25 results on '"Saleh Y"'
Search Results
2. Knowledge, attitude and community preparedness in facing flood disasters.
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Dapun, E., Saleh, Y., Ghazali, M. K. A., Mahat, H., Hashim, M., Nayan, N., Hayati, R., and Kurnia, R.
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COMMUNITY attitudes , *PEARSON correlation (Statistics) , *PREPAREDNESS , *DISASTERS , *FLOODS - Abstract
The purpose of this study is to look at the residents of Kota Belud, Sabah, Malaysia's knowledge, attitude, and preparedness in the event of a flood disaster. This study used a questionnaire instrument and a quantitative survey design method. Simple random selection was used to choose the study sample, which included 384 persons from the Kota Belud community. The study outcomes were analysed using descriptive analysis (frequency, percentage, mean, and standard deviation) and inferential analysis (One-Way ANOVA & Pearson Correlation). The results of the analysis showed that the level of knowledge (M= 4.51, SD= 0.40) and attitude (M= 4.62, SD= 0.35) was high while the preparedness (M= 3.62, SD= 0.46) was at a moderate level. The ANOVA results showed no significant difference between the knowledge (F= 2.489, p= 0.060) and attitudes (F= 2.252, p= 0.082) of the population-based on residence. However, there was a significant difference between population preparedness based on residence (F= 5.936, p= 0.001). Pearson correlation analysis showed a weak significant relationship between knowledge and attitudes towards community preparedness in the face of flood disasters with values of r= 0.128, p= 0.012 and r= 0.101, p= 0.048. The implications from the findings of this study show that most of the people of Kota Belud have a high level of knowledge and attitude in facing flood disasters, but the level of preparedness to face flood disasters is at a moderate level. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Understanding the element of 21st century education among teachers in Malaysia.
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Nayan, N., Khalid, N. H. Muhammad, Mahat, H., Hashim, M., Saleh, Y., Kurniawan, E., and Khotimah, N.
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TEACHER educators ,TEACHERS ,TEACHER education ,EDUCATIONAL planning ,LITERACY education - Abstract
Malaysia has introduced 21st-century learning initiatives through the Malaysia Education development plan 2013-2925. Among the focus are learning, teaching, and facilitation (TLF) by teachers in schools. This study aims to understand the knowledge, attitude, and practice of 21st-century education among teachers in the Rompin District, Pahang. This study employs a quantitative approach with the help of a questionnaire. The sample comprised 152 school teachers with simple random sampling techniques. This research employed a descriptive analysis and inferential analysis (Pearson correlation, t-test. The findings showed the moderate level for knowledge (M=2.95, SD=0.22), attitude (M=2.94, SD=0.23) and practices (M=2.90, SD=0.29). The t-test showed a significance difference between knowledge (t=-2.11, df=157, p<0.05) and attitude (t=-2.26, df=157, p<0.05) while there are no significant differences in practice (t=-1.81, df=157, p>0.05). Pearson correlation analysis showed a modest positive relationship between knowledge and practices (r=0.677, p<.01) and a high positive relationship between attitudes and practices (r=0.837, p<.1). In conclusion, the knowledge, attitude, and practices level are moderate among teachers. So, teachers need to improve their 21st-century education from time to time with, among others, short courses. Help from the obligatory authorities and academicians will increase teachers' awareness of 21st-century learning in their lives. This study's implications showed that 21st-century education literacy among teachers can increase the teachers' knowledge, attitude, and practice and always use 21st-century education in their teaching process. [ABSTRACT FROM AUTHOR]
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- 2024
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4. The competencies of non-option teachers in the teaching and learning of geography.
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Mahat, H., Hasan, S. N. Abu, Saleh, Y., Nayan, N., Hashim, M., Norkhaidi, S. B., Hamid, N., and Bikar, S. S.
