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18 results on '"Sawada, S."'

1. Measurement of inclusive jet cross section and substructure in $p$$+$$p$ collisions at $\sqrt{s_{_{NN}}}=200$ GeV

Author

PHENIX Collaboration, Abdulameer, N. J., Acharya, U., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Alexander, J., Alfred, M., Andrieux, V., Antsupov, S., Aoki, K., Apadula, N., Asano, H., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bai, X., Bandara, N. S., Bannier, B., Bannikov, E., Barish, K. N., Bathe, S., Baublis, V., Baumann, C., Baumgart, S., Bazilevsky, A., Beaumier, M., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Black, D., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Butsyk, S., Campbell, S., Cervantes, R., Chen, C. -H., Chen, D., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Choi, S., Christiansen, P., Chujo, T., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Corliss, R., Cronin, N., Crossette, N., Csanád, M., Csörgő, T., D'Orazio, L., Danley, T. W., Datta, A., Daugherity, M. S., David, G., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Ding, L., Dion, A., Dixit, D., Doomra, V., Do, J. H., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., En'yo, H., Engelmore, T., Enokizono, A., Esha, R., Eyser, K. O., Fadem, B., Fan, W., Feege, N., Fields, D. E., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Fukuda, Y., Fusayasu, T., Gainey, K., Gallus, P., Gal, C., Garg, P., Garishvili, A., Garishvili, I., Ge, H., Giordano, F., Glenn, A., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, T., Guragain, H., Gu, Y., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamilton, H. F., Hanks, J., Han, S. Y., Hasegawa, S., Haseler, T. O. S., Hashimoto, K., Hayano, R., Hemmick, T. K., Hester, T., He, X., Hill, J. C., Hill, K., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Hotvedt, N., Huang, J., Ichihara, T., Ikeda, Y., Imai, K., Imazu, Y., Inaba, M., Iordanova, A., Isenhower, D., Isinhue, A., Ivanishchev, D., Jeon, S. J., Jezghani, M., Jiang, X., Ji, Z., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kamin, J., Kanda, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapukchyan, D., Kapustinsky, J., Karthas, S., Kawall, D., Kazantsev, A. V., Key, J. A., Khachatryan, V., Khandai, P. K., Khanzadeev, A., Kijima, K. M., Kim, C., Kim, D. J., Kim, E. -J., Kim, M., Kim, Y. -J., Kim, Y. K., Kincses, D., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Kofarago, M., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Kovacs, L., Krizek, F., Kudo, S., Kurita, K., Kurosawa, M., Kwon, Y., Lai, Y. S., Lajoie, J. G., Lebedev, A., Lee, D. M., Lee, G. H., Lee, J., Lee, K. B., Lee, K. S., Lee, S., Lee, S. H., Leitch, M. J., Leitgab, M., Leung, Y. H., Lewis, B., Lim, S. H., Liu, M. X., Li, X., Loggins, V. -R., Lokos, S., Loomis, D. A., Lovasz, K., Lynch, D., Maguire, C. F., Majoros, T., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Meles, A., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Mitsuka, G., Miyasaka, S., Mizuno, S., Mohanty, A. K., Mohapatra, S., Montuenga, P., Moon, T., Morrison, D. P., Moskowitz, M., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagae, T., Nagai, K., Nagamiya, S., Nagashima, K., Nagashima, T., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Netrakanti, P. K., Nihashi, M., Niida, T., Nouicer, R., Novitzky, N., Novák, T., Nukazuka, G., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Oide, H., Okada, K., Koop, J. D. Orjuela, Orosz, M., Osborn, J. D., Oskarsson, A., Ottino, G. J., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, I. H., Park, J. S., Park, S., Park, S. K., Patel, L., Patel, M., Pate, S. F., Peng, J. -C., Perepelitsa, D. V., Perera, G. D. N., Peressounko, D. Yu., PerezLara, C. E., Perry, J., Petti, R., Phipps, M., Pinkenburg, C., Pisani, R. P., Potekhin, M., Purschke, M. L., Qu, H., Rak, J., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Richford, D., Rinn, T., Riveli, N., Roach, D., Rolnick, S. D., Rosati, M., Rowan, Z., Ryu, M. S., Safonov, A. S., Sahlmueller, B., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Sawada, S., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seele, J., Seidl, R., Sekiguchi, Y., Seleznev, A., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shaver, A., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shioya, T., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Skolnik, M., Slunečka, M., Smith, K. L., Snowball, M., Solano, S., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Steinberg, P., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Stone, M. R., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Sun, Z., Sziklai, J., Takahara, A., Taketani, A., Tanaka, Y., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarnai, G., Tennant, E., Tieulent, R., Timilsina, A., Todoroki, T., Tomášek, M., Torii, H., Towell, C. L., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Virius, M., Vrba, V., Vukman, N., Vznuzdaev, E., Vértesi, R., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Whitaker, S., Wolin, S., Woody, C. L., Wysocki, M., Xia, B., Xue, L., Xu, C., Xu, Q., Yalcin, S., Yamaguchi, Y. L., Yamamoto, H., Yanovich, A., Yokkaichi, S., Yoon, I., Yoo, J. H., Younus, I., You, Z., Yushmanov, I. E., Yu, H., Zajc, W. A., Zelenski, A., Zhou, S., and Zou, L.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

The jet cross-section and jet-substructure observables in $p$$+$$p$ collisions at $\sqrt{s}=200$ GeV were measured by the PHENIX Collaboration at the Relativistic Heavy Ion Collider (RHIC). Jets are reconstructed from charged-particle tracks and electromagnetic-calorimeter clusters using the anti-$k_{t}$ algorithm with a jet radius $R=0.3$ for jets with transverse momentum within $8.0

Published
2024

2. Centrality dependence of L\'evy-stable two-pion Bose-Einstein correlations in $\sqrt{s_{_{NN}}}=200$ GeV Au$+$Au collisions

