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Introduction and Importance: Minimal invasive surgery is preferred as it offers the same benefit with less tissue damage, especially in the cervical area where a lot of critical structure resides. Mesenchymal stem cells (MSCs) and its secretome provide a promising regenerative intervention to damaged tissue. We report a cervical spinal tuberculosis case with hemiparesis treated with minimally invasive surgery combined with a regenerative approach., Case Presentation: A 13-year-old boy presented with weakness in his left arm and left leg, accompanied by hemiparesthesia. The patient was unable to get up from bed, run, and jumpRadiology examination showed compression fracture, intervertebral disc retropulsion, spinal cord compression, and paravertebral cold abscess. The patient was treated with a single minimal invasive surgery consisting of closed system abscess evacuation, and percutaneous laser disc decompression combined with umbilical cord-derived mesenchymal stem cells., Clinical Discussion: The pain, weakness, and numbness were gone two days after surgery. The patient could carry out normal activities, even doing sports such as mini soccer and badminton. This clinical improvement was obtained as he carried out some procedures. The cold abscess aspiration removed infection focus which prevents further vertebra destruction, PLDD which decompresses the retropulsed discs, and implantation of MSCs and secretomes which regenerate and strengthen the destructed bone and surrounding tissue., Conclusion: Closed system abscess evacuation, and percutaneous laser disc degeneration combined with secretome derived from UC-MSC are minimally-invasive strategies with promising results. Further studies are required to investigate its efficacy., Competing Interests: Declaration of competing interest The authors declare no conflicts of interest., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Introduction and Importance: Degenerative disc disease (DDD) is a common cause of low back pain, often leading to significant discomfort for patients. Current treatment options such as spinal fusion and physical therapy focus on symptom management rather than addressing the underlying degeneration. Percutaneous laser disc decompression (PLDD) has shown efficacy in treating radicular pain associated with disc herniation. However, there is a growing interest in utilizing tissue engineering approaches to reverse the pathological process of DDD. While results in larger vertebrates have been inconsistent, mesenchymal stem cells (MSCs) have demonstrated promise in small animal models., Case Presentation: A 46-year-old male presented with low back pain as well as urinary and fecal incontinence. Magnetic resonance imaging revealed disc bulging and foraminal stenosis at the L2-L4 levels. The patient underwent PLDD combined with umbilical cord-derived mesenchymal stem cells (UC-MSCs) injection, which later resulted in significant pain reduction and improved motor function. At six months of follow-up, the patient reported sustained pain relief and functional improvement., Clinical Discussion: Percutaneous decompression techniques not only substantially reduce intradiscal pressure and facilitate the implosion of herniation inward but also concurrently expedite the degeneration of the intervertebral disc. Therefore, in addition to performing PLDD, stem cell injection is also carried out. This report underscores the importance of integrating mechanical and biological interventions for degenerative disc diseases, suggesting PLDD combined with MSC therapy as a promising strategy for managing DDD and potentially reversing its progression. We found that the patient had decreased pain postoperatively; he no longer complained of pain after six months of follow-up., Conclusion: PLDD combined with UC-MSCs might be an alternative treatment for patients with DDD. In addition to mechanical treatment, biological treatment with MSC injections is believed to be a potent combination for treating degenerative diseases such as DDD., Competing Interests: Declaration of competing interest The authors declare no conflicts of interest., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Introduction: Intraosseous schwannomas or neurilemomas are rare benign neoplasms. Total resection of the intraosseous schwannoma is considered risky in immunocompromised patients, thus minimally invasive vertebroplasty was conducted in this study., Case Report: In this case, we presented A 40-year-old male presented with intermittent back pain for the last two years. Imaging and histopathological examination conclude the diagnosis of intraosseous schwannoma. Vertebroplasty was conducted without the resection of the tumor. Excellent pain improvement and functional outcome were reported on one-year follow-up., Clinical Discussion: Minimally invasive surgery could decrease post-operative pain and morbidity such as atelectasis and venous thrombosis, earlier hospital discharge, and improved cosmetics. We considered the use of minimally invasive vertebroplasty due to HIV infection comorbidities in the subject. Extensive tumor resection in this population could increase the risks of infection significantly thus affecting the outcome of the surgery. The aim of percutaneous vertebroplasty is to increase the stability of the collapsed vertebra and improve the symptoms, especially with severe back pain., Conclusion: Intraosseous schwannoma of the vertebrae could be treated effectively with vertebroplasty with excellent pain improvement and functional outcome., Competing Interests: Conflict of interest statement None declared., (Copyright © 2024. Published by Elsevier Ltd.)

Introduction and Importance: Spinal cord injury (SCI) is a debilitating medical condition that possesses the potential to exert a substantial influence on an individual's quality of life. Traditional treatments involve surgery, however a less invasive alternative is Percutaneous Laser Disc Decompression (PLDD), which offers several advantages over conventional surgery, including reduced invasiveness, shorter hospitalization periods, and faster recovery rates., Case Presentation: A 64-year-old male presented with bilateral limb weakness and back pain. The patient underwent PLDD of L2-3 and L3-4, was followed by the administration of Umbilical Cord-Derived Mesenchymal Stem Cell (UC-MSC) secretomes at multiple sites. Postoperatively, the patient had significant reduction in discomfort (VAS score: 2), improved motor strength, and enhanced postural stability. Monthly assessments demonstrated continued pain reduction, bone rebuilding, and positive outcomes in bone mineral density (BMD) at the 3 and 6-month follow-ups. At one year of follow-up, the patient could walk without walking aid, and there was no complication., Clinical Discussion: PLDD, conducted within 24 h, significantly alleviated the patient's discomfort. Subsequently, UC-MSC secretomes were administered to enhance the regenerative process. This intervention demonstrated safety advantages and, when combined with PLDD, led to increased bone mineral density (BMD) over three to six months, indicating ongoing spine regeneration. The secretome's anti-inflammatory properties further contributed to disc regeneration., Conclusion: We found that PLDD combined with UC-MSC secretomes may help in the regenerative process of SCI. The approach not only provides immediate relief but also contributes to long-term spinal quality improvement, presenting a promising option for those at higher surgical risks., Competing Interests: Declaration of competing interest The authors certify that They have NO affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript., (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)