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TEACHER competencies ,GEOGRAPHY ,GEOGRAPHY teachers ,PROFESSIONAL employee training ,VALUES (Ethics) ,STATISTICAL sampling - Abstract
This study aims to identify the competencies of non-option geography teachers in teaching and learning geography in Malaysian high schools. The survey method and questionnaires have been adopted while conducting this study. In the meantime, the respondents were chosen by using simple random sampling consisting of 142 non-option geography teachers who teach the subject in high schools registered under the Malaysian Ministry of Education. Several analyses are used to obtain a comprehensive outcome, including the descriptive and t-test analyses. The results show that the respondents are highly competent in the aspects of knowledge (Mean = 4.124, SD = 0.451); teaching and learning skills (Mean = 3.927, SD = 0.488) as well as professionalism values (Mean = 4.308, SD = 0.457). According to the t-test analysis, there are significant differences in knowledge competency, teaching and learning skills and professional values based on the duration of teaching experiences in geography (t = -2.38, df = 140, p < 0.05; t = -2.29, df = 140, p < 0.05; t = -2.09, df = 140, p < 0.05 respectively). To conclude, this study implies that non-option geography teachers have the ability to deliver a comprehensive knowledge due to their high competencies in teaching and learning skills in geography. The implication is that the schools as well as the Ministry of Education should encourage the development of competencies among non-option teachers through constructive programmes such as Program Intervensi Tambah Opsyen (PITO). [ABSTRACT FROM AUTHOR]
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- 2024
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5. Water quality index analysis in the upstream of Sook river, Sabah, Malaysia.
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Jupinis, J. N., Hashim, M., Nayan, N., Mahat, H., Saleh, Y., Zahid, M. S., and Koh, L. S.
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WATER quality ,WATER treatment plants ,WATER supply ,RUBBER plantations ,CONSUMPTION (Economics) ,WATER sampling - Abstract
Rivers are indispensable water resources for human needs such as domestic consumption, agricultural, and industrial purposes. This study aimed to determine the water quality in the upstream of Sook River, district of Keningau, Sabah, Malaysia. The field study was conducted between October 2018 and March 2019, during the wet season due to the Northeast Monsoon. Five water quality sampling stations in the upstream of Sook River area were chosen. And, six quality parameters, namely DO, BOD, COD, pH, NH
3 −N, and TSS, were collected to examine the water quality index of the Sook River. The results showed that only the DO parameter was in Class II, indicating that the Sook River was in good condition; COD, pH, and TSS parameters were in Class III (moderately polluted); and BOD and NH3 −N parameters were in Class IV (polluted). Based on the Malaysian WQI, the water quality during the study period was 59 (Class III), indicating a polluted condition. The field observations revealed that the primary sources of pollution in the upstream of Sook River were domestic waste discharge from settlement areas, agricultural activity (oil palm and rubber plantations), and logging near the upstream area. In conclusion, the water quality in the upstream of Sook River is classified as polluted (Class III). Thus, the upstream of Sook River's is unsafe for domestic consumption and must be treated further. Authorities must mitigate efforts to conserve the Sook River's water resources that supply raw water to the Lanas Village water treatment plant for domestic consumption. [ABSTRACT FROM AUTHOR]- Published
- 2024
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6. Understanding the element of 21st century education among teachers in Malaysia
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Nayan, N., primary, Khalid, N. H. Muhammad, additional, Mahat, H., additional, Hashim, M., additional, Saleh, Y., additional, Kurniawan, E., additional, and Khotimah, N., additional
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- 2024
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7. The Effect of Different Coating Agents on the Microhardness, Water Sorption, and Solubility of EQUIA Forte ® HT.
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Alqasabi, Saleh Y., Sulimany, Ayman M., Almohareb, Thamer, Alayad, Abdullah S., and Bawazir, Omar A.
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BOND strengths ,DENTAL glass ionomer cements ,SOLUBILITY ,MICROHARDNESS ,SORPTION ,SURFACE coatings ,WATER hardness ,ONE-way analysis of variance - Abstract
Objective: This study aimed to assess the effect of four different surface-coating agents on the microhardness, water sorption, and solubility of the highly viscous glass ionomer cement EQUIA Forte
® HT. Materials and methods: A total of 100 cylindrical EQUIA Forte® HT samples were examined, with 50 tested for Vickers hardness and the other 50 for water sorption and solubility. For each test, the specimens were divided into five groups (10 specimens/group) according to coating method: Group 1—no coating (control), Group 2—EQUIA Forte® Coat, Group 3—Single Bond™ Universal Adhesive, Group 4—ExciTE® F adhesive, and Group 5—petroleum jelly. Data were analyzed using the paired t-test, one-way analysis of variance, and Tukey's post hoc test for multiple comparisons. Statistical significance was set at p < 0.05. Results: The mean microhardness of the coated groups was significantly higher than that of the uncoated group. Moreover, a significant difference in the microhardness value was detected between the coated groups. Furthermore, EQUIA Forte® Coat had the highest mean hardness value. The mean water sorption at 7 days showed that EQUIA Forte® Coat had the lowest values. In terms of water solubility, a statistically significant difference was found between no coating and all groups except EQUIA Forte® , between Single Bond Universal Adhesive and petroleum jelly, between petroleum jelly and EQUIA Forte Coat, and between EQUIA Forte® Coat and ExciTE® F. Conclusions: The study revealed that all coating agents significantly increased the microhardness of EQUIA Forte® HT, with EQUIA Forte® Coat showing the highest hardness and the lowest water sorption values. [ABSTRACT FROM AUTHOR]- Published
- 2024
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8. Enhancing local garlic industry performance through marketing chain analysis.
