12 results on '"Savi, M"'
Search Results
2. Step-by-step of 3D printing a head-and-neck phantom: Proposal of a methodology using fused filament fabrication (FFF) technology
- Author
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Savi, M., Villani, D., Andrade, B., Soares, F.A.P., Rodrigues Jr., O., Campos, L.L., and Potiens, M.P.A.
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- 2024
- Full Text
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3. Enhancing trustworthiness in ML-based network intrusion detection with uncertainty quantification
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Talpini, J, Sartori, F, Savi, M, Talpini J., Sartori F., Savi M., Talpini, J, Sartori, F, Savi, M, Talpini J., Sartori F., and Savi M.
- Abstract
A crucial role in the security of modern networks is played by Intrusion Detection Systems (IDSs), security devices designed to identify and mitigate attacks to networks structure. Data-driven approaches based on Machine Learning (ML) have gained more and more popularity for executing the classification tasks required by signature-based IDSs. However, typical ML models adopted for this purpose do not properly take into account the uncertainty associated with their prediction. This poses significant challenges, as they tend to produce misleadingly high classification scores for both misclassified inputs and inputs belonging to unknown classes (e.g. novel attacks), limiting the trustworthiness of existing ML-based solutions. In this paper, we argue that ML-based IDSs should always provide accurate uncertainty quantification to avoid overconfident predictions. In fact, an uncertainty-aware classification would be beneficial to enhance closed-set classification performance, would make it possible to carry out Active Learning, and would help recognize inputs of unknown classes as truly unknowns, unlocking open-set classification capabilities and Out-of-Distribution (OoD) detection. To verify it, we compare various ML-based methods for uncertainty quantification and open-set classification, either specifically designed for or tailored to the domain of network intrusion detection. Moreover, we develop a custom model based on Bayesian Neural Networks that stands out for its OoD detection capabilities and robustness, with a lower variance in the results over different scenarios, compared to other baselines, thus showing how proper uncertainty quantification can be exploited to significantly enhance the trustworthiness of ML-based IDSs.
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- 2024
4. Introducing packet-level analysis in programmable data planes to advance Network Intrusion Detection
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Doriguzzi-Corin, R, Knob, L, Mendozzi, L, Siracusa, D, Savi, M, Doriguzzi-Corin R., Knob L. A. D., Mendozzi L., Siracusa D., Savi M., Doriguzzi-Corin, R, Knob, L, Mendozzi, L, Siracusa, D, Savi, M, Doriguzzi-Corin R., Knob L. A. D., Mendozzi L., Siracusa D., and Savi M.
- Abstract
Programmable data planes offer precise control over the low-level processing steps applied to network packets, serving as a valuable tool for analysing malicious flows in the field of intrusion detection. Albeit with limitations on physical resources and capabilities, they allow for the efficient extraction of detailed traffic information, which can then be utilised by Machine Learning (ML) algorithms responsible for identifying security threats. In addressing resource constraints, existing solutions in the literature rely on compressing network data through the collection of statistical traffic features in the data plane. While this compression saves memory resources in switches and minimises the burden on the control channel between the data and the control plane, it also results in a loss of information available to the Network Intrusion Detection System (NIDS), limiting access to packet payload, categorical features, and the semantic understanding of network communications, such as the behaviour of packets within traffic flows. This paper proposes P4DDLe, a framework that exploits the flexibility of P4-based programmable data planes for packet-level feature extraction and pre-processing. P4DDLe leverages the programmable data plane to extract raw packet features from the network traffic, categorical features included, and to organise them in a way that the semantics of traffic flows are preserved. To minimise memory and control channel overheads, P4DDLe selectively processes and filters packet-level data, so that only the features required by the NIDS are collected. The experimental evaluation with recent Distributed Denial of Service (DDoS) attack data demonstrates that the proposed approach is very efficient in collecting compact and high-quality representations of network flows, ensuring precise detection of DDoS attacks.
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- 2024
5. Unleashing Dynamic Pipeline Reconfiguration of P4 Switches for Efficient Network Monitoring
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Sadi, A, Savi, M, Melis, A, Prandini, M, Callegati, F, Sadi A. A., Savi M., Melis A., Prandini M., Callegati F., Sadi, A, Savi, M, Melis, A, Prandini, M, Callegati, F, Sadi A. A., Savi M., Melis A., Prandini M., and Callegati F.
