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Background: The use of an observer tool (OT) has been shown to improve learning of technical skills through observation in simulation. The objective was to assess the impact of a non-technical OT on anaesthesia residents' learning of non-technical skills (NTS) during simulation., Methods: After consent, residents were randomised into 2 groups: OT+ (with an OT based on NTS to be systematically completed during observation of others) and OT- (without OT). Both groups observed a high-fidelity simulation of crisis management (with or without OT), then were asked to perform actively another simulation. The primary outcome was NTS performance, assessed by an evaluator using the Anaesthesia Non-Technical Skills score (ANTS score out of 16) on video recording. Secondary outcomes were results of score items, satisfaction, team performance, and professional impact., Results: No significant difference was found between OT + group (n = 33) and OT- group (n = 30) for the ANTS score (OT + 12 [9.5-12.5], OT- 10.5 [8.75-12]/16 (p = 0.13)). Among sub-items of the ANTS score, decision-making was significantly better in the OT + group (3 [2-3] versus 2 [2-3], p = 0.01). Satisfaction, team performance and perception of professional impact were not significantly different between groups., Conclusions: This study showed no significant difference in learning of observational anaesthesia resident's NTS whether or not they were provided a non-technical OT during crisis management simulation. Decision-making was better with an OT. Further work is necessary to define the place of OT in observer-based learning., Competing Interests: Declarations. Ethical approval: Approval was obtained from the Research Ethics Committee of the French Society of Anaesthesia and Intensive Care Medicine (SFAR, CERAR: IRB 00010254-2022-068). All participants gave written informed consent. Investigators of the study were not in a position of authority which can significantly affect the career progression of the residents included. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests., (© 2024. The Author(s).)

Background: Snakebite (SB) envenoming is an acute emergency requiring early care delivery. However, sometimes, patients can take several hours before receiving antivenom (AV). We conducted this study to assess the effectiveness of antivenom in the recovery of clotting parameters in patients consulting tardily after SB envenoming in French Guiana. The primary endpoint of our study was to investigate the time needed from SB to recovery from SB-induced coagulopathy. The secondary endpoint was to investigate the time needed from AV administration to recovery from SB-induced coagulopathy in patients receiving AV (late or very late administration)., Methods: This prospective observational study was conducted in the Intensive Care Unit (ICU) of Cayenne General Hospital between January 2016 and September 2023. We included all patients hospitalized for SB envenoming who either did not receive AV or received it more than 6 h after SB. We excluded patients who received antivenom in less than 6 h from the SB and those who received incomplete AV doses., Findings: We included 58 patients in the No AV group, 51 in the late AV group (6 h ≤ AV < 12 h), and 50 in the very late AV group (AV≥12 h). The median age of patients was 42 years (IQR: 29-53), 65.4% were male and 34.6% were female (104 and 55 out of 159 patients) without difference regarding the demographic parameters between groups. Data regarding ethnicity was not available. The median time from SB to AV was 8.5 h (IQR: 6.9-10) in the late AV group and 21.1 h (IQR: 16.7-27.4) in the very late AV group (p < 0.001). The time from SB to normal clotting parameters was shorter in patients receiving late AV than in those receiving very late AV and those not receiving AV. No differences were observed in the time from SB and recovery of fibrinogen and activated partial thromboplastin time (aPTT) between very late AV and no AV. However, the International Normalized Ratio (INR) recovery was shorter in the very late AV group than in the no AV group. On the other hand, the time from AV to normal fibrinogen was shorter in patients receiving very late AV than in patients receiving late AV (Log-Rank = 0.020). Meanwhile, the time from AV to normal INR or normal aPTT was similar in patients receiving very late AV compared to patients receiving late AV (Log-Rank = 0.722 and 0.740, respectively)., Interpretation: Late AV administration effectively reverses coagulopathic manifestations after SB envenoming. However, very late AV administration did not improve the correction of some clotting parameters when compared to patients not receiving AV. Our findings could be explained by the combination of venom toxicokinetics and the kinetics of the synthesis of clotting factors., Funding: No funding., Competing Interests: All authors declare no competing interests., (© 2025 The Authors.)

