remained unchanged (p-value range = 0.71–0.77). Body weight and waist circumference showed significant negative associations with fever duration and/or number of complications. Significant positive associations were found between mid-upper arm muscle circumference (MUAMC) and physical functioning and between PG-SGA-scores and fatigue. Body weight and MUAMC were also negatively associated with LOS. Conclusion: Despite MNT in AML/MDS patients undergoing intensive chemotherapy, muscle/FFM decreased while FM remained unchanged. Maintenance of nutritional status was associated with improved physical and clinical outcomes.

Published
2024
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3. Myeloablative Conditioning for Allogeneic Transplantation Results in Superior Disease-Free Survival for Acute Myelogenous Leukemia and Myelodysplastic Syndromes with Low/Intermediate but not High Disease Risk Index: A Center for International Blood and Marrow Transplant Research Study

Author

Bejanyan, Nelli, Zhang, Meijie, Bo-Subait, Khalid, Brunstein, Claudio, Wang, Hailin, Warlick, Erica D., Giralt, Sergio, Nishihori, Taiga, Martino, Rodrigo, Passweg, Jakob, Dias, Ajoy, Copelan, Edward, Hale, Gregory, Gale, Robert Peter, Solh, Melhem, Kharfan-Dabaja, Mohamed A., Diaz, Miguel Angel, Ganguly, Siddhartha, Gore, Steven, Verdonck, Leo F., Hossain, Nasheed M., Kekre, Natasha, Savani, Bipin, Byrne, Michael, Kanakry, Christopher, Cairo, Mitchell S., Ciurea, Stefan, Schouten, Harry C., Bredeson, Christopher, Munker, Reinhold, Lazarus, Hillard, Cahn, Jean-Yves, van Der Poel, Marjolein, Rizzieri, David, Yared, Jean A., Freytes, Cesar, Cerny, Jan, Aljurf, Mahmoud, Palmisiano, Neil D., Pawarode, Attaphol, Bacher, Vera Ulrike, Grunwald, Michael R., Nathan, Sunita, Wirk, Baldeep, Hildebrandt, Gerhard C., Seo, Sachiko, Olsson, Richard F., George, Biju, de Lima, Marcos, Hourigan, Christopher S., Sandmaier, Brenda M., Litzow, Mark, Kebriaei, Partow, Saber, Wael, and Weisdorf, Daniel

Abstract

•Myeloablative conditioning (MAC) results in lower relapse and better disease-free survival (DFS) after hematopoietic cell transplantation for acute myelogenous leukemia (AML)/myelodysplastic syndrome (MDS) with low/intermediate-risk Disease Risk Index (DRI).•MAC and RIC regimens yield similar DFS and overall survival for AML/MDS with high/very high-risk DRI.

Published
2024
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