Author

PHENIX Collaboration, Abdulameer, N. J., Acharya, U., Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Ta'ani, H., Alexander, J., Angerami, A., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Aschenauer, E. C., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bannier, B., Barish, K. N., Bassalleck, B., Bathe, S., Baublis, V., Baumgart, S., Bazilevsky, A., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Buesching, H., Bumazhnov, V., Butsyk, S., Campbell, S., Castera, P., Chen, C. -H., Chen, D., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chvala, O., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Corliss, R., Csanád, M., Csörgő, T., D'Orazio, L., Dairaku, S., Datta, A., Daugherity, M. S., David, G., Denisov, A., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Donadelli, M., Doomra, V., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Edwards, S., Efremenko, Y. V., Engelmore, T., Enokizono, A., Esha, R., Eyser, K. O., Fadem, B., Fields, D. E., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garishvili, A., Garishvili, I., Glenn, A., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, L., Guo, T., Gustafsson, H. -Å., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hanks, J., Hashimoto, K., Haslum, E., Hayano, R., Hemmick, T. K., Hester, T., He, X., Hill, J. C., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Ichihara, T., Iinuma, H., Ikeda, Y., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Issah, M., Ivanishchev, D., Jacak, B. V., Javani, M., Jiang, X., Ji, Z., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kamin, J., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Karatsu, K., Kasai, M., Kasza, G., Kawall, D., Kazantsev, A. V., Kempel, T., Khanzadeev, A., Kijima, K. M., Kim, B. I., Kim, C., Kim, D. J., Kim, E. -J., Kim, H. J., Kim, K. -B., Kim, Y. -J., Kim, Y. K., Kinney, E., Kiss, Á., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Komatsu, Y., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Kovacs, L., Krizek, F., Král, A., Kunde, G. J., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Kyle, G. S., Lai, Y. S., Lajoie, J. G., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K. B., Lee, K. S., Lee, S. H., Lee, S. R., Leitch, M. J., Leite, M. A. L., Leitgab, M., Lewis, B., Lim, S. H., Levy, L. A. Linden, Liu, M. X., Lökös, S., Loomis, D. A., Love, B., Maguire, C. F., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., Masumoto, S., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Miyachi, Y., Miyasaka, S., Mohanty, A. K., Mohapatra, S., Moon, H. J., Morrison, D. P., Motschwiller, S., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagae, T., Nagamiya, S., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Nihashi, M., Nouicer, R., Novák, T., Novitzky, N., Nukazuka, G., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Okada, K., Orosz, M., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, B. H., Park, I. H., Park, J. S., Park, S., Park, S. K., Patel, L., Pate, S. F., Pei, H., Peng, J. -C., Pereira, H., Peressounko, D. Yu., Petti, R., Pinkenburg, C., Pisani, R. P., Potekhin, M., Proissl, M., Purschke, M. L., Qu, H., Rak, J., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Richford, D., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Sahlmueller, B., Saito, N., Sakaguchi, T., Samsonov, V., Sano, M., Sarsour, M., Sawada, S., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Sukhanov, A., Sun, J., Sun, Z., Sziklai, J., Takagui, E. M., Takahara, A., Taketani, A., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tennant, E., Themann, H., Todoroki, T., Tomášek, L., Tomášek, M., Torii, H., Towell, R. S., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Ujvari, B., Vale, C., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Virius, M., Vossen, A., Vrba, V., Vznuzdaev, E., Vértesi, R., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., White, S. N., Winter, D., Wolin, S., Woody, C. L., Wysocki, M., Xia, B., Yamaguchi, Y. L., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., Younus, I., You, Z., Yushmanov, I. E., Zajc, W. A., and Zelenski, A.

Subjects
Nuclear Experiment
Abstract

The PHENIX experiment measured the centrality dependence of two-pion Bose-Einstein correlation functions in $\sqrt{s_{_{NN}}}=200$~GeV Au$+$Au collisions at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory. The data are well represented by L\'evy-stable source distributions. The extracted source parameters are the correlation-strength parameter $\lambda$, the L\'evy index of stability $\alpha$, and the L\'evy-scale parameter $R$ as a function of transverse mass $m_T$ and centrality. The $\lambda(m_T)$ parameter is constant at larger values of $m_T$, but decreases as $m_T$ decreases. The L\'evy scale parameter $R(m_T)$ decreases with $m_T$ and exhibits proportionality to the length scale of the nuclear overlap region. The L\'evy exponent $\alpha(m_T)$ is independent of $m_T$ within uncertainties in each investigated centrality bin, but shows a clear centrality dependence. At all centralities, the L\'evy exponent $\alpha$ is significantly different from that of Gaussian ($\alpha=2$) or Cauchy ($\alpha=1$) source distributions. Comparisons to the predictions of Monte-Carlo simulations of resonance-decay chains show that in all but the most peripheral centrality class (50%-60%), the obtained results are inconsistent with the measurements, unless a significant reduction of the in-medium mass of the $\eta'$ meson is included. In each centrality class, the best value of the in-medium $\eta'$ mass is compared to the mass of the $\eta$ meson, as well as to several theoretical predictions that consider restoration of $U_A(1)$ symmetry in hot hadronic matter., Comment: 401 authors from 75 institutions, 20 pages, 15 figures, 2 tables. v1 is version submitted to Physical Review C. HEPdata tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2024

3. Measurement of $J/\psi$ and $\psi\left(2S\right)$ production in $p+p$ and $p+d$ interactions at 120 GeV

Author

Leung, C. H., Nagai, K., Nakano, K., Nawarathne, D., Dove, J., Prasad, S., Wuerfel, N., Aidala, C. A., Arrington, J., Ayuso, C., Barker, C. L., Brown, C. N., Chang, W. C., Chen, A., Christian, D. C., Dannowitz, B. P., Daugherity, M., Fassi, L. El, Geesaman, D. F., Gilman, R., Goto, Y., Guo, R., Hague, T. J., Holt, R. J., Hossain, M. F., Isenhower, D., Kinney, E., Klein, A., Kleinjan, D. W., Kudo, Y., Lin, P. -J., Liu, K., Liu, M. X., Lorenzon, W., McClellan, R. E., McGaughey, P. L., Medeiros, M. M., Miyachi, Y., Miyasaka, S., Morton, D. H., Nakahara, K., Nara, S., Pate, S. F., Peng, J. C., Pun, A., Ramson, B. J., Reimer, P. E., Rubin, J. G., Sanftl, F., Sawada, S., Sawada, T., Scott, M. B. C., Shibata, T. -A., Tadepalli, A. S., Teo, M., Towell, R. S., Uemura, S., Wang, S. G., Wickes, A. B., Wu, J., and Ye, Z. H.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