- Abstract
As it is happening in many fields that need efficient and effective classification of data, Machine Learning (ML) is becoming increasingly popular in network management and monitoring. In general we can say that ML algorithms are complex, therefore better suited for execution in the centralized control plane of modern networks, but are also heavily reliant on data, that are necessarily collected in the data plane. The inevitable consequence is that may arise the need to transfer lots of data from the data plane to the control plane, with the risk to cause congestion on the control communication channel. This may turn into a major drawback, since congestion on the control channel may have a significant impact on network operations. Therefore it is of paramount importance to design systems capable of minimizing the interaction between data and control planes while ensuring good monitoring performance. The most recent generation of data plane programmable switches supporting the P4 language can help mitigate this problem by preprocessing traffic data at line rate. In this manuscript we follow this approach and propose P4RTHENON: an architecture to distill in the data plane the relevant information to be mirrored to the control plane, where complex analysis can be performed. P4RTHENON leverages the P4-native support for runtime data plane pipeline reconfiguration to minimize the interaction between data and control planes while ensuring good monitoring performance. We tested our scheme on the volumetric DDoS detection use case: P4RTHENON reduces the volume of exchanged data by almost 75% compared to a pure control-plane-based solution, guarantees low memory consumption in the data plane, and does not degrade the overall DDoS detection capabilities.
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- 2024
6. Hierarchical Multiclass Continual Learning for Network Intrusion Detection
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Talpini, J, Sartori, F, Savi, M, Talpini, J, Sartori, F, and Savi, M
- Abstract
The evolution of Internet and its related communication technologies have consistently increased the risk of cyberattacks. In this context, a crucial role is played by Intrusion Detection Systems (IDSs), which are security devices designed to identify and mitigate attacks to modern networks. In the last decade, data-driven approaches based on Machine Learning (ML) have gained more and more popularity for executing the classification tasks required by signature based IDSs. However, typical ML models adopted for this purpose are trained in static settings while new attacks – and variants of known attacks – dynamically emerge over time. As a consequence, there is the need of keeping the IDS capability constantly updated, which poses peculiar challenges especially in resourced-constrained scenarios. To this end, we propose a novel hierarchical model based on a binary classification of benign and malicious traffic performed by a Bayesian Neural Network that is trained continuously and efficiently by exploiting Continual Learning. A generative multiclass classifier is then adopted to incrementally classify new kinds of attacks with respect to the malicious traffic. We prove the effectiveness of our approach showing that it removes the need of storing network traffic data samples related to historical data, representative of all the kinds of attacks, while ensuring good detection capabilities.
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- 2024
7. Comparing Actor-Critic and Neuroevolution Approaches for Traffic Offloading in FaaS-powered Edge Systems
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Petriglia, E, Filippini, F, Pracucci, G, Savi, M, Ciavotta, M, Petriglia, E, Filippini, F, Pracucci, G, Savi, M, and Ciavotta, M
- Abstract
In a computing context characterized by a complex and interconnected network of heterogeneous devices, which generate enormous amounts of data requiring exchange and near-real-time processing, the collaboration between Edge Computing and Function as a Service (FaaS) models holds significant potential to enhance the flexibility, cost-effectiveness, and responsiveness of applications. However, traditional FaaS encounters challenges in distributed edge environments due to dynamic traffic demands and resource limitations. Effective methodologies must be developed to address the load management issue, which involves determining the allocation of incoming requests to each node and deciding whether to process them locally, reject them, or offload them to neighboring nodes with available resources. This paper investigates and compares various approaches for managing incoming requests in a Decentralized FaaS environment. On the one hand, it considers Actor-Critic Reinforcement Learning algorithms, namely Proximal Policy Optimization (PPO) and Soft Actor-Critic (SAC). On the other hand, it examines the NeuroEvolution of Augmenting Topologies (NEAT) method. Experimental validation underscores the promising results of PPO, which ensures an average rejection rate of less than 4%.
