26 results on '"S Paz"'
Search Results
2. BEBIDAS REFRESCANTES Y ZUMOS COMO FUENTES DIETÉTICAS DE EXPOSICIÓN A FLUORURO.
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Vega S., Alejandro, De La Torre A., Hardisson, Armendáriz C., Rubio, Fernández A. J., Gutiérrez, and Montelongo S., Paz
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ESSENTIAL oils ,SOFT drinks ,WATER supply ,FLUORIDES ,FLUOROSIS - Abstract
Copyright of Revista de Toxicología is the property of Asociacion Espanola de Toxicologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
3. SITUACIÓN ACTUAL DE LA FLUOROSIS ENDÉMICA EN LA ISLA DE TENERIFE, ESPAÑA.
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Marrero J. R., Jáudenes, Montelongo S., Paz, de la Torre A., Hardisson, Fernández A. J., Gutiérrez, and Armendáriz C., Rubio
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FLUOROSIS ,WATER supply ,WATER sampling ,FLUORIDES ,CITIES & towns - Abstract
Copyright of Revista de Toxicología is the property of Asociacion Espanola de Toxicologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
4. IMPACT OF THE LOCKDOWN PERIOD DURING THE COVID-19 PANDEMIC ON THE METAL CONTENT OF THE ANEMONE ANEMONIA SULCATA IN THE CANARY ISLANDS (CE ATLANTIC, SPAIN).
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Marrero J. R., Jáudenes, Bilbao E., Lozano, Suárez I., Delgado, De La Torre A., Hardisson, Weller D., González, Montelongo S., Paz, and Fernández A. J., Gutiérrez
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COVID-19 pandemic ,MARINE pollution ,MARINE ecology ,COPPER ,BIOINDICATORS ,SUSTAINABLE tourism - Abstract
The species Anemonia sulcata, are cnidarians that serve as bioindicators in marine ecosystems, indicating the health of the environment and changes in environmental conditions. Monitoring anemone populations and studying their well-being and distribution provide valuable insights into marine ecosystem conditions. This study aimed to investigate the impact of the COVID pandemic on the metal content (Al, Cd, Cu, Fe, Pb, and Zn), 120 A. sulcata collected during a six-year period (2017-2022). The results showed a constant decreasing trend, but with the lowest concentrations occurring in 2020, matching with the two-month lockdown from March to May. This findings suggest that the reduced anthropogenic pressure on the coast due to the absence of tourism significantly decreased pollution levels. Therefore, the study supports the importance of promoting sustainable tourism worldwide, highlighting that minimizing human impact on coastal areas through responsible tourism practices can effectively reduce pollution in marine ecosystems. [ABSTRACT FROM AUTHOR]
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- 2024
5. Human and hamster sera correlate well in identifying antigenic drift among SARS-CoV-2 variants, including JN.1.
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Wang W, Bhushan G, Paz S, Stauft CB, Selvaraj P, Goguet E, Bishop-Lilly KA, Subramanian R, Vassell R, Lusvarghi S, Cong Y, Agan B, Richard SA, Epsi NJ, Fries A, Fung CK, Conte MA, Holbrook MR, Wang TT, Burgess TH, Pollett SD, Mitre E, Katzelnick LC, and Weiss CD
- Abstract
Antigenic assessments of SARS-CoV-2 variants inform decisions to update COVID-19 vaccines. Primary infection sera are often used for assessments, but such sera are rare due to population immunity from SARS-CoV-2 infections and COVID-19 vaccinations. Here, we show that neutralization titers and breadth of matched human and hamster pre-Omicron variant primary infection sera correlate well and generate similar antigenic maps. The hamster antigenic map shows modest antigenic drift among XBB sub-lineage variants, with JN.1 and BA.4/BA.5 variants within the XBB cluster, but with fivefold to sixfold antigenic differences between these variants and XBB.1.5. Compared to sera following only ancestral or bivalent COVID-19 vaccinations, or with post-vaccination infections, XBB.1.5 booster sera had the broadest neutralization against XBB sub-lineage variants, although a fivefold titer difference was still observed between JN.1 and XBB.1.5 variants. These findings suggest that antibody coverage of antigenically divergent JN.1 could be improved with a matched vaccine antigen.IMPORTANCEUpdates to COVID-19 vaccine antigens depend on assessing how much vaccine antigens differ antigenically from newer SARS-CoV-2 variants. Human sera from single variant infections are ideal for discriminating antigenic differences among variants, but such primary infection sera are now rare due to high population immunity. It remains unclear whether sera from experimentally infected animals could substitute for human sera for antigenic assessments. This report shows that neutralization titers of variant-matched human and hamster primary infection sera correlate well and recognize variants similarly, indicating that hamster sera can be a proxy for human sera for antigenic assessments. We further show that human sera following an XBB.1.5 booster vaccine broadly neutralized XBB sub-lineage variants but titers were fivefold lower against the more recent JN.1 variant. These findings support updating the current COVID-19 vaccine variant composition and developing a framework for assessing antigenic differences in future variants using hamster primary infection sera.
