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IntroductionThe advanced maternal age (AMA) pregnancies escalate rapidly, which are frequently linked to higher risks of adverse outcomes. Advanced maternal age (AMA) placenta exhibited premature aging, presumably resulting in trophoblast dysfunction, inadequate placentation. However, the precise reasons and mechanisms of trophoblast aging in AMA placenta remain unclear, posing a significant limitation to provide effective guidance for prenatal healthcare in clinical settings. Notably, the organism shows heightened vulnerability to oxidative damage as it ages. YAP (Yes-associated protein) was reported to play a critical role in regulation of aging and resisting oxidative damage, yet these roles had not been elucidated in the placenta. Therefore, this study explored the relationship between trophoblast cell aging and oxidative injury and YAP in AMA pregnancy, which not only provided an insight into the mechanisms of trophoblast cell aging, but also provide valuable directions for healthcare during AMA pregnancy.MethodsIn this study, human term placentas were collected from AMA and normal pregnancies for the analysis of aging, oxidative damage and YAP level. HTR8/SVneo cells were manipulated with (hydrogen peroxide) H2O2 to explore the effects of oxidative damage on trophoblast cell senescence and YAP levels. YAP expression in HTR8/SVneo cells was manipulated to investigate its role in trophoblastic senescence and oxidative damage.ResultsCompared with the control group, the AMA placenta exhibits increased aging biomarkers, which is coupled with an elevation in oxidative damage within placental trophoblast cells and a notable decline in YAP levels. Cellular experiments demonstrated that oxidative damage from H2O2 triggered trophoblast cell senescence and resulted in a reduction of YAP levels. Furthermore, employing molecular modification to silence YAP expression in these cells led to an induction of aging. Conversely, overexpressing YAP ameliorated both trophoblast cell aging and the associated DNA oxidative damage that arised from H2O2.ConclusionThe decline of YAP in AMA pregnancy should be responsible for the increased oxidative injury and premature placenta aging, indicating that YAP plays a significant role in combating oxidative damage and delaying aging, thereby providing a new guidance for prenatal care in AMA pregnancies. Maintaining YAP levels or implementing anti-oxidative stress interventions could potentially mitigate the incidence of complications involved AMA pregnancy.

BackgroundSleep duration and physical activity (PA) are critical factors influencing mortality risk. However, the interaction between sleep duration and PA with mortality risk among cancer survivors has not been well explored.MethodsThis cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007–2018. Multivariable Cox regression analysis and restricted cubic splines were employed to evaluate the hazard ratios (HRs) and 95% confidence intervals (CIs) of the association of sleep duration and PA with mortality risk in cancer survivors. Multiplicative and additive interaction terms were constructed to assess interaction effects.ResultsThe study included a total of 2,528 adult cancer survivors (aged≥20 years). Sleep duration exhibited a U-shaped association with all-cause and cancer-specific mortality, while demonstrating an inverted L-shaped association with cardiovascular disease (CVD) mortality. Compared to physically inactive participants, those with adequate PA had lower risks of all-cause mortality (HR = 0.542, 95% CI: 0.540–0.543), cancer mortality (HR = 0.486, 95% CI: 0.484–0.488), and CVD mortality (HR = 0.759, 95% CI: 0.755–0.763) among cancer survivors. A significant additive interaction was found between extreme sleep duration and PA on all-cause mortality risk among cancer survivors (long sleep duration: relative excess risk due to interaction (RERI) = 1.514, 95% CI: 1.504–1.525; short sleep duration: RERI = 0.725, 95% CI: 0.713–0.737).ConclusionExtreme sleep duration and lack of PA were associated with mortality risk in cancer survivors independently and jointly. Maintain appropriate sleep duration and doing regular PA may synergistically improve cancer survival among cancer survivors.

PurposeBody Mass Index (BMI) is an important indicator for assessing obesity and related health risks. With the rapid socio-economic development and changes in lifestyle, abnormal BMI (such as underweight, overweight, and obesity) has become an increasingly serious public health issue. This study aims to explore the impact of exercise frequency on BMI among Chinese adults aged 19 to 59, and to analyze the role of dietary behaviors in regulating BMI, providing a basis for BMI intervention strategies.MethodThe study employs a multi-stage sampling method across 23 provinces, provincial capitals, and four municipalities in China, randomly selecting 120 cities from each region. Online surveys were conducted using Wenjuanxing by trained surveyors.ResultA total of 8,611 individuals participated in the survey. Among them, 1,066 (12.38%) had a BMI

In recent years, there has been an increase in complications related to heat stroke (HS), especially those affecting the neurological system. The co-occurrence of HS and Guillain–Barré syndrome (GBS) is exceptionally rare, with fewer than 15 documented cases. This case report describes a patient who developed GBS following an HS and includes a literature review that highlights the rarity of this neurological complication. This study aimed to increase awareness and aid in clinical decision-making regarding the management of classic HS.

Auroral Kilometric Radiation (AKR) is a common radio emission, which can contribute to the magnetosphere−ionosphere−atmosphere coupling. Similar emissions have been observed in all magnetic planet magnetospheres of the solar system. In this study, using observations from the FAST satellite from 30 August 1996 to 9 September 2001, the distribution of AKR in altitude = 500−4500 km and invariant latitude (|ILAT|) = 60°−80° has been analyzed. 63045 AKR samples have been identified with ~48% (52%) samples on the dayside (nightside). Of considerable interest, there is a distinct MLT asymmetry with the high occurrence rate in MLT = 05−08 and 18−22 (02−05 and 12−17) in the northern (southern) hemisphere. The distinct MLT asymmetry is associated with the direction of \begin{document}$B_x$\end{document} of the interplanetary magnetic field. In addition, the occurrence rate on the nightside clearly increases as the \begin{document}$AE^*$\end{document} index increases. This study further enriches the information and understanding of AKR in the magnetosphere as well as other similar radio emissions.

Background: A relatively well-established link was observed between metal mixtures exposure and neurodegenerative diseases. However, the relationship between metal mixtures exposure and serum neurofilament light chain (sNfL) concentrations, a valuable non-invasive biomarker of neurodegenerative diseases, in general adult populations remains understudied and unclear. Objective: This study seeks to elucidate the potential impact of metal mixtures exposure on sNfL concentrations in a representative sample of U.S. general adults. Methods: Twelve urinary metal levels, including barium (Ba), cadmium (Cd), cobalt (Co), cesium (Cs), molybdenum (Mo), lead (Pb), antimony (Sb), tin (Sn), strontium (Sr), thallium (Tl), tungsten (W) and uranium (U), were analyzed in U.S. general adults recruited from the 2013–2014 National Health and Nutrition Examination Survey using inductively coupled plasma mass spectrometry (ICP-MS) after a simple dilution step. Urine samples are diluted with 2 % concentrated nitric acid (1:9). We employed a two-pronged approach, combining weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) models, to examine the association between the multiple-metals effect and sNfL concentrations. Survey-weighted multivariate linear regression was used to explore the correlation between single-metal effect and sNfL concentrations. Results: With the increasing quartiles of log-transformed sNfL (log-sNfL) concentrations, the fourth quartile had a higher proportion of smokers and hypertensive individuals (P