We report the $p+p$ and $p+d$ differential cross sections measured in the SeaQuest experiment for $J/\psi$ and $\psi\left(2S\right)$ production at 120 GeV beam energy covering the forward $x$-Feynman ($x_F$) range of $0.5 < x_F <0.9$. The measured cross sections are in good agreement with theoretical calculations based on the nonrelativistic QCD (NRQCD) using the long-distance matrix elements deduced from a recent global analysis of proton- and pion-induced charmonium production data. The $\sigma_{\psi\left(2S\right)} / \sigma_{J/\psi}$ cross section ratios are found to increase as $x_F$ increases, indicating that the $q \bar{q}$ annihilation process has larger contributions in the $\psi\left(2S\right)$ production than the $J/\psi$ production. The $\sigma_{pd}/2\sigma_{pp}$ cross section ratios are observed to be significantly different for the Drell-Yan process and $J/\psi$ production, reflecting their different production mechanisms. We find that the $\sigma_{pd}/2\sigma_{pp}$ ratios for $J/\psi$ production at the forward $x_F$ region are sensitive to the $\bar{d}/ \bar{u}$ flavor asymmetry of the proton sea, analogous to the Drell-Yan process. The transverse momentum ($p_T$) distributions for $J/\psi$ and $\psi\left(2S\right)$ production are also presented and compared with data collected at higher center-of-mass energies., Comment: 8 pages, 7 figures

Published
2024

4. Jet modification via $\pi^0$-hadron correlations in Au$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV

Author

PHENIX Collaboration, Abdulameer, N. J., Acharya, U., Adare, A., Afanasiev, S., Aidala, C., Ajitanand, N. N., Akiba, Y., Al-Bataineh, H., Alexander, J., Alfred, M., Aoki, K., Apadula, N., Aphecetche, L., Asai, J., Asano, H., Atomssa, E. T., Averbeck, R., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Baksay, G., Baksay, L., Baldisseri, A., Bandara, N. S., Bannier, B., Barish, K. N., Barnes, P. D., Bassalleck, B., Basye, A. T., Bathe, S., Batsouli, S., Baublis, V., Baumann, C., Bazilevsky, A., Beaumier, M., Beckman, S., Belikov, S., Belmont, R., Bennett, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Bickley, A. A., Blankenship, B., Blau, D. S., Boissevain, J. G., Bok, J. S., Borel, H., Borisov, V., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Bunce, G., Butsyk, S., Camacho, C. M., Campbell, S., Chang, B. S., Chang, W. C., Charvet, J. L., Chen, C. -H., Chen, D., Chernichenko, S., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Choudhury, R. K., Chujo, T., Chung, P., Churyn, A., Cianciolo, V., Citron, Z., Cole, B. A., Connors, M., Constantin, P., Corliss, R., Csanád, M., Csörgő, T., d'Enterria, D., Dahms, T., Dairaku, S., Danley, T. W., Das, K., Datta, A., Daugherity, M. S., David, G., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Dietzsch, O., Dion, A., Diss, P. B., Donadelli, M., Doomra, V., Do, J. H., Drapier, O., Drees, A., Drees, K. A., Dubey, A. K., Durham, J. M., Durum, A., Dutta, D., Dzhordzhadze, V., Efremenko, Y. V., Ellinghaus, F., En'yo, H., Engelmore, T., Enokizono, A., Esha, R., Eyser, K. O., Fadem, B., Feege, N., Fields, D. E., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S. L., Fraenkel, Z., Frantz, J. E., Franz, A., Frawley, A. D., Fujiwara, K., Fukao, Y., Fusayasu, T., Gallus, P., Gal, C., Garg, P., Garishvili, I., Ge, H., Giordano, F., Glenn, A., Gong, H., Gonin, M., Gosset, J., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guo, T., Gustafsson, H. -Å., Hachiya, T., Henni, A. Hadj, Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamilton, H. F., Hanks, J., Han, R., Han, S. Y., Hartouni, E. P., Haruna, K., Hasegawa, S., Haseler, T. O. S., Hashimoto, K., Haslum, E., Hayano, R., Heffner, M., Hemmick, T. K., Hester, T., He, X., Hill, J. C., Hodges, A., Hohlmann, M., Hollis, R. S., Holzmann, W., Homma, K., Hong, B., Horaguchi, T., Hornback, D., Hoshino, T., Hotvedt, N., Huang, J., Ichihara, T., Ichimiya, R., Iinuma, H., Ikeda, Y., Imai, K., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Ishihara, M., Isobe, T., Issah, M., Isupov, A., Ivanishchev, D., Jacak, B. V., Jezghani, M., Jiang, X., Jin, J., Ji, Z., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kajihara, F., Kametani, S., Kamihara, N., Kamin, J., Kanda, S., Kang, J. H., Kapustinsky, J., Kawall, D., Kazantsev, A. V., Kempel, T., Key, J. A., Khachatryan, V., Khanzadeev, A., Kijima, K. M., Kikuchi, J., Kimelman, B., Kim, B. I., Kim, C., Kim, D. H., Kim, D. J., Kim, E., Kim, E. -J., Kim, G. W., Kim, M., Kim, S. H., Kinney, E., Kiriluk, K., Kiss, Á., Kistenev, E., Kitamura, R., Klatsky, J., Klay, J., Klein-Boesing, C., Kleinjan, D., Kline, P., Koblesky, T., Kochenda, L., Komkov, B., Konno, M., Koster, J., Kotov, D., Kovacs, L., Kozlov, A., Kravitz, A., Král, A., Kunde, G. J., Kurgyis, B., Kurita, K., Kurosawa, M., Kweon, M. J., Kwon, Y., Kyle, G. S., Lai, Y. S., Lajoie, J. G., Layton, D., Lebedev, A., Lee, D. M., Lee, K. B., Lee, S., Lee, S. H., Lee, T., Leitch, M. J., Leite, M. A. L., Lenzi, B., Liebing, P., Lim, S. H., Litvinenko, A., Liu, H., Liu, M. X., Liška, T., Li, X., Lokos, S., Loomis, D. A., Love, B., Lynch, D., Maguire, C. F., Makdisi, Y. I., Makek, M., Malakhov, A., Malik, M. D., Manion, A., Manko, V. I., Mannel, E., Mao, Y., Masui, H., Matathias, F., Mašek, L., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Means, N., Meles, A., Mendoza, M., Meredith, B., Miake, Y., Mignerey, A. C., Mikeš, P., Miki, K., Milov, A., Mishra, D. K., Mishra, M., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Miyasaka, S., Mizuno, S., Mohanty, A. K., Montuenga, P., Moon, T., Morino, Y., Morreale, A., Morrison, D. P., Moukhanova, T. V., Mukhopadhyay, D., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagamiya, S., Nagashima, K., Nagle, J. L., Naglis, M., Nagy, M. I., Nakagawa, I., Nakagomi, H., Nakamiya, Y., Nakamura, T., Nakano, K., Nattrass, C., Netrakanti, P. K., Newby, J., Nguyen, M., Niida, T., Nishimura, S., Nouicer, R., Novitzky, N., Novák, T., Nukazuka, G., Nyanin, A. S., O'Brien, E., Oda, S. X., Ogilvie, C. A., Okada, K., Oka, M., Onuki, Y., Koop, J. D. Orjuela, Orosz, M., Osborn, J. D., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Palounek, A. P. T., Pantuev, V., Papavassiliou, V., Park, J., Park, J. S., Park, S., Park, W. J., Patel, M., Pate, S. F., Pei, H., Peng, J. -C., Pereira, H., Perepelitsa, D. V., Perera, G. D. N., Peresedov, V., Peressounko, D. Yu., Perry, J., Petti, R., Pinkenburg, C., Pinson, R., Pisani, R. P., Potekhin, M., Purschke, M. L., Purwar, A. K., Qu, H., Rakotozafindrabe, A., Rak, J., Ramson, B. J., Ravinovich, I., Read, K. F., Rembeczki, S., Reygers, K., Reynolds, D., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Rosendahl, S. S. E., Rosnet, P., Rowan, Z., Rubin, J. G., Rukoyatkin, P., Ružička, P., Rykov, V. L., Sahlmueller, B., Saito, N., Sakaguchi, T., Sakai, S., Sakashita, K., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Sato, T., Sawada, S., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seele, J., Seidl, R., Semenov, A. Yu., Semenov, V., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Silvestre, C., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Snowball, M., Soldatov, A., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Staley, F., Stankus, P. W., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Suire, C., Sukhanov, A., Sumita, T., Sun, J., Sun, Z., Sziklai, J., Takagui, E. M., Taketani, A., Tanabe, R., Tanaka, Y., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarján, P., Themann, H., Thomas, T. L., Tieulent, R., Timilsina, A., Todoroki, T., Togawa, M., Toia, A., Tomita, Y., Tomášek, L., Tomášek, M., Torii, H., Towell, C. L., Towell, R., Towell, R. S., Tram, V-N., Tserruya, I., Tsuchimoto, Y., Ujvari, B., Vale, C., Valle, H., van Hecke, H. W., Veicht, A., Velkovska, J., Vinogradov, A. A., Virius, M., Vrba, V., Vznuzdaev, E., Vértesi, R., Wang, X. R., Watanabe, Y., Watanabe, Y. S., Wei, F., Wessels, J., White, A. S., White, S. N., Winter, D., Woody, C. L., Wysocki, M., Xia, B., Xie, W., Xue, L., Yalcin, S., Yamaguchi, Y. L., Yamaura, K., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., Yoon, I., Yoo, J. H., Young, G. R., Younus, I., Yushmanov, I. E., Yu, H., Zajc, W. A., Zaudtke, O., Zelenski, A., Zhang, C., Zhou, S., Zolin, L., and Zou, L.

