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Non-contact anterior cruciate ligament (ACL) rupture is a common serious orthopaedic disease in humans and dogs. Familial risk has been recognized in both species but interactions between genetic effects and environmental risk are not understood. We investigated ACL rupture heritability, genetic architecture, selection pressure, sharing of risk genes and biological pathways, and polygenic risk score (PRS) prediction of disease risk. In both species, ACL rupture has moderate heritability, is likely under negative selection, and has a highly polygenic architecture where thousands of variant effects act together to influence disease risk. In dogs, we found hotspots of regional heritability. We also confirmed sharing of multiple risk genes. Our findings challenge the dogma that non-contact ACL rupture is predominantly due to a single overload injury event. Our results also suggest that accurate PRS prediction of ACL rupture risk is an achievable goal in both species, enabling identification of individuals for personalized medical care. Cross-species genetic analysis in humans and dogs sheds light on the complexity of the intrinsic genetic contribution and the biological pathways that influence risk of non-contact anterior cruciate ligament rupture, a heritable disease. [ABSTRACT FROM AUTHOR]

Developing a new diagnostic prediction model for osteoarthritis (OA) to assess the likelihood of individuals developing OA is crucial for the timely identification of potential populations of OA. This allows for further diagnosis and intervention, which is significant for improving patient prognosis. Based on the NHANES for the periods of 2011–2012, 2013–2014, and 2015–2016, the study involved 11,366 participants, of whom 1,434 reported a diagnosis of OA. LASSO regression, XGBoost algorithm, and RF algorithm were used to identify significant indicators, and a OA prediction nomogram was developed. The nomogram was evaluated by measuring the AUC, calibration curve, and DCA curve of training and validation sets. In this study, we identified 5 predictors from 19 variables, including age, gender, hypertension, BMI and caffeine intake, and developed an OA nomogram. In both the training and validation cohorts, the OA nomogram exhibited good diagnostic predictive performance (with AUCs of 0.804 and 0.814, respectively), good consistency and stability in calibration curve and high net benefit in DCA. The nomogram based on 5 variables demonstrates a high accuracy in predicting the diagnosis of OA, indicating that it is a convenient tool for clinicians to identify potential populations of OA. [ABSTRACT FROM AUTHOR]

Background: The incidence of anterior cruciate ligament reconstruction (ACLR) graft failure is inversely related to the diameter of the ACLR graft. When the diameter of a 4-stranded hamstring tendon graft with a doubled semitendinosus and doubled gracilis tendon (ST×2 + G×2) configuration is <8 mm, the gracilis tendon is often thin. Hypothesis: (1) The diameter of the doubled semitendinosus tendon (ST×2) alone would be able to predict the probability of a 4-stranded ACLR graft having a diameter of ≥8 mm, and (2) there would be a specific cutoff value for the ST×2 diameter such that the addition of a doubled gracilis tendon (G×2) will not result in a 4-stranded graft with a ≥8-mm diameter. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Included were patients who had undergone 4-stranded hamstring ACLR between 2008 and 2018. Patients were excluded if the diameter measurements of the tendons or ACLR graft were missing. A receiver operating characteristic (ROC) analysis was performed to assess the predictability of ST×2 on an ACLR graft with a diameter of ≥8 mm. The effect of including G×2 on the final graft size was reported. Results: A total of 314 patients were included, and the mean diameters of ST×2 and G×2 were 6.5 ± 0.8 mm and 5.0 ± 0.7 mm, respectively. There was a moderate to strong correlation between the diameter of ST×2 and that of G×2 (men: r = 0.678; women: r = 0.654; P <.001 for both). An ST×2 with a diameter <6 mm predicted a 4-stranded ACLR graft of <8 mm (area under the ROC = 0.917; P <.001). When ST×2 was <6 mm, the addition of a G×2 did not result in the ACLR graft's having a diameter of ≥8 mm, regardless of patient sex or G×2 diameter. Conclusion: When the diameter of the doubled semitendinosus was <6 mm, the addition of the doubled gracilis was unlikely to produce a 4-stranded ACLR graft with a diameter of ≥8 mm. Surgeons should consider alternative methods such as tripling or quadrupling the semitendinosus tendon to increase the size of the ACLR graft, rather than routinely harvesting the gracilis tendon. [ABSTRACT FROM AUTHOR]

We examined the effectiveness of occupational therapy intervention combined with standard rehabilitation in patients undergoing high tibial osteotomy (HTO). Overall, 115 patients with HTO for knee osteoarthritis were examined. An intervention group (n = 50), who received occupational therapy and standard rehabilitation, was compared to a control group (n = 65), who underwent standard rehabilitation only (n = 65). Compared with the control group, the intervention group had significantly lower Hospital Anxiety and Depression Scale depression and anxiety scores (both p < 0.05), with between-group differences showing large- and medium-effect sizes, respectively (d = 1.06 and 0.61). Results suggest occupational therapy with rehabilitation during hospitalization improves depression and anxiety rates in patients post-HTO. [ABSTRACT FROM AUTHOR]