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- 2024
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6. Metal variability of the shrimp Palaemon elegans across coastal zones: anthropogenic and geological impacts.
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Lozano-Bilbao E, Hardisson A, González-Weller D, Paz S, Rubio C, and Gutiérrez ÁJ
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- Animals, Metals, Heavy analysis, Palaemonidae, Environmental Monitoring, Water Pollutants, Chemical analysis, Metals analysis
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This study focused on 120 specimens of the shrimp Palaemon elegans collected in intertidal zones in eight selected areas. This study aimed to assess the suitability of P. elegans as a bioindicator of natural and anthropogenic marine pollution. Metal concentrations of aluminum (Al), cadmium (Cd), copper (Cu), iron (Fe), lead (Pb), and zinc (Zn) were measured in shrimp collected from various sites in the Canary Islands, including areas affected by volcanic activity, industrial activity, and control zones. The determination of metal concentrations was conducted using inductively coupled plasma optical emission spectrophotometry (ICP-OES). The results showed significant differences in metal concentrations across the studied sites, with the highest levels of Al, Cu, Fe, Pb, and Zn observed in areas impacted by the Tajogaite volcanic eruption and harbor activity. Sites near old landfills and sewage pipes also exhibited elevated levels of Cd, Cu, and Pb, indicating strong anthropogenic influence. Al was found in the highest concentration in Harbour, reaching 25.7 ± 6.2 mg/kg, while the lowest concentration was observed in Control Lp at 11.5 ± 0.69 mg/kg. Conversely, lower metal concentrations were detected in control zones and areas with high dinoflagellate presence, suggesting a potential role of bioremediation by marine phytoplankton. The ability of P. elegans to accumulate metals in its tissues, particularly in areas of high pollution, highlights its potential as a bioindicator species. This study underscores the importance of P. elegans in monitoring marine pollution and provides insights into the environmental impact of both natural and human-induced contamination on coastal ecosystems., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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7. Impact of tourism on metal concentrations in Phorcus sauciatus due to the COVID-19 pandemic period in Canary Islands (CE Atlantic, Spain).
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Lozano-Bilbao E, Hardisson A, González-Weller D, Paz S, and Gutiérrez ÁJ
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- Spain, Animals, Snails, Humans, Water Pollutants, Chemical analysis, SARS-CoV-2, Pandemics, COVID-19, Tourism, Environmental Monitoring, Metals analysis
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The pandemic (COVID-19) had diverse effects on marine pollution. Throughout the lockdown periods, temporary enhancements in water quality and biodiversity were observed due to reduced human activity and constraints on travel and maritime transportation. The marine snail, Phorcus sauciatus, served as an indicator for marine pollution, and samples were collected in Tenerife, Canary Islands, during various months in 2020. The findings indicated that metal concentrations in Phorcus sauciatus were higher in February but declined in July and December as a result of reduced tourist activity during the pandemic. This underscores the significance of promoting sustainable tourism in the Canary Islands to mitigate high metal concentrations in the marine environment. The COVID-19 pandemic had a positive impact on reducing metal concentrations in marine pollution, underscoring the importance of adopting sustainable tourism practices to protect marine ecosystems., Competing Interests: Declaration of competing interest All authors declare that the use of animals for this research complies with the requirements of European legislation on the use of animals for experimentation. All anemone samples have been taken with fishing permits and permission from the Spanish ministry. Samples were obtained from broodstock captured, so these organisms were not slaughtered by the authors of this manuscript, therefore we faithfully comply with the Code of Practice for Housing and Care of Animals Used in Scientific Procedures., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
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- 2024
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8. Implementation of cancer prevention practices in primary care: results of a cohort study in Chile 2018-2022.