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Puspitasari, Kiloes, A M, Saleh, Y, Hayati, N Q, Nurmalinda, Sugandi, D, Swastika, D K S, Sulistyaningrum, A, Waryat, and Rinaldi, J
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- 2024
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9. Understanding the element of 21stcentury education among teachers in Malaysia
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Nayan, N., Khalid, N. H. Muhammad, Mahat, H., Hashim, M., Saleh, Y., Kurniawan, E., and Khotimah, N.
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- 2024
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10. The effects of social media platforms in influencing consumer behavior and improving business objectives
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Ahmad Hanandeh, Ghazy Al-Badaineh, Qais Kilani, Saleh Yahya AL Freijat, Ghaith Abualfalayeh, and Mohamad Ahmad Saleem Khasawneh
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Social Sciences ,Management. Industrial management ,HD28-70 - Abstract
This research focuses on studying the effect of using social media platforms on customer behavior and business objectives in Jordan. The research chose three of the most famous platforms of social media and those platforms are Facebook, Instagram, and Twitter. By using a quantitative model this research collected around 350 research questionnaires using digital surveys designed by using Google drive and distributed online on previous social media platforms. The research analysis process is executed by using AMOS software, and this comprised structural equations (SEM) modeling and regression analyses. The research study output found strong effects and relationships between social media platforms engagement and a variety of consumer expenditure variables, including brand loyalty, product suggestions, and purchase decisions. Important components of each platform, including user interaction, influencer endorsements, and content relevancy, were also identified by the study as having a direct effect on consumer behavior. The research also showed how businesses may achieve their marketing objectives, boost customer engagement, and enhance their reputation by utilizing social media strategies. The significance of social media website platforms in shaping consumer behavior and propelling business success is highlighted by these studies. To reach their goals and have the most influence on customer decisions, businesses should think about using platform-specific features and investing in targeted social media advertising.
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- 2024
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11. Status and long-term changes of coral reefs around Zanzibar
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Ali M. Ussi, Mohammed S. Mohammed, Rashid J. Rashid, Mohammed A. Sheikh, Peter A. Staehr, Christopher A. Muhando, Saleh Yahya, and Karsten Dahl
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coral reef ,community structure ,zonation ,seasonality ,long-term changes ,Zanzibar ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
IntroductionCoral reefs as key ecosystems in Zanzibar are exposed to several anthropogenic and natural stressors.MethodsThe benthic composition and coverage of coral reefs were investigated on three data sets involving ten coral reefs monitored from 1992 to 2016. Firstly, we investigated differences in the reef composition using data from seven reefs in 2015. Secondly, we analyzed communities on three distinctive reefs (2010 to 2012) to understand the importance of seasons and reef zones (slope, crest and flat) on species abundance. Finally, we investigated long-term changes (1992 to 2016) of five reefs.ResultsBranching Porites and Acropora, and soft coral order Corallimorpharia, characterized sheltered reef communities. Soft corals and algal species characterized the reef communities exposed to strong hydrodynamic conditions, which also displayed greater cover of rocks and rubbles. The average dissimilarity between reefs ranged between 60% and 75%. The seasonal changes in community structure for reefs near Stone Town were mostly associated with soft coral Corallimorpharia. Indeed, the bare rock and algae distinguished the northern exposed reef from more sheltered reefs. Acropora was a key genus for the sheltered Chumbe reef, which explained between 14% and 18% of the dissimilarities among the three reefs. Hard corals covered between 40% and 70% in most years, with severe declines following El Niño events in 1998 and 2016. The dominating genus Acropora showed a strong decline from the late 1990s’ with signs of recovery at remote reefs compared to reefs closer to human residence.DiscussionOur results highlight the importance of seasonality and spatial differences, reflecting differences in human impact and physical exposure and significant long-term changes in coral communities. Continued monitoring of reef health is essential to evaluate the success of ongoing management to sustain the reef services.
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- 2024
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12. Is it justified to use liver graft from living donor for retransplantation? Single center experience.
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Zakaria, H., Saleh, Y., Zidan, A., Sturdevant, M., Alabbad, S., Elsheikh, Y., Alhamoudi, W., Albenmousa, A., Troisi, R., and Broering, D.
