Background and Aims: EUS-guided drainage and, if required, endoscopic necrosectomy (EN) has become the criterion standard for the treatment of pancreatic walled-off necrosis (WON). A dedicated powered endoscopic debridement system, the EndoRotor (Interscope Inc, Northbridge, Mass, USA), has been introduced as an alternative to snare necrosectomy. This study evaluates the novel EndoRotor catheter, NecroMax 6.0 (Interscope Inc, Whitinsville, Mass, USA), for EN in patients with WON., Methods: This single-center retrospective case series included consecutive patients with WON treated with the NecroMax 6.0 catheter. Safety, ability to perform EN, and clinical resolution were evaluated., Results: Twenty patients underwent 30 EN procedures with the NecroMax 6.0 catheter. One suspected device-related adverse event was observed (3.3%). In 1 procedure, EN could not be performed because of excessive bending of the endoscope. Eighteen patients (90.0%) achieved clinical resolution., Conclusions: EN with the NecroMax 6.0 catheter was technically feasible in 96.7% of patients with a low rate of adverse events., Competing Interests: Disclosure The following authors disclosed financial relationships: P. N. Schmidt: Consultant for Ambu and Boston Scientific; speaker for Norgine. J. G. Karstensen: Consultant for Ambu, Boston Scientific, and SNIPR BIOME; speaker for Norgine. All other authors disclosed no financial relationships. Research support for this study (J. G. K. and G. A. O.) was provided in part by The Novo Nordisk Foundation (NNF21OC0072262)., (Copyright © 2024 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.)