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Puschel K, Rioseco A, Soto M, Paz S, Martinez J, Soto G, Faundez M, Arenas E, Vescovi Z, Fuentes I, Thompson B, and Emery J
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Objectives: The burden of cancer is increasing rapidly in Latin America. Primary care has an essential role in cancer prevention, but implementation levels of prevention practices are not well known. This study evaluated implementation levels and associated factors of cancer preventive practices in primary care over time., Study Design: The study incorporated a retrospective multicentre cohort study., Methods: A population of 59,949 patients registered at three primary care clinics was followed from January 2018 to December 2022 in Santiago, Chile. We studied human papillomavirus (HPV) and hepatitis B virus (HBV) immunisation, brief counselling for smoking cessation and alcohol consumption, and cervical and breast cancer screening practices. Standardised electronic medical records were utilised as the source of information. Social, clinical, and organisational factors associated with prevention practices were studied., Results: The cohort attrition level was 17.1%. Most of the population was of a low socioeconomic status, and 70% visited a primary health centre yearly. Implementation rates of immunisation practices were 90.84% for HPV and 80.94% for HBV in 2022. In contrast, brief counselling for smoking and alcohol consumption was below 20% during the study period. Cervical cancer screening decreased by 25.58% between 2018 and 2022, whereas breast cancer screening reached only 41.71% of the target population. Opportunistic medical visits were strongly associated with brief counselling and breast cancer screening., Conclusion: Implementation practices for cancer prevention in a Chilean primary care cohort are high for immunisation and very low for brief counselling and screening practices. A comprehensive non-medical-based model is needed to improve cancer prevention in primary care., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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9. Human Exposure to Trace Elements (Al, B, Ba, Cd, Cr, Li, Ni, Pb, Sr, V) from Consumption of Dried Fruits Acquired in Spain.
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Jáudenes-Marrero JR, Paz-Montelongo S, Darias-Rosales J, González-Weller D, Gutiérrez ÁJ, Hardisson A, Rubio C, and Alejandro-Vega S
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Dried fruits are one of the most frequently consumed products by the population. Drying fruits prolongs their shelf life and also concentrates more nutrients. However, these products may contain dangerous levels of trace elements that can be harmful to health. The content of trace elements (Al, B, Ba, Cd, Cr, Li, Ni, Pb, Sr, V) in 42 samples of different dried fruits (dates, prunes, sultanas, dried apricot kernels, and dried figs) was determined by inductively coupled plasma spectrometry (ICP-OES). The concentrations of Al found in prunes (12.7 ± 5.13 mg Al/kg) and the concentrations of B found in dried plums (6.26 ± 4.45 mg B/kg) were significantly higher ( p < 0.05). Regarding the risk assessment, the percentages of contribution to the maximum recommended intakes by Li in all the dried fruits studied stand out, reaching 35.3% in the case of dried plums. This study concludes that the recommended daily intake of dried fruit (30 g/day) does not pose a toxicological risk about these trace elements.
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- 2024
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10. Indifferent minds, broken system: a critical examination of mental health care provision for Spain's incarcerated population with serious mental illnesses.
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Calcedo-Barba A, Antón Basanta J, Paz Ruiz S, Muro Alvarez A, Elizagárate Zabala E, Estévez Closas V, López López A, and Barrios Flores LF
- Abstract
Background: Spain healthcare system is decentralized, with seventeen autonomous regions overseeing healthcare. However, penitentiary healthcare is managed nationally, except in Catalonia, the Basque Country, and Navarra. These variations impact mental health care provision for inmates with serious mental illness (SMI)., Objective: To delineate differences between regions in terms of mental health care provision for individuals with SMI, available resources, and the perspectives of healthcare professionals operating in the Spanish prison environment., Methods: Employing an explanatory sequential mixed-method approach, the study conducted an extensive literature review, quantitative data collection through structured questionnaires, and qualitative data collection via focus groups and four in-depth interviews. Analysis involved calculating percentages and ratios for quantitative data and thematic analysis for qualitative data interpretation to comprehensively understand mental healthcare provision., Results: In December 2021, about 4% of inmates in Spain had SMI. There are three distinct models of mental healthcare within the Spanish prison system. The traditional penitentiary model, representing 83% of the incarcerated population, operates independently under the General Secretariat of Penitentiary Institutions at a national level. This model relies on an average of 5.2 penitentiary General Practitioners (pGP) per 1,000 inmates for psychiatric and general healthcare. External psychiatrists are engaged for part-time psychiatric assessment. Acute psychiatric hospitalization occurs in general nursing modules within penitentiary centers or in Restricted Access Units (RAUs) in reference hospitals. Two penitentiary psychiatric hospitals provide care to unimputable SMI inmates from all over Spain. Innovative penitentiary models, constituting 17% of the prison population, integrate penitentiary healthcare within regional public health systems. The Basque Country features a Mental Health Unit with full-time care teams within the penitentiary center. Catalonia emphasizes community care, providing full-time dedicated psychiatric services within and outside prisons, ensuring continued care in the community. Both models prioritize personnel with specialized mental health training and compensation akin to non-prison healthcare settings., Conclusions: Regional disparities in penitentiary mental healthcare models in Spain result in resource inequalities, impacting specialized care for inmates with SMI and opportunities for healthcare professionals. The models in the Basque Country and Catalonia offer valuable experiences for penitentiary healthcare., Competing Interests: SPR and VEC were employed by company SmartWorking4u. The authors declare that this study received funding from Janssen Pharmaceuticals. The funder had the following involvement in the study: data collection, analysis, and manuscript preparation. The funding source had no role in the conception, analysis, or communication of the results of this study. The research was developed and published independently by the authors., (Copyright © 2024 Calcedo-Barba, Antón Basanta, Paz Ruiz, Muro Alvarez, Elizagárate Zabala, Estévez Closas, López López and Barrios Flores.)
