1. Validation of a Monte Carlo-based dose calculation engine including the 1.5 T magnetic field for independent dose-check in MRgRT.
- Author
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Ruggieri R, Bianchi N, Gurrera D, Naccarato S, Borgese RF, Simone A, Sicignano G, Stavrev P, Stavreva N, Pellegrini R, Rigo M, Ricchetti F, Nicosia L, Giaj-Levra N, Pastorello E, Allegra A, De-Colle C, and Alongi F
- Abstract
Purpose: Adaptive MRgRT by 1.5 T MR-linac requires independent verification of the plan-of-the-day by the primary TPS (Monaco
TM ) (M). Here we validated a Monte Carlo-based dose-check including the magnetostatic field, SciMoCaTM (S)., Methods: M and S were validated first in water, by comparison with commissioning-dosimetry. PDD(2x2cm2 ) through a lung(air)-equivalent virtual-slab was then calculated. Clinical validation retrospectively included 161 SBRT plans, from five patients per-site: Pelvic-Nodes, Prostate, Liver, Pancreas, and Lungs. S-minus-M percentage differences (Δ%) were computed for target- and OARs-related dose-volume metrics. In-phantom dose verification per-patient was performed., Results: γ(2 %,1mm)-passing-rates (PR%) of in-water-computed PDD and transverse-dose-profiles vs. commissioning-dosimetry were (99.1 ± 2.0)% for M, and (99.3 ± 1.5)% for S. Calculated output-factors (OF) were typically within 1 % from measurements, except for OF(1x1cm2 ) which was misestimated by -4.4 % and + 2.2 %, by M and S respectively. Dose spikes (valleys) on the PDD(2x2cm2 ) by S across the lung-equivalent virtual-slab were slightly reduced with respect to M. In clinical plans, S computed higher V95% (p <0.05*, for pancreas and lung) and D2% (p <0.05*, for all sites) for the target, while D%>2% resulted for duodenal D(1cm3 ), in Pancreas-SBRT, and for mean-lung-dose, in Lung-SBRT. All mostly due to the underestimated OF(1x1cm2 ) by M. In-phantom dose verifications showed an average 1% increase in PR% by S vs. M., Conclusions: Beam-model quality in S resulted equivalent to M, thus making S useful both for an independent validation of the same beam-model in M, and for a daily validation of the M-based online approval decisions, without significantly delaying the clinical workflow (2-3 min)., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr. Pellegrini serves as Director of Clinical Science at Elekta AB (Stockholm, Sweden). Prof. Alongi and Dr. Ruggieri received speaker honoraria from Elekta AB. The other authors have no personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article., (Copyright © 2025 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.)- Published
- 2025
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