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- 2024
8. Analysis and Evaluation of Load Management Strategies in a Decentralized FaaS Environment: A Simulation-Based Framework
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Filippini, F, Calmi, N, Cavenaghi, L, Petriglia, E, Savi, M, Ciavotta, M, Filippini, F, Calmi, N, Cavenaghi, L, Petriglia, E, Savi, M, and Ciavotta, M
- Abstract
The Edge Computing paradigm has emerged to address new requirements in data processing. This approach enables the decentralization of computation by bringing computing capabilities to the edge of the network, i.e., close to the data sources, offering various benefits such as reduced latency and minimal network bandwidth consumption. In this context, Function as a Service (FaaS) emerges as a versatile and efficient solution, representing a specific instantiation of the Serverless Computing model. FaaS provides a scalable and reactive infrastructure that can be effectively applied to Edge Computing. Given the limited resource capacity of Edge nodes, appropriate load balancing is crucial. However, conducting on-field testing of any designed solution for this purpose can be arduous and time-consuming. This work addresses this challenge by proposing a simulation-based framework to design and evaluate load-management policies in decentralized FaaS environments. Additionally, we validate and compare four different load-balancing strategies, each characterized by varying degrees of complexity. Our experimental campaign demonstrates the effectiveness of the framework and our load-management methods across different operational scenarios.
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- 2024
9. Adaptive control of cardiac rhythms.
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da Silva Lima G, Amorim Savi M, and Moreira Bessa W
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- Humans, Heart physiology, Computer Simulation, Electrocardiography, Sinoatrial Node physiology, Sinoatrial Node physiopathology, Heart Rate physiology, Models, Cardiovascular
- Abstract
Cardiac rhythms are related to heart electrical activity, being the essential aspect of the cardiovascular physiology. Usually, these rhythms are represented by electrocardiograms (ECGs) that are useful to detect cardiac pathologies. Essentially, the heart activity starts in the sinoatrial node (SA) node, the natural pacemaker, propagating to the atrioventricular node (AV), and finally reaching the His-Purkinje complex (HP). This paper investigates the control of cardiac rhythms in order to induce normal rhythms from pathological responses. A mathematical model that presents close agreement with experimental measurements is employed to represent the heart functioning. The adopted model comprises a network of three nonlinear oscillators that represent each one of the cardiac nodes, connected by delayed couplings. The pathological behavior is induced by an external stimulus in the SA node. An adaptive controller is proposed acting in the SA node considering an strategy based on the signal obtained by the natural pacemaker and its regularization. The incorporation of adaptive compensation in a Lyapunov-based control scheme allows the compensation for the unknown dynamics. The controller ability to deal with interpatient variability is evaluated by assuming that the heart model is not available to the controller design, being used only in the simulator to assess the control performance. Results show that the adaptive term can reduce the control effort by around 3% while reducing the tracking error by 20%, when compared to the conventional feedback approach. Additionally, the controller can avoid abnormal rhythms, turning the ECG closer to the expected normal behavior and preventing critical cardiac responses. Therefore, this work demonstrates that an adaptive controller can be used to regulate the ECG signal without prior information about the system and disregarding inter- and intrapatient variability., (© 2024. The Author(s).)
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- 2024
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10. Targeting NETosis in Acute Brain Injury: A Systematic Review of Preclinical and Clinical Evidence.
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Savi M, Su F, Sterchele ED, Bogossian EG, Demailly Z, Baggiani M, Casu GS, and Taccone FS
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- Animals, Humans, Biomarkers metabolism, Biomarkers blood, Extracellular Traps metabolism, Nucleosomes metabolism, Brain Injuries metabolism, Brain Injuries blood, Brain Injuries therapy
- Abstract
Acute brain injury (ABI) remains one of the leading causes of death and disability world-wide. Its treatment is challenging due to the heterogeneity of the mechanisms involved and the variability among individuals. This systematic review aims at evaluating the impact of anti-histone treatments on outcomes in ABI patients and experimental animals and defining the trend of nucleosome levels in biological samples post injury. We performed a search in Pubmed/Medline and Embase databases for randomized controlled trials and cohort studies involving humans or experimental settings with various causes of ABI. We formulated the search using the PICO method, considering ABI patients or animal models as population (P), comparing pharmacological and non-pharmacological therapy targeting the nucleosome as Intervention (I) to standard of care or no treatment as Control (C). The outcome (O) was mortality or functional outcome in experimental animals and patients affected by ABI undergoing anti-NET treatments. We identified 28 studies from 1246 articles, of which 7 were experimental studies and 21 were human clinical studies. Among these studies, only four assessed the effect of anti-NET therapy on circulating markers. Three of them were preclinical and reported better outcome in the interventional arm compared to the control arm. All the studies observed a significant reduction in circulating NET-derived products. NETosis could be a target for new treatments. Monitoring NET markers in blood and cerebrospinal fluid might predict mortality and long-term outcomes. However, longitudinal studies and randomized controlled trials are warranted to fully evaluate their potential, as current evidence is limited.