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- 2024
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11. Olive Leaf Mottling Virus: A New Member of the Genus Olivavirus .
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Ruiz-García AB, Candresse T, Malagón J, Ruiz-Torres M, Paz S, Pérez-Sierra A, and Olmos A
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Studies of the virome of olive trees with symptoms of leaf mottling by high-throughput sequencing (HTS) revealed the presence of a new virus. Full coding genome sequences of two isolates were determined and consisted of a single RNA segment of 16,516 nt and 16,489, respectively. The genomic organization contained 10 open reading frames (ORFs) from 5' to 3': ORF1a, ORF1b (RdRp), ORF2 (p22), ORF3 (p7), ORF4 (HSP70h), ORF5 (HSP90h), ORF6 (CP), ORF7 (p19), ORF8 (p12), ORF9 (p23) and ORF10 (p9). Phylogenetic analyses clustered this virus in the genus Olivavirus , family Closteroviridae, with the closest species being Olivavirus flaviolae , commonly named olive leaf yellowing-associated virus (OLYaV). However, amino acid sequences of all taxonomically relevant proteins showed, in all cases, a divergence higher than 25% between OLYaV and the new virus, indicating that it represents a new species in the genus Olivavirus for which the common name of olive leaf mottling virus (OLMV) is proposed. This study represents an advance in the genus Olivavirus and provides new insights into the olive virome.
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- 2024
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12. Metal concentrations in echinoderms: Assessing bioindicator potential and ecological implications.
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González-Delgado S, Lozano-Bilbao E, Hardisson A, Paz S, Gonález-Weller D, Rubio C, and Gutiérrez ÁJ
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- Animals, Spain, Environmental Monitoring methods, Echinodermata, Water Pollutants, Chemical analysis, Metals, Heavy analysis
- Abstract
This study investigates the concentrations of heavy metals and trace elements in five echinoderm species: Holothuria (Platyperona) sanctori, Arbacia lixula, Coscinasterias tenuispina, Ophioderma longicaudum, and Antedon bifida. Given their ecological significance and potential as a food source, understanding the presence and transfer of heavy metals in these species is crucial. Sampling was conducted in 2022 in Canary Islands. Analysis using ICP-OES revealed concentrations of Zn, Cd, Pb, Cu, Ni, Cr, and Fe in mg/kg. The results showed a consistent sequence of metals across all species, with Fe > Zn > Cu > Ni > Cr > Pb > Cd. Holothurians exhibiting the highest levels, followed by sea urchins. Starfish and brittle stars showed similar, lower concentrations, while crinoids exhibited the lowest levels, consistent with their filter-feeding behavior. The findings highlight the potential of holothurians as bioindicators for environmental pollutants. Understanding the role of these echinoderms as bioindicators is essential for assessing ecosystem health and informing conservation efforts in subtropical marine environments., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could appear to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
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- 2024
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13. Metal variability in small pelagic fish Scomber colias as influenced by volcanic events in the Canary Islands.
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Lozano-Bilbao E, Delgado-Suárez I, Lorenzo JM, González JA, Hardisson A, González-Weller D, Paz S, Rubio C, and Gutiérrez ÁJ
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- Animals, Perciformes, Water Pollutants, Chemical analysis, Spain, Trace Elements analysis, Volcanic Eruptions, Environmental Monitoring, Metals analysis
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Offshore volcanic activity occurs when an underwater volcano erupts. These volcanoes can be located underwater or on land and can be very dangerous to marine life. The aim of this study is to examine whether the influence of two volcanoes has an effect on the concentrations of metals and trace elements in the Atlantic mackerel Scomber colias in the Canary Islands. For the study, ten specimens of S. colias were obtained from each sampling area in March 2022. Metal concentrations were determined by inductively coupled plasma optical emission spectrophotometry (ICP-OES). The specimens of Scomber colias from the area affected by the Tajogaite volcano (La Palma) showed higher concentrations of all metals and trace elements analyzed than those from the other study areas. The specimens from the area of influence of the Tagoro Volcano (El Hierro) showed the second highest concentration of the elements studied, although this volcanic process is in a state of degassing., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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14. Soft Drinks as a Dietary Source of Fluoride Exposure.