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- 2024
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13. Analysis of thermal decomposition kinetics of chicken feather fiber reinforced Poly-lactic acid composites filament
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Adil Khan, Saleh Yahya Alghamdi, Ali Saeed Almuflih, Amal Abdulrahman, Karishma M. Qureshi, Naif Almakayeel, and Mohamed Rafik N. Qureshi
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Chicken feather fiber (CFF) ,Polylactic acid (PLA) ,Biocomposites ,TGA ,Activation energy ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Derivative Thermogravimetric analysis under air was used to observe the thermal decomposition process of Chicken feather fiber (CFF) reinforced Poly-lactic acid (PLA) composite filament of 2.2 mm diameter. The thermal degradation of the sample was initiated at 140 ֯C. Approximately 75 % of the thermal degradation occurred between the temperature of 357 ֯C and 399 ֯C. The composite's activation energy was established using the Coats-Redfern method. The results showed that the activation energy of 112.06 kJ/mol is utilized for the sample throughout the temperature range of 23 ֯C to 398 ֯C. A low activation energy is indicative of rapid chemical reactions between the CFF and PLA molecules. The results from TGA and DTGA indicate that the addition of CFF in the PLA matrix enhanced the thermal stability.
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- 2024
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14. The potential utilisation of rice biomass for biochar to support sustainable rice farming development in Indonesia
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Ariningsih Ening, Ashari, Mardiharini Maesti, Sujianto, Irawan, Rahayu Heni S.P., Saleh Yopi, Slameto, Suharyon, and Septanti Kartika S.
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Microbiology ,QR1-502 ,Physiology ,QP1-981 ,Zoology ,QL1-991 - Abstract
As a rice-producing country, Indonesia has abundant rice biomass in the forms of rice straw and rice husk (hull). Nevertheless, this resource has not been utilised to its fullest potential. This paper aims to assess the potential utilisation of rice biomass for biochar to support sustainable rice farming development through circular economics. A literature review method was applied in this paper, exploring the relevant articles published primarily in journals within the last ten years. The study results show that biochar serves as a soil amendment, and its application on agricultural land can improve soil properties and soil fertility, resulting in higher crop productivity and enhancing sustainability. Based on rice production data released by BPS-Statistics Indonesia, it is estimated that approximately 10.10 million tons of rice husk and 83.29 tons of dry rice straw are generated annually during 2018−2022, which can potentially be processed into 33.04 million tons of biochar. Applying 2 tons of biochar per hectare can increase rice productivity by at least 4%, resulting in a potential increase in rice production of at least 2.22 million tons annually. The government needs to facilitate farmers in rice-producing centres with biochar processing units using appropriate technology on a proper scale.
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- 2024
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15. Association of body shape phenotypes and body fat distribution indexes with inflammatory biomarkers in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank.
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González-Gil EM, Peruchet-Noray L, Sedlmeier AM, Christakoudi S, Biessy C, Navionis AS, Mahamat-Saleh Y, Jaafar RF, Baurecht H, Guevara M, Etxezarreta PA, Verschuren WMM, Boer JMA, Olsen A, Tjønneland A, Simeon V, Castro-Espin C, Aune D, Heath AK, Gunter M, Colorado-Yohar SM, Zilhão NR, Dahm CC, Llanaj E, Schulze MB, Petrova D, Sieri S, Ricceri F, Masala G, Key T, Viallon V, Rinaldi S, Freisling H, and Dossus L
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- Female, Humans, Male, Anthropometry methods, Body Mass Index, C-Reactive Protein analysis, Cross-Sectional Studies, Europe epidemiology, Inflammation, Phenotype, Prospective Studies, UK Biobank, United Kingdom epidemiology, Biomarkers blood, Body Fat Distribution
- Abstract
Background: The allometric body shape index (ABSI) and hip index (HI), as well as multi-trait body shape phenotypes, have not yet been compared in their associations with inflammatory markers. The aim of this study was to examine the relationship between novel and traditional anthropometric indexes with inflammation using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts., Methods: Participants from EPIC (n = 17,943, 69.1% women) and UK Biobank (n = 426,223, 53.2% women) with data on anthropometric indexes and C-reactive protein (CRP) were included in this cross-sectional analysis. A subset of women in EPIC also had at least one measurement for interleukins, tumour necrosis factor alpha, interferon gamma, leptin, and adiponectin. Four distinct body shape phenotypes were derived by a principal component (PC) analysis on height, weight, body mass index (BMI), waist (WC) and hip circumferences (HC), and waist-to-hip ratio (WHR). PC1 described overall adiposity, PC2 tall with low WHR, PC3 tall and centrally obese, and PC4 high BMI and weight with low WC and HC, suggesting an athletic phenotype. ABSI, HI, waist-to-height ratio and waist-to-hip index (WHI) were also calculated. Linear regression models were carried out separately in EPIC and UK Biobank stratified by sex and adjusted for age, smoking status, education, and physical activity. Results were additionally combined in a random-effects meta-analysis., Results: Traditional anthropometric indexes, particularly BMI, WC, and weight were positively associated with CRP levels, in men and women. Body shape phenotypes also showed distinct associations with CRP. Specifically, PC2 showed inverse associations with CRP in EPIC and UK Biobank in both sexes, similarly to height. PC3 was inversely associated with CRP among women, whereas positive associations were observed among men., Conclusions: Specific indexes of body size and body fat distribution showed differential associations with inflammation in adults. Notably, our results suggest that in women, height may mitigate the impact of a higher WC and HC on inflammation. This suggests that subtypes of adiposity exhibit substantial variation in their inflammatory potential, which may have implications for inflammation-related chronic diseases., (© 2024. The Author(s).)