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- 2024
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11. Management of hepatorenal syndrome and treatment-related adverse events.
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Peluso L, Savi M, Coppalini G, Veliaj D, Villari N, Albano G, Petrou S, Pace MC, and Fiore M
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- Humans, Liver Cirrhosis complications, Liver Cirrhosis epidemiology, Liver Cirrhosis therapy, Vasoconstrictor Agents therapeutic use, Vasoconstrictor Agents adverse effects, Hepatorenal Syndrome therapy, Hepatorenal Syndrome etiology, Hepatorenal Syndrome epidemiology, Hepatorenal Syndrome diagnosis
- Abstract
Hepatorenal Syndrome is a critical complication of liver failure, mainly in cirrhotic patients and rarely in patients with acute liver disease. It is a complex spectrum of conditions that leads to renal dysfunction in the liver cirrhosis population; the pathophysiology is characterized by a specific triad: circulatory dysfunction, nitric oxide (NO) dysfunction and systemic inflammation but a specific kidney damage has never been demonstrated, in a clinicopathological study, kidney biopsies of patients with cirrhosis showed a wide spectrum of kidney damage. In addition, the absence of significant hematuria or proteinuria does not exclude renal damage. It is estimated that 40% of cirrhotic patients will develop hepatorenal syndrome with in-hospital mortality of about one-third of these patients. The burden of the problem is dramatic considering the worldwide prevalence of more than 10 million decompensated cirrhotic patients, and the age-standardized prevalence rate of decompensated cirrhosis has gone through a significant rise between 1990 and 2017. Given the syndrome's poor prognosis, the clinician must know how to manage early treatment and any complications. The widespread adoption of albumin and vasopressors has increased Hepatorenal syndrome-acute kidney injury reversal and may increase overall survival, as previously shown. Further research is needed to define whether the subclassification of patients may allow to find a personalized strategy to treat Hepatorenal Syndrome and to define the role of new molecules and extracorporeal treatment may allow better outcomes with a reduction in treatment-related adverse effects. This review aims to examine both pharmacological and non-pharmacological treatment of hepatorenal syndrome, with a particular focus on managing adverse events caused by treatment.
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- 2024
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12. Circulating Nucleosomes as a Novel Biomarker for Sepsis: A Scoping Review.
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Su F, Moreau A, Savi M, Salvagno M, Annoni F, Zhao L, Xie K, Vincent JL, and Taccone FS
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Circulating nucleosome levels are commonly elevated in physiological and pathological conditions. Their potential as biomarkers for diagnosing and prognosticating sepsis remains uncertain due, in part, to technical limitations in existing detection methods. This scoping review explores the possible role of nucleosome concentrations in the diagnosis, prognosis, and therapeutic management of sepsis. A comprehensive literature search of the Cochrane and Medline libraries from 1996 to 1 February 2024 identified 110 potentially eligible studies, of which 19 met the inclusion criteria, encompassing a total of 39 SIRS patients, 893 sepsis patients, 280 septic shock patients, 117 other ICU control patients, and 345 healthy volunteers. The enzyme-linked immunosorbent assay [ELISA] was the primary method of nucleosome measurement. Studies consistently reported significant correlations between nucleosome levels and other NET biomarkers. Nucleosome levels were higher in patients with sepsis than in healthy volunteers and associated with disease severity, as indicated by SOFA and APACHE II scores. Non-survivors had higher nucleosome levels than survivors. Circulating nucleosome levels, therefore, show promise as early markers of NETosis in sepsis, with moderate diagnostic accuracy and strong correlations with disease severity and prognosis. However, the available evidence is drawn mainly from single-center, observational studies with small sample sizes and varied detection methods, warranting further investigation.
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- 2024
- Full Text
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