Subjects
Nuclear Experiment
Abstract

High-momentum two-particle correlations are a useful tool for studying jet-quenching effects in the quark-gluon plasma. Angular correlations between neutral-pion triggers and charged hadrons with transverse momenta in the range 4--12~GeV/$c$ and 0.5--7~GeV/$c$, respectively, have been measured by the PHENIX experiment in 2014 for Au$+$Au collisions at $\sqrt{s_{_{NN}}}=200$~GeV. Suppression is observed in the yield of high-momentum jet fragments opposite the trigger particle, which indicates jet suppression stemming from in-medium partonic energy loss, while enhancement is observed for low-momentum particles. The ratio and differences between the yield in Au$+$Au collisions and $p$$+$$p$ collisions, $I_{AA}$ and $\Delta_{AA}$, as a function of the trigger-hadron azimuthal separation, $\Delta\phi$, are measured for the first time at the Relativistic Heavy Ion Collider. These results better quantify how the yield of low-$p_T$ associated hadrons is enhanced at wide angle, which is crucial for studying energy loss as well as medium-response effects., Comment: 534 authors from 83 institutions, 12 pages, 7 figures. v1 is version submitted to Physical Review C. HEPdata tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2024

5. The present and future of QCD

Author

Achenbach, P., Adhikari, D., Afanasev, A., Afzal, F., Aidala, C.A., Al-bataineh, A., Almaalol, D.K., Amaryan, M., Androić, D., Armstrong, W.R., Arratia, M., Arrington, J., Asaturyan, A., Aschenauer, E.C., Atac, H., Avakian, H., Averett, T., Ayerbe Gayoso, C., Bai, X., Barish, K.N., Barnea, N., Basar, G., Battaglieri, M., Baty, A.A., Bautista, I., Bazilevsky, A., Beattie, C., Behera, S.C., Bellini, V., Bellwied, R., Benesch, J.F., Benmokhtar, F., Bernardes, C.A., Bernauer, J.C., Bhatt, H., Bhatta, S., Boer, M., Boettcher, T.J., Bogacz, S.A., Bossi, H.J., Brandenburg, J.D., Brash, E.J., Briceño, R.A., Briscoe, W.J., Brodsky, S.J., Brown, D.A., Burkert, V.D., Caines, H., Cali, I.A., Camsonne, A., Carman, D.S., Caylor, J., Cerci, D.S., Cerci, S., Chamizo Llatas, M., Chatterjee, S., Chen, J.P., Chen, Y., Chen, Y.-C., Chien, Y.-T., Chou, P.-C., Chu, X., Chudakov, E., Cline, E., Cloët, I.C., Cole, P.L., Connors, M.E., Constantinou, M., Cosyn, W., Covrig Dusa, S., Cruz-Torres, R., D'Alesio, U., da Silva, C., Davoudi, Z., Dean, C.T., Dean, D.J., Demarteau, M., Deshpande, A., Detmold, W., Deur, A., Devkota, B.R., Dhital, S., Diefenthaler, M., Dobbs, S., Döring, M., Dong, X., Dotel, R., Dow, K.A., Downie, E.J., Drachenberg, J.L., Dumitru, A., Dunlop, J.C., Dupre, R., Durham, J.M., Dutta, D., Edwards, R.G., Ehlers, R.J., El Fassi, L., Elaasar, M., Elouadrhiri, L., Engelhardt, M., Ent, R., Esumi, S., Evdokimov, O., Eyser, O., Fanelli, C., Fatemi, R., Fernando, I.P., Flor, F.A., Fomin, N., Frawley, A.D., Frederico, T., Fries, R.J., Gal, C., Gamage, B.R., Gamberg, L., Gao, H., Gaskell, D., Geurts, F., Ghandilyan, Y., Ghimire, N., Gilman, R., Gleason, C., Gnanvo, K., Gothe, R.W., Greene, S.V., Grießhammer, H.W., Grossberndt, S.K., Grube, B., Hackett, D.C., Hague, T.J., Hakobyan, H., Hansen, J.-O., Hatta, Y., Hattawy, M., Havener, L.B., Hen, O., Henry, W., Higinbotham, D.W., Hobbs, T.J., Hodges, A.M., Holmstrom, T., Hong, B., Horn, T., Howell, C.R., Huang, H.Z., Huang, M., Huang, S., Huber, G.M., Hyde, C.E., Isupov, E.L., Jacobs, P.M., Jalilian-Marian, J., Jentsch, A., Jheng, H., Ji, C.-R., Ji, X., Jia, J., Jones, D.C., Jones, M.K., Joosten, S., Kalantarians, N., Kalicy, G., Kang, Z.B., Karthein, J.M., Keller, D., Keppel, C., Khachatryan, V., Kharzeev, D.E., Kim, H., Kim, M., Kim, Y., King, P.M., Kinney, E., Klein, S.R., Ko, H.S., Koch, V., Kohl, M., Kovchegov, Y.V., Krintiras, G.K., Kubarovsky, V., Kuhn, S.E., Kumar, K.S., Kutz, T., Lajoie, J.G., Lauret, J., Lavrukhin, I., Lawrence, D., Lee, J.H., Lee, K., Lee, S., Lee, Y.-J., Li, S., Li, W., Li, Xiaqing, Li, Xuan, Liao, J., Lin, H.-W., Lisa, M.A., Liu, K.-F., Liu, M.X., Liu, T., Liuti, S., Liyanage, N., Llope, W.J., Loizides, C., Longo, R., Lorenzon, W., Lunkenheimer, S., Luo, X., Ma, R., McKinnon, B., Meekins, D.G., Mehtar-Tani, Y., Melnitchouk, W., Metz, A., Meyer, C.A., Meziani, Z.-E., Michaels, R., Michel, J.K.L., Milner, R.G., Mkrtchyan, H., Mohanmurthy, P., Mohanty, B., Mokeev, V.I., Moon, D.H., Mooney, I.A., Morningstar, C., Morrison, D.P., Müller, B., Mukherjee, S., Mulligan, J., Munoz Camacho, C., Murillo Quijada, J.A., Murray, M.J., Nadeeshani, S.A., Nadel-Turonski, P., Nam, J.D., Nattrass, C.E., Nijs, G., Noronha, J., Noronha-Hostler, J., Novitzky, N., Nycz, M., Olness, F.I., Osborn, J.D., Pak, R., Pandey, B., Paolone, M., Papandreou, Z., Paquet, J.-F., Park, S., Paschke, K.D., Pasquini, B., Pasyuk, E., Patel, T., Patton, A., Paudel, C., Peng, C., Peng, J.C., Pereira Da Costa, H., Perepelitsa, D.V., Peters, M.J., Petreczky, P., Pisarski, R.D., Pitonyak, D., Ploskon, M.A., Posik, M., Poudel, J., Pradhan, R., Prokudin, A., Pruneau, C.A., Puckett, A.J.R., Pujahari, P., Putschke, J., Pybus, J.R., Qiu, J.-W., Rajagopal, K., Ratti, C., Read, K.F., Reed, R., Richards, D.G., Riedl, C., Ringer, F., Rinn, T., Rittenhouse West, J., Roche, J., Rodas, A., Roland, G., Romero-López, F., Rossi, P., Rostomyan, T., Ruan, L., Ruimi, O.M., Saha, N.R., Sahoo, N.R., Sakaguchi, T., Salazar, F., Salgado, C.W., Salmè, G., Salur, S., Santiesteban, S.N., Sargsian, M.M., Sarsour, M., Sato, N., Satogata, T., Sawada, S., Schäfer, T., Scheihing-Hitschfeld, B., Schenke, B., Schindler, S.T., Schmidt, A., Seidl, R., Shabestari, M.H., Shanahan, P.E., Shen, C., Sheng, T.-A., Shepherd, M.R., Sickles, A.M., Sievert, M.D., Smith, K.L., Song, Y., Sorensen, A., Souder, P.A., Sparveris, N., Srednyak, S., Stahl Leiton, A.G., Stasto, A.M., Steinberg, P., Stepanyan, S., Stephanov, M., Stevens, J.R., Stewart, D.J., Stewart, I.W., Stojanovic, M., Strakovsky, I., Strauch, S., Strickland, M., Sunar Cerci, D., Suresh, M., Surrow, B., Syritsyn, S., Szczepaniak, A.P., Tadepalli, A.S., Tang, A.H., Tapia Takaki, J.D., Tarnowsky, T.J., Tawfik, A.N., Taylor, M.I., Tennant, C., Thiel, A., Thomas, D., Tian, Y., Timmins, A.R., Tribedy, P., Tu, Z., Tuo, S., Ullrich, T., Umaka, E., Upton, D.W., Vary, J.P., Velkovska, J., Venugopalan, R., Vijayakumar, A., Vitev, I., Vogelsang, W., Vogt, R., Vossen, A., Voutier, E., Vovchenko, V., Walker-Loud, A., Wang, F., Wang, J., Wang, X., Wang, X.-N., Weinstein, L.B., Wenaus, T.J., Weyhmiller, S., Wissink, S.W., Wojtsekhowski, B., Wong, C.P., Wood, M.H., Wunderlich, Y., Wyslouch, B., Xiao, B.W., Xie, W., Xiong, W., Xu, N., Xu, Q.H., Xu, Z., Yaari, D., Yao, X., Ye, Z., Ye, Z.H., Yero, C., Yuan, F., Zajc, W.A., Zhang, C., Zhang, J., Zhao, F., Zhao, Y., Zhao, Z.W., Zheng, X., Zhou, J., and Zurek, M.

Published
2024
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6. Comparative analysis of two dose-volume histogram prediction tools for treatment planning in volumetric-modulated arc therapy: A multi-planner study.