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Alejandro-Vega S, Hardisson A, Rubio C, Gutiérrez ÁJ, Jaudenes-Marrero JR, and Paz-Montelongo S
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- Humans, Dietary Exposure analysis, Dietary Exposure adverse effects, Fruit and Vegetable Juices analysis, Female, Fluorides analysis, Fluorides adverse effects, Carbonated Beverages analysis
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High fluoride exposures can lead to adverse effects such as dental and bone fluorosis, as well as endocrine and cognitive developmental problems. Water is the main dietary source of this ion, although significant concentrations have also been detected in other beverages widely consumed by the population such as soft drinks. A total of 200 soft drink samples (60 flavoured, 70 extracts, 60 fruit juice and 10 soft drinks) were analysed by fluoride ion selective potentiometry. A consumption of 330 mL was estimated for exposure assessment and subsequent F-risk assessment by soft drink consumption. The highest average concentration was found in extract soft drinks (2.45 ± 1.15 mg/L), followed by flavoured (1.71 ± 2.29 mg/L) and carbonated soft drinks (1.38 ± 0.40 mg/L), while the lowest was found in fruit juice soft drinks (1.09 ± 0.62 mg/L). The flavours with the highest concentration were tea-melon and tea-passion fruit with 3.66 ± 0.40 and 3.17 ± 0.56 mg/L respectively and the lowest was lemon flavour with 0.69 mg/L. The contribution of these beverages, considering the UL (Upper level) reference values set by EFSA (European Food Safety Authority) are between 3.28-41.78%, depending on age group and sex., (© 2023. The Author(s).)
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- 2024
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15. The potential of climatic suitability indicator for Leishmania transmission modelling in Europe: insights and suggested directions.
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Paz S
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Competing Interests: The author declares that there is no conflict of interest.
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- 2024
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16. Environmental Factors Influencing Metal Concentrations in Scomber colias Along the Canary Islands.
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Lozano-Bilbao E, Jurado-Ruzafa A, Lorenzo JM, González JA, Hardisson A, González-Weller D, Paz S, Rubio C, and Gutiérrez ÁJ
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A total of 140 specimens of Scomber colias were collected from the Canary archipelago waters during the first semester of 2021, with 20 samples from each of the seven main islands. After analyzing the concentrations of metals (Al, Zn, Cd, Pb, Fe, and Cu) with ICP-OES, significant variations were observed among islands, with specimens from Tenerife and Gran Canaria containing higher levels of Al, Cd, and Pb, while those from Lanzarote and Fuerteventura had elevated levels of Zn, Fe, and Cu. These differences are probably related to greater anthropogenic activity around Tenerife and Gran Canaria coasts, leading to higher pollution levels, and the influence of Saharan dust and African upwelling on Lanzarote and Fuerteventura, enriching the waters with nutrients. Specific management strategies to mitigate marine pollution and continuous monitoring are crucial to safeguard marine ecosystems and to ensure food security., (© 2024. The Author(s).)
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- 2024
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17. Dengue Burden and Factors Influencing Severity in Honduras: A Descriptive and Analytical Study.
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Zúniga-Gutiérrez M, Meléndez M, Montoya SSR, Escobar HAF, López J, Paz S, and Sauceda-Acosta D
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- Humans, Honduras epidemiology, Male, Adolescent, Child, Female, Adult, Young Adult, Child, Preschool, Infant, Middle Aged, Risk Factors, Severe Dengue epidemiology, Dengue epidemiology, Severity of Illness Index
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Background: Dengue is a disease that accounts for a major morbidity and mortality in Honduras., Methods: This descriptive study used an analytical component based on the data from the National Virology Laboratory between 2016-2022. Ordinal logistic regression was used to identify the factors associated with the classification of dengue without warning signs (DWOS), dengue with warning signs (DWS), and severe dengue (SD)., Results: Overall, 14,687 dengue cases were included; 50.1% had DWOS, 36.5% had DWS, and 13.4% had SD. Patients that were more associated with a higher probability of DWS and SD were patients in the age groups 1-4 years (DWS OR 1.61; 95%CI:1.33-1.94), (SD OR 1.52; 95% CI:1.26-1.84), 5-9 years (DWS OR 2.01; 95% CI:1.68-2.40), (SD OR 2.00; 95% CI:1.67-2.40), and 10-19 years (DWS OR 1.55; 95% CI:1.30-1.85) (SD OR 1.57; 95% CI:1.31-1.88). The departments that were associated with a higher probability of DWS and SD were La Paz (OR 6.35; 95% CI:3.53-11.42), (OR 10.94; 95% CI:5.96-20.08), Copán (OR 6.94; 95% CI:5.05-9.53) (OR 7.33; 95% CI: 5.35-10.03), Valle (OR 5.22; 95% CI:1.25-21.82) (OR 10.71; 95% CI:2.21-51.88)., Conclusions: During the study period, dengue presented endemic behavior, with peaks consistent with the last two epidemics in Honduras in 2015 and 2019. The main factors associated with dengue severity were age< 19 years, male sex, and being from La Paz, Copán, or Valle.