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- 2024
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16. Cancer Care Terminology in African Languages.
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Simba H, Mutebi M, Galukande M, Mahamat-Saleh Y, Aglago E, Addissie A, Abebe LG, Onwuka J, Odongo GA, Onyije FM, Chimera B, Motlhale M, de Paula Silva N, Malope D, Narh CT, Msoka EF, Schüz J, Prah E, and McCormack V
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- Humans, Africa ethnology, Female, Male, Surveys and Questionnaires, Adult, Middle Aged, Health Personnel psychology, Neoplasms therapy, Language, Terminology as Topic
- Abstract
Importance: Effective communication between patients and health care teams is essential in the health care setting for delivering optimal cancer care and increasing cancer awareness. While the significance of communication in health care is widely acknowledged, the topic is largely understudied within African settings., Objective: To assess how the medical language of cancer and oncology translates into African languages and what these translations mean within their cultural context., Design, Setting, and Participants: In this multinational survey study in Africa, health professionals, community health workers, researchers, and scientists involved in cancer care and research and traditional healers were invited to participate in an online survey on a voluntary basis through online platforms. The survey provided 16 cancer and oncologic terms used in cancer diagnosis and treatment (eg, cancer, radiotherapy) to participants, mostly health care workers, who were asked to provide these terms in their local languages (if the terms existed) followed by a direct or close translation of the meaning in English. The survey was open from February to April 2023., Main Outcomes and Measures: Patterns of meaning that recurred across languages were identified using thematic analysis of 16 English-translated terms categorized into 5 themes (neutral, negative, positive, phonetic or borrowed, and unknown)., Results: A total of 107 responses (response rate was unavailable given the open and widespread distribution strategy) were collected from 32 countries spanning 44 African languages, with most participants (63 [59%]) aged 18 to 40 years; 54 (50%) were female. Translations for cancer were classified as phonetic or borrowed (34 [32%]), unknown (30 [28%]), neutral (24 [22%]), and negative (19 [18%]), with the latter category including universal connotations of fear, tragedy, incurability, and fatality. Similar elements connoting fear or tragedy were found in translations of terms such as malignant, chronic, and radiotherapy. The term radiotherapy yielded a high percentage of negative connotations (24 [22%]), with a prevailing theme of describing the treatment as being burned or burning with fire, heat, or electricity, which may potentially hinder treatment., Conclusions and Relevance: In this survey study of cancer communication and the translation of oncology terminology in African languages, the findings suggest that the terminology may contribute to fear, health disparities, and barriers to care and pose communication difficulties for health professionals. The results reinforce the need for culturally sensitive cancer terminology for improving cancer awareness and communication.
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- 2024
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17. IOF position on scientists and societies operating in conflict zones.
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Kanis JA, Dawson-Hughes B, Campusano C, Cooper C, Ebeling PR, Halbout P, Harvey NC, McCloskey EV, McClung MR, Reginster JY, Saleh Y, Zakraoui L, and Jiwa F
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- Humans, Societies, Medical, Osteoporosis, Biomedical Research standards, Armed Conflicts
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This position paper of the International Osteoporosis Foundation reports the findings of an IOF Commission to consider to recommend rules of partnership with scientists belonging to a country which is currently responsible for an armed conflict, anywhere in the world. The findings and recommendations have been adopted unanimously by the Board of IOF., (© 2024. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.)
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- 2024
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18. The single point insulin sensitivity estimator (SPISE) is associated with bone health in Arab adults.