Author

Sasaki M, Nakaguchi Y, Kamomae T, Tsuzuki A, Sawada S, Shibuya K, Oita M, Tominaga M, Tominaga Y, and Ikushima H

Subjects
Humans, Organs at Risk, Radiotherapy Planning, Computer-Assisted methods, Radiotherapy, Intensity-Modulated methods, Radiotherapy Dosage
Abstract

The increase in high-precision radiation therapy, particularly volumetric-modulated arc therapy (VMAT), has increased patient numbers and expanded treatment sites. However, a significant challenge in VMAT treatment planning is the inconsistent plan quality among different planners and facilities. This study explored the use of dose-volume histogram (DVH) prediction tools to address these disparities, specifically focusing on RapidPlan (Varian Medical Systems) and PlanIQ (Sun Nuclear). RapidPlan predicts achievable DVHs and automatically generates optimization objectives. While it has demonstrated organ-at-risk (OAR) dose reduction benefits, the quality of the plan used to build its model significantly affects its predictions. On the other hand, PlanIQ offers ease of use and does not require prior model-building. Five planners participated in this study, each creating two treatment plans: one referencing RapidPlan and the other using PlanIQ. The planners had the freedom to adjust parameters while referencing the DVH predictions. The plans were evaluated using "Plan Quality Metric" (PQM) scores to assess the planning target volume excluding the rectum and OARs. The results revealed that RapidPlan-referenced plans often outperformed PlanIQ-based plans, with less interplanner variability. PlanIQ played a pivotal role in the construction of the RapidPlan model. This study is the first to compare plans generated by multiple planners using both tools. This study provides insights into optimizing treatment planning by considering the characteristics of both RapidPlan and PlanIQ., Competing Interests: Declaration of competing interest Yuji Nakaguchi is an employee of TOYO MEDIC Co., Ltd., (Copyright © 2024 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.)

Published
2024
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8. Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation.

Author

Kawana Y, Imai J, Morizawa YM, Ikoma Y, Kohata M, Komamura H, Sato T, Izumi T, Yamamoto J, Endo A, Sugawara H, Kubo H, Hosaka S, Munakata Y, Asai Y, Kodama S, Takahashi K, Kaneko K, Sawada S, Yamada T, Ito A, Niizuma K, Tominaga T, Yamanaka A, Matsui K, and Katagiri H

Subjects
Animals, Mice, Choline O-Acetyltransferase metabolism, Choline O-Acetyltransferase genetics, Vagus Nerve Stimulation methods, Male, Insulin-Secreting Cells metabolism, Insulin metabolism, Cell Proliferation, Insulin Secretion, Optogenetics methods, Vagus Nerve metabolism, Vagus Nerve physiology, Glucose metabolism
Abstract

The enhancement of insulin secretion and of the proliferation of pancreatic β cells are promising therapeutic options for diabetes. Signals from the vagal nerve regulate both processes, yet the effectiveness of stimulating the nerve is unclear, owing to a lack of techniques for doing it so selectively and prolongedly. Here we report two optogenetic methods for vagal-nerve stimulation that led to enhanced glucose-stimulated insulin secretion and to β cell proliferation in mice expressing choline acetyltransferase-channelrhodopsin 2. One method involves subdiaphragmatic implantation of an optical fibre for the photostimulation of cholinergic neurons expressing a blue-light-sensitive opsin. The other method, which suppressed streptozotocin-induced hyperglycaemia in the mice, involves the selective activation of vagal fibres by placing blue-light-emitting lanthanide microparticles in the pancreatic ducts of opsin-expressing mice, followed by near-infrared illumination. The two methods show that signals from the vagal nerve, especially from nerve fibres innervating the pancreas, are sufficient to regulate insulin secretion and β cell proliferation., (© 2023. The Author(s).)

Published
2024
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9. Postoperative Recurrence of Medication-Related Osteonecrosis of the Jaw: A Retrospective Study of 150 Patients Undergoing Surgery.

Author

Sawada S, Sakamoto Y, Kirihigashi M, and Kojima Y

Abstract

Introduction Surgery is the recommended treatment for medication-related osteonecrosis of the jaw (MRONJ). However, the disease may recur postoperatively. We reviewed imaging findings in patients undergoing three or more surgeries. Patients and methods One hundred fifty patients with MRONJ underwent surgery at our hospital. Here, we present the characteristics of 34 surgeries in nine patients (two men and seven women; mean age, 73.9 years) who underwent surgery at least three times. Results Three and six patients had maxillary and mandibular lesions, respectively. The primary disease was malignancy in eight patients, and denosumab was used in seven patients. All patients initially underwent either partial maxillectomy or marginal mandibulectomy, and segmental mandibulectomy was not performed. The number of surgeries ranged from three to six (average, 3.8). Healing was eventually achieved in seven cases, but not in two cases. Of the 27 unsuccessful surgeries, postoperative cone-beam computed tomography revealed no residual osteolysis, periosteal reaction, or osteosclerosis after seven surgeries and some residual lesions after 19 surgeries; imaging was not performed after one surgery. In contrast, among the seven successful surgeries, no residual osteolysis, periosteal reaction, or osteosclerosis was observed in all six cases in which postoperative computed tomography was performed. Conclusion Recurrence is more common in patients with residual areas of osteolysis, periosteal reactions, or mixed-type osteosclerosis, and including these areas in the resection is desirable., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Institutional Review Board (IRB) of Kansai Medical University issued approval 2022166. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Sawada et al.)

Published
2024
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10. Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022.

Author

Okamura T, Tsukamoto K, Arai H, Fujioka Y, Ishigaki Y, Koba S, Ohmura H, Shoji T, Yokote K, Yoshida H, Yoshida M, Deguchi J, Dobashi K, Fujiyoshi A, Hamaguchi H, Hara M, Harada-Shiba M, Hirata T, Iida M, Ikeda Y, Ishibashi S, Kanda H, Kihara S, Kitagawa K, Kodama S, Koseki M, Maezawa Y, Masuda D, Miida T, Miyamoto Y, Nishimura R, Node K, Noguchi M, Ohishi M, Saito I, Sawada S, Sone H, Takemoto M, Wakatsuki A, and Yanai H

Subjects
Humans, Japan epidemiology, Cardiovascular Diseases prevention & control, Societies, Medical, Atherosclerosis prevention & control
Published
2024
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11. A rapid simultaneous antigen detection of Haemophilus influenzae and Streptococcus pneumoniae for predicting the prognosis of acute otitis media.