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- 2024
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18. ATP release mediated by pannexin-3 is required for plasma cell survival via P2X4 receptors in bone marrow.
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Paz-López S
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- 2024
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19. Impact of natural events on metal bioaccumulation in Anemonia sulcata.
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Lozano-Bilbao E, González JA, Lorenzo JM, Jurado-Ruzafa A, Delgado-Suárez I, Hardisson A, Rubio C, González-Weller D, Paz S, and Gutiérrez ÁJ
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- Animals, Sea Anemones, Dinoflagellida, Spain, Metals, Heavy analysis, Water Pollutants, Chemical analysis, Metals analysis, Metals metabolism, Environmental Monitoring, Bioaccumulation
- Abstract
Samples of Anemonia sulcata were collected in 2022 from different areas of the Canary Islands affected by different natural contamination sources, such sandstorms, submarine volcanic activity, continuous rainfall, upwelling and dinoflagellate blooms. Significant differences were observed between the zones for the metals and trace elements analyzed (Al, Zn, Cd, Pb, Ni, Co, Fe, B, Cu, Mg and Li). Anemones from volcanic areas showed higher levels of Cd, Pb and Ni. Individuals from sandstorm areas showed elevated levels of Al, Zn and Fe. Samples collected from areas affected by upwelling processes had higher concentrations of Cu, Mg and Li. Finally, the areas affected by dinoflagellates showed lower levels of Zn, Pb, Fe, Mg and Li. The study reveals how natural phenomena dramatically influence metal accumulation in A. sulcata, which is of great value for anticipating and managing potential problems associated with public health., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
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- 2024
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20. Antigenic cartography using hamster sera identifies SARS-CoV-2 JN.1 evasion seen in human XBB.1.5 booster sera.
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Wang W, Bhushan GL, Paz S, Stauft CB, Selvaraj P, Goguet E, Bishop-Lilly KA, Subramanian R, Vassell R, Lusvarghi S, Cong Y, Agan B, Richard SA, Epsi NJ, Fries A, Fung CK, Conte MA, Holbrook MR, Wang TT, Burgess TH, Mitre E, Pollett SD, Katzelnick LC, and Weiss CD
- Abstract
Antigenic assessments of SARS-CoV-2 variants inform decisions to update COVID-19 vaccines. Primary infection sera are often used for assessments, but such sera are rare due to population immunity from SARS-CoV-2 infections and COVID-19 vaccinations. Here, we show that neutralization titers and breadth of matched human and hamster pre-Omicron variant primary infection sera correlate well and generate similar antigenic maps. The hamster antigenic map shows modest antigenic drift among XBB sub-lineage variants, with JN.1 and BA.4/BA.5 variants within the XBB cluster, but with five to six-fold antigenic differences between these variants and XBB.1.5. Compared to sera following only ancestral or bivalent COVID-19 vaccinations, or with post-vaccination infections, XBB.1.5 booster sera had the broadest neutralization against XBB sub-lineage variants, although a five-fold titer difference was still observed between JN.1 and XBB.1.5 variants. These findings suggest that antibody coverage of antigenically divergent JN.1 could be improved with a matched vaccine antigen., Competing Interests: Competing interests S. D. P. and T. H. B report that the Uniformed Services University (USU) Infectious Diseases Clinical Research Program (IDCRP), a US Department of Defense institution, and the Henry M. Jackson Foundation (HJF) were funded under a Cooperative Research and Development Agreement to conduct an unrelated phase III COVID-19 monoclonal antibody immunoprophylaxis trial sponsored by AstraZeneca. The HJF, in support of the USU IDCRP, was funded by the Department of Defense Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense to augment the conduct of an unrelated phase III vaccine trial sponsored by AstraZeneca. Both trials were part of the US Government COVID-19 response. Neither is related to the work presented here. The contents of this publication are the sole responsibility of the author (s) and do not necessarily reflect the views, opinions, or policies of Uniformed Services University of the Health Sciences (USUHS); the Department of Defense (DoD); the Departments of the Army, Navy, or Air Force; the Defense Health Agency; the Henry M. Jackson Foundation for the Advancement of Military Medicine Inc; the National Institutes of Health; the Department of Energy, ORISE; the US Food and Drug Administration, or the Department of Health and Human Services. Mention of trade names, commercial products, or organizations does not imply endorsement by the U.S. Government. The investigators have adhered to the policies for protection of human subjects as prescribed in 45 CFR 46. K.B-L, A.F., T.H.B, E.M., C.B.S., S.L., P.S., R.V., C.D.W, T.T.W, W.W., Y.C., M.R.H., and L.C.K. are employees of the US Government. This work was prepared as part of their official duties. Title 17 U.S.C. §105 provides that “Copyright protection under this title is not available for any work of the United States Government.” Title 17 U.S.C. §101 defines a US Government work as a work prepared by a military service member or employee of the US Government as part of that person’s official duties.