This study aimed to determine whether the internalization of body ideals and sociocultural pressures to adhere to body ideals are associated with a greater likelihood of having probable muscle dysmorphia. Cross-sectional data from 1553 boys and men ages 15-35 from Canada and the United States were used. Multiple logistic regression analyses determined the association between the internalization of three body ideals, sociocultural pressures to adhere to body ideals from four sources, and having probable muscle dysmorphia. The odds of having probable muscle dysmorphia were significantly greater for those who internalized the muscular ideal and general attractiveness ideal. Conversely, endorsing the thin/low body fat ideal was significantly associated with lower odds of having probable muscle dysmorphia. Pressure from peers, but no other sources, showed a significant association with greater odds of having probable muscle dysmorphia. Findings expand prior research by investigating correlates of muscle dysmorphia versus muscle dysmorphia symptomatology. The strong association with internalization of the general attractiveness ideal provides new insights into how overall appearance may be highly relevant for boys and men with muscle dysmorphia, warranting future investigation., Competing Interests: Declaration of competing interest All authors declare none., (Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α-diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e., γ-diversity), either due to reduced β-diversity amplifying diversity loss or increased β-diversity dampening diversity loss. Additionally, studies often focus on taxonomic diversity, while other important biodiversity components, including phylogenetic diversity, can exhibit differential responses. Here, we evaluated how agricultural and urban land use alters the taxonomic and phylogenetic α-, β-, and γ-diversity of an important pollinator taxon-bees. Using a multicontinental dataset of 3117 bee assemblages from 157 studies, we found that taxonomic α-diversity was reduced by 16%-18% in both agricultural and urban habitats relative to natural habitats. Phylogenetic α-diversity was decreased by 11%-12% in agricultural and urban habitats. Compared with natural habitats, taxonomic and phylogenetic β-diversity increased by 11% and 6% in urban habitats, respectively, but exhibited no systematic change in agricultural habitats. We detected a 22% decline in taxonomic γ-diversity and a 17% decline in phylogenetic γ-diversity in agricultural habitats, but γ-diversity of urban habitats was not significantly different from natural habitats. These findings highlight the threat of agricultural expansions to large-scale bee diversity due to systematic γ-diversity decline. In addition, while both urbanization and agriculture lead to consistent declines in α-diversity, their impacts on β- or γ-diversity vary, highlighting the need to study the effects of land use change at multiple scales., (© 2025 John Wiley & Sons Ltd.)

Cannabis sativa L., known for its medicinal and psychoactive properties, has recently experienced rapid market expansion but remains understudied in terms of its fundamental biology due to historical prohibitions. This pioneering study implements GS and ML to optimize cannabinoid profiles in cannabis breeding. We analyzed a representative population of drug-type cannabis accessions, quantifying major cannabinoids and utilizing high-density genotyping with 250K SNPs for GS. Our evaluations of various models-including ML algorithms, statistical methods, and Bayesian approaches-highlighted Random Forest's superior predictive accuracy for single and multi-trait genomic predictions, particularly for THC, CBD, and their precursors. Multi-trait analyses elucidated complex genetic interdependencies and identified key loci crucial to cannabinoid biosynthesis. These results demonstrate the efficacy of integrating GS and ML in developing cannabis varieties with tailored cannabinoid profiles., (© 2024 The Author(s). The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd.)

Salivary gland tumors represent a diagnostic challenge for pathologists due to their rarity, their very wide histopathological and immuno-phenotypic spectrum, and the recent identification of new entities. This article presents the main molecular characteristics of these tumors in order to allow any pathologist to perceive the diagnostic tracks of these ENT tumors and to better guide the molecular approach to establish the diagnosis and guide therapy., (Copyright © 2024. Published by Elsevier Masson SAS.)