Author

Kono M, Kamide Y, Tanaka T, Uno Y, Kanesada K, Suzuki C, Sawaki S, Kunimoto M, Kayama C, Suzuki K, Kudo F, Matsubara S, Sawada S, Goto Y, Uchizono A, Murakami D, Miyata T, Okamura N, and Hotomi M

Abstract

Background: Rapid identification of causative bacteria in treatment of acute otitis media (AOM) is of paramount importance for appropriate antibiotic use., Materials and Methods: This prospective observational study was conducted in 15 hospitals and clinics in Japan between 2018 and 2020. A new rapid antigen test kit (AOS-116), which simultaneously detects antigens for Streptococcus pneumoniae (Sp) and Haemophilus influenzae (Hi), was applied for middle ear fluids (MEFs) and nasopharyngeal secretions (NPSs) in patients with moderate to severe AOM. We investigated relationship between the results of rapid test, severity at initial visit, and clinical course., Results: Regarding performance accuracy based on culture results, AOS-116 showed 1) high (>80%) sensitivity, specificity, and negative predictive value (NPV) in MEFs for both antigens, 2) high sensitivity, specificity, and positive predictive value (PPV) in NPSs for Hi antigen, and 3) high specificity, and PPV in NPSs for Sp antigen. Regarding predictive value of nasopharyngeal culture and antigen detection for causative middle ear pathogens, similar results were observed between AOS-116 and culture, which was characterized with high sensitivity and NPV for both pathogens. MEFs/NPSs positive for Hi antigen were significantly associated with eardrum findings, and severity. MEFs/NPSs positive for pneumococcal antigen were significantly associated with severity of otalgia, fever, and otorrhea. Among patients with prior antimicrobial treatment, improvement tended to be slower in cases positive for Hi than in cases negative., Conclusion: The rapid antigen detection test is useful as a decision-making tool for prescribing antimicrobial agents and may play an important role in promoting appropriate antimicrobial use., Competing Interests: Declaration of competing interest The authors declare financial support from ASAHI KASEI Corporation. Takuji Miyata and Norikazu Okamura are employees of Asahi Kasei Corporation. The funder had no role in the experimental design, implementation of the study, interpretation of the data, or decision to submit the manuscript for publication. This does not alter the authors’ adherence to any publication policies on sharing data and materials., (Copyright © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.)

Published
2024
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12. Pathogenesis of Medication-Related Osteonecrosis of the Jaw: Odontogenic Infection-Preceding Type and Osteonecrosis-Preceding Type.

Author

Sakamoto Y, Sawada S, and Kojima Y

Abstract

Introduction Medication-related osteonecrosis of the jaw (MRONJ) develops from odontogenic infection. However, there are also some cases of MRONJ developing from sites with no teeth, no root canal lesions, or no periodontal disease. This study aimed to retrospectively review radiographic images of MRONJ cases and examine the differences in characteristics between MRONJ suspected to be related to dental infection (odontogenic MRONJ) and MRONJ that occurred without dental involvement or of unknown cause (non-odontogenic MRONJ). Materials and methods One hundred and forty-five patients were diagnosed with MRONJ at Kansai Medical University Hospital and Kansai Medical University Medical Center. The following variables were investigated: sex, age, primary disease, MRONJ site, body mass index, smoking habit, diabetes, corticosteroids, type of antiresorptive agent, administration period, CT findings (separation of sequestrum, osteolysis, periosteal reaction, and osteosclerosis), trigger, leukocytes, neutrocytes, neutrophil-lymphocyte ratio, serum albumin, and serum creatinine levels. Results In the univariate analysis, significant differences between odontogenic and non-odontogenic MRONJs were found in patients whose primary disease was malignancy, receiving denosumab (DMB), and with short administration period of antiresorptive agent, no osteolysis, periosteal reaction, and serum creatinine level. In multivariate analysis, non-odontogenic MRONJ was significantly more common in patients with no osteolysis and with periosteal reaction. Conclusion Non-odontogenic MRONJ tends to occur more frequently in patients treated with high-dose DMB, and there were significantly more cases of non-osteolytic MRONJ without radiographic evidence of osteolysis or with periosteal reactions., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Sakamoto et al.)

Published
2024
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14. CD69 Signaling in Eosinophils Induces IL-10 Production and Apoptosis via the Erk1/2 and JNK Pathways, Respectively.

Author

Bui DV, Nguyen LM, Kanda A, Chu HH, Thi Le NK, Yun Y, Kobayashi Y, Suzuki K, Mitani A, Shimamura A, Fukui K, Sawada S, Dombrowicz D, and Iwai H

Subjects
Animals, Humans, Mice, Antigens, CD metabolism, Apoptosis, Interleukin-10 genetics, Interleukin-10 metabolism, MAP Kinase Signaling System, Asthma metabolism, Eosinophils metabolism
Abstract

Introduction: Eosinophils contribute to the pathogenesis of allergic diseases, including asthma, allergic rhinitis, and atopic dermatitis. We previously reported that human tissue eosinophils have high CD69 expression compared to blood eosinophils, and its expression is correlated with disease severity and the number of infiltrated eosinophils. However, biological CD69 signaling activity in eosinophils remains unclear., Methods: CD69 expression on lung tissue eosinophils obtained from mice with ovalbumin-induced asthma was measured using flow cytometry. CD69 crosslinking was performed on eosinophils purified from the spleen of IL-5 transgenic mice to investigate CD69 signaling and its function in eosinophils. Then, qPCR, Western blot, enzyme-linked immunosorbent assay, and survival assay results were analyzed., Results: Surface CD69 expression on lung tissue eosinophils in the asthma mice model was 2.91% ± 0.76%, whereas no expression was detected in the healthy group. CD69-expressed eosinophils intrinsically have an upregulation of IL-10 mRNA expression. Moreover, CD69 crosslinking induced further pronounced IL-10 production and apoptosis; these responses were mediated via the Erk1/2 and JNK pathways, respectively., Conclusions: Our results suggested that CD69 + eosinophils play an immunoregulator role in type 2 inflammation, whereas activated tissue eosinophils contribute to the pathogenesis of asthma.

Published
2024
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15. Impact of Tumor Grade Distribution on Genetic Alterations in Clear Cell Renal Cell Carcinoma and Prostate Cancer.