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- 2024
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21. Climate change: A driver of increasing vector-borne disease transmission in non-endemic areas.
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Paz S
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- Humans, Climate Change, Vector Borne Diseases epidemiology
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In this Perspective, Shlomit Paz discusses the link between climate change and transmission of vector-borne diseases in non-endemic areas., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Shlomit Paz. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2024
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22. Speech-language pathologists' perceptions of childhood bilingualism.
- Author
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Paz S, Alfano AR, Medina AM, and Hayes T
- Subjects
- Child, Humans, Pathologists, Speech, Surveys and Questionnaires, Multilingualism, Communication Disorders, Speech-Language Pathology
- Abstract
The value of learning multiple languages has increased in the past 20 years. Despite this, some professionals continue to provide misinformation about bilingualism to many families around the United States, resulting in recommendations of implementing a monolingual approach for children. This study investigated the perceptions held by speech-language pathologists (SLPs) regarding childhood bilingualism. A total of 320 SLPs completed a survey stating their perceptions on childhood bilingualism for typically developing children and children with disabilities. Based on the number of responses, 292 participants were analysed quantitatively utilising a binary logistic regression to identify whether SLPs thought childhood bilingualism was advantageous or neutral, while incorporating the predictors of bilingual status and bilingualism education received. Additionally, a qualitative content analysis was conducted on 173 participants' responses to an open-ended question about their perceptions on childhood bilingualism. Results revealed that SLPs' bilingual status did not predict the probability of an advantageous perception for typically developing children, but it did for children with disabilities; however, SLPs who had received bilingualism education had a higher probability of having advantageous perceptions in both populations. Qualitative results revealed the use of appraisals related to multiple themes. This study served to understand the thoughts of SLPs in relation to the education they are providing to parents and the services they are providing to different populations - whether it be typically developing children or children with disabilities. There are implications for bilingual and cultural-linguistic education to be implemented across graduate programmes to ensure that optimal services are provided to the diverse groups in our case loads.
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- 2024
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23. A combined phylogenetic strategy illuminates the evolution of Goniodorididae nudibranchs (Mollusca, Gastropoda, Heterobranchia).
- Author
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Paz-Sedano S, Moles J, Smirnoff D, Gosliner TM, and Pola M
- Subjects
- Animals, Phylogeny, Bayes Theorem, Mollusca genetics, RNA, Ribosomal, 16S genetics, Gastropoda
- Abstract
Goniodorididae is a family of small dorid nudibranchs distributed worldwide that feed on entoprocts, ascidians, and bryozoans. The evolutionary relationships between its taxa have been uncertain due to the limited taxa available for phylogenetic analyses; some genera being paraphyletic. The family includes a remarkable number of synonymized genera in which the species richness is unequally distributed, while some genera have dozens of species others are monospecific. Some clades are very uniform morphologically while others are considered highly variable. To increase backbone phylogenetic resolution a target enrichment approach of ultra-conserved elements was aimed at representative Goniodorididae species for the first time. Additionally, we increase species representation by including mitochondrial markers cytochrome c oxidase subunit I and ribosomal RNA 16S as well as nuclear Histone 3 and ribosomal RNA 18S from 109 Goniodorididae species, out of approximately 160 currently valid species. Maximum likelihood and Bayesian inference analyses were performed to infer the phylogeny of the family. As a result, two subfamilies and eleven genera were elucidated. The synonymized genera Bermudella, Cargoa, and Ceratodoris are here resurrected and a new genus, Naisdoris gen. nov., is described. The clades included taxa with shared prey preference, showing that trophic behavior could have driven species evolution and morphological uniqueness within the family Goniodorididae., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Data accessibility statement Raw reads for newly sequenced samples are deposited in the NCBI Sequence Read Archive (BioProject PRJNA1051643)., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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24. Comparative analysis of metal pollution in the Atlantic Ocean and Mediterranean Sea: insights from Anemonia sulcata study.