Background Knee joint osteoarthritis (OA) is among the most prevalent degenerative diseases of the joints in the body. Various scoring system exists for grading OA, such as (1) magnetic resonance imaging (MRI) Osteoarthritis Knee Score (MOAKS), (2) clinical grading by Western Ontario and McMaster Universities Arthritis Index (WOMAC), and (3) X-ray grading of the Kellgren–Lawrence grading system (K-L). Objectives To study MRI findings and MOAKS scoring of knee OA and correlation with WOMAC and K-L scoring. Setting and Design Cross-sectional study in hospital population. Materials and Methods A total 40 knee OA cases underwent an MRI of the knee. MOAKS scoring was done and compared with K-L grading and WOMAC scores. Statistical Analysis Collected data were compiled systematically and interpreted using IBM SPSS statistics software 25.0. A p -value of less than 0.05 was considered significant. Results The mean total WOMAC score was 9. K-L grade 2 was the most prevalent X-ray grade. Bone marrow lesion (BML) and cartilage loss in MOAKS score were greater in the medial femorotibial region. A moderate positive correlation was noted between the WOMAC score and K-L grade; full-thickness articular cartilage loss score at the medial femorotibial joint (MFTJ) and WOMAC score; partial-thickness articular cartilage loss score at lateral femorotibial joint (LFTJ) and WOMAC total pain score. No correlation was found between BML and pain severity score. Conclusion Higher WOMAC scores were associated with higher grades of K-L scoring and score of cartilage loss (partial and full thickness) of the MOAKS scoring system. The rest of the features of the MOAKS score (BML score, osteophyte, and synovitis) had no significant association with pain severity and K-L grading. [ABSTRACT FROM AUTHOR]

Aims: The primary aims of this study were to determine the time to sonographic correction of decentred hips during treatment with Pavlik harness for developmental dysplasia of the hip (DDH) and investigate potential risk factors for a delayed response to treatment., Methods: This was a retrospective cohort study of infants with decentred hips who underwent a comprehensive management protocol with Pavlik harness between 2012 and 2016. Ultrasound assessments were performed at standardized intervals and time to correction from centring of the femoral head was quantified. Hips with < 40% femoral head coverage (FHC) were considered decentred, and hips with > 50% FHC and α angles > 60° were considered corrected. Survival analyses using log-rank tests and Cox regression were performed to investigate potential risk factors for delayed time to correction., Results: A total of 108 infants (158 hips) successfully completed the bracing protocol and were included in the study. Mean age at treatment initiation was 6.9 weeks (SD 3.8). All included hips centred within two weeks of treatment initiation. At two, five, eight, and 12 weeks following centring of the femoral head, 13% (95% CI 8 to 19), 67% (95% CI 60 to 74), 98% (95% CI 95 to 99), and 99% (95% CI 98 to 100) of hips had cumulatively achieved sonographic correction, respectively. Low α angles at presentation were found to be a risk factor for delayed time to correction (hazard ratio per 1° decrease in α angle 1.04 (95% CI 1.01 to 1.06); p = 0.006)., Conclusion: The majority of decentred hips undergoing Pavlik treatment achieved sonographic correction within eight weeks of centring and radiological severity at presentation was a predictor for slower recovery. These findings provide valuable insights into hip development during Pavlik treatment and will inform the design of future prospective studies investigating the optimal time required in harness., Competing Interests: S. P. Kelley is an unpaid member of the editorial board on the Journal of Pediatric Orthopaedics and an unpaid member of the Medical Advisory Board of the International Hip Dysplasia Institute., (© 2025 Bavan et al.)

Purpose: This study aimed to investigate the development of patellofemoral joint (PFJ) cartilage lesions following anterior cruciate ligament reconstruction (ACLR) using hamstring tendon (HT) autograft through a systematic review., Methods: A comprehensive search was conducted in PubMed, Embase, Cochrane Library and Google Scholar databases to find articles published from database inception until 15 November 2023. The search terms were [('Anterior Cruciate Ligament' [mesh] OR 'anterior cruciate ligament' OR 'ACL') AND 'reconstruction' AND 'cartilage' AND ('second look arthroscopy' OR 'second-look arthroscopy' OR 'MRI' OR 'magnetic resonance imaging')]. Inclusion criteria were studies that reported on the occurrence of PFJ cartilage lesions following ACLR using HT autograft, as determined by second-look arthroscopy or follow-up magnetic resonance imaging (MRI)., Results: Fifteen studies (1084 patients) met the inclusion criteria, with follow-up periods ranging from 1 to 5 years. In the results of second-look arthroscopy, cartilage grade deterioration was observed, ranging from MDs of 0.1 to 2.0 in the patella and from 0 to 1.0 in the trochlea. Follow-up MRI results reported the incidence of PFJ cartilage degeneration with rates ranging from 20% to 44%. Patient-reported outcome measures often showed no significant association with PFJ cartilage lesions. The studies included in this review reported various risk factors for cartilage lesion development., Conclusion: Cartilage lesions in the PFJ, detected using second-look arthroscopy or follow-up MRI, frequently develop shortly after ACLR using HT autograft. At this stage, patients might not show specific symptoms; however, those with risk factors require careful observation and evaluation by clinicians during follow-up., Level of Evidence: Level IV., (© 2024 European Society of Sports Traumatology, Knee Surgery and Arthroscopy.)