Author

Mizutani K, Sugiyama S, Kameyama K, Kamei S, Yokoi S, Morikawa A, Takeuchi M, Seike K, Yamada T, Ehara H, Sawada S, Hirade K, Furuta H, Matsunaga K, Yamada T, Sakamoto I, Kato Y, Nishihara H, Ishihara S, and Deguchi T

Subjects
Male, Humans, Retrospective Studies, Mutation, Carcinoma, Renal Cell genetics, Prostatic Neoplasms genetics, Kidney Neoplasms genetics
Abstract

Background/aim: A genomic analysis based on next-generation sequencing is important for deciding cancer treatment strategies. Cancer tissue sometimes displays intratumor heterogeneity and a pathologic specimen may contain more than two tumor grades. Although tumor grades are very important for the cancer prognosis, the impact of higher tumor grade distribution in a specimen used for a genomic analysis is unknown., Patients and Methods: We retrospectively analyzed the data of 61 clear cell carcinoma and 46 prostate cancer patients that were diagnosed between December 2018 and August 2022 using the GeneRead Human Comprehensive Cancer Panel or SureSelect PrePool custom Tier2. Genome annotation and curation were performed using the GenomeJack software., Results: Tumor mutation burden (TMB) was increased in proportion to the higher tumor grade distribution in grade 2 clear cell renal cell carcinoma (ccRCC). In PC, Grade Group 3/4 specimens that included an increased distribution of Gleason pattern 4 had more frequent gene mutations., Conclusion: Our results suggest the importance of selecting the maximum distribution of higher tumor grade areas to obtain results on the precise gene alterations for genomics-focused treatments., (Copyright © 2024, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2024
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16. Medication-related osteonecrosis of the lower jaw without osteolysis on computed tomography images.

Author

Kojima Y, Sawada S, and Sakamoto Y

Subjects
Humans, Aged, Retrospective Studies, Diphosphonates therapeutic use, Tomography, X-Ray Computed, Bisphosphonate-Associated Osteonecrosis of the Jaw diagnostic imaging, Bisphosphonate-Associated Osteonecrosis of the Jaw surgery, Bisphosphonate-Associated Osteonecrosis of the Jaw drug therapy, Osteolysis diagnostic imaging, Osteolysis chemically induced, Bone Density Conservation Agents adverse effects, Neoplasms, Osteoporosis drug therapy
Abstract

Introduction: Surgery is the standard treatment for medication-related osteonecrosis of the jaw (MRONJ). This study reviewed patients with mandibular MRONJ who underwent surgical treatment, and in particular the characteristics of non-osteolytic MRONJ with no evidence of osteolysis on CT were described., Materials and Methods: We conducted a retrospective study of patients with mandibular MRONJ who underwent surgery between January 2016 and September 2022. Various clinical and imaging factors regarding treatment outcomes were investigated and analyzed. Additionally, the disease course of non-osteolytic MRONJ was examined in detail., Results: This study included 55 patients (66 surgeries) with a mean age of 74.7. The primary disease was osteoporosis (24 patients) and malignancy (31 patients); the type of antiresorptive agent was bisphosphonate (BP) in 21 patients and denosumab (DMB) in 26. BP was initially administered; however, it was changed to DMB in eight patients. Preoperatively, the cumulative cure rates for all 66 surgeries were 72.8% at 1 year and 77.3% at 2 years. Cure rates were significantly lower in patients with malignancy, those without osteolysis, and those who underwent sequestrum removal or marginal mandibulectomy than those with osteoporosis, osteolysis, and segmental mandibulectomy. Non-osteolytic MRONJ was observed in eight patients, all with malignancy and receiving high-dose DMB. Only two patients were cured after the initial surgery, and most patients ultimately underwent segmental mandibulectomy., Conclusions: Surgical treatment yielded good treatment outcomes in most patients with mandibular MRONJ; however, the cure rate was lower in patients with malignancy who showed no osteolysis on CT images., (© 2024. The Japanese Society Bone and Mineral Research.)

Published
2024
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17. Lower Risks of Gastrointestinal Perforation and Intestinal Obstruction in Patients with Atypical Antipsychotics in Comparison with Typical Antipsychotics Based on Real-World Data from the MID-NET ® in Japan.

Author

Hasegawa T, Sawada S, Saito T, Kohama M, Kajiyama K, Ishiguro C, Nonaka T, Okamura T, Iwasaki Y, Ueda T, Iguchi T, Horiuchi N, and Uyama Y

Subjects
Humans, Japan, Case-Control Studies, Benzodiazepines adverse effects, Antipsychotic Agents adverse effects, Intestinal Obstruction chemically induced
Abstract

Intestinal perforation and obstruction are known to be one of the adverse events caused by antipsychotics; however, warning information on package inserts varies among antipsychotics. To investigate the risks of gastrointestinal perforation and intestinal obstruction in patients prescribed atypical antipsychotics compared with those in patients prescribed typical antipsychotics, a nested case-control study was conducted utilizing real-world data from the MID-NET ® medical information database in Japan. The study period spanned from January 1, 2009, to December 31, 2018. We found that the risks of gastrointestinal perforation and intestinal obstruction in patients prescribed atypical antipsychotics were significantly lower than those in patients prescribed typical antipsychotics (adjusted odds ratio, 0.48; 95% confidence interval, 0.29-0.80). This finding was supported with prolonged periods for the exposure definition in the sensitivity analyses. In addition, no major differences in the risks of atypical antipsychotics, such as risperidone, quetiapine, olanzapine, and aripiprazole, were identified in this study. The safety profile regarding the lower risks of gastrointestinal perforation and intestinal obstruction in patients prescribed atypical antipsychotics should be considered when choosing antipsychotics in clinical practice in terms of the proper use of such drugs., (© 2023. The Author(s).)

Published
2024
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18. An Autopsy Case of Fulminant Myocarditis with Massive Left Ventricular Calcification.

Author

Yagi-Nakajima S, Miura M, Sawada S, Funaki T, Uchimura K, Susukita K, Hatakeyama T, Kagaya Y, Saito H, Sato K, Kanazawa M, Kondo M, Endo H, Yaegashi H, and Nakamura A

Subjects
Male, Humans, Middle Aged, Heart Ventricles, Myocardium pathology, Autopsy, Myocarditis pathology, Cardiomyopathies
Abstract

Myocardial calcification in myocarditis is rare and may be linked to poor outcomes. We herein report a case of fulminant myocarditis with massive myocardial calcification and its pathological outcomes at autopsy. A 49-year-old man experienced chest pain and was diagnosed with acute myocarditis. His cardiac function did not recover despite mechanical circulatory support in combination with V-A extracorporeal membrane oxygenation and IMPELLA CP ® . He eventually developed sepsis and gastrointestinal bleeding and died on day 27. Diffuse myocardial calcification was observed on computed tomography at autopsy. The pathological autopsy depicted that calcification filled every myocardial cell in the left ventricle.

Published
2024
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