- Author
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Lozano-Bilbao E, Paz S, Hardisson A, Rubio C, González-Weller D, and Gutiérrez ÁJ
- Subjects
- Humans, Mediterranean Sea, Atlantic Ocean, Environmental Pollution, Environmental Monitoring, Ecosystem, Metals
- Abstract
In this study, we investigated metal concentrations in Anemonia sulcata specimens from various locations in the Atlantic Ocean and the Mediterranean Sea. A total of 84 individuals were sampled from specific zones, and their tissue samples were processed for metal analysis using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES). The results revealed notable differences in metal concentrations among the studied regions. The Atlantic Ocean and the Mediterranean Sea were found to have distinct patterns of marine pollution, influenced by a complex interplay of geographical, demographic, industrial, and environmental policy factors. Conversely, the semi-enclosed Mediterranean Sea has a lower natural dilution capacity, leading to the accumulation and prolonged presence of pollutants. Population density and industrial activities in coastal areas play a significant role in pollution disparities between the Mediterranean Sea and the Atlantic Ocean. The Mediterranean coasts, with higher population densities and intensive industrial operations, experience greater strain on marine ecosystems due to increased pollution sources. Additionally, environmental policies and management approaches differ between the two regions, contributing to variations in pollution response and regulation., Competing Interests: Declaration of competing interest All authors declare that the use of animals for this research complies with the requirements of European legislation on the use of animals for experimentation. All samples were collected by researchers in the Canary Islands. Therefore, we faithfully comply with the Code of Practice for Housing and Care of Animals Used in Scientific Procedures., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
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- 2024
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25. Human health risk assessment of metals in soil samples of a Brazilian city with a historic contamination complex.
- Author
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Ramires PF, de Lima Brum R, Dos Santos M, Mirlean N, Paz-Montelongo S, Rubio-Armendáriz C, and da Silva Júnior FMR
- Subjects
- Child, Adult, Humans, Environmental Monitoring methods, Brazil, Lead, Risk Assessment, Carcinogens analysis, Soil chemistry, China, Metals, Heavy analysis, Mercury, Soil Pollutants analysis
- Abstract
Rio Grande is a city located on a narrow industrialized and urbanized Brazilian peninsula, characterized by wetlands. Due to population growth, numerous urban backfilled regions were built to expand the territorial area of the city. Currently, more than 60% of the central area of the city comes from the grounding of wetlands. The material used for the expansion of the territory had a history of contamination from metals from the tannery and textile industries (mainly Hg) and urban solid waste. In addition to past sources, the city has an active industrial complex with fertilizer, petrochemical, and grain industries. This study evaluated the risks to human health caused by metals (Hg, Fe, Ni, Cr, Cu, Pb, and Zn) in original soils and backfills, considering the oral, inhalation, and dermal routes of exposure for children and adults using the tool human health risk assessment (HHRA) proposed methodology by USEPA. A total of 63.81% of the original soil samples and 57.14% of the backfill soil samples showed a non-carcinogenic risk (HInc>1) for at least one evaluated metal. Still, approximately 10% of the samples presented carcinogenic risk when the Cr was considered in the hexavalent form. The dermal (Hg, Ni, and Cr) and oral (Fe, Cu, and Zn) exposure routes had the greatest contribution to the total risk. The non-carcinogenic risk for Hg, Cr(VI), and Pb was heterogeneously distributed between the original soils and backfills and associated with the proximity to some pollution sources. Given the complexity of historical occupation in the municipality and the increasing industrialization, both the original areas and the backfills should be included in the risk management strategy to minimize risks., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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26. Metal content in Sardina pilchardus during the period 2014-2022 in the Canary Islands (Atlantic EC, Spain).
- Author
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Lozano-Bilbao E, Jurado-Ruzafa A, Hardisson A, González-Weller D, Paz S, Techetach M, and Gutiérrez ÁJ
- Subjects
- Animals, Spain, Fishes, Oceans and Seas, Ecosystem, Lead
- Abstract
The contamination present in an organism varies depending on biological and oceanographic conditions, so monitoring the same species is of great importance to understand the state of the ecosystem. Fifteen specimens in Sardina pilchardus between 12 and 15 cm in total length were collected during the second half of January of each of the study years (2014, 2016, 2018, 2020 and 2022). Samples were analyzed with Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) to measure metals (Al, Cd, Cu, Fe, Li, Ni, Pb and Zn) in mg/Kg. There was a progressive decrease in Pb content over the period, with the highest concentration being obtained in 2014 (0.086 ± 0.065 mg/kg). Locally important oceanic-atmospheric events may occur in the study period that strongly impact the tissue composition of marine organisms. In this case, discontinuous trends were evident in some of the metal concentrations analyzed in the muscle of European sardine in the Canary Islands., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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