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Al-Daghri NM, Wani K, Khattak MNK, Alnaami AM, Al-Saleh Y, and Sabico S
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- Humans, Female, Male, Middle Aged, Saudi Arabia, Osteoporosis, Aged, Adult, Bone Density physiology, Arabs, Insulin Resistance physiology
- Abstract
Background: The Single Point Insulin Sensitivity Estimator (SPISE) index is a surrogate marker for insulin sensitivity. Given the emerging role of bone as an active endocrine organ, its associations with non-invasive measures of extra-skeletal functions such as insulin sensitivity warrant investigation., Aims: This study aimed to explore the relationship between the SPISE index and Bone Mineral Density (BMD) in an adult population., Methods: Data from a total of 1270 Arab adults (84% females, mean age 56.7 ± 8.1 years) from the Osteoporosis Registry Database of the Chair for Biomarkers of Chronic Diseases in King Saud University, Riyadh, Saudi Arabia was used in this study. T-scores and SPISE were calculated. Regression models were used to determine associations between SPISE and bone health indices., Results: The low BMD group (N = 853; T-score <-1.0) had significantly higher SPISE values than those with normal BMD (N = 417; T-score - 1.0 and above) (4.6 ± 1.3 vs. 4.3 ± 1.2, p < 0.001). Multivariate linear regression, adjusted for covariates, confirmed a significant inverse association between SPISE and BMD for all participants (β=-0.22, p < 0.001), as well as both groups [normal BMD (β = -0.10, p = 0.02) and low BMD groups (β = -0.15, p < 0.001)]. SPISE, family history of T2DM, and history of fractures collectively account for 17% of the variances perceived in T-score for all participants (p < 0.001)., Conclusions: A significant inverse association between the SPISE index and BMD was observed in adults, suggesting a link between BMD and extra-skeletal health. Underlying mechanisms need to be investigated prospectively using BMD as secondary outcomes in lifestyle modification programs., (© 2024. The Author(s).)
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- 2024
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19. Hepatocellular Carcinoma: The Evolving Role of Systemic Therapies as a Bridging Treatment to Liver Transplantation.
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Saleh Y, Abu Hejleh T, Abdelrahim M, Shamseddine A, Chehade L, Alawabdeh T, Mohamad I, Sammour M, and Turfa R
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Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths. Classically, liver transplantation (LT) can be curative for HCC tumors within the Milan criteria. Bridging strategies to reduce the dropouts from LT waiting lists and/or to downstage patients who are beyond the Milan criteria are widely utilized. We conducted a literature-based review to evaluate the role of systemic therapies as a bridging treatment to liver transplantation (LT) in HCC patients. Tyrosine kinase inhibitors (TKIs) can be used as a systemic bridging therapy to LT in patients with contraindications for locoregional liver-directed therapies. Immune checkpoint inhibitor (ICI) treatment can be utilized either as a monotherapy or as a combination therapy with bevacizumab or TKIs prior to LT. Acute rejection after liver transplantation is a concern in the context of ICI treatment. Thus, a safe ICI washout period before LT and cautious post-LT immunosuppression strategies are required to reduce post-LT rejections and to optimize clinical outcomes. Nevertheless, prospective clinical trials are needed to establish definitive conclusions about the utility of systemic therapy as a bridging modality prior to LT in HCC patients.
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- 2024
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20. Evidence-Based Guideline for the management of osteoporosis in men.
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Fuggle NR, Beaudart C, Bruyère O, Abrahamsen B, Al-Daghri N, Burlet N, Chandran M, Rosa MM, Cortet B, Demonceau C, Dere W, Halbout P, Hiligsmann M, Kanis JA, Kaufman JM, Kurth A, Lamy O, Laslop A, Maggi S, Matijevic R, McCloskey E, Mobasheri A, Prieto Yerro MC, Radermecker RP, Sabico S, Al-Saleh Y, Silverman S, Veronese N, Rizzoli R, Cooper C, Reginster JY, and Harvey NC
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- Male, Female, Humans, Bone Density, Osteoporosis diagnosis, Osteoporosis drug therapy, Fractures, Bone, Musculoskeletal Diseases, Osteoarthritis complications
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Historically, osteoporosis has been viewed as a disease of women, with research, trials of interventions and guidelines predominantly focused as such. It is apparent, however, that this condition causes a substantial health burden in men also, and that its assessment and management must ultimately be addressed across both sexes. In this article, an international multidisciplinary working group of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases presents GRADE-assessed recommendations for the diagnosis, monitoring and treatment of osteoporosis in men. The recommendations are based on a comprehensive review of the latest research related to diagnostic and screening approaches for osteoporosis and its associated high fracture risk in men, covering disease burden, appropriate interpretation of bone densitometry (including the use of a female reference database for densitometric diagnosis in men) and absolute fracture risk, thresholds for treatment, and interventions that can be used therapeutically and their health economic evaluation. Future work should specifically address the efficacy of anti-osteoporosis medications, including denosumab and bone-forming therapies., (© 2024. Springer Nature Limited.)
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- 2024
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21. The influence of reward sensitivity on weight in treatment-resistant chronic schizophrenia.
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Jarratt Barnham I, Saleh Y, Hussain M, and Fernandez-Egea E
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- 2024
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22. Dietary index based on the Food Standards Agency nutrient profiling system and risk of Crohn's disease and ulcerative colitis.
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Meyer A, Dong C, Chan SSM, Touvier M, Julia C, Huybrechts I, Nicolas G, Oldenburg B, Heath AK, Tong TYN, Key TJ, Tjønneland A, Kyrø C, Kaaks R, Katzke VA, Bergman MM, Palli D, Masala G, Tumino R, Sacerdote C, Colorado-Yohar SM, Sánchez MJ, Guevara M, Grip O, Holmgren J, Cross A, Karling P, Hultdin J, Murphy N, Deschasaux-Tanguy M, Hercberg S, Galan P, Mahamat-Saleh Y, Amiot A, Gunter MJ, Boutron-Ruault MC, and Carbonnel F
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- Humans, Female, Middle Aged, Male, Prospective Studies, Diet adverse effects, Fruit, Nutrients, Risk Factors, Colitis, Ulcerative diagnosis, Colitis, Ulcerative epidemiology, Colitis, Ulcerative etiology, Crohn Disease diagnosis, Crohn Disease epidemiology, Crohn Disease etiology
- Abstract
Background: Nutri-score is now widely available in food packages in Europe., Aim: To study the overall nutritional quality of the diet in relation to risks of Crohn's disease (CD) and ulcerative colitis (UC), in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort METHODS: We collected dietary data at baseline from validated food frequency questionnaires. We used a dietary index based on the UK Food Standards Agency modified nutrient profiling system (FSAm-NPS-DI) underlying the Nutri-Score label, to measure the nutritional quality of the diet. We estimated the association between FSAm-NPS-DI score, and CD and UC risks using Cox models stratified by centre, sex and age; and adjusted for smoking status, BMI, physical activity, energy intake, educational level and alcohol intake., Results: We included 394,255 participants (68.1% women; mean age at recruitment 52.1 years). After a mean follow-up of 13.6 years, there were 184 incident cases of CD and 459 incident cases of UC. Risk of CD was higher in those with a lower nutritional quality, that is higher FSAm-NPS-DI Score (fourth vs. first quartile: aHR: 2.04, 95% CI: 1.24-3.36; p-trend: <0.01). Among items of the FSAm-NPS-DI Score, low intakes of dietary fibre and fruits/vegetables/legumes/nuts were associated with higher risk of CD. Nutritional quality was not associated with risk of UC (fourth vs. first quartile of the FSAm-NPS-DI Score: aHR: 0.91, 95% CI: 0.69-1.21; p-trend: 0.76)., Conclusions: A diet with low nutritional quality as measured by the FSAm-NPS-DI Score is associated with a higher risk of CD but not UC., (© 2023 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
23. Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation in Vitro , in Both a Normal and Inflammatory Milieu.
- Author
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Ricotti L, Cafarelli A, Manferdini C, Trucco D, Vannozzi L, Gabusi E, Fontana F, Dolzani P, Saleh Y, Lenzi E, Columbaro M, Piazzi M, Bertacchini J, Aliperta A, Cain M, Gemmi M, Parlanti P, Jost C, Fedutik Y, Nessim GD, Telkhozhayeva M, Teblum E, Dumont E, Delbaldo C, Codispoti G, Martini L, Tschon M, Fini M, and Lisignoli G
- Subjects
- Nanogels, Hydrogels pharmacology, Cell Differentiation, Tissue Engineering, Chondrogenesis, Proteomics
- Abstract
The use of piezoelectric nanomaterials combined with ultrasound stimulation is emerging as a promising approach for wirelessly triggering the regeneration of different tissue types. However, it has never been explored for boosting chondrogenesis. Furthermore, the ultrasound stimulation parameters used are often not adequately controlled. In this study, we show that adipose-tissue-derived mesenchymal stromal cells embedded in a nanocomposite hydrogel containing piezoelectric barium titanate nanoparticles and graphene oxide nanoflakes and stimulated with ultrasound waves with precisely controlled parameters (1 MHz and 250 mW/cm
2 , for 5 min once every 2 days for 10 days) dramatically boost chondrogenic cell commitment in vitro . Moreover, fibrotic and catabolic factors are strongly down-modulated: proteomic analyses reveal that such stimulation influences biological processes involved in cytoskeleton and extracellular matrix organization, collagen fibril organization, and metabolic processes. The optimal stimulation regimen also has a considerable anti-inflammatory effect and keeps its ability to boost chondrogenesis in vitro , even in an inflammatory milieu. An analytical model to predict the voltage generated by piezoelectric nanoparticles invested by ultrasound waves is proposed, together with a computational tool that takes into consideration nanoparticle clustering within the cell vacuoles and predicts the electric field streamline distribution in the cell cytoplasm. The proposed nanocomposite hydrogel shows good injectability and adhesion to the cartilage tissue ex vivo , as well as excellent biocompatibility in vivo, according to ISO 10993. Future perspectives will involve preclinical testing of this paradigm for cartilage regeneration.- Published
- 2024
- Full Text
- View/download PDF
24. Assessment of genetic familiarity and genetic knowledge among Palestinian university students.
- Author
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Rabayaa M, Ghanim M, Saleh Y, Abuawad M, and Shawahna R
- Subjects
- Female, Humans, Male, Cross-Sectional Studies, Universities, Surveys and Questionnaires, Arabs genetics, Students, Medical
- Abstract
Background and Aims: Genetic knowledge and familiarity among the population represent the lane toward effective participation in social decisions regarding genetic issues. This cross sectional research aimed to assess genetic knowledge and familiarity among university students in Palestine., Methods: The familiarity with genetics was evaluated using the Genetic Literacy and Comprehension instrument (GLAC), and genetic knowledge was measured using a 16-item scale of prevalent genetic concepts., Results: Among the 624 participants, 59.5% were females. 38.8% reported family history of genetic diseases. The genetic familiarity mean score was 4.83 and the genetic knowledge mean total score was 11.5. Students' genetic familiarity was high for the terms chromosome and genetic while it was low for the terms sporadic and vulnerability. Genetic knowledge was highest for gene definition while it was the lowest regarding the number of human genes. The age group, year of study, and learning genetic courses were the significant predictors of familiarity among medical students. The year of study, family history of genetic diseases, parental consanguinity, and learning genetic courses were the significant variables associated with genetic knowledge among medical students. Regarding the non-medical group of participants, all study variables were significant for both familiarity and knowledge scores except for age group with familiarity., Conclusion: Genetic familiarity and knowledge among Palestinian university students are inadequate. Consanguinity and hereditary disorders are prevalent in Palestine. These findings encourage university stakeholders to take action to improve genetic knowledge and familiarity among students through both appropriate pedagogical and non-pedagogical interventions., (© 2023. The Author(s).)
- Published
- 2024
- Full Text
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25. APOE2 Heterozygosity Reduces Hippocampal Soluble Amyloid-β42 Levels in Non-Hyperlipidemic Mice.
- Author
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Valencia-Olvera AC, Balu D, Moore A, Shah M, Ainis R, Xiang B, Saleh Y, Cai D, LaDu MJ, and Tai LM
- Subjects
- Animals, Mice, Apolipoprotein E3, Apolipoprotein E4 metabolism, Apolipoproteins E genetics, Apolipoproteins E metabolism, Hyperlipidemias genetics, Mice, Inbred Strains, Mice, Transgenic, Alzheimer Disease genetics, Alzheimer Disease pathology, Amyloid beta-Peptides metabolism, Apolipoprotein E2 genetics, Hippocampus pathology
- Abstract
APOE2 lowers Alzheimer's disease (AD) risk; unfortunately, the mechanism remains poorly understood and the use of mice models is problematic as APOE2 homozygosity is associated with hyperlipidemia. In this study, we developed mice that are heterozygous for APOE2 and APOE3 or APOE4 and overexpress amyloid-β peptide (Aβ) (EFAD) to evaluate the effect of APOE2 dosage on Aβ pathology. We found that heterozygous mice do not exhibit hyperlipidemia. Hippocampal but not cortical levels of soluble Aβ42 followed the order E2/2FAD > E2/3FAD≤E3/3FAD and E2/2FAD > E2/4FAD < E4/4FAD without an effect on insoluble Aβ42. These findings offer initial insights on the impact of APOE2 on Aβ pathology.
- Published
- 2024
- Full Text